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MSEKAEPEQLSIGILATSRKADERRLPIHPAHLSRIGRAVGRRVFLEQGYGSHFGATDDAVSDHVGGVRS RKELIAECDVILLPKVHAEDLAECRTGQIIWGWPHCVQDTGLTQVAIDRKLTLIAFEAMNHWRADGGFGL HVFHKNNELAGYCSVLHATQLAGVTGTYGRRLSAAVLGFGATARGAVTALNALGVDDVHVLTNRDTAAVG SPIHSTQISQMGPEPDAPDRIWADTPDGRIPVAQFLSDKDIVVNCVLQDPNAPLTFVSEEDLSSFAPRSL IIDVSCDVGMGFSWARPTSFARPVVALPNGLLYYAVDHSPSYLWDSATWEISEALLPHLAPLLEGPATWD TMPTLSRAIEIREGVVVNENILTFQHRASAYPHEVSVTAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5223 | - | - | 100% (390) | NAD(P) transhydrogenase subunit alpha |
| M. gilvum PYR-GCK | Mflv_4017 | - | 2e-10 | 21.90% (379) | alanine dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2803 | aldb | 8e-09 | 24.60% (126) | L-alanine dehydrogenase |
| M. tuberculosis H37Rv | Rv2780 | ald | 2e-15 | 24.41% (381) | secreted L-alanine dehydrogenase ALD (40 kDa antigen) (TB43) |
| M. leprae Br4923 | MLBr_01532 | ald | 5e-11 | 22.63% (380) | L-alanine dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3100 | - | 4e-11 | 23.58% (386) | L-alanine dehydrogenase (ALD) |
| M. marinum M | MMAR_1928 | ald | 2e-08 | 20.37% (378) | secreted L-alanine dehydrogenase Ald (40 kDa antigen) |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2154 | ald | 2e-08 | 20.37% (378) | secreted L-alanine dehydrogenase Ald (40 kDa antigen) |
| M. vanbaalenii PYR-1 | Mvan_1044 | - | 0.0 | 83.33% (390) | NAD(P) transhydrogenase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1928|M.marinum_M ---------MRVGIPTETKD-NEFRVAITPAGVAALTKR-GHEVLIQAGA
MUL_2154|M.ulcerans_Agy99 ---------MRVGIPTETKD-NEFRVAITPAGVAALTKR-GHEVLIQVGA
Mb2803|M.bovis_AF2122/97 --------------------------------------------------
Rv2780|M.tuberculosis_H37Rv ---------MRVGIPTETKN-NEFRVAITPAGVAELTRR-GHEVLIQAGA
MLBr_01532|M.leprae_Br4923 ---------MRVGIPTETKN-NEFRVAITPAGVAALTHR-GHEVLVQAGA
MAB_3100|M.abscessus_ATCC_1997 ---------MRVGIPTEIKN-NEYRVATTPAGVAELTRR-GHEVIIQSGA
Mflv_5223|M.gilvum_PYR-GCK MSEKAEPEQLSIGILATSRKADERRLPIHPAHLSRIGRAVGRRVFLEQGY
Mvan_1044|M.vanbaalenii_PYR-1 MPESTEKEQLSIGILAGSRKPDERRLPIHPAHLGRIDRAVASRVFLEHGY
MMAR_1928|M.marinum_M GEGSAISDSDFKAAGAQLISTADQVWADADLLLKVKEPIESEYGRLRRGQ
MUL_2154|M.ulcerans_Agy99 GEGSAISDSDFKAAGAQLISTADQVWADADLLLKVKEPIESEYGRLRRGQ
Mb2803|M.bovis_AF2122/97 --------------------------------------------------
Rv2780|M.tuberculosis_H37Rv GEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQ
MLBr_01532|M.leprae_Br4923 GEGSAIADAEFKAAGAQLISTPEQVWTEVDLLLKVKEPMPAEYVHLRHGQ
MAB_3100|M.abscessus_ATCC_1997 GDGSSISDVDFKAAGAQVINGAEQVWAEADLLLKVKEPIEPEYALMRRGQ
Mflv_5223|M.gilvum_PYR-GCK GSHFGATDDAVSDHVGGVR-SRKELIAECDVILLP-KVHAEDLAECRTGQ
Mvan_1044|M.vanbaalenii_PYR-1 GSRFGATDAGLSDHVGGIR-TREELFAECDVILLP-KVQAEDLAECSVGQ
MMAR_1928|M.marinum_M TLFTYLHLAASRPCTDALLKSGTTSIAYETVQTADG----ALPLLAPMSE
MUL_2154|M.ulcerans_Agy99 TLFTYLHLAASRPCTDALLKSGTTSIAYETVQTADG----ALPLLAPMSE
Mb2803|M.bovis_AF2122/97 -----------------------------------------------MSE
Rv2780|M.tuberculosis_H37Rv ILFTFLHLAASRACTDALLDSGTTSIAYETVQTADG----ALPLLAPMSE
MLBr_01532|M.leprae_Br4923 ILFTYLHLAASRPCTDALLASGTTSIAYETVQTADG----ALPLLAPMSE
MAB_3100|M.abscessus_ATCC_1997 TLFTYLHLAASLPCTQALLKSETTSIAYETVQTSDG----ALPLLAPMSE
Mflv_5223|M.gilvum_PYR-GCK IIWGWPHCVQDTGLTQVAIDRKLTLIAFEAMNHWRADGGFGLHVFHKNNE
Mvan_1044|M.vanbaalenii_PYR-1 IVWGWPHCVQDADLTQVAIDRKLTLVAFEAMNHWRPDGGFSLHVFHKNNE
.*
MMAR_1928|M.marinum_M VAGRLSAQAGAYHLMRTHGGRG-VLMGGVPGVKP-ADVVVIGAGTAGYNA
MUL_2154|M.ulcerans_Agy99 VAGRLSAQAGAYHLMRTHGGRG-VLMGGVPGVKP-ADVVVIGAGTAGYNA
Mb2803|M.bovis_AF2122/97 VAGRLAAQVGAYHLMRTQGGRG-VLMGGVPGVEP-ADVVVIGAGTAGYNA
Rv2780|M.tuberculosis_H37Rv VAGRLAAQVGAYHLMRTQGGRG-VLMGGVPGVEP-ADVVVIGAGTAGYNA
MLBr_01532|M.leprae_Br4923 VAGRLSAQVGAYHLMRTHRGCG-VLMGGVPGVEP-ADVVVIGGGTAGYNA
MAB_3100|M.abscessus_ATCC_1997 VAGRLAAQVGAYHLMTPVGGRG-LVMGGVPGVGP-ADVVVIGGGVAGYNA
Mflv_5223|M.gilvum_PYR-GCK LAG-YCSVLHATQLAGVTGTYGRRLSAAVLGFGATARGAVTALNALGVDD
Mvan_1044|M.vanbaalenii_PYR-1 LAG-YCSVLHSTQLAGVTGSYGRRLSAAILGFGATARGAVTALNALGVDD
:** .: : :* * : ..: *. . * .* . .. * :
MMAR_1928|M.marinum_M ARVANGMGAMVTVLDVNINKLRQIDAEFGGRVRTRYSS---TLDLEDAAV
MUL_2154|M.ulcerans_Agy99 ARVANGMGAMVTVLDVNINKLRQIDAEFGGRVRTRYSS---TLDLEDAAV
Mb2803|M.bovis_AF2122/97 ARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSS---AYELEGAVK
Rv2780|M.tuberculosis_H37Rv ARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSS---AYELEGAVK
MLBr_01532|M.leprae_Br4923 ARIANGMGATVTVFDVNINRLRELDAEFGGRLRTRYSS---AYDLEGAVK
MAB_3100|M.abscessus_ATCC_1997 ARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSS---TMELEGAVK
Mflv_5223|M.gilvum_PYR-GCK VHVLTNRDTAAVGSPIHSTQISQMGPEPDAPDRIWADTPDGRIPVAQFLS
Mvan_1044|M.vanbaalenii_PYR-1 VHVLTNRDTAAVGSPIHSTQISQMGRDEGAPDRIWADVPDGRVPLAQFLA
.:: . .: .. :: :: ::. : . : . :
MMAR_1928|M.marinum_M NADLLIGAVLVPGAKAPKLIPNSLVARMKKGAVLVDISIDQGGCFEDSRP
MUL_2154|M.ulcerans_Agy99 NADLLIGAVLVPGAKAPKLIPNSLVARMKKGAVLVDISIDQGGCFEDSRP
Mb2803|M.bovis_AF2122/97 RADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRP
Rv2780|M.tuberculosis_H37Rv RADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRP
MLBr_01532|M.leprae_Br4923 HADLVIGAVLVPGAKAPRLISNSLVAHMKPGAVLVDIAIDQGGCFEDSQP
MAB_3100|M.abscessus_ATCC_1997 RADLVIGAVLIPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRP
Mflv_5223|M.gilvum_PYR-GCK DKDIVVNCVLQDPNAPLTFVSEEDLSSFAPRSLIIDVSCDVGMGFSWARP
Mvan_1044|M.vanbaalenii_PYR-1 DRDIVVNCVLQDPNAPLIFATEDDLSSFAPRSLIVDVSCDVGMGFSWARP
*:::..** . : .:. :: : ::::*:: * * * ::*
MMAR_1928|M.marinum_M TTHTSPTFTVH-DTVFYCVANMPGAAPRTSTYALTNATMPYVLKLADLGW
MUL_2154|M.ulcerans_Agy99 TTHTSPTFTVH-DTVFYCVANMPGAAPRTSTYALTNATMPYVLKLADLGW
Mb2803|M.bovis_AF2122/97 TTYDHPTFAVH-DTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGW
Rv2780|M.tuberculosis_H37Rv TTYDHPTFAVH-DTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGW
MLBr_01532|M.leprae_Br4923 TTHDQPTFAVH-DTLFYCVANMPSAVPKTSTFALTNATMPYILKLADQGW
MAB_3100|M.abscessus_ATCC_1997 TTHDEPTYTVH-DSVFYCVANMPGAVPRTSTFALTNATMPYVLALADKGW
Mflv_5223|M.gilvum_PYR-GCK TSFARPVVALPNGLLYYAVDHSPSYLWDSATWEISEALLPHLAPLLEG--
Mvan_1044|M.vanbaalenii_PYR-1 TSFARPVVTLPNDVLYYAVDHSPSYLWDSATWEISEALLPHLRPLLEG--
*:. *. :: . ::*.* : *. ::*: :::* :*:: * :
MMAR_1928|M.marinum_M QAACLSDSALAKGLSTHEGALLADHVAADLDLPFTDPANVLG---
MUL_2154|M.ulcerans_Agy99 QAACLSDSALAKGLSTHEGALLADHVAADLDLPFTDPASVLG---
Mb2803|M.bovis_AF2122/97 RAACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA---
Rv2780|M.tuberculosis_H37Rv RAACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA---
MLBr_01532|M.leprae_Br4923 QEACQSDPALAKGLSTHNGALLSEQVATDLGLAFTEPASVLA---
MAB_3100|M.abscessus_ATCC_1997 RQACRDDAALAQGLSTHEGALLNTHVAHDLGLAFTDPAEVLG---
Mflv_5223|M.gilvum_PYR-GCK PATWDTMPTLSRAIEIREGVVVNENILTFQHRASAYPHEVSVTAR
Mvan_1044|M.vanbaalenii_PYR-1 PATWAVTPTIARAIEIHDGVVLNEDILSYQHRDSAYPHEVGTGHR
: .::::.:. ::*.:: : : * .*