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MSRFLFTLGAASFRRRWLVLGTWLAVLLGVGLAFVGFRGEPSDNFTIPGTESQRAVEQLQQNLPDFSGAQ TQITIAAPDGTTLTDPRIAAPIDGAVATLNTLPDVAVAAGPAQTRQISEDGRVGLGTVQWTAPIGEVSDG ALTELEKAMQPAIDAGATVEYAGAVFPGYKVAVPHTPEIIGIGVAFLILLITFGAVVAAGLPILTAAIGV GIGALGIFVVAAFVDMPTASLSLALMLGLSCGIDYALFILNRYRNNLLLLMPRQEAAGLAVGTAGGAVVF AALTVIIALCGLSVVGIPFLTYMGVAAAVAVLIAMLIALTLLPALLGFAGGRVAKFIEPPLQPHRPKEVA QVAAYTPQRTMGAAWARFVVRFRKPLLVGGSAALIVIGLPALGMQLGLPSGSSQPESNTSRQAYDLTAEH LGPGFNGPLLVVADLTRATDPNAAQIIASNISREDGVLAATPAGGDQRTAVIQVIPDTGPNDAATADLVA KIRADRDAIEADTGATFLVGGTTASNIDTSDKLATALPIFLVVVVGLAFILLTIAFRAALVPLTSIAGFL LSVFAALGVQVAIFQWGWGADLLGVTPGETISFLPIIALAIIFGLSSDYQVFVVSRIKEELSKGDHGALD AVRSGVGLSARVVTAAALIMFGVFIAFLAAGDPIIKSVGLTLAVGVFLDAFVVRLTLIPAAMAVLGDRMW SRSKWFDRYVPDLDIEGTALEVEHRAPVTASA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5232 | - | - | 100% (732) | putative membrane transport protein |
M. gilvum PYR-GCK | Mflv_0464 | - | 4e-78 | 31.07% (737) | MmpL11 |
M. gilvum PYR-GCK | Mflv_5139 | - | 4e-60 | 29.60% (733) | MMPL domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0208c | mmpL11 | 2e-73 | 30.95% (727) | transmembrane transport protein MmpL11 |
M. tuberculosis H37Rv | Rv0202c | mmpL11 | 2e-73 | 30.95% (727) | transmembrane transport protein MmpL11 |
M. leprae Br4923 | MLBr_02617 | - | 7e-70 | 29.56% (734) | hypothetical protein MLBr_02617 |
M. abscessus ATCC 19977 | MAB_4529 | - | 7e-80 | 32.17% (743) | putative membrane protein, MmpL |
M. marinum M | MMAR_0442 | mmpL11 | 1e-70 | 28.94% (743) | transmembrane transport protein MmpL11 |
M. avium 104 | MAV_4973 | - | 9e-75 | 29.29% (734) | MmpL11 protein |
M. smegmatis MC2 155 | MSMEG_0241 | - | 9e-78 | 29.09% (739) | MmpL11 protein |
M. thermoresistible (build 8) | TH_3087 | - | 4e-81 | 31.04% (741) | PUTATIVE MmpL11 |
M. ulcerans Agy99 | MUL_1092 | mmpL11 | 4e-71 | 29.07% (743) | transmembrane transport protein MmpL11 |
M. vanbaalenii PYR-1 | Mvan_0188 | - | 1e-77 | 30.64% (731) | MmpL11 |
CLUSTAL 2.0.9 multiple sequence alignment Mb0208c|M.bovis_AF2122/97 ----MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAG Rv0202c|M.tuberculosis_H37Rv ----MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAG MMAR_0442|M.marinum_M ----MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAG MUL_1092|M.ulcerans_Agy99 ----MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAG MAV_4973|M.avium_104 ----MMRLSRSLRKYRWLVFAGWLLALVPAVYLALTQSGNLTGGGFDVAG MLBr_02617|M.leprae_Br4923 -----MRLSSYLRRFRWLVFTGWLLALVPAIYLAMTQSGKLTGGGFEVAG MSMEG_0241|M.smegmatis_MC2_155 ----MMRLSSTLRRFRWAVFATWLLLLVPSIYLALNQSSNLTGGGFEVEG Mvan_0188|M.vanbaalenii_PYR-1 ----MLRVSSNLRRFRWAVFAVWLLLLVPSIYLALNQSSHLTGGGFEVEG TH_3087|M.thermoresistible__bu ----MMRLSNALRRYRWAVFSGWVLLLLPSIWLALSGTGQLTGGGFEVAG MAB_4529|M.abscessus_ATCC_1997 ----MMRTSDYLRRYRWLTVAVWLILIVAAVGLVAGRGEKLTGGGFEVAG Mflv_5232|M.gilvum_PYR-GCK MSRFLFTLGAASFRRRWLVLGTWLAVLLG-VGLAFVGFRGEPSDNFTIPG : . : ** .. *: :: : *. ....* : * Mb0208c|M.bovis_AF2122/97 SQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASE Rv0202c|M.tuberculosis_H37Rv SQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASE MMAR_0442|M.marinum_M SQSLQVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGE MUL_1092|M.ulcerans_Agy99 SQSLRVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGE MAV_4973|M.avium_104 SQSLAVHDQLEDLYHDQGGSSLALVAAPRADASYQDMNDAVAQLRRIAAE MLBr_02617|M.leprae_Br4923 SQSLLVHDQLQEQYPDQGAVSLALVAAPRSDASYQDMNDAVALLRRIVSE MSMEG_0241|M.smegmatis_MC2_155 SQSLHVQRQLEEHFPDQGASPLALVAAPRADASYEDMNAAVVHLEKLAAE Mvan_0188|M.vanbaalenii_PYR-1 SQSLYVQRQLEAQFPDQGASPLALVAAPRSDASYDDMTSAVSHLERLAAE TH_3087|M.thermoresistible__bu SQSLRVQHELEDHFPDEGASPLALVAAPRADATFEDMNAAVAFLEQVAAE MAB_4529|M.abscessus_ATCC_1997 SQSLKVHDAMETGFREQGASPLALVAAPRPDATVSDMAAAVDYLKQVAAQ Mflv_5232|M.gilvum_PYR-GCK TESQRAVEQLQQNLPDFSGAQTQITIAAPDGTTLTDPRIAAPIDGAVATL ::* . :: : .. :. :. .:: * *. :. Mb0208c|M.bovis_AF2122/97 LP----GVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIG Rv0202c|M.tuberculosis_H37Rv LP----GVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIG MMAR_0442|M.marinum_M FP----GVSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVG MUL_1092|M.ulcerans_Agy99 FP----GVSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVG MAV_4973|M.avium_104 VP----GTTEIPNPTQRPPQPDRPYVLSVRLDSRN--TSDVAKQLRTKVG MLBr_02617|M.leprae_Br4923 FP----GVSEVPNPTQLPPRPDRPYGVSLRLDDRNSVTSDVAKQLRTKVG MSMEG_0241|M.smegmatis_MC2_155 VP----SVKIVPNPQQPAPQPDRPYVITLQLDFNNTGAVDVAKQLRQKVG Mvan_0188|M.vanbaalenii_PYR-1 VP----SVTVVPTPQQPPPRPDRPYVITLQLDFENTGAVDVAKQLREKVG TH_3087|M.thermoresistible__bu VSD---DVRIKPNPQQPPPRPDRPYVLTLQLDFDNTGAVDVSNQLREKVG MAB_4529|M.abscessus_ATCC_1997 IP----QVSVEPIPPQLTPQPDRPFVVTLRIGFDNTGATDIAKSLRKKIG Mflv_5232|M.gilvum_PYR-GCK NTLPDVAVAAGPAQTRQISEDGRVGLGTVQWTAPIGEVSDGALTELEKAM . . * : .. .* ::: . * : : Mb0208c|M.bovis_AF2122/97 VKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMV Rv0202c|M.tuberculosis_H37Rv VKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMV MMAR_0442|M.marinum_M VEGDKPGQTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIV MUL_1092|M.ulcerans_Agy99 VEGDKPGQTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIV MAV_4973|M.avium_104 IKGDQPGQTANGRVRLYVIGQGALSAAAAANTKHDIAAAEKWNLPVILIV MLBr_02617|M.leprae_Br4923 IKGDQAGRTANGKVRLYVIGQGALSAAVAANSKHDIAEAERWNLPIILIV MSMEG_0241|M.smegmatis_MC2_155 IHGEEPGESQNGKVKFYVIGQGALGAAATQATKHDIAAAEKWNMPIVLIV Mvan_0188|M.vanbaalenii_PYR-1 VDGEEPGEMENGKVRLYVIGQGALGAAATLATKHDIAQAEKWNFPIVLVI TH_3087|M.thermoresistible__bu IDGDRPGETDNGRVRLYVVGQGALGAAASEATKHDIAQAERWNLPIVLII MAB_4529|M.abscessus_ATCC_1997 VHGGQPGQIAGGRVSLYVIGQGALGAAMTEQIAGDIKKAEKWNIPVILIV Mflv_5232|M.gilvum_PYR-GCK QPAIDAGAT-----------VEYAGAVFPGYKVAVPHTPEIIGIGVAFLI . .* .*. . .* .: : ::: Mb0208c|M.bovis_AF2122/97 LVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFG Rv0202c|M.tuberculosis_H37Rv LVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFG MMAR_0442|M.marinum_M LLAVFGSLTAAAIPLALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFG MUL_1092|M.ulcerans_Agy99 LLAVFGSLTAAAIALALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFG MAV_4973|M.avium_104 LLAVFGSLAAAAIPLALGICTVVVTMGLVYLLSAYTTMSVFVTSTVSMFG MLBr_02617|M.leprae_Br4923 LLAVFGSLAAAAVPLALGVCTVVVTMGLVDLVSMHTIMSVFVTSTVSMFG MSMEG_0241|M.smegmatis_MC2_155 LLAVFGSLAAAALPLVLGVCTVVVTMGLVYLLSMFTTMSVFVTSTVSMFG Mvan_0188|M.vanbaalenii_PYR-1 LLAVFGSLAAAAMPLLLGVCTVVVTMGLVFLLSMYTTMSVFVTSTVSMFG TH_3087|M.thermoresistible__bu LLAVFGSLAAAAVPLVLGVCTVVVTMGVVYLLSLVTTMSVFVASTVSMLG MAB_4529|M.abscessus_ATCC_1997 LIAAFGSLAAASLPLLLGVCTVALSVAIVLALSNITTISVFALPTVTMIG Mflv_5232|M.gilvum_PYR-GCK LLITFGAVVAAGLPILTAAIGVGIGALGIFVVAAFVDMPTASLSLALMLG *: .**::.**.:.: . * : : :: . :.. . . *:* Mb0208c|M.bovis_AF2122/97 IALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIAS Rv0202c|M.tuberculosis_H37Rv IALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIAS MMAR_0442|M.marinum_M IALAVDYSLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVVAS MUL_1092|M.ulcerans_Agy99 IALAVDYSLFILMRFREELRSGRQPQEAADAAMATSGLAVVLSGMTVVAS MAV_4973|M.avium_104 IALAVDYSLFILMRFREELRSGRQPREAVDAAMATSGLAVVLSGMTVIAS MLBr_02617|M.leprae_Br4923 IALAVDYSLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVIAS MSMEG_0241|M.smegmatis_MC2_155 IAVAIDYSLFILMRFREELRAGRDQQDAIDAAMATSGLAVALSGLTVIAS Mvan_0188|M.vanbaalenii_PYR-1 IAVAIDYSLFILMRFREELRAGREPEDAADAAMATSGLAVLLSGLTVIAS TH_3087|M.thermoresistible__bu IALAIDYSLFILMRFREELRAGRDVDQAADAAMATSGLAVVLSGLTVIAS MAB_4529|M.abscessus_ATCC_1997 LAVAVDYSLFILMRYREELNSGKNRQEAIAGAMATSGLTVTFSGLTVIAA Mflv_5232|M.gilvum_PYR-GCK LSCGIDYALFILNRYRNNLLLLMPRQEAAGLAVGTAGGAVVFAALTVIIA :: .:**:**** *:*::* :* *:.*:* :* ::.:**: : Mb0208c|M.bovis_AF2122/97 LTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSA Rv0202c|M.tuberculosis_H37Rv LTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSA MMAR_0442|M.marinum_M LSGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSA MUL_1092|M.ulcerans_Agy99 LSGIYLINTPALRSMATGAILAVAVAILTSATLTPAVLATFARAAAKRSA MAV_4973|M.avium_104 LTGIYVINTPALKSMATGAILAVAVAMLTSTTLTPAALATFGRAAAKRSA MLBr_02617|M.leprae_Br4923 LTGIYLINTAALKSMATGAILAVAIAMLASITLTPAALATFGRAAVKRSV MSMEG_0241|M.smegmatis_MC2_155 VTGIYLINTPVLVSMATGAILAVAVAVLTSTTLTPAVLATFGKAAAKRSS Mvan_0188|M.vanbaalenii_PYR-1 VTGIYLINTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSS TH_3087|M.thermoresistible__bu VTGLYLINTPVLRSMATGAVLAVAVAVLAATTLTPAVLATFGRAAARRSS MAB_4529|M.abscessus_ATCC_1997 LAGIYLIGTPALASMASGAIIVVAIAVLTSTTLMPALLAIFGKAAANQSR Mflv_5232|M.gilvum_PYR-GCK LCGLSVVGIPFLTYMGVAAAVAVLIAMLIALTLLPALLGFAGGRVAKFIE : *: ::. . * *. .* :.* :*:* : ** ** *. . ... Mb0208c|M.bovis_AF2122/97 LVHWSRRPA--------STQSWFWSRWVGWVMRRPWITALAASTVLLVMA Rv0202c|M.tuberculosis_H37Rv LVHWSRRPA--------STQSWFWSRWVGWVMRRPWITALAASTVLLVMA MMAR_0442|M.marinum_M LLHWSRRPE--------STQSRFWTRWVGWVMHRPWITALSASVVLLLMA MUL_1092|M.ulcerans_Agy99 LLHWSRRPE--------STQSRFWTRWVGWVMHRPWITALSASVVLLLMA MAV_4973|M.avium_104 LLHWSRRPE--------STQSKFWNRWIGWVMRRPWMSALAASLVLLVMA MLBr_02617|M.leprae_Br4923 LMHWSQRSE--------CTQSLFWTRWVGWVMHRPWISASAASTILIIMA MSMEG_0241|M.smegmatis_MC2_155 YLHWSRRAE--------AAQSRFWTRWTGAVMRRPWASAIAAAILLLVLA Mvan_0188|M.vanbaalenii_PYR-1 YLHWGRGVE--------ATQSKFWSRWTGWVMRRPWVSATAAAAVLLAFA TH_3087|M.thermoresistible__bu YLHWSRRPE--------TTQSPFWTRWTGQVMRRPWVSAAAASAVLLVMA MAB_4529|M.abscessus_ATCC_1997 FLRVSPLRK--------HSIP-FWRKWTQQVMRRPWLSALGASIFLLALA Mflv_5232|M.gilvum_PYR-GCK PPLQPHRPKEVAQVAAYTPQRTMGAAWARFVVRFRKPLLVGGSAALIVIG . : * *:: ..: *: :. Mb0208c|M.bovis_AF2122/97 APATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG Rv0202c|M.tuberculosis_H37Rv APATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG MMAR_0442|M.marinum_M APAASMVLGNSLLRQFDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG MUL_1092|M.ulcerans_Agy99 APAASMVLGNSLLRQFDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG MAV_4973|M.avium_104 APAASMVLGNSLLRQFDSSHEIRAGVGAAAQALGPGALGPIRVLINFPDG MLBr_02617|M.leprae_Br4923 TPVTSMMLGNSLLRQFNSSHEIRAGVAAAAQALGPGALGPVQVLITFPDD MSMEG_0241|M.smegmatis_MC2_155 APAFNMVLGNSMQRQFDPTHEIRGGVNAAADALGPGALGPIRVLVTFPGE Mvan_0188|M.vanbaalenii_PYR-1 APAFSMMLGNSMQRQFDPTHEIRGGVNAAAEALGPGALGPIRVLVTFP-- TH_3087|M.thermoresistible__bu APTVAMELGNSMQRQFEPTHEIRGGVNAAAEALGPGALGPVRVMVSFP-D MAB_4529|M.abscessus_ATCC_1997 APSLQMHVSNSMLRQFDSSHEIRRGIDAAAVAMGPGALGPVQVLLTFKDS Mflv_5232|M.gilvum_PYR-GCK LPALGMQLGLPSGSSQPESNTSRQAYDLTAEHLGPGFNGPLLVVADLTRA * * :. . . :: * . :* :*** **: *: : Mb0208c|M.bovis_AF2122/97 ---GASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSV Rv0202c|M.tuberculosis_H37Rv ---GASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSV MMAR_0442|M.marinum_M ---GASTPAHSQTVGAVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSV MUL_1092|M.ulcerans_Agy99 ---GASTPAHSQTVGAVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSV MAV_4973|M.avium_104 ---GAASPEHSHTVGAVRQRMAQAPNIVSVSPPQFAEDNGSALLSAVLSV MLBr_02617|M.leprae_Br4923 PNTQASSPKHRQTIGAIRNRMLQAKNVMSVAPPQFADNNCSALLGAVLSV MSMEG_0241|M.smegmatis_MC2_155 --GDASSQAATTTIEAVRQQMTKAPSVVSVQPPVVSDDNDSALLSAVLSV Mvan_0188|M.vanbaalenii_PYR-1 --VDDGAEAAAPLLESLRQKMGQAPNTVSVSPPVFGSDGRSALLSAVLSV TH_3087|M.thermoresistible__bu --GAASQPANAGTLDAVRQEISRAPNVVSVSPPVFADDDSSALLSAVLSV MAB_4529|M.abscessus_ATCC_1997 -----PAHAHAQALETAKETIAQAPNIARVSDVSFSTDGHDALISAVLSV Mflv_5232|M.gilvum_PYR-GCK --------TDPNAAQIIASNISREDGVLAATP--AGGDQRTAVIQVIPDT : : . . . : *:: .: .. Mb0208c|M.bovis_AF2122/97 DPEDLGARDTITWMRTQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQP Rv0202c|M.tuberculosis_H37Rv DPEDLGARDTITWMRTQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQP MMAR_0442|M.marinum_M DPEDMGARHTVDWMRSELPQV--AGGAQVDVGGSTALIKDFDDRVSATEP MUL_1092|M.ulcerans_Agy99 DPEDMGARHTVDWMRSELPQV--AGGAQFDVGGSTALIKDFDDRVSATEP MAV_4973|M.avium_104 DPEDMKARETVGWMRAELPKVSEAGTARVDVGGPTALIKDFDDRVSATEP MLBr_02617|M.leprae_Br4923 DPEDLGARETVDWMRTELPKV--PGAAHVNVGGPTALINDFDDRVAKTEP MSMEG_0241|M.smegmatis_MC2_155 DPEDMAAREAIDWMRAELPGVA-GQNATIDVGGPTALIKDFDDRVSATQP Mvan_0188|M.vanbaalenii_PYR-1 DPEDMGARDTVDWMREQLPPVA-GDAARVDVGGPTALIKDFDDRVSQTQP TH_3087|M.thermoresistible__bu DPEDMRARDTIDWLREHLPAAA-GDGARTDVGGPTALIKDFDDEVATTQP MAB_4529|M.abscessus_ATCC_1997 DPEANAARDTVSWLRANVPDALENSGADINVGGPTALLFDYDTRVEHSLL Mflv_5232|M.gilvum_PYR-GCK GPNDAATADLVAKIRADRDAIEADTGATFLVGGTTASNIDTSDKLATALP .*: : . : :* . * ***.** * . .: : Mb0208c|M.bovis_AF2122/97 LVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGW Rv0202c|M.tuberculosis_H37Rv LVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGW MMAR_0442|M.marinum_M LVLAFVALIAFVMLLISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGW MUL_1092|M.ulcerans_Agy99 LVLAFVALIAFVMLLISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGW MAV_4973|M.avium_104 LVLGFVALIAFVMLLVSIHSVFLALKGVLMTLLSVAAAYGSLVMVFQWGW MLBr_02617|M.leprae_Br4923 LMLVFVALIAFVMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGW MSMEG_0241|M.smegmatis_MC2_155 LVFVFVALIAFVMLLVSIRSVVLAFKGVLMTVLSVAAAYGSLVVVFQWGW Mvan_0188|M.vanbaalenii_PYR-1 LVFVFVALIAFVMLLVSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGW TH_3087|M.thermoresistible__bu LVFVFVAVIAFVMLLIAIRSPVLALKGVLMTVLSVAAAYGSLVAVFQWGW MAB_4529|M.abscessus_ATCC_1997 GVFAFVCVLAFVMLLATLRSPVLALKGVVMTVLSVAAAYGSLVIVFQWGW Mflv_5232|M.gilvum_PYR-GCK IFLVVVVGLAFILLTIAFRAALVPLTSIAGFLLSVFAALGVQVAIFQWGW .: .* :**::* :::: .:.:..: :*** ** * * :***** Mb0208c|M.bovis_AF2122/97 ARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQ-T Rv0202c|M.tuberculosis_H37Rv ARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQ-T MMAR_0442|M.marinum_M GERLGFPQLTSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGR-T MUL_1092|M.ulcerans_Agy99 GERLGFPQLTSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGR-T MAV_4973|M.avium_104 LRDLGFAQISSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLHSGN-T MLBr_02617|M.leprae_Br4923 LENLGFTHINSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGH-T MSMEG_0241|M.smegmatis_MC2_155 LEQLGFPRISSLDSTIPPLVLAMTFGLSMDYEIFLLTRIRERFLQTNS-T Mvan_0188|M.vanbaalenii_PYR-1 LADLGFKQISSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTGN-T TH_3087|M.thermoresistible__bu LAPLGFEPISSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTQD-T MAB_4529|M.abscessus_ATCC_1997 LEFLGFHKAN-IDSSIPPLALALTFGLTMDYEIFLLARVRERYLRTGD-C Mflv_5232|M.gilvum_PYR-GCK GADLLGVTPGETISFLPIIALAIIFGLSSDYQVFVVSRIKEELSKGDHGA * * :* :.**: ***: **::*:::*::*. : Mb0208c|M.bovis_AF2122/97 RDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAV Rv0202c|M.tuberculosis_H37Rv RDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAV MMAR_0442|M.marinum_M RDAVAYGVSTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAV MUL_1092|M.ulcerans_Agy99 RDAVAYGVSTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAV MAV_4973|M.avium_104 RDAVAYGVSTSARTITSAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAV MLBr_02617|M.leprae_Br4923 RDAVAYGVSTSARTITSAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAV MSMEG_0241|M.smegmatis_MC2_155 RDAVAYGVSTSARTITSAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAV Mvan_0188|M.vanbaalenii_PYR-1 RDAVAYGVSTSARTITSAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAV TH_3087|M.thermoresistible__bu RDAVAYGVSTSARTITSAALIMIAVFTGFAFAGMPLVAQLGVACAVAIAV MAB_4529|M.abscessus_ATCC_1997 GDAVSYGVRTSARTITSAALIMIAVFIGFAFVGMPLVAQLGVACAVAIAV Mflv_5232|M.gilvum_PYR-GCK LDAVRSGVGLSARVVTAAALIMFGVFIAFLAAGDPIIKSVGLTLAVGVFL *** ** ***.:*:*****:.** .* .* *:: .:*:: **.: : Mb0208c|M.bovis_AF2122/97 DATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--D Rv0202c|M.tuberculosis_H37Rv DATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--D MMAR_0442|M.marinum_M DATIVRLIMVPALMAMFSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--D MUL_1092|M.ulcerans_Agy99 DATIVRLIMVPALMAMFSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--D MAV_4973|M.avium_104 DATVVRLVMVPALMAMFAQWNWWLPPWLSRVLPSVDFDRPLPEVDLG--D MLBr_02617|M.leprae_Br4923 DVTAVRLVLVPTLMAMFAQWNWWLPRWLSRALPAVDFDKPFPPVDLN--E MSMEG_0241|M.smegmatis_MC2_155 DATVVRLVLVPALMAMFDQWNWWLPRWLDKILPEVDFEKPLPKIEVT--D Mvan_0188|M.vanbaalenii_PYR-1 DATIVRLVLVPALMAMFDEWNWWLPRWLDRILPSVDFEKPLPKADIG--D TH_3087|M.thermoresistible__bu DATVVRLVLVPALMAMFDKWNWWLPPWLDRLLPSVDFEKPLPHTDIG--D MAB_4529|M.abscessus_ATCC_1997 DATVVRLVLVPALMAMFDKRNWWLPGWLDHVLPTVDFETPCVDELPGPHS Mflv_5232|M.gilvum_PYR-GCK DAFVVRLTLIPAAMAVLGDRMWSRSKWFDRYVPDLDIEGTALEVEHR--- *. *** ::*: **:: * . *: : :* :*:: . Mb0208c|M.bovis_AF2122/97 VVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGC Rv0202c|M.tuberculosis_H37Rv VVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGC MMAR_0442|M.marinum_M VVVIPEDIAATIPPGADLRMVLKSAAKLKQLAP-DTICVADPLAFTGCER MUL_1092|M.ulcerans_Agy99 VVVIPEDIAATIPPGADLRMVLKSAAKLKQLAP-DTICVADPLAFTGCEG MAV_4973|M.avium_104 VVVIPDDISALTAPSADLRMVLKSAAKLKHLAP-DAICVTDPLAFTGCGR MLBr_02617|M.leprae_Br4923 IVVLPADISATKVPCGDLRMVLKLAAKLKNLAP-DAICVADPLAFTGCGR MSMEG_0241|M.smegmatis_MC2_155 LVIIPDNIAALGPSGSDLRTMVRTAARMKTLAP-QTISVADPLAFSGCT- Mvan_0188|M.vanbaalenii_PYR-1 LVIIPDDISALAPSGSDLRTVVKSAAKLKTLAP-QAITVADPLAFSGCLP TH_3087|M.thermoresistible__bu LVIIPDDISALMPPGSQLRSVVRSAAKLKSLAP-ETITVADPLAFSGCVR MAB_4529|M.abscessus_ATCC_1997 ESALRLQGSGFEEPRIDYHAIAVSAARLKRLADGGTITAPDTQAVLADR- Mflv_5232|M.gilvum_PYR-GCK ---APVTASA---------------------------------------- :. Mb0208c|M.bovis_AF2122/97 DGK----------------------------------------------A Rv0202c|M.tuberculosis_H37Rv DGK----------------------------------------------A MMAR_0442|M.marinum_M VGKGPERIPELVKDG-------LNLAGGTDTAGPGGAAEAKNGSNGQSAA MUL_1092|M.ulcerans_Agy99 VGKGPERIPELVKDG-------LNLAGGTDTAGPGGGAEAKNGSKGQSAA MAV_4973|M.avium_104 TTAAGADPARGLGPGQIPHQVALREEKVGVAAGPGEKTGSNGHTNGSAGA MLBr_02617|M.leprae_Br4923 NNKRSDRVLPGAATQESEEDPAMGKASDSTAALTAAQVGPVTRTNGHWTA MSMEG_0241|M.smegmatis_MC2_155 ----------------------------------------------RPTT Mvan_0188|M.vanbaalenii_PYR-1 CGKISGNRV---------------------------------GRDERITA TH_3087|M.thermoresistible__bu SGEPLGPRIK--------------------------------GGDDGTTV MAB_4529|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_5232|M.gilvum_PYR-GCK -------------------------------------------------- Mb0208c|M.bovis_AF2122/97 LDQVQ-LAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGG Rv0202c|M.tuberculosis_H37Rv LDQVQ-LAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGG MMAR_0442|M.marinum_M RKAVG-LAYRSGIARAMSWAERPVHPVTVWRGRLSIALDALETNASERRA MUL_1092|M.ulcerans_Agy99 RKAVG-LAYRSGIARAMSWAERPVHPVTVWRGRLSIALDALETNASERRA MAV_4973|M.avium_104 KKPAA-RNGRNGIAKAIAGADRPVHPVTLWRGRLSVALDALQTDP----- MLBr_02617|M.leprae_Br4923 RNLVIGLTHRNSITRVMPWSDRPVHPFTLWRSRFSVAIDALEAHIAVQ-- MSMEG_0241|M.smegmatis_MC2_155 RLST----QRAGRPKAHTPG---LHPVTMWRGRLSVAVDALQTEA----- Mvan_0188|M.vanbaalenii_PYR-1 AVTN----RAHGKTVAVKLP---KHPVTMWRGRLDVALDALAVEQ----- TH_3087|M.thermoresistible__bu PVRTGGGGRRAGTAVATRPA---VHPVTLWLDRLEVALDALHTAA----- MAB_4529|M.abscessus_ATCC_1997 -----------------------------WRDNLTVALEALQTSK-NGTD Mflv_5232|M.gilvum_PYR-GCK -------------------------------------------------- Mb0208c|M.bovis_AF2122/97 VQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNS Rv0202c|M.tuberculosis_H37Rv VQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNS MMAR_0442|M.marinum_M GPGGGREPSYRRRSPVETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNS MUL_1092|M.ulcerans_Agy99 GPGSGREPNYRRRSPVETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNS MAV_4973|M.avium_104 -DSGADRPRFRRRSPVETTNVQLPTGDRLLVPTGAEALRLKGYLLMCRNS MLBr_02617|M.leprae_Br4923 -ADAPDQPNYQRCSPVETAHVQLPTGDRLLIPTGAETLRLVSYLIMCRNS MSMEG_0241|M.smegmatis_MC2_155 -DTEQAP--VERRGPVETTNVQLPTGDRLQIPTGAETLRLAGYLIMCRNT Mvan_0188|M.vanbaalenii_PYR-1 -SAGNGEPRIERISPMETTNVLLPTGDRLQIPTGAETLRLKGFLIMSRNT TH_3087|M.thermoresistible__bu -DLDGAP--VERRSPMETTTVQLPTGDRLQIPTGAETVRLMGYLIMCRNS MAB_4529|M.abscessus_ATCC_1997 TDIVEMPGPLSRVTPVEITQVKLPTGQKCVVPTDAEALRMQGLLLMRRNA Mflv_5232|M.gilvum_PYR-GCK -------------------------------------------------- Mb0208c|M.bovis_AF2122/97 SHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLAD Rv0202c|M.tuberculosis_H37Rv SHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLAD MMAR_0442|M.marinum_M SRDYAELADMVEAMEPETAAVVLAGMDRYYCCQPPRRQWIATQLVRRLAD MUL_1092|M.ulcerans_Agy99 SRDYAELADMVEAMEPETAAVVLAGMDRYYCCQPPRRQWIATQLVRRLAD MAV_4973|M.avium_104 RRDYADFADMVDALEPETAAVVLAGMDRYYCCESSRRQWIATQLVRRLAD MLBr_02617|M.leprae_Br4923 IRDYAELADMVDAIEPETAAVVLTELDRYYSCQLPMRQWMATQLVRRLSD MSMEG_0241|M.smegmatis_MC2_155 TKDFEDFARLVDLMDSHTAALVLASMDRYYCGRDPSNRWVATQLVRRLAD Mvan_0188|M.vanbaalenii_PYR-1 ARDYRDFTELVDSMDVDTAADVLAGMDRYYAGQPARAHWVATQLVRRLAE TH_3087|M.thermoresistible__bu ARDYAEFADLVECMDAETAAAVLARMDRYYCGQYPRQHWVATQLVRRLAD MAB_4529|M.abscessus_ATCC_1997 ERDYTEFARLASAMEPRMAAKVLAGIDQHYCVQ-SNQRWVSSQLVRRLAD Mflv_5232|M.gilvum_PYR-GCK -------------------------------------------------- Mb0208c|M.bovis_AF2122/97 PQPSD-LGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR Rv0202c|M.tuberculosis_H37Rv PQPSD-LGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR MMAR_0442|M.marinum_M PHPSD-VDVEWPQPDDKADWEEVRQRCLAVAVAMLEEAR MUL_1092|M.ulcerans_Agy99 PHPSD-VDVEWPQPDDKADWEEVRQRCLAVAVAMLEEAR MAV_4973|M.avium_104 PDPCDYPDDQGPDADAPADWEQIRQRCLAVAVAMLEEAR MLBr_02617|M.leprae_Br4923 PHPVDLTEDQWSDPDNKAEWQDVRQRCLSVAVAMLEEAR MSMEG_0241|M.smegmatis_MC2_155 PQPSDEHDVRMSGPDAAEDWEKVRQRCLSVAVAMLEEAK Mvan_0188|M.vanbaalenii_PYR-1 PLPSDGPDIAAAGADEETEWAKVRQRCLSVAVAMLEETR TH_3087|M.thermoresistible__bu PHPSDVDDDGETESSAVADWDEVRKRCLSVAVAMLEEAR MAB_4529|M.abscessus_ATCC_1997 PKPGD----------GAMECPTVRRQCLSVAVAMLEDAR Mflv_5232|M.gilvum_PYR-GCK ---------------------------------------