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TPDQLDAFGKELDALKESVIADLGERDATYIRRMIKAQRGLEIGGRALLFGGIFPPFWLAGTTMLGLSKI IDNMEIGHNVMHGQYDWMGDPAISSKGFEWDTACPADQWRHSHNYMHHTYTNIVGLDRDIGYGILRMSSD QKWRPYYLGNPVYAFLLMVLFQYGVALHEMESEKIAAGEITLTDKREILREIWAKTKRQTLKDYVAFPLL AGPFAPWVFAGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAETRGQWYFRQVLGSANLTGGKLFH ILSGNLSFQIEHHLFPDIPAFRHAEIAPKVREICERYGVPYNTGPLPRQFASVVRKIVKFALPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4814 | - | - | 100% (345) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_5246 | - | e-102 | 45.69% (394) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_4698 | - | 5e-97 | 47.41% (348) | fatty acid desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 4e-95 | 47.70% (348) | linoleoyl-CoA desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 4e-95 | 47.70% (348) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1587c | - | 1e-130 | 59.88% (339) | fatty acid desaturase |
| M. marinum M | MMAR_0336 | desA3_2 | 1e-175 | 83.04% (342) | linoleoyl-CoA desaturase, DesA3_2 |
| M. avium 104 | MAV_5167 | - | 1e-169 | 79.36% (344) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1743 | - | 1e-176 | 82.32% (345) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 5e-98 | 48.85% (348) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. ulcerans Agy99 | MUL_4785 | desA3_2 | 1e-172 | 81.58% (342) | linoleoyl-CoA desaturase, DesA3_2 |
| M. vanbaalenii PYR-1 | Mvan_1628 | - | 0.0 | 94.20% (345) | fatty acid desaturase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4814|M.gilvum_PYR-GCK --------------------------------MTPDQLDAFGKELDALKE
Mvan_1628|M.vanbaalenii_PYR-1 MTEVLETPTTPTQQTTPTQQTITKTVAGKTVTLTPEQAEAFGRELDALKD
MSMEG_1743|M.smegmatis_MC2_155 -------------MSTP------------TYTLTPDQAEEFGRELDAIRE
MMAR_0336|M.marinum_M ----------MGNNNIATIAETADTATRANFALTPEQAEAFGRELDAIKE
MUL_4785|M.ulcerans_Agy99 ----------MGNNNIATIAETADTATRANFALTPEQAEAFGRELDAIKE
MAV_5167|M.avium_104 ----------MTHNKIT---------------LTPEQAEEFGRELDALKE
MAB_1587c|M.abscessus_ATCC_199 ----------MTSNEIT---------------ISAADIEALGKDLDELRD
Mb3258c|M.bovis_AF2122/97 ----------MAITDVD-----------VFAHLTDADIENLAAELDAIRR
Rv3229c|M.tuberculosis_H37Rv ----------MAITDVD-----------VFAHLTDADIENLAAELDAIRR
TH_0650|M.thermoresistible__bu ----------MAITDVP-----------AYAHLTEVDIDALAVELDAIRR
:: : : :. :** ::
Mflv_4814|M.gilvum_PYR-GCK SVIADLGERDATYIRRMIKAQRGLEIGGRALLFGGIFPPFWLAGTTMLGL
Mvan_1628|M.vanbaalenii_PYR-1 SVIADLGERDATYIRKMIKAQRGLEIGGRALLFGGIFPPFWLAGTAMLGL
MSMEG_1743|M.smegmatis_MC2_155 RVIADLGERDATYIRNVIKAQRTLEVGGRALLFGGIFPPFWLAGTAMLAV
MMAR_0336|M.marinum_M RVIADLGEADADYIRRVIKAQRALEVGGRALLFAGILPPAWLAGTAMLGL
MUL_4785|M.ulcerans_Agy99 RVIADLGEADADYIRRVIKAQRALEVGGRALLFAGILPPTWLAGTAMLGL
MAV_5167|M.avium_104 RVMADLGEKDADYIRRVIKAQRALEVGGRALLF---LPPAWLLGTTMLGL
MAB_1587c|M.abscessus_ATCC_199 RIVADLGDRDREYIYSIIKTQRGCEVAGRALMYLGFIPPVWLAAVGALSV
Mb3258c|M.bovis_AF2122/97 DVEESRGERDARYIRRTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGV
Rv3229c|M.tuberculosis_H37Rv DVEESRGERDARYIRRTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGV
TH_0650|M.thermoresistible__bu DIEDSLGERDARYIRRTIATQRGLEVAGRLLLAASSRRSAWWAGAVTLAA
: . *: * ** * :** *:.** *: * .. *.
Mflv_4814|M.gilvum_PYR-GCK SKIIDNMEIGHNVMHGQYDWMGDPAISSKGFEWDTACPADQWRHSHNYMH
Mvan_1628|M.vanbaalenii_PYR-1 SKIIDNMEIGHNVMHGQYDWMGDPAISSKGFEWDTACPADQWRHSHNYMH
MSMEG_1743|M.smegmatis_MC2_155 SKILDNMEIGHNVMHGQYDWMGDPALSSKTFEWDTACPADQWRHSHNYMH
MMAR_0336|M.marinum_M SKILDNMEIGHNVMHGQYDWMRDPAISGRSFEWDTACPADQWRHSHNYMH
MUL_4785|M.ulcerans_Agy99 SKILDNMEIGHNVMHDQYDWMRDPAISGRSFEWDTACPADQWRHSHNYMH
MAV_5167|M.avium_104 SKILDNMEIGHNVMHGQYDWMRDPAISGRSFEWDTACPADQWRHSHNYMH
MAB_1587c|M.abscessus_ATCC_199 SKILDNMEIGHNVMHGQYDWMREKGLNSREFEWDTVCPADQWRHSHNYMH
Mb3258c|M.bovis_AF2122/97 AKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMSGSSKHWRYTHNFVH
Rv3229c|M.tuberculosis_H37Rv AKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMSGSSKHWRYTHNFVH
TH_0650|M.thermoresistible__bu AKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMTGASKHWRFTHNFMH
:**::**********.*:*** : : . :*** .:.:**.:**::*
Mflv_4814|M.gilvum_PYR-GCK HTYTNIVGLDRDIGYGILRMSSDQKWRPYYLGNPVYAFLLMVLFQYGVAL
Mvan_1628|M.vanbaalenii_PYR-1 HTYTNIVGLDRDIGYGILRMSSDQKWRPYYLGNPVYAFLLMVLFQYGVAL
MSMEG_1743|M.smegmatis_MC2_155 HTYTNIVDMDRDIGYGILRMSPDQKWSPYYLGNPVYAFLLMVLFQYGVAL
MMAR_0336|M.marinum_M HTHTNIVGMDRDIGYGIIRMSEDQPWQPYYLGNPVYAFLLMVLFQYGVAL
MUL_4785|M.ulcerans_Agy99 HTHTNILGMDRDIGYGIIRMSEDQPWQPYYLGNPVYAFLLMVLFQYGVAL
MAV_5167|M.avium_104 HTHTNIVGMDRDIGYGILRMSEDQPWQPYFLGNPLYAFLLMVLFQYGVAL
MAB_1587c|M.abscessus_ATCC_199 HTYTNIVDMDRDVGYGILRMAPEQKWNPYYLGNLAWATALMVFFEWGVMV
Mb3258c|M.bovis_AF2122/97 HKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNVVWNTILAIGFEWGVAL
Rv3229c|M.tuberculosis_H37Rv HKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNVVWNTILAIGFEWGVAL
TH_0650|M.thermoresistible__bu HKYTNILGMDDDVGYGLLRVTRDQKWKPFNLGNLLYNTLLALAFEWGVGL
*.:***:.:* *:***::*:: :* * : : * : * : *::** :
Mflv_4814|M.gilvum_PYR-GCK HEMESEKIAAGEITLTDKREILREIWAKTKRQTLKDYVAFPLLA----GP
Mvan_1628|M.vanbaalenii_PYR-1 HEMESEKIAAGEITLTDKREILEGIWRKTKRQTLKDYVAFPLLA----GP
MSMEG_1743|M.smegmatis_MC2_155 HELETERIRAGEISIADKREVLREIWHKTKGQTVKDYVAFPLLA----GP
MMAR_0336|M.marinum_M HELETERIRSGEITLRDKRETLMEIWKKTRRQTLKDYVAFPLLA----GP
MUL_4785|M.ulcerans_Agy99 HELETERIRSGEITLRDKRETLTEIWKKTRRQTLKDYVAFPLLA----GP
MAV_5167|M.avium_104 HELETERIRSGEIRLADKREVLREIWQKTRRQTLKDYVAFPLLA----GP
MAB_1587c|M.abscessus_ATCC_199 HELEAENIVRGKRKWYDLKPLIKGMWRKASKQVLKDYVIFPALT----GP
Mb3258c|M.bovis_AF2122/97 QHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPALTSLSPGA
Rv3229c|M.tuberculosis_H37Rv QHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPALTSLSPGA
TH_0650|M.thermoresistible__bu QHVELGKIFKRRHDPDESRVRVREFLRKAGRQVFKDYVAYPALSSLSPAA
:.:* .* . : : : *: *..**** :* *: ..
Mflv_4814|M.gilvum_PYR-GCK FAPWVFAGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAETRGQWY
Mvan_1628|M.vanbaalenii_PYR-1 FAPWVFAGNMTANLMRNVWAYMIIFCGHFPEDVQEFSIEETKAETRGQWY
MSMEG_1743|M.smegmatis_MC2_155 FAPLVFAGNLTANLTRNVWAFMIIFCGHFPEGTQEFSREQAENESRGMWY
MMAR_0336|M.marinum_M FAPFVFAGNLTANLMRNVWSYMIIFCGHFPDGTQEFSVEETQNESRGQWY
MUL_4785|M.ulcerans_Agy99 FAPFVFAGNLTANLMRNVWSYMIIFCGHFPDGTQEFSVEETQNESRGQWY
MAV_5167|M.avium_104 FAPFVFTGNLTANLIRNVWSYMIIFCGHFPDGTQEFTVEETQDESRGMWY
MAB_1587c|M.abscessus_ATCC_199 LFPITFLGNMSANFVRNLWTFSIIFCGHFPSGTQTFSKEETANETRGEWY
Mb3258c|M.bovis_AF2122/97 TYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWY
Rv3229c|M.tuberculosis_H37Rv TYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWY
TH_0650|M.thermoresistible__bu SYRSTLTANAMANVIRNVWSNAVIFCGHFPDGAEKFTKTDMVGESKGQWY
.: .* **. **:*: :*******...: *: : *.:* **
Mflv_4814|M.gilvum_PYR-GCK FRQVLGSANLTGGKLFHILSGNLSFQIEHHLFPDIPAFRHAEIAPKVREI
Mvan_1628|M.vanbaalenii_PYR-1 FRQVLGSANLTGGKLFHILSGNLSFQIEHHLFPDIPAFRHAEIAPKVQEI
MSMEG_1743|M.smegmatis_MC2_155 FRQLLGSANLTGGKWFHILSGNLSFQIEHHLFPDIPAHRHAEISAEVREI
MMAR_0336|M.marinum_M FRQVLGSANLTGGKTFHLLSGNLSHQIEHHLFPDIPARRYAEIAPEVQEI
MUL_4785|M.ulcerans_Agy99 FRQVLGSANLTGGKTFHLLSGNLSHQREHHLFPDIPARRYAEIAPEVQEI
MAV_5167|M.avium_104 FRQILGSANLTGGKLFHLLSGNLSHQIEHHLFPDMPARRYAEIAPEVQAI
MAB_1587c|M.abscessus_ATCC_199 LRQLLGSANIEGGRLFHIMSGNLSHQIEHHLFPDLPANRYPEMATEVREL
Mb3258c|M.bovis_AF2122/97 LRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREV
Rv3229c|M.tuberculosis_H37Rv LRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREV
TH_0650|M.thermoresistible__bu LRQMLGSANFEGGWLLRFMSGNLCHQIEHHLYPDLPSNRLHEASIRVREV
:**:*****: .* ::::****..* ****:**:*: * * : .*: :
Mflv_4814|M.gilvum_PYR-GCK CERYGVPYNTGPLPRQFASVVRKIVKFALPF-------------------
Mvan_1628|M.vanbaalenii_PYR-1 CERYGVPYNKGSLPHQFGTVVRKIIKFALPF-------------------
MSMEG_1743|M.smegmatis_MC2_155 CERYGLPYNSGPLVKQFGTVVRKIVRLALPWGSKPKSPEP-----ADTRA
MMAR_0336|M.marinum_M CERYGIPYNRGPLLRQFGTVVRKIVKLAFR-----GSDR------QEAHA
MUL_4785|M.ulcerans_Agy99 CELYGIPYNRGPLLRQFGTVVRQIVKLAFR-----GSDR------QEAHA
MAV_5167|M.avium_104 CQRYGVAYNRGPLLRQFGTVVRKIVKLSFPNAWIPGAAKP-----ADREP
MAB_1587c|M.abscessus_ATCC_199 CQKYGLPYNTGGLFAQLSSTWKKIARLSLPNGWFRGDDQLVVHIERNKHK
Mb3258c|M.bovis_AF2122/97 CDRYDLPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMF
Rv3229c|M.tuberculosis_H37Rv CDRYDLPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMF
TH_0650|M.thermoresistible__bu CDKYDLPYTTGPFLVQYAKTWRTLAKLSLPDRFLKATADNAPETRSERMF
*: *.:.*. * : * ... : : ::::
Mflv_4814|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1628|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1743|M.smegmatis_MC2_155 EPVSDTEPEAELALAH----------------------------------
MMAR_0336|M.marinum_M LA------------------------------------------------
MUL_4785|M.ulcerans_Agy99 LA------------------------------------------------
MAV_5167|M.avium_104 VAA-----------------------------------------------
MAB_1587c|M.abscessus_ATCC_199 EAATTPEPEVIVVDERGNVMSPASGAGELVDA------------------
Mb3258c|M.bovis_AF2122/97 AGLGPGFAGADPVTGRRRGLKTAIAAVRGRRRSKRMAKS-----------
Rv3229c|M.tuberculosis_H37Rv AGLGPGFAGADPVTGRRRGLKTAIAAVRGRRRSKRMAKS-----------
TH_0650|M.thermoresistible__bu AELGPGFAGVDPATGRRRGLKSAFAAVRNWRRDKQAAKAXXXGELYPRPG
Mflv_4814|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1628|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1743|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0336|M.marinum_M --------------------------------------------------
MUL_4785|M.ulcerans_Agy99 --------------------------------------------------
MAV_5167|M.avium_104 --------------------------------------------------
MAB_1587c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3258c|M.bovis_AF2122/97 --------------VTEPDDLAA---------------------------
Rv3229c|M.tuberculosis_H37Rv --------------VTEPDDLAA---------------------------
TH_0650|M.thermoresistible__bu TLRRDVGVRLRRGGVPGPAGLWSGEHDRRGHRPPRSGPQRIRRPRGHAVL
Mflv_4814|M.gilvum_PYR-GCK ---------
Mvan_1628|M.vanbaalenii_PYR-1 ---------
MSMEG_1743|M.smegmatis_MC2_155 ---------
MMAR_0336|M.marinum_M ---------
MUL_4785|M.ulcerans_Agy99 ---------
MAV_5167|M.avium_104 ---------
MAB_1587c|M.abscessus_ATCC_199 ---------
Mb3258c|M.bovis_AF2122/97 ---------
Rv3229c|M.tuberculosis_H37Rv ---------
TH_0650|M.thermoresistible__bu RRRDRAVRR