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VQEETTQEKTSKPERGTIYAAHLRSSAVVAVQFIAVAAALWVLAWVLGKTWVVVLPLALALVVCTVLWPP VRWLRNKGVPPAAAVLVVLLLAVGVLAGVVAAVAPAIVEQSQELAEQATAGIVQVRDWLGGPPLNISEAQ LNSGVAAITDRLNSSSAQIASGVFTGVGAATSALVTLFAAIVVTFFFLKDGPGFIPWLRRTVGQPAAPHL AEVLDRVWTTLGGFIRTQALVSFVDAVLIGIGLVVLGVPLAYALAIITFIGGFIPIVGAFVAGGLAVLIA LVSNGPVDALIVLGIIVAVQQLEGNVLQPWLQSKSMKLHAVIVLLAVTLGASTFGVIGAFLAVPVAAAAA VMIRYYGEQVGRAAGEDPPPEAAEDENTEDENTEDDGAAVVKT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4850 | - | - | 100% (394) | hypothetical protein Mflv_4850 |
| M. gilvum PYR-GCK | Mflv_0457 | - | 1e-55 | 33.61% (366) | hypothetical protein Mflv_0457 |
| M. gilvum PYR-GCK | Mflv_2069 | - | 1e-10 | 23.61% (360) | hypothetical protein Mflv_2069 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0211 | - | 8e-54 | 36.45% (332) | transmembrane protein |
| M. tuberculosis H37Rv | Rv0205 | - | 2e-53 | 36.14% (332) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4521c | - | 1e-47 | 30.42% (355) | hypothetical protein MAB_4521c |
| M. marinum M | MMAR_0445 | - | 2e-50 | 31.54% (371) | transmembrane protein |
| M. avium 104 | MAV_4969 | - | 1e-55 | 33.70% (359) | hypothetical protein MAV_4969 |
| M. smegmatis MC2 155 | MSMEG_0249 | - | 3e-55 | 33.54% (325) | integral membrane protein |
| M. thermoresistible (build 8) | TH_1309 | - | 7e-40 | 37.26% (263) | integral membrane protein |
| M. ulcerans Agy99 | MUL_0177 | - | 4e-08 | 22.19% (347) | hypothetical protein MUL_0177 |
| M. vanbaalenii PYR-1 | Mvan_0195 | - | 4e-54 | 33.15% (362) | hypothetical protein Mvan_0195 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0249|M.smegmatis_MC2_155 ---------MALDPVADEAVSPLVRKAAAWSWRLLIIGGAIVALLWLIKR
Mvan_0195|M.vanbaalenii_PYR-1 -----MSAGPCFDTFADDSVSPLVRKAAAWSWRLLLILGAIVTLLWLILR
TH_1309|M.thermoresistible__bu --------------------------------------------------
Mb0211|M.bovis_AF2122/97 ----------MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNK
Rv0205|M.tuberculosis_H37Rv ----------MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNK
MMAR_0445|M.marinum_M ----------MSASLDDASVAPLVRKTAAWSWRLLVILAALVALLLVIKK
MAV_4969|M.avium_104 ----------MSANVDDASVEPIVRKTAAWAWRLLVILAAALALFWVLAK
MAB_4521c|M.abscessus_ATCC_199 ----------MTHADAAESVHPYVRKGAAWAWRLLVLLAFGLTVLWLFWH
Mflv_4850|M.gilvum_PYR-GCK MVQEETTQEKTSKPERGTIYAAHLRSSAVVAVQFIAVAAALWVLAWVLGK
MUL_0177|M.ulcerans_Agy99 -------------------MNTEFTLSQKRALAIVTLAALLFGAYFLRSY
MSMEG_0249|M.smegmatis_MC2_155 LEILFVPVALATMVAALLLPAVDFMDR--RGAPRGSAVALVLLGGIAVVG
Mvan_0195|M.vanbaalenii_PYR-1 LEIIVVPVALATILAALLLPVVDFLDR--RGAPRGGAVALVLLSGFALFG
TH_1309|M.thermoresistible__bu --------------------------------------------------
Mb0211|M.bovis_AF2122/97 FEVIVVPVLLALMLSALLVPPVDWLDS--RGLPRAVAVTLVLLSGFAVLG
Rv0205|M.tuberculosis_H37Rv FEVIVVPVLLALMLSALLVPPVDWLDS--RGLPHAVAVTLVLLSGFAVLG
MMAR_0445|M.marinum_M LEIIVVPVLLALMLSALLVPVVDWLDA--RGLPRGAAVSLVLLGGFSILG
MAV_4969|M.avium_104 LEVIVVPVLVALLLSALLVPVVDWLDR--HGLPRGGAVALVLLGGFAILG
MAB_4521c|M.abscessus_ATCC_199 LKTITIPLLLALMGSALLVPTVNFLQR--HKIPRSLAVVVVLLTGTAAIV
Mflv_4850|M.gilvum_PYR-GCK TWVVVLPLALALVVCTVLWPPVRWLRN--KGVPPAAAVLVVLLLAVGVLA
MUL_0177|M.ulcerans_Agy99 FVLIVVAAVGAYLFTPLFNWFNKRLNAGLSATLTLLTALVVVIVPVGLLV
MSMEG_0249|M.smegmatis_MC2_155 GILTFVVTQFIQGAP------DLVEQMTRSIDGVRNWLIDGPLHLSKEQI
Mvan_0195|M.vanbaalenii_PYR-1 GLLAFVITQFVEGAP------ALVGQVTTSIEGVGTWLTDGPLDVSPQQI
TH_1309|M.thermoresistible__bu ---------------------------------VQDWLIEGPFKLSRDQI
Mb0211|M.bovis_AF2122/97 GILTFVVSQFIAGLP------HLVTEVERSIDSARRWLIEGPAHLRGEQI
Rv0205|M.tuberculosis_H37Rv GILTFVVSQFIAGLP------HLVTEVERSIDSARRWLIEGPAHLRGEQI
MMAR_0445|M.marinum_M GILTFVISQFIVGLP------DLAYQVEHSIDSSRKWLIEGPPHLRREQI
MAV_4969|M.avium_104 GILAFVVLQFIDGLP------GLTEQVTQSIESTRRWLINGPAHLRSEQI
MAB_4521c|M.abscessus_ATCC_199 GILTFVVDQFIKGLP------DLSAQLTNSIESLKNWAIHSRFHISEDQI
Mflv_4850|M.gilvum_PYR-GCK GVVAAVAPAIVEQSQ------ELAEQATAGIVQVRDWLGGPPLNISEAQL
MUL_0177|M.ulcerans_Agy99 GLAVVQIARMVENIAGWVKTTDLSSLGDKALQLVNELLARVPFLHVTVTA
MSMEG_0249|M.smegmatis_MC2_155 DSAGNTAIEALQRNQEKVTTGALSTAGTLTELLTGAVLTLFTLIFLLQGG
Mvan_0195|M.vanbaalenii_PYR-1 NQLRDAAIEALRSNQEKLTSGALSTAGTVTEIVTGALLVLFTLIFLLHGG
TH_1309|M.thermoresistible__bu DQAGTAAIEALRNNQERLTSGALSTATTITEILAGAVLALFTLIFLLHGG
Mb0211|M.bovis_AF2122/97 DNAGNAAIEALRNNQAKLTSGALSTAATITELVTAAVLVLFTLIFFLYGG
Rv0205|M.tuberculosis_H37Rv DNAGNAAIEALRNNQAKLTSGALSTAATITELVTAAVLVLFTLIFFLYGG
MMAR_0445|M.marinum_M DNAGNAAIEALHNNQAKLTSGAISTAATITELLTAAVLVLFTLIFFLYGG
MAV_4969|M.avium_104 DSAGNAAIEALHNNQAKLTSGALSTAATVTELVTAAVLVLFTLIFFLYGG
MAB_4521c|M.abscessus_ATCC_199 GKAGDALVNTIKDNQGRVTSGALATATTVTEIITGAVLTLFTTIFFLYGG
Mflv_4850|M.gilvum_PYR-GCK NSGVAAITDRLNSSSAQIASGVFTGVGAATSALVTLFAAIVVTFFFLKDG
MUL_0177|M.ulcerans_Agy99 EALRQMMISVAQNVGLWLLHFLQNAAGSLAGAVTSGIIFLYVFMALLLNC
. . : . : : :. . : . : :* .
MSMEG_0249|M.smegmatis_MC2_155 RNIFAFVTKAFPEDVRERVRDAGRAGFHSLIGYVRATFLVALVDAIGIGT
Mvan_0195|M.vanbaalenii_PYR-1 RNIFAFVTKMFPVHVRDRVRDAGRAGFRSLIGYIRATFLVALVDATGIGV
TH_1309|M.thermoresistible__bu RNIFAFITLPFPPEVRERVRDAGRAGFRSLVGFVRATFAVALVDAIGIGA
Mb0211|M.bovis_AF2122/97 RSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARATFLVALTDAAGVGA
Rv0205|M.tuberculosis_H37Rv RSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARATFLVALTDAAGVGA
MMAR_0445|M.marinum_M RNIWQYVAKIIPAHVRDRAMAAGRAGYGSLIGYVRATFLVALTDAAGVGT
MAV_4969|M.avium_104 RNIWRYVVQIVPAHARERVHEAGSAGYGSLIGYVRATFLVALTDAAGVGA
MAB_4521c|M.abscessus_ATCC_199 KEIWEFVTRIFPTAVRPRVRRAGVLGFGSLIGYVRATVAVALVDAIGIGV
Mflv_4850|M.gilvum_PYR-GCK PGFIPWLRRTVGQPAAPHLAEVLDRVWTTLGGFIRTQALVSFVDAVLIGI
MUL_0177|M.ulcerans_Agy99 EKLRTLIGQLNPLGEEVTDLYLRKMG-SMVRGTVIGQFVIALCQGVAGAA
: : : * ::: :. .
MSMEG_0249|M.smegmatis_MC2_155 GLAIMGIPLALPLASLVFLG-AFVPLVGAVIAGFLAVVVALLAKGLVYAL
Mvan_0195|M.vanbaalenii_PYR-1 GLAIMGVPLALPLASLVFLG-AFIPLVGAVVTGFLAVIVALIAKGWIYAL
TH_1309|M.thermoresistible__bu GLAILGVPLALPLASLVFLG-AFIPLIGAFVTGFLAVVVALIAKGFIYAL
Mb0211|M.bovis_AF2122/97 GLAVMGVPLALPLASLVFFG-AFIPLIGAVVAGFLAVVVALLAKGIGYAL
Rv0205|M.tuberculosis_H37Rv GLAVMGVPLALPLASLVFFG-AFIPLIGAVVAGFLAVVVALLAKGIGYAL
MMAR_0445|M.marinum_M GLAVMGVPLALPLASIVFLG-AFIPLIGALISGLLAVVVALLAKGLVYAL
MAV_4969|M.avium_104 GLAIMGIPLALPLASLVFLG-AFIPLVGAVVAGFLAVVVALLAKGIVYAL
MAB_4521c|M.abscessus_ATCC_199 GLAAFSVPLALPLASLVFLG-AFIPIIGAAISGFVAVFIALITKGAFTAA
Mflv_4850|M.gilvum_PYR-GCK GLVVLGVPLAYALAIITFIG-GFIPIVGAFVAGGLAVLIALVSNGPVDAL
MUL_0177|M.ulcerans_Agy99 SIYVAGFHHGFFIFAIVLTAMSIIPLGGGIVTIPFGIGMAFYGNIGGGAF
.: .. . : :.: . .::*: *. :: ..: :*: : *
MSMEG_0249|M.smegmatis_MC2_155 ITLGLIIAVQQLEGHVLQPLVMGRAVSIHPLAVVLAIAGGGVLAGIVGAL
Mvan_0195|M.vanbaalenii_PYR-1 ITLGLIIAVQQLEGHVLQPLVMGRAVAIHPLAIVLAIAGGGVLAGIVGAL
TH_1309|M.thermoresistible__bu ITLGLIVAVQQLEGHVLQPLIMGYAVRIHPLAIVLAIGAGGVLAGIIGAL
Mb0211|M.bovis_AF2122/97 ITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGAL
Rv0205|M.tuberculosis_H37Rv ITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGAL
MMAR_0445|M.marinum_M LTLALLITVNQLEAHLLQPLVMGRAVSIHPLGVVLAISTGGVLAGIVGAL
MAV_4969|M.avium_104 ITLGLLVAVNQIEAHLLQPLVMGRAVSIHPLAVVLAISTGGVLAGIVGAL
MAB_4521c|M.abscessus_ATCC_199 MILVIVIVVMQVEGHVLQPLIMGHAVQIHALAVVLAIAAGGVLGGIIGAL
Mflv_4850|M.gilvum_PYR-GCK IVLGIIVAVQQLEGNVLQPWLQSKSMKLHAVIVLLAVTLGASTFGVIGAF
MUL_0177|M.ulcerans_Agy99 VVLWHLLVVTNIDN-FLRPVLVPRDARLNSALMLTSAFAGIGMFGPWGII
: : ::.* ::: .*:* : ::. :: : * * * :
MSMEG_0249|M.smegmatis_MC2_155 LAVPAVAFLNSATRVLLA----RDPHAEEE---ALVAESTTIIAAESDDL
Mvan_0195|M.vanbaalenii_PYR-1 LAVPALAFVNSAMRVLLA----EDPAAEEA---AMEAEDGPVVRAEPDDV
TH_1309|M.thermoresistible__bu LAVPIMAFVNSAGRVLLA----PDPAREEA---ELEAEEGPLIGAEPDPV
Mb0211|M.bovis_AF2122/97 LAVPTAAFFNNAVQVLLG----GNPFADVA---DVSSDHLTEV-------
Rv0205|M.tuberculosis_H37Rv LAVPTVAFFNNAVQVLLG----GNPFADVA---DVSSDHLTEV-------
MMAR_0445|M.marinum_M LAVPTVAFLNNAMRVLLA----EDPIAEAQ---QQDQDPLALIAAQPDEP
MAV_4969|M.avium_104 LAVPTVAFLNNAFQVLLA----PNPSAEAVKQEEESDEQNTILQAEPDKP
MAB_4521c|M.abscessus_ATCC_199 LAVPTVAVLNTAIRALIEPFDADDPYLREGEEEAEVLDPEMVPDGGPSAL
Mflv_4850|M.gilvum_PYR-GCK LAVPVAAAAAVMIRYYGEQVG--RAAGEDPPPEAAEDENTEDENTEDDGA
MUL_0177|M.ulcerans_Agy99 IGPVLMILIVTTIDVYLVVYKGVELKDRSAKPARRNWLPRRTGNAPANAA
:.
MSMEG_0249|M.smegmatis_MC2_155 PERE-------------------------
Mvan_0195|M.vanbaalenii_PYR-1 ETPQE------------------------
TH_1309|M.thermoresistible__bu DDAEPVPAGDAEPAPAGDAEPDPPERAGD
Mb0211|M.bovis_AF2122/97 -----------------------------
Rv0205|M.tuberculosis_H37Rv -----------------------------
MMAR_0445|M.marinum_M DEGTEAEAGADQTRP--------------
MAV_4969|M.avium_104 ENGSG------------------------
MAB_4521c|M.abscessus_ATCC_199 GAKPGNGVPELGPAPPKD-----------
Mflv_4850|M.gilvum_PYR-GCK AVVKT------------------------
MUL_0177|M.ulcerans_Agy99 TDSTAQ-----------------------