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FVAMSLSILPCPQAGRQSRITTGPLRRAHLIRTVSVYNLSRANLARPAAELAAVYNASIYFFSELIPTHF DPADCTIRLHGDRSLLPLDYVAAAEALEGAAPRGDFCINILAAYDAFDELRGAHFRAQQQGCDIATAFDI PPVDLVIRTTAEPLLSGFLPLQCQYAELTFLATPLNELTATDIDAVIAEHRRFPQRRGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4751 | - | - | 100% (200) | di-trans-poly-cis-decaprenylcistransferase |
| M. gilvum PYR-GCK | Mflv_2055 | - | 6e-06 | 27.98% (193) | undecaprenyl diphosphate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1115 | - | 1e-05 | 26.84% (190) | short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP |
| M. tuberculosis H37Rv | Rv1086 | - | 2e-05 | 29.19% (161) | short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP |
| M. leprae Br4923 | MLBr_02467 | - | 1e-07 | 29.38% (194) | putative undecaprenyl pyrophosphate synthetase |
| M. abscessus ATCC 19977 | MAB_1209 | - | 1e-05 | 27.89% (190) | short-chain Z-isoprenyl diphosphate synthetase |
| M. marinum M | MMAR_4380 | uppS | 8e-07 | 29.81% (161) | short (C15) chain Z-isoprenyl diphosphate synthase, UppS |
| M. avium 104 | MAV_1211 | - | 1e-05 | 25.26% (190) | short-chain Z-isoprenyl diphosphate synthetase |
| M. smegmatis MC2 155 | MSMEG_5256 | uppS | 1e-05 | 28.19% (188) | undecaprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_2165 | uppS | 2e-05 | 27.08% (192) | undecaprenyl diphosphate synthase |
| M. ulcerans Agy99 | MUL_0193 | uppS | 5e-07 | 29.81% (161) | short (C15) chain Z-isoprenyl diphosphate synthase, UppS |
| M. vanbaalenii PYR-1 | Mvan_1705 | - | 3e-57 | 66.27% (169) | di-trans-poly-cis-decaprenylcistransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4380|M.marinum_M ---------MEIIPPRLKEPLYRLYELRLRQGLAATSSELPRHIAVLCDG
MUL_0193|M.ulcerans_Agy99 MRVTVVWILVEIIPPRLKEPLYRLYELRLRQGLAATSSELPRHIAVLCDG
MLBr_02467|M.leprae_Br4923 ---------MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDG
Mb1115|M.bovis_AF2122/97 ---------MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDG
Rv1086|M.tuberculosis_H37Rv ---------MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDG
MAV_1211|M.avium_104 -------MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDG
MSMEG_5256|M.smegmatis_MC2_155 ---------MDIIPPRLKEPAYRIYEMRLRHELVRSKAQLPRHIAVLCDG
TH_2165|M.thermoresistible__bu ---------VDIIPPRLKEPAYRLYEMRLRQELARSKSQLPRHIAVLCDG
MAB_1209|M.abscessus_ATCC_1997 ---------MEIIPPRLKEPLYKLYEMRLRQELVKASK--PRHIAVLCDG
Mflv_4751|M.gilvum_PYR-GCK -------------------------------------MFVAMSLSILP--
Mvan_1705|M.vanbaalenii_PYR-1 --------------------------------------MKPAHVGLIPDG
. :.::
MMAR_4380|M.marinum_M NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
MUL_0193|M.ulcerans_Agy99 NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
MLBr_02467|M.leprae_Br4923 NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
Mb1115|M.bovis_AF2122/97 NRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQ
Rv1086|M.tuberculosis_H37Rv NRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQ
MAV_1211|M.avium_104 NRRWARDAGYDDVSYGYRMGAVKIAEMLRWCQAAGIEMTTVYLLSTENLQ
MSMEG_5256|M.smegmatis_MC2_155 NRRWARDAGYDDVSIGYRKGAAKIAEMLRWCQAAGIEMATIYLLSTENLQ
TH_2165|M.thermoresistible__bu NRRWARDAGHDDVSYGYRKGAAKIAEMLRWCQDTGIELATIYLLSTENLQ
MAB_1209|M.abscessus_ATCC_1997 NRRWARSAGYTDVSHGYRMGARKISEMLGWCQDAGVEMATVYLLSAENLT
Mflv_4751|M.gilvum_PYR-GCK -CPQAGRQ-SRITTGPLRR-------------AHLIRTVSVYNLSRANLA
Mvan_1705|M.vanbaalenii_PYR-1 LRRWARAN-DTTLTDAYRRGAETVVELLLALQRNQVQTVTVYNLSRANLA
* : * :. .::* ** **
MMAR_4380|M.marinum_M RDADELAALIEIITDVVEEICAP---ANRWSVRTVGDLELLGDEPARRLR
MUL_0193|M.ulcerans_Agy99 RDADELAALIEIITDVVEEICAP---ANRWSVRTVGDLELLGDEPARRLR
MLBr_02467|M.leprae_Br4923 RDPDELAALIEIITDVVEEICAP---ANRWSVRTVGDLELLGEEPACRLR
Mb1115|M.bovis_AF2122/97 RDPDELAALIEIITDVVEEICAP---ANHWSVRTVGDLGLIGEEPARRLR
Rv1086|M.tuberculosis_H37Rv RDPDELAALIEIITDVVEEICAP---ANHWSVRTVGDLGLIGEEPARRLR
MAV_1211|M.avium_104 RDPDELAGLIEIITDVVEEICAP---ANRWSVRTVGDLELLGEEPARRLR
MSMEG_5256|M.smegmatis_MC2_155 RDPDELTALIEIITDVVEEICAP---YNKWSVRTVGDLELLGDEPARRLR
TH_2165|M.thermoresistible__bu RDPDELTALIEIITEVVEEICAP---ANKWSVRTVGDLALLGEEPARRLR
MAB_1209|M.abscessus_ATCC_1997 RDPDQLTELLEIITDVVEELCAP---QNKWSVRSVGDLDLLPDEVAERMR
Mflv_4751|M.gilvum_PYR-GCK RPAAELAAVYNASIYFFSELIPTHFDPADCTIRLHGDRSLLPLDYVAAAE
Mvan_1705|M.vanbaalenii_PYR-1 RPSDELDAVYAASTYFLSTLIPARFDPADCGVRVHGDRSLLPDAFAAAAR
* . :* : ... : .. :* ** *: . .
MMAR_4380|M.marinum_M EAVESTPATA---QFHVNVAVGYGGRREIVDAVRALLSKELANGATAEEL
MUL_0193|M.ulcerans_Agy99 EAVESTPATA---QFHVNVAVGYGGRREIVDAVRALLSKELANGATAEEL
MLBr_02467|M.leprae_Br4923 GAVESTPGVA---PFHVNVAVGYGGRREIVGAVRALLGKELANGATAEEL
Mb1115|M.bovis_AF2122/97 GAVESTPEVA---SFHVNVAVGYGGRREIVDAVRALLSKELANGATAEEL
Rv1086|M.tuberculosis_H37Rv GAVESTPEVA---SFHVNVAVGYGGRREIVDAVRALLSKELANGATAEEL
MAV_1211|M.avium_104 GAVESTPVEA---SFHVNVAVGYGGRREIVDAVRSLLSKELANGATAEEL
MSMEG_5256|M.smegmatis_MC2_155 EAVESTTTKG--ANFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQL
TH_2165|M.thermoresistible__bu EAVDRTETVADAAAFHVNVAVGYGGRQEIVDAVRALLSKELANGASPEQL
MAB_1209|M.abscessus_ATCC_1997 QAVKSAPSDA---GFHVNVAVGYGGRQEITDAVRTLLNKELANGASAEQL
Mflv_4751|M.gilvum_PYR-GCK ALEGAAPRGD----FCINILAAY----DAFDELRGAHFRAQQQGCDIATA
Mvan_1705|M.vanbaalenii_PYR-1 DIETAMTGGG----FRINMLAAY----DAADELRAAHQRALRDDCDINDA
* :*: ..* : . :* : :..
MMAR_4380|M.marinum_M IDAVSVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
MUL_0193|M.ulcerans_Agy99 IDAVSVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
MLBr_02467|M.leprae_Br4923 VEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
Mb1115|M.bovis_AF2122/97 VDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
Rv1086|M.tuberculosis_H37Rv VDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
MAV_1211|M.avium_104 IDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
MSMEG_5256|M.smegmatis_MC2_155 IEAVTVDGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
TH_2165|M.thermoresistible__bu IQSVTIDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTE
MAB_1209|M.abscessus_ATCC_1997 VQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTD
Mflv_4751|M.gilvum_PYR-GCK FDIPPVD---------------LVIRTTAEPLLSGFLPLQCQYAELTFLA
Mvan_1705|M.vanbaalenii_PYR-1 FEIGEVD---------------LVIRTTAEPLLSGFLPMQSQYAQLLFLT
.: :: *****:.* ***** *. *::: *
MMAR_4380|M.marinum_M AHWPAFRRVDFLRALRDYSMRHRRYGK
MUL_0193|M.ulcerans_Agy99 AHWPAFRRVDFLRALRDYSMRHRRYGK
MLBr_02467|M.leprae_Br4923 THWPAFRRVDFLRALRDYSMRHRRYGK
Mb1115|M.bovis_AF2122/97 AHWPAFRHVDFLRALRDYSARHRRYGR
Rv1086|M.tuberculosis_H37Rv AHWPAFRHVDFLRALRDYSARHRSYGR
MAV_1211|M.avium_104 AHWPAFRRVDFLRALRDYSQRHRRYGK
MSMEG_5256|M.smegmatis_MC2_155 AYWPAFRRVDFLRALRDYTARHRRFGK
TH_2165|M.thermoresistible__bu AHWPAFRRVDFLRALRDYTRRHRRFGM
MAB_1209|M.abscessus_ATCC_1997 AYWPEFRRVDFLRALRDYAARNRRFGQ
Mflv_4751|M.gilvum_PYR-GCK TPLNELTATDIDAVIAEHRRFPQRRGR
Mvan_1705|M.vanbaalenii_PYR-1 TPLNELTPQHIDGFIEDYRHSPQLRGR
: : .: : :: : *