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MSPGGKLIDVLPDRVDTRAPVYLENREGLIAQLHALAEQLALANGGGGEKYVARHRSRGKMLARERVELL LDPDTAFLELCPFAAWGTKFPVGGSVVVGIGIVEGVESMIIAHDPTVRGGASNPYTFRKVFRGMAVAREN RLPIINVVESGGADLPTQAEIFVPGGQLFNDLTQHSALGLPTLALVFGNSTAGGAYIPGMCDYVVMVRNR SKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGLADYMAEDEQDAIRIGRRIMARLNWRKLGPGPTQP PTPPLRDPDQLLGIASVDPKVPFDPRDVIARIVDGSTFDEFKPLYGTSLVTGWASIHGYPVGILANARGI LFSEEAEKAAQFIQLANQIDTPLVFLQNTTGYMVGAEYEQGGIIKDGAKMINAVSNSAVPHLTIVMGASY GAGNYGMCGRSYSPRFLFTWPNSRSAVMGPAQLAGVLSIVARESAADRGLPFDEEADAQMRAAVEGQIER ESLALANSGRLYDDGIIDPRDTRTVLGFCLSVVHNSEIRGQRGYGVFRM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4613 | - | - | 100% (539) | carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_1883 | - | 0.0 | 67.62% (525) | propionyl-CoA carboxylase |
| M. gilvum PYR-GCK | Mflv_2552 | - | e-131 | 48.56% (521) | propionyl-CoA carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0999c | accD2 | 0.0 | 68.11% (530) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. tuberculosis H37Rv | Rv0974c | accD2 | 0.0 | 67.92% (530) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. leprae Br4923 | MLBr_00731 | accD5 | 7e-56 | 29.64% (523) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_2067c | - | 0.0 | 91.37% (533) | acetyl/propionyl-CoA carboxylase beta subunit AccD2 |
| M. marinum M | MMAR_4533 | accD2 | 0.0 | 67.67% (532) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 |
| M. avium 104 | MAV_1090 | - | 0.0 | 68.49% (530) | acetyl-CoA carboxylase carboxyltransferase |
| M. smegmatis MC2 155 | MSMEG_5492 | - | 0.0 | 68.24% (529) | acetyl-CoA carboxylase carboxyltransferase |
| M. thermoresistible (build 8) | TH_2815 | - | 1e-133 | 50.00% (510) | PUTATIVE Carboxyl transferase domain protein |
| M. ulcerans Agy99 | MUL_4705 | accD2 | 0.0 | 67.11% (532) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 |
| M. vanbaalenii PYR-1 | Mvan_4848 | - | 0.0 | 67.66% (538) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4613|M.gilvum_PYR-GCK -----------MSPGGKLIDVLPDRVDTRAPVYLENREGLIAQLHALAEQ
MAB_2067c|M.abscessus_ATCC_199 -----------------MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQ
Mb0999c|M.bovis_AF2122/97 --------------------MLQSTLDPNASAYDEAAATMSGKLDEINAE
Rv0974c|M.tuberculosis_H37Rv --------------------MLQSTLDPNASAYDEAAATMSGKLDEINAE
MMAR_4533|M.marinum_M ------------------MTVLRSTLDPNGAAFSEAASAATTKLDEIDAE
MUL_4705|M.ulcerans_Agy99 ----------------MRVTVLRSTLDPNGAAFSEAASAATTKLDEIDAE
MAV_1090|M.avium_104 ------------------MTVLQSTLDREATAFTDAASAAMAKLEEIDTE
MSMEG_5492|M.smegmatis_MC2_155 ------------------MTALHSTIDATSPGFNEAAAVMTAKLSELDAE
Mvan_4848|M.vanbaalenii_PYR-1 MTTATSDGGTSRSRGTDRASILQTAIDTASPAFLEAAEVMTAKLAELEAE
TH_2815|M.thermoresistible__bu ----------------------------------------------LRSK
MLBr_00731|M.leprae_Br4923 ---------------MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKR
: .
Mflv_4613|M.gilvum_PYR-GCK LALANGGGGEKYVARHRSRGKMLARERVELLLDPDTAFLELCPFAAWGT-
MAB_2067c|M.abscessus_ATCC_199 LALVNGGGGAKYVARHRKRGKLLVRERIELMLDPDTAFLELCPFAAWGS-
Mb0999c|M.bovis_AF2122/97 LAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAYGS-
Rv0974c|M.tuberculosis_H37Rv LAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAYGS-
MMAR_4533|M.marinum_M LANALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAWGS-
MUL_4705|M.ulcerans_Agy99 LANALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAWGS-
MAV_1090|M.avium_104 LANALAGGGPKYVERHHARGKLTARERIELLVDQDSPFLELSPLAAWGS-
MSMEG_5492|M.smegmatis_MC2_155 HAKALGGGGPKYVDRHHARGKLTARERVELLLDPDSPFLELSPLAAWGT-
Mvan_4848|M.vanbaalenii_PYR-1 HTKALAGGGEKYVARHHARGKMTARERIEALLDPDSPFLELSPLAAWGT-
TH_2815|M.thermoresistible__bu LAAAARGGPERARERHVSRGKLLPRDRVDGLLDPGSPFLEVAPLAANGMY
MLBr_00731|M.leprae_Br4923 TEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDS-FVELDALARHRST
. : :*:: *:*: ::* .: *:*: .:*
Mflv_4613|M.gilvum_PYR-GCK ------KFPVGGSVVVGIGIVEGVESMIIAHDPTVRGGASNPYTFRKVFR
MAB_2067c|M.abscessus_ATCC_199 ------KFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYTFRKVFR
Mb0999c|M.bovis_AF2122/97 ------NFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILR
Rv0974c|M.tuberculosis_H37Rv ------NFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILR
MMAR_4533|M.marinum_M ------AFKVGASTVTGIGVVAGVECMIVANDPTVKGGTSNPWTLKKILR
MUL_4705|M.ulcerans_Agy99 ------AFKVGASTVTGIGVVAGVECMIVANDPTVKGGTSNPWTLKKILR
MAV_1090|M.avium_104 ------SFKVGASTVTGIGVVEGVECMIVANDPTVKGGTSNPWTLKKILR
MSMEG_5492|M.smegmatis_MC2_155 ------DFAVGASVVTGIGAVEGVECLIVANDPTVKGGTSNPWTLKKILR
Mvan_4848|M.vanbaalenii_PYR-1 ------DFTVGASIVVGIGAVSGVECLLVANDPTVKGGTSNPWTLRKILR
TH_2815|M.thermoresistible__bu -----DDECPGAGMITGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLR
MLBr_00731|M.leprae_Br4923 NFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVK
* . :.* * : * : :.::* ** **: .* .:
Mflv_4613|M.gilvum_PYR-GCK GMAVARENRLPIINVVESGGADLPTQAEIFVPG---GQLFNDLTQHSALG
MAB_2067c|M.abscessus_ATCC_199 GMAIARENRLPIINIVESGGADLPTQAEIFVPG---GQLFHDLTQHSAAG
Mb0999c|M.bovis_AF2122/97 ANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLSAAG
Rv0974c|M.tuberculosis_H37Rv ANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLSAAG
MMAR_4533|M.marinum_M ANQIAFENRLPVVSLVESGGADLPTQKEIFIPG---GRMFRDLTRLSAAG
MUL_4705|M.ulcerans_Agy99 ANQIAFENRLPVVSLVESGGADLPTQKEIFIPG---GRMFRDLTRLSAAG
MAV_1090|M.avium_104 ANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GRMFRDLTRLSAAG
MSMEG_5492|M.smegmatis_MC2_155 ANQIALQNRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLSAAG
Mvan_4848|M.vanbaalenii_PYR-1 ANQIALQNRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLSAAG
TH_2815|M.thermoresistible__bu AQEIAAQNHLPCIYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQATLSAQG
MLBr_00731|M.leprae_Br4923 VQELAIKTGRPLIGINDGAGARIQEGVVSLGLY---SRIFRNN-ILASGV
:* :. * : : :..** : : .::* : ::
Mflv_4613|M.gilvum_PYR-GCK LPTLALVFGNSTAGGAYIPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVS
MAB_2067c|M.abscessus_ATCC_199 LPTLALVFGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVS
Mb0999c|M.bovis_AF2122/97 IPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEES
Rv0974c|M.tuberculosis_H37Rv IPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEES
MMAR_4533|M.marinum_M IPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEES
MUL_4705|M.ulcerans_Agy99 IPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEES
MAV_1090|M.avium_104 IPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEES
MSMEG_5492|M.smegmatis_MC2_155 IPTIALVFGNSTAGGAYVPGMSDHVVMIRERSKVFLAGPPLVKMATGEES
Mvan_4848|M.vanbaalenii_PYR-1 IPTIALVFGNSTAGGAYIPGMSDHVVMIRERSKVFLAGPPLVKMATGEES
TH_2815|M.thermoresistible__bu IPQIAAVMGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLVRAATGEVV
MLBr_00731|M.leprae_Br4923 IPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDV
:* :: ::* .:.* .* *.: * .*:: : . :*: ** ::: .***
Mflv_4613|M.gilvum_PYR-GCK DDESLGGADMHARTSGLADYMAEDEQDAIRIGRRIMARLNWRKLGPGPTQ
MAB_2067c|M.abscessus_ATCC_199 DDESLGGADMHARTSGLADYMAEDEQDAIRIGRRIMARLNWRKSGPGPTT
Mb0999c|M.bovis_AF2122/97 DDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAP-A
Rv0974c|M.tuberculosis_H37Rv DDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAP-A
MMAR_4533|M.marinum_M DDESLGGAEMHARISGLADYFAVDELDAIRIGRRIVARLNWVKQGPAP-A
MUL_4705|M.ulcerans_Agy99 DDESLGGAEMHARISGLADYFAVDEFDAIRIGRRIVARLNWVKQGPAP-A
MAV_1090|M.avium_104 DDESLGGAEMHARVSGLADYFAVDELDAIRIGRRIVARLNWVKQGPTP-K
MSMEG_5492|M.smegmatis_MC2_155 DDESLGGAEMHARTSGLADYFALDEPDAIRIGRRIVARLNWRKQGPAP-A
Mvan_4848|M.vanbaalenii_PYR-1 DDESLGGAEMHARTSGLADYFAVDELDALRIGRRIVARLNWRKQGPAP-R
TH_2815|M.thermoresistible__bu TAEELGGGDLHAKTSGVTDHLAHDDRDALRIVRRIVATLGPRHPSPWEIA
MLBr_00731|M.leprae_Br4923 TMEELGGAHTHMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRY
*.***.. * ** :.:.* .: **: * ::: * :
Mflv_4613|M.gilvum_PYR-GCK PPTPPLRDPDQ--------LLGIASVDPKVPFDPRDVIARIVDGSTFDEF
MAB_2067c|M.abscessus_ATCC_199 PPHPPVHDPDQ--------LLGIASVDPKVPFDPRDVIARVVDGSTFDEF
Mb0999c|M.bovis_AF2122/97 PVTEPLFDAEE--------LIGIVPPDLRIPFDPREVIARIVDGSEFDEF
Rv0974c|M.tuberculosis_H37Rv PVTEPLFDAEE--------LIGIVPPDLRIPFDPREVIARIVDGSEFDEF
MMAR_4533|M.marinum_M PVTEPLFDAEE--------LIGIVPSDLRVPFDPREVIARIVDGSEFDEF
MUL_4705|M.ulcerans_Agy99 PVTEPLFDAEE--------LIGIVPSDLRVPFEPREVIARIVDGSEFDEF
MAV_1090|M.avium_104 PVTEPLFDTEE--------LIGIVPADLRIPFDPREVIARIVDGSEFDEF
MSMEG_5492|M.smegmatis_MC2_155 EVVEPRYNAEE--------LIGIVPADLRVPFDPRDVIARIVDDSDFDEF
Mvan_4848|M.vanbaalenii_PYR-1 PVVVPRYDENE--------LIGVVPPDLRIPFDPREVIARIVDGSEFDEF
TH_2815|M.thermoresistible__bu PTVDPVADQTE--------LYDVVPVDPRIPYDVHEVVDRIVDGGDFAEF
MLBr_00731|M.leprae_Br4923 SKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEV
* . : * : . . . *:: ::*: *::* * *.
Mflv_4613|M.gilvum_PYR-GCK KPLYGTSLVTGWASIHGYPVGILANAR----GILFSEEAEKAAQFIQLAN
MAB_2067c|M.abscessus_ATCC_199 KPLYGTSLVTGWASIHGFPVGILANAR----GILFSEEAEKGSQFIQLAN
Mb0999c|M.bovis_AF2122/97 KPLYGSSLVTGWARLHGYPLGILANAR----GVLFSEESQKATQFIQLAN
Rv0974c|M.tuberculosis_H37Rv KPLYGSSLVTGWARLHGYPLGILANAR----GVLFSEESQKATQFIQLAN
MMAR_4533|M.marinum_M KPLYGSSLVTGWARLHGYPVGILANAR----GVLFSEESQKATQFIQLAN
MUL_4705|M.ulcerans_Agy99 KPLYGSSLVTGWARLHGYPVGILANAR----GVLFSEESQKATQFIQLAN
MAV_1090|M.avium_104 KPLYGSSLVTGWARLHGYPIGILANAR----GVLFSEESQKATQFIQLAN
MSMEG_5492|M.smegmatis_MC2_155 KPLYGSSLVTGWARLWGYPVGILANAR----GVLFSEESQKATQFIQLAN
Mvan_4848|M.vanbaalenii_PYR-1 KPLYGGSLVTGWATLHGYPLGILANAR----GVLFSAESQKATQFIQLAN
TH_2815|M.thermoresistible__bu KAEYGATLVTGFARIHGHPVGIIANN-----GVLFSESALKGAHFIELCD
MLBr_00731|M.leprae_Br4923 QAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCD
:. *. .:*.* . : . *:**:** * * : *.::*:.:.:
Mflv_4613|M.gilvum_PYR-GCK QIDTPLVFLQNTTGYMVGAEYEQGGIIKDGAKMINAVSNSAVPHLTIVMG
MAB_2067c|M.abscessus_ATCC_199 QIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSNSTVPHVTITMG
Mb0999c|M.bovis_AF2122/97 RADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIG
Rv0974c|M.tuberculosis_H37Rv RADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIG
MMAR_4533|M.marinum_M RADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSKVPHISLLLG
MUL_4705|M.ulcerans_Agy99 RADTPLLFLHNTTGYMVGKDYEEGGMIKHASMMINAVSNSKVPHISLLLG
MAV_1090|M.avium_104 RSNTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIG
MSMEG_5492|M.smegmatis_MC2_155 RADTPLLFLHNTTGYMVGKQYEEGGMVKHGSMMINAVSNSTVPHISLLIG
Mvan_4848|M.vanbaalenii_PYR-1 RSNTPLLFLHNTTGYMVGKDYEEGGMIKHGAMMINAVSNSTVPHISLLIG
TH_2815|M.thermoresistible__bu KRKIPLLFLQNISGFMVGREYEAGGIAKHGAKMVTAVACARVPKLTVVIG
MLBr_00731|M.leprae_Br4923 CFNIPIVMLVDVPGFLPGTEQEYDGIIRRGAKLLFAYGEATVPKITVITR
. *:::* : .*:: * : * .*: : .: :: * . : **::::
Mflv_4613|M.gilvum_PYR-GCK ASYGAGNYGMCGRSYSPRFLFTWPNSRSAVMGPAQLAGVLSIVARESAAD
MAB_2067c|M.abscessus_ATCC_199 ASYGAGNYGMCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAAD
Mb0999c|M.bovis_AF2122/97 ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEA
Rv0974c|M.tuberculosis_H37Rv ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEA
MMAR_4533|M.marinum_M ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEA
MUL_4705|M.ulcerans_Agy99 ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEA
MAV_1090|M.avium_104 ASYGAGHYGMCGRAYDPRFLFAWPTSKSAVMGGAQLAGVLSIVARAAAEA
MSMEG_5492|M.smegmatis_MC2_155 ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVSRAAAEA
Mvan_4848|M.vanbaalenii_PYR-1 ASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVNRAATEA
TH_2815|M.thermoresistible__bu GSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVR------
MLBr_00731|M.leprae_Br4923 KAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAK
:**.. * .: . . **.:: :*** ..:
Mflv_4613|M.gilvum_PYR-GCK RGLPFDEEADAQMRAAVEGQIERESL-ALANSGRLYDDGIIDPRDTRTVL
MAB_2067c|M.abscessus_ATCC_199 RGLPFDEEADAQMRAAVEEQIERESV-ALANSGRLYDDGIIDPRDTRTVL
Mb0999c|M.bovis_AF2122/97 RGQQVDEAADAAMRAAVEGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVL
Rv0974c|M.tuberculosis_H37Rv RGQQVDEAADAAMRAAVEGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVL
MMAR_4533|M.marinum_M RGQQVDEAADAAMRAAVEGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVL
MUL_4705|M.ulcerans_Agy99 RGQQVDEAADAAMRAAVDGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVL
MAV_1090|M.avium_104 RGQQFDEQADAAMRAAVEGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVL
MSMEG_5492|M.smegmatis_MC2_155 RGQTVDEDADAALRAAVEAQIEAESL-PMFLSGRLYDDGVIDPRDTRTVL
Mvan_4848|M.vanbaalenii_PYR-1 RGGQVDEAADAALRAAVEAQIEAESL-PMFLSGRLYDDGVIDPRDTRTVL
TH_2815|M.thermoresistible__bu --GDMTPEEEEAFKVPIRQQYEDQGN-PYYSTARLWDDGVIDPADTRTVV
MLBr_00731|M.leprae_Br4923 NGANVD-----ELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYI
. :: : : * . : : *.:* * .** :
Mflv_4613|M.gilvum_PYR-GCK GFCLSVVHN-SEIRGQRGYGVFRM
MAB_2067c|M.abscessus_ATCC_199 GFCLSVIHN-GEVRGQRGYGVFRM
Mb0999c|M.bovis_AF2122/97 GMCLSAIAN-GPIKGTSNFGVFRM
Rv0974c|M.tuberculosis_H37Rv GMCLSAIAN-GPIKGTSNFGVFRM
MMAR_4533|M.marinum_M GMCLSAIAN-GPIKGTSNFGVFRM
MUL_4705|M.ulcerans_Agy99 GMCLSAIAN-GPIKGTSNFGVFRM
MAV_1090|M.avium_104 GMCLSAIAN-GPIEGTSNFGVFRM
MSMEG_5492|M.smegmatis_MC2_155 GMCLSAIAN-APVEGTSNFGVFRM
Mvan_4848|M.vanbaalenii_PYR-1 GMCLSAIAN-GPIEGTSNFGVFRM
TH_2815|M.thermoresistible__bu GLALSIVGQ-APLEPVS-YGVFRM
MLBr_00731|M.leprae_Br4923 ATALHLLERKIAHLPPKKHGNIPL
. .* : . .* : :