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TTAESAANRASAPPTPAIDTRSAAYTEAAAEMAVKIAELEAEHAKALAGGGEKYVARHHARGKLTARERI EALLDPDSPFLELSPLAAWGTEFTVGASVVTGIGVVSDVECVIVANDPTVKGGTSNPWTLRKILRANQIA LENRLPVISLVESGGADLPTQKEIFIPGGRMFRDLTRLSAAGIPTIAVVFGNSTAGGAYIPGMSDHVVMI RERSKVFLAGPPLVKMATGEESDDEALGGAEMHARTSGLGDYLAIDELDALRIGRRIVARLNWRKQGPAP KPFTAPRFDENELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGGSLVTGWATLHGYPLGILANAR GVLFSEESQKATQFIQLANRSDTPLLFLHNTTGYMVGKAYEEGGMIKHGSMMINAVSNSTVPHLSLLIGA SYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVNRAATEARGNTYDDATDAVMRAAIEAQI DAESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIAGAPIEGTSNFGVFRM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1883 | - | - | 100% (542) | propionyl-CoA carboxylase |
| M. gilvum PYR-GCK | Mflv_4613 | - | 0.0 | 67.62% (525) | carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_2552 | - | e-134 | 51.17% (514) | propionyl-CoA carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0999c | accD2 | 0.0 | 86.45% (524) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. tuberculosis H37Rv | Rv0974c | accD2 | 0.0 | 86.26% (524) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. leprae Br4923 | MLBr_00731 | accD5 | 2e-59 | 31.05% (525) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_1072c | - | 0.0 | 83.05% (525) | pobable propionyl-CoA carboxylase beta subunit AccD2 |
| M. marinum M | MMAR_4533 | accD2 | 0.0 | 85.31% (524) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 |
| M. avium 104 | MAV_1090 | - | 0.0 | 85.50% (524) | acetyl-CoA carboxylase carboxyltransferase |
| M. smegmatis MC2 155 | MSMEG_5492 | - | 0.0 | 86.83% (524) | acetyl-CoA carboxylase carboxyltransferase |
| M. thermoresistible (build 8) | TH_2815 | - | 1e-139 | 52.26% (509) | PUTATIVE Carboxyl transferase domain protein |
| M. ulcerans Agy99 | MUL_4705 | accD2 | 0.0 | 84.54% (524) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 |
| M. vanbaalenii PYR-1 | Mvan_4848 | - | 0.0 | 89.28% (541) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0999c|M.bovis_AF2122/97 ----MLQS-------------------TLDPNASAYDEAAATMSGKLDEI
Rv0974c|M.tuberculosis_H37Rv ----MLQS-------------------TLDPNASAYDEAAATMSGKLDEI
MMAR_4533|M.marinum_M --MTVLRS-------------------TLDPNGAAFSEAASAATTKLDEI
MUL_4705|M.ulcerans_Agy99 MRVTVLRS-------------------TLDPNGAAFSEAASAATTKLDEI
MAV_1090|M.avium_104 --MTVLQS-------------------TLDREATAFTDAASAAMAKLEEI
Mflv_1883|M.gilvum_PYR-GCK --MTTAES--------AANRASAPPTPAIDTRSAAYTEAAAEMAVKIAEL
Mvan_4848|M.vanbaalenii_PYR-1 --MTTATSDGGTSRSRGTDRASILQT-AIDTASPAFLEAAEVMTAKLAEL
MSMEG_5492|M.smegmatis_MC2_155 --MTALHS-------------------TIDATSPGFNEAAAVMTAKLSEL
MAB_1072c|M.abscessus_ATCC_199 --MTVLRT-------------------AVNTNSPEYMAAAEAMLIKLAEV
TH_2815|M.thermoresistible__bu -------------------------------------------------L
MLBr_00731|M.leprae_Br4923 --MTSVTDHS----------------AHSMERAAEHTINIHTTAGKLAEL
:
Mb0999c|M.bovis_AF2122/97 NAELAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAY
Rv0974c|M.tuberculosis_H37Rv NAELAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAY
MMAR_4533|M.marinum_M DAELANALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAW
MUL_4705|M.ulcerans_Agy99 DAELANALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAW
MAV_1090|M.avium_104 DTELANALAGGGPKYVERHHARGKLTARERIELLVDQDSPFLELSPLAAW
Mflv_1883|M.gilvum_PYR-GCK EAEHAKALAGGGEKYVARHHARGKLTARERIEALLDPDSPFLELSPLAAW
Mvan_4848|M.vanbaalenii_PYR-1 EAEHTKALAGGGEKYVARHHARGKMTARERIEALLDPDSPFLELSPLAAW
MSMEG_5492|M.smegmatis_MC2_155 DAEHAKALGGGGPKYVDRHHARGKLTARERVELLLDPDSPFLELSPLAAW
MAB_1072c|M.abscessus_ATCC_199 NAETAKALAGGGPKYVARHHERGKLLARERIELLIDPDSPFLELCPLAAW
TH_2815|M.thermoresistible__bu RSKLAAAARGGPERARERHVSRGKLLPRDRVDGLLDPGSPFLEVAPLAAN
MLBr_00731|M.leprae_Br4923 HKRTEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDS-FVELDALARH
. * : :*:: .*:*: *:* .* *:*: .**
Mb0999c|M.bovis_AF2122/97 GS-------NFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
Rv0974c|M.tuberculosis_H37Rv GS-------NFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
MMAR_4533|M.marinum_M GS-------AFKVGASTVTGIGVVAGVECMIVANDPTVKGGTSNPWTLKK
MUL_4705|M.ulcerans_Agy99 GS-------AFKVGASTVTGIGVVAGVECMIVANDPTVKGGTSNPWTLKK
MAV_1090|M.avium_104 GS-------SFKVGASTVTGIGVVEGVECMIVANDPTVKGGTSNPWTLKK
Mflv_1883|M.gilvum_PYR-GCK GT-------EFTVGASVVTGIGVVSDVECVIVANDPTVKGGTSNPWTLRK
Mvan_4848|M.vanbaalenii_PYR-1 GT-------DFTVGASIVVGIGAVSGVECLLVANDPTVKGGTSNPWTLRK
MSMEG_5492|M.smegmatis_MC2_155 GT-------DFAVGASVVTGIGAVEGVECLIVANDPTVKGGTSNPWTLKK
MAB_1072c|M.abscessus_ATCC_199 GS-------DFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTLRK
TH_2815|M.thermoresistible__bu GMY-----DDECPGAGMITGIGRVSGRECMIVANDATVKGGTYYPVTVKK
MLBr_00731|M.leprae_Br4923 RSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEK
* . :.* * : . : :.::* ** **: .*
Mb0999c|M.bovis_AF2122/97 ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLS
Rv0974c|M.tuberculosis_H37Rv ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLS
MMAR_4533|M.marinum_M ILRANQIAFENRLPVVSLVESGGADLPTQKEIFIPG---GRMFRDLTRLS
MUL_4705|M.ulcerans_Agy99 ILRANQIAFENRLPVVSLVESGGADLPTQKEIFIPG---GRMFRDLTRLS
MAV_1090|M.avium_104 ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPG---GRMFRDLTRLS
Mflv_1883|M.gilvum_PYR-GCK ILRANQIALENRLPVISLVESGGADLPTQKEIFIPG---GRMFRDLTRLS
Mvan_4848|M.vanbaalenii_PYR-1 ILRANQIALQNRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLS
MSMEG_5492|M.smegmatis_MC2_155 ILRANQIALQNRLPVISLVESGGADLPTQKEIFIPG---GQMFRDLTRLS
MAB_1072c|M.abscessus_ATCC_199 VLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPG---GQMFRDLTRLS
TH_2815|M.thermoresistible__bu HLRAQEIAAQNHLPCIYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQATLS
MLBr_00731|M.leprae_Br4923 IVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLY---SRIFRNN-ILA
::.:::* :. * : : :..** : : .::* : *:
Mb0999c|M.bovis_AF2122/97 AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATG
Rv0974c|M.tuberculosis_H37Rv AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATG
MMAR_4533|M.marinum_M AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATG
MUL_4705|M.ulcerans_Agy99 AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATG
MAV_1090|M.avium_104 AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATG
Mflv_1883|M.gilvum_PYR-GCK AAGIPTIAVVFGNSTAGGAYIPGMSDHVVMIRERSKVFLAGPPLVKMATG
Mvan_4848|M.vanbaalenii_PYR-1 AAGIPTIALVFGNSTAGGAYIPGMSDHVVMIRERSKVFLAGPPLVKMATG
MSMEG_5492|M.smegmatis_MC2_155 AAGIPTIALVFGNSTAGGAYVPGMSDHVVMIRERSKVFLAGPPLVKMATG
MAB_1072c|M.abscessus_ATCC_199 AAGIPTIALVFGNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATG
TH_2815|M.thermoresistible__bu AQGIPQIAAVMGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLVRAATG
MLBr_00731|M.leprae_Br4923 SGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTG
: ** *: ::* .:.* .* *.::* .*:: : . :*: ** ::: .**
Mb0999c|M.bovis_AF2122/97 EESDDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWI--KQG
Rv0974c|M.tuberculosis_H37Rv EESDDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWI--KQG
MMAR_4533|M.marinum_M EESDDESLGGAEMHARISGLADYFAVDELDAIRIGRRIVARLNWV--KQG
MUL_4705|M.ulcerans_Agy99 EESDDESLGGAEMHARISGLADYFAVDEFDAIRIGRRIVARLNWV--KQG
MAV_1090|M.avium_104 EESDDESLGGAEMHARVSGLADYFAVDELDAIRIGRRIVARLNWV--KQG
Mflv_1883|M.gilvum_PYR-GCK EESDDEALGGAEMHARTSGLGDYLAIDELDALRIGRRIVARLNWR--KQG
Mvan_4848|M.vanbaalenii_PYR-1 EESDDESLGGAEMHARTSGLADYFAVDELDALRIGRRIVARLNWR--KQG
MSMEG_5492|M.smegmatis_MC2_155 EESDDESLGGAEMHARTSGLADYFALDEPDAIRIGRRIVARLNWR--KQG
MAB_1072c|M.abscessus_ATCC_199 EESDDESLGGAEMHSRVSGLGDYLAVDEQDAVRLGRQIVSRLNWV--KKG
TH_2815|M.thermoresistible__bu EVVTAEELGGGDLHAKTSGVTDHLAHDDRDALRIVRRIVATLGPR--HPS
MLBr_00731|M.leprae_Br4923 EDVTMEELGGAHTHMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDA
* * ***.. * ** .:.* .: **. * ::: * .
Mb0999c|M.bovis_AF2122/97 P-APAPVTEPLFDA------EELIGIVPPDLRIPFDPREVIARIVDGSEF
Rv0974c|M.tuberculosis_H37Rv P-APAPVTEPLFDA------EELIGIVPPDLRIPFDPREVIARIVDGSEF
MMAR_4533|M.marinum_M P-APAPVTEPLFDA------EELIGIVPSDLRVPFDPREVIARIVDGSEF
MUL_4705|M.ulcerans_Agy99 P-APAPVTEPLFDA------EELIGIVPSDLRVPFEPREVIARIVDGSEF
MAV_1090|M.avium_104 P-TPKPVTEPLFDT------EELIGIVPADLRIPFDPREVIARIVDGSEF
Mflv_1883|M.gilvum_PYR-GCK P-APKPFTAPRFDE------NELIGIVPPDLRIPFDPREVIARIVDGSEF
Mvan_4848|M.vanbaalenii_PYR-1 P-APRPVVVPRYDE------NELIGVVPPDLRIPFDPREVIARIVDGSEF
MSMEG_5492|M.smegmatis_MC2_155 P-APAEVVEPRYNA------EELIGIVPADLRVPFDPRDVIARIVDDSDF
MAB_1072c|M.abscessus_ATCC_199 P-KPAAVIEPIADQ------EELIGIVPGDLRIPFDPREVIARIVDGSEF
TH_2815|M.thermoresistible__bu PWEIAPTVDPVADQ------TELYDVVPVDPRIPYDVHEVVDRIVDGGDF
MLBr_00731|M.leprae_Br4923 PRYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRLLDEEEF
* : ** ::* . . *:: ::*: *::* :*
Mb0999c|M.bovis_AF2122/97 DEFKPLYGSSLVTGWARLHGYPLGILANAR----GVLFSEESQKATQFIQ
Rv0974c|M.tuberculosis_H37Rv DEFKPLYGSSLVTGWARLHGYPLGILANAR----GVLFSEESQKATQFIQ
MMAR_4533|M.marinum_M DEFKPLYGSSLVTGWARLHGYPVGILANAR----GVLFSEESQKATQFIQ
MUL_4705|M.ulcerans_Agy99 DEFKPLYGSSLVTGWARLHGYPVGILANAR----GVLFSEESQKATQFIQ
MAV_1090|M.avium_104 DEFKPLYGSSLVTGWARLHGYPIGILANAR----GVLFSEESQKATQFIQ
Mflv_1883|M.gilvum_PYR-GCK DEFKPLYGGSLVTGWATLHGYPLGILANAR----GVLFSEESQKATQFIQ
Mvan_4848|M.vanbaalenii_PYR-1 DEFKPLYGGSLVTGWATLHGYPLGILANAR----GVLFSAESQKATQFIQ
MSMEG_5492|M.smegmatis_MC2_155 DEFKPLYGSSLVTGWARLWGYPVGILANAR----GVLFSEESQKATQFIQ
MAB_1072c|M.abscessus_ATCC_199 DEFKEQYGSSLVTGWARLHGYPIGILANAR----GVLFSEEAQKATQFIQ
TH_2815|M.thermoresistible__bu AEFKAEYGATLVTGFARIHGHPVGIIANN-----GVLFSESALKGAHFIE
MLBr_00731|M.leprae_Br4923 LEVQAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVR
*.: *. .:*.* . : . *:**:** * * : *.::*:.
Mb0999c|M.bovis_AF2122/97 LANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISL
Rv0974c|M.tuberculosis_H37Rv LANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISL
MMAR_4533|M.marinum_M LANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSKVPHISL
MUL_4705|M.ulcerans_Agy99 LANRADTPLLFLHNTTGYMVGKDYEEGGMIKHASMMINAVSNSKVPHISL
MAV_1090|M.avium_104 LANRSNTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISL
Mflv_1883|M.gilvum_PYR-GCK LANRSDTPLLFLHNTTGYMVGKAYEEGGMIKHGSMMINAVSNSTVPHLSL
Mvan_4848|M.vanbaalenii_PYR-1 LANRSNTPLLFLHNTTGYMVGKDYEEGGMIKHGAMMINAVSNSTVPHISL
MSMEG_5492|M.smegmatis_MC2_155 LANRADTPLLFLHNTTGYMVGKQYEEGGMVKHGSMMINAVSNSTVPHISL
MAB_1072c|M.abscessus_ATCC_199 LANQTNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNSTVPHLSL
TH_2815|M.thermoresistible__bu LCDKRKIPLLFLQNISGFMVGREYEAGGIAKHGAKMVTAVACARVPKLTV
MLBr_00731|M.leprae_Br4923 VCDCFNIPIVMLVDVPGFLPGTEQEYDGIIRRGAKLLFAYGEATVPKITV
:.: . *:::: : .*:: * * .*: ::.: :: * . : **::::
Mb0999c|M.bovis_AF2122/97 LIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAA
Rv0974c|M.tuberculosis_H37Rv LIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAA
MMAR_4533|M.marinum_M LLGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAA
MUL_4705|M.ulcerans_Agy99 LLGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAA
MAV_1090|M.avium_104 LIGASYGAGHYGMCGRAYDPRFLFAWPTSKSAVMGGAQLAGVLSIVARAA
Mflv_1883|M.gilvum_PYR-GCK LIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVNRAA
Mvan_4848|M.vanbaalenii_PYR-1 LIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVNRAA
MSMEG_5492|M.smegmatis_MC2_155 LIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGTQLAGVLSIVSRAA
MAB_1072c|M.abscessus_ATCC_199 IVGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAA
TH_2815|M.thermoresistible__bu VIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVR---
MLBr_00731|M.leprae_Br4923 ITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQ
: :**.. * .: . . **.:: :***. ..:
Mb0999c|M.bovis_AF2122/97 AEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTR-
Rv0974c|M.tuberculosis_H37Rv AEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTR-
MMAR_4533|M.marinum_M AEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTR-
MUL_4705|M.ulcerans_Agy99 AEARGQQVDEAADAAMRAAVDGQIEAESLPLVLSGMLYDDGVIDPRDTR-
MAV_1090|M.avium_104 AEARGQQFDEQADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTR-
Mflv_1883|M.gilvum_PYR-GCK TEARGNTYDDATDAVMRAAIEAQIDAESLPMFLSGRLYDDGVIDPRDTR-
Mvan_4848|M.vanbaalenii_PYR-1 TEARGGQVDEAADAALRAAVEAQIEAESLPMFLSGRLYDDGVIDPRDTR-
MSMEG_5492|M.smegmatis_MC2_155 AEARGQTVDEDADAALRAAVEAQIEAESLPMFLSGRLYDDGVIDPRDTR-
MAB_1072c|M.abscessus_ATCC_199 AAARGQQVDDAADAALKAAIEAQIEAESLPMFMSGRLYDDGVIDPRDTR-
TH_2815|M.thermoresistible__bu -----GDMTPEEEEAFKVPIRQQYEDQGNPYYSTARLWDDGVIDPADTR-
MLBr_00731|M.leprae_Br4923 AAKNGANVDELRLQLQQEYEDTLVN----PYIAAERGYVDAVIPPSHTRG
: : * : : *.** * .**
Mb0999c|M.bovis_AF2122/97 ---TVLGMCLSAIANGPIKGTSNFGVFRM
Rv0974c|M.tuberculosis_H37Rv ---TVLGMCLSAIANGPIKGTSNFGVFRM
MMAR_4533|M.marinum_M ---TVLGMCLSAIANGPIKGTSNFGVFRM
MUL_4705|M.ulcerans_Agy99 ---TVLGMCLSAIANGPIKGTSNFGVFRM
MAV_1090|M.avium_104 ---TVLGMCLSAIANGPIEGTSNFGVFRM
Mflv_1883|M.gilvum_PYR-GCK ---TVLGMCLSAIAGAPIEGTSNFGVFRM
Mvan_4848|M.vanbaalenii_PYR-1 ---TVLGMCLSAIANGPIEGTSNFGVFRM
MSMEG_5492|M.smegmatis_MC2_155 ---TVLGMCLSAIANAPVEGTSNFGVFRM
MAB_1072c|M.abscessus_ATCC_199 ---AVLGMCLSAIANGPIEGTSNFGVFRM
TH_2815|M.thermoresistible__bu ---TVVGLALSIVGQAPLEPVS-YGVFRM
MLBr_00731|M.leprae_Br4923 YIATALHLLERKIAHLPPKKHGNIPL---
:.: : :. * : . :