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KTSERLWRIGSDFAGVLPRAHSAVAVGQAWNPLSVRGLRQLGEVALDELALTGMTLTAPPPRLERSEASC AAAAAELAGLGVTGANADPDPVDIGSLRRRRLGRHRYEQLTFDHDPHLPDTLSAEGFGGAATAVAHLCRT DSKRRPWLVWVHGAGQGQPIDLLFSRARRIQDELGVNVALPVQPGCGVRASAWPEYPTMDPLANVAGMLR VVSEVRALVRWLRPQATAIAVAGVSMGSPVAGLVSHLEPVDAVAVYTPIFGLNAMIAAHLGRWGPSVDDT VALLRSEVVEQVSAAVDYQAVEPSASPDRRLIVGAWHDRMAMREPAQVLHARWGGELYWHQGSHVGHLFA PGVHTASEKFLRSLTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4331 | - | - | 100% (367) | hypothetical protein Mflv_4331 |
| M. gilvum PYR-GCK | Mflv_4981 | - | 8e-19 | 27.95% (347) | hypothetical protein Mflv_4981 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2660c | - | 1e-23 | 27.58% (359) | hypothetical protein Mb2660c |
| M. tuberculosis H37Rv | Rv2627c | - | 1e-23 | 27.58% (359) | hypothetical protein Rv2627c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4327 | - | 1e-06 | 24.63% (341) | hypothetical protein MAB_4327 |
| M. marinum M | MMAR_2072 | - | 2e-20 | 27.27% (363) | hypothetical protein MMAR_2072 |
| M. avium 104 | MAV_1605 | - | 1e-112 | 57.67% (352) | hypothetical protein MAV_1605 |
| M. smegmatis MC2 155 | MSMEG_0625 | - | 1e-06 | 24.52% (208) | hypothetical protein MSMEG_0625 |
| M. thermoresistible (build 8) | TH_1422 | - | 1e-23 | 28.87% (336) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1215 | - | 2e-06 | 26.14% (241) | hypothetical protein MUL_1215 |
| M. vanbaalenii PYR-1 | Mvan_2014 | - | 1e-165 | 75.89% (365) | hypothetical protein Mvan_2014 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0625|M.smegmatis_MC2_155 -----------------MEPSSVDPVDPPIPIPDVPGADATSRGLPRRID
MUL_1215|M.ulcerans_Agy99 ----------MSEISETSGTSETDPIDPPVPIPDVPGGEAGAEGLPPLSA
MAB_4327|M.abscessus_ATCC_1997 -----------------MTAELSEHIEQPR-ITPRPAPTARPQ-LPRPGD
Mflv_4331|M.gilvum_PYR-GCK -------------------------MKTSERLWRIGSDFAGVLPRAHSAV
Mvan_2014|M.vanbaalenii_PYR-1 -------------------------MRVTERIWRTGSDFAGLLPRVYAAV
MAV_1605|M.avium_104 ---------------------MAKALSGLSLARDAARELAMLVPRTVAGL
Mb2660c|M.bovis_AF2122/97 MASSASDGTHERSAFRLSPPVLSGAMG----PFMHTGLYVAQSWRDYLGQ
Rv2627c|M.tuberculosis_H37Rv MASSASDGTHERSAFRLSPPVLSGAMG----PFMHTGLYVAQSWRDYLGQ
MMAR_2072|M.marinum_M MAKPAGDDAQESPGARQVNPIGLGGLGSVVTPFVHTGRYFAESWRDYLDQ
TH_1422|M.thermoresistible__bu --------------------VVR--------PFRRTGRYYGGLWREYLRR
MSMEG_0625|M.smegmatis_MC2_155 LTLRQKAIVDASAAADIALRTGVASVVAASMLPRTAATILR-RRDSRIEH
MUL_1215|M.ulcerans_Agy99 LSLRQRLVVESSAVGDIALRTYASSLLSTTVAPAVVAHALR-RLDSGGER
MAB_4327|M.abscessus_ATCC_1997 LTLRERAMVETSALTDIALRTVGALSVMGVVAP---SLVID-REFVARER
Mflv_4331|M.gilvum_PYR-GCK AVGQAWNPLSVRGLRQLGEVALDELALTGMTLTAPPPRLERSEASCAAAA
Mvan_2014|M.vanbaalenii_PYR-1 AADRDWNPLSPSGIRRFGEVALDEMALTGMTLTAPPPKLERSVDSCADAG
MAV_1605|M.avium_104 QESTGWAPLSPRGARQFGEVMLDELVLSAFSLLGGSPAALRPVDACAAAA
Mb2660c|M.bovis_AF2122/97 QP--DKLPIARPTIALAAQAFRDEIVLLGLKARRPVSNHRVFERISQEVA
Rv2627c|M.tuberculosis_H37Rv QP--DKLPIARPTIALAAQAFRDEIVLLGLKARRPVSNHRVFERISQEVA
MMAR_2072|M.marinum_M DS--DGLPIARPTIALAAQAFRDEIVLMGLKARRPVSDPHVFERIDDEVA
TH_1422|M.thermoresistible__bu TPQEEELPLTRPTLALAAEAFRDEVVLLGLRTRRPVSDVRAFERITAEVR
: . : .
MSMEG_0625|M.smegmatis_MC2_155 EHMRFYADLAEAKDPERSFPRPTEPPRVSSRPANPVAEWVAHGRVENIRF
MUL_1215|M.ulcerans_Agy99 ANLNFYAELAAEQDPRKSFPAPTELPRISARPASPLAEWIARGSVDDISF
MAB_4327|M.abscessus_ATCC_1997 DNLAFYGELAAMGDADLSFPEPEITPVVFSRPAGRVAQALAKATVENLDF
Mflv_4331|M.gilvum_PYR-GCK AELAGLG-------VTGANADPDPVDIGSLRRRR-----LGRHRYEQLTF
Mvan_2014|M.vanbaalenii_PYR-1 AELSSRG-------VAGAHADPEPLRVRSCRQRR-----FGRQAYERLRF
MAV_1605|M.avium_104 EELAALG-------IDGAHAAPNPLRPTSIRRRS-----IAGLDYERMAF
Mb2660c|M.bovis_AF2122/97 AGLEFYGNRGWLEKPSGFFAQPPPLTEVAVRKVK-----DRRRSFYRIFF
Rv2627c|M.tuberculosis_H37Rv AGLEFYGNRRWLEKPSGFFAQPPPLTEVAVRKVK-----DRRRSFYRIFF
MMAR_2072|M.marinum_M LALQFYGDQGWLQRPRTFFADPPPPSEVTVRKVK-----GRKRSFYRMFF
TH_1422|M.thermoresistible__bu EALEFFGSRGCLDDPEKFFTPPPALDEVTVLPRE-----GRRRDHDRIRW
: . . * : :
MSMEG_0625|M.smegmatis_MC2_155 QSSFR-AVNPALRERCRGHVRNNIVRAQHWRHNDGPHPTLCVIHG-FMGS
MUL_1215|M.ulcerans_Agy99 TSGFR-AKNPNMRQHWSALTSNNVVRAQHWRHDDGPRPTLCVIHG-FMGS
MAB_4327|M.abscessus_ATCC_1997 ESPYQ-TRNPALRDYWKRFPHNSVARAQHWRHDDGPRPTLCVIHG-FFGS
Mflv_4331|M.gilvum_PYR-GCK DH----DPHLPDTLSAEGFGGAATAVAHLCRTDSKRRPWLVWVHGAGQG-
Mvan_2014|M.vanbaalenii_PYR-1 DH----DPHLPESLAA--FGGPATAVVHLCRVTDERRPWLVWVHGAGQG-
MAV_1605|M.avium_104 EH----DPALPATLVADGLGGPARAVVHLRRHRDGPRPWLVWVHGAGQG-
Mb2660c|M.bovis_AF2122/97 DSGFTPHPGEPGSQRWLSYTANNREYALLLRHPE-PRPWLVCVHGTEMGR
Rv2627c|M.tuberculosis_H37Rv DSGFTPHPGEPGSQRWLSYTANNREYALLLRHPE-PRPWLVCVHGTEMGR
MMAR_2072|M.marinum_M DSGYTPLPGEPGGQRWLGYTANNREYALLLRHRE-PRPWLVCVHGTEMGR
TH_1422|M.thermoresistible__bu DSGYAPLPGAPGGQRYAGYSANDRCYALLLRHAE-PRPWLIGIHGTEMGR
. * . :* * :** *
MSMEG_0625|M.smegmatis_MC2_155 PYLANGLFLSLPWFYRAGYDVLLYTLPFHGLRAERFSPFSGYGYFANGLA
MUL_1215|M.ulcerans_Agy99 SYLLNGLFFSLPWYYRSGYDVLLYTLPFHGKRAERFSPFSGFGFFASGLS
MAB_4327|M.abscessus_ATCC_1997 PYLLNGAFFALPWFFRNGYDVLLYTLPFHGRRAEKYSPFSGAGYFSHGFT
Mflv_4331|M.gilvum_PYR-GCK QPIDLLFSRARRIQDELGVNVALPVQPGCGVRASAWP-----EYPTMDPL
Mvan_2014|M.vanbaalenii_PYR-1 QPVDLLFSRARRLQEELGFNVALPVQPGCGVRRGRWP-----EYPSMDPL
MAV_1605|M.avium_104 GTEDLLLSGIGRIHRELGFNIAMPVQPGHGCRRRQWP-----VYPDMDPL
Mb2660c|M.bovis_AF2122/97 APLDLAVFRAWKLHDELGLNIVMPVLPMHGPRGQGLPKGA--VFPGEDVL
Rv2627c|M.tuberculosis_H37Rv APLDLAVFRAWKLHDELGLNIVMPVLPMHGPRGQGLPKGA--VFPGEDVL
MMAR_2072|M.marinum_M APLDLALFRSWKLHRELGLNIVMPVLPMHGPRARDLPKGA--VYPGEDVL
TH_1422|M.thermoresistible__bu AAVDLAVFRARRLHRELGLNVVLPVLPMHGPRGRGLPKGA--VFPGEDVL
. * :: : . * * * . : .
MSMEG_0625|M.smegmatis_MC2_155 GFAEAMAQAVHDFRSVMDHLEFTGVDR-IALTGISLGGFTSALLASVDHR
MUL_1215|M.ulcerans_Agy99 GFAESMAQAVYDFRSIVDYLHHTGVTR-IALTGISLGGYTSALVSSVENR
MAB_4327|M.abscessus_ATCC_1997 GFSESMCQAVHDFRIFVNYLRGTGVEK-IGLTGLSLGGYTTGLISTVERR
Mflv_4331|M.gilvum_PYR-GCK ANVAGMLRVVSEVRALVRWLRPQATA--IAVAGVSMGSPVAGLVSHLEP-
Mvan_2014|M.vanbaalenii_PYR-1 ANVAGMMRAVSEVRALVRWLRPQAAS--IAVAGVSMGSPVAGLVSHLEP-
MAV_1605|M.avium_104 GNVAGMMRAVSEVRAVVRWARSQAST--LVVAGISMGSPVAALVSHLERQ
Mb2660c|M.bovis_AF2122/97 DDVHGTAQAVWDIRRLLSWIRSQEEESLIGLNGLSLGGYIASLVASLEEG
Rv2627c|M.tuberculosis_H37Rv DDVHGTAQAVWDIRRLLSWIRSQEEESLIGLNGLSLGGYIASLVASLEEG
MMAR_2072|M.marinum_M DNVHATAQAVWDIRRLISWIRMQEPESLIGINGLSLGGYIASLVASLEDD
TH_1422|M.thermoresistible__bu DNVHATGQAVWDVRRLISWIRAQEPDSAIGLNGISLGGFVTSLVVSLEDG
. :.* :.* .: . : : *:*:*. :.*: ::
MSMEG_0625|M.smegmatis_MC2_155 IQAVIPNVPVVTPDRTVDEWFPANMLVALERHIAHTDPELTEAAARYASP
MUL_1215|M.ulcerans_Agy99 LEAVIPNCPVVTPAELFEQWFPASKLVRLGLCLSSISRGELDAGLAFHSP
MAB_4327|M.abscessus_ATCC_1997 IDVTIPNVPVVDVKSLLHSWIPAEPTIKLAARLGHLDQGRLDGALSYSSP
Mflv_4331|M.gilvum_PYR-GCK VDAVAVYTPIFGLNAMIAAHLGRWGPSVDDT-VALLRSEVVEQVSAAVDY
Mvan_2014|M.vanbaalenii_PYR-1 VDAVAVYTPISGLNAMIAAHLGRWGPSVGET-VALLRSQAVERVASAVDY
MAV_1605|M.avium_104 VDAVALYTPILGLNAMIARHLQRWGPARDGF-RELLQSPVVTRLTSVIDP
Mb2660c|M.bovis_AF2122/97 LACAILGVPVADLIELLGRHCG----LRHKD-PRRHTVKMAEPIGRMISP
Rv2627c|M.tuberculosis_H37Rv LACAILGVPVADLIELLGRHCG----LRHKD-PRRHTVKMAEPIGRMISP
MMAR_2072|M.marinum_M LTCAILGVPVADLVDLLGRHSG----FGRDD-PRRETVALAEPIGHMISP
TH_1422|M.thermoresistible__bu LTCAILGVPVADLIELLGRHAG----LRRGD-PRRETMELARPLGRMISP
: . *: . .
MSMEG_0625|M.smegmatis_MC2_155 LHYQPLVAKERRLIITGLGDRLAP-PQQAELLWEHWDRCAFHWFPGNHLL
MUL_1215|M.ulcerans_Agy99 LNYRPQLPKHRRMIIAGLGDRMAP-PDHAEPLWEHWDRCALHWFPGSHVL
MAB_4327|M.abscessus_ATCC_1997 LTYQPVVPREQRLIITGLGDRLAP-PEQSEMLWEHWDRCALHWFPGNHIL
Mflv_4331|M.gilvum_PYR-GCK QAVEPSASPDRRLIVGAWHDRMAM-REPAQVLHARWGG-ELYWHQGSHVG
Mvan_2014|M.vanbaalenii_PYR-1 HSVAPSAPPERRLIVGAWHDRMAR-REPALALHDRWGG-RLYWHRGSHVG
MAV_1605|M.avium_104 LAVTPAPPPERRLIVGAWHDRMAM-REPANALQDRWAG-QLYWYDGSHVG
Mb2660c|M.bovis_AF2122/97 LSLTPLVPMPGRFIYAGIADRLVHPREQVTRLWEHWGKPEIVWYPGGHTG
Rv2627c|M.tuberculosis_H37Rv LSLTPLVPMPGRFIYAGIADRLVHPREQVTRLWEHWGKPEIVWYPGGHTG
MMAR_2072|M.marinum_M LALTPLVPRAGRFIYAGVADQLVHPRRQVARLWEHWGKPDIVWYPGGHTG
TH_1422|M.thermoresistible__bu LSLRPRVPPRGRFVYGGIADRVVHPREQVVRLWEHWDRPDIVWYRGGHTG
* . *:: . *::. * :* : *. *.*
MSMEG_0625|M.smegmatis_MC2_155 HVSQPDYLRRMTRFLRGFMFD-----------
MUL_1215|M.ulcerans_Agy99 HVSQLDYLRRMTAFLGDFMFD-----------
MAB_4327|M.abscessus_ATCC_1997 HVNQGDYLRRMTEFLDRHLNV-----------
Mflv_4331|M.gilvum_PYR-GCK HLFAPGVHTASEKFLRSLTG------------
Mvan_2014|M.vanbaalenii_PYR-1 HLFAGGVQDASEEFLRSVAADRP---------
MAV_1605|M.avium_104 HIFSRRVQRITDRFLRDAVLA-----------
Mb2660c|M.bovis_AF2122/97 FFQSRPVRRFVQAALEQSGLLDAPRTQRDRSA
Rv2627c|M.tuberculosis_H37Rv FFQSRPVRRFVQAALEQSGLLDAPRTQRDRSA
MMAR_2072|M.marinum_M FFRSRPVQQFVEDALQQSGLLDDPSEQRDRPA
TH_1422|M.thermoresistible__bu FFQSRSVQRFVEDALAQSGLIEAPGRA-----
.. *