For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VNAGVTNYTEITGSVRSVSMTGSSTPASALLARAGGVRGLVYTALPVTTFAAGNAIAGLMPALIAAVVAG ALVMTVQLVRRESTRPAMFGFAGVAAGAGFALVTGRAKDFYLPGIWMYLALAVLFTASVLARRPLIGVVW AWMTGRDDTWRRTRRVRIAFDLVTLMMAAVSATRFAVQFYLYDTDQEGLLAVARIAMGWPVFLLTSTLIY LAIRTAMRTLPRGVPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4236 | - | - | 100% (227) | putative integral membrane alanine and leucine rich protein |
| M. gilvum PYR-GCK | Mflv_3929 | - | 2e-46 | 47.28% (184) | hypothetical protein Mflv_3929 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2712c | - | 1e-50 | 47.76% (201) | integral membrane alanine and leucine rich protein |
| M. tuberculosis H37Rv | Rv2693c | - | 1e-50 | 47.76% (201) | integral membrane alanine and leucine rich protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2996c | - | 7e-39 | 40.00% (195) | hypothetical protein MAB_2996c |
| M. marinum M | MMAR_2021 | - | 2e-50 | 47.03% (202) | integral membrane alanine and leucine rich protein |
| M. avium 104 | MAV_3584 | - | 7e-48 | 47.26% (201) | hypothetical protein MAV_3584 |
| M. smegmatis MC2 155 | MSMEG_2770 | - | 8e-43 | 42.71% (192) | integral membrane alanine and leucine rich protein |
| M. thermoresistible (build 8) | TH_2214 | - | 3e-46 | 45.18% (197) | PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH |
| M. ulcerans Agy99 | MUL_3331 | - | 5e-50 | 46.53% (202) | integral membrane alanine and leucine rich protein |
| M. vanbaalenii PYR-1 | Mvan_2125 | - | 1e-103 | 84.02% (219) | putative integral membrane alanine and leucine rich protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2770|M.smegmatis_MC2_155 ----------------MTQADNSPLPESAGEAEVPRARGGRAVLEQMGGI
TH_2214|M.thermoresistible__bu ------------VNPAADESETRTGDQPPEKATDERSVGAHTMLEQMGGF
Mb2712c|M.bovis_AF2122/97 --------------------------MNANRTSAQR------LLAQAGGV
Rv2693c|M.tuberculosis_H37Rv --------------------------MNANRTSAQR------LLAQAGGV
MMAR_2021|M.marinum_M --------------------------MSANRVSAES------LLAQAGGV
MUL_3331|M.ulcerans_Agy99 --------------------------MSANRVSAES------LLAQVGGV
MAV_3584|M.avium_104 --------------------------MTANRINPER------LLAQAGGV
MAB_2996c|M.abscessus_ATCC_199 MPETPSHEPDGSGGLDAHEGPHLKISVPGTKPEEPGSSPLHEMWHQAGGW
Mflv_4236|M.gilvum_PYR-GCK --------MVNAGVTNYTEITGSVRSVSMTGSSTPAS----ALLARAGGV
Mvan_2125|M.vanbaalenii_PYR-1 -------------MTNYTEIVRSVLSMIMTGTSTPAT----VLLARAGGI
: : **
MSMEG_2770|M.smegmatis_MC2_155 SGLIYSSLPVVVFVPVSSLFGLTAAIASALAVATLILIWRLIRRDSVQPA
TH_2214|M.thermoresistible__bu SGLIYSSLPVVAFVPISNMFGLTSAIVAALGTAAAILVWRLIRRESAQPA
Mb2712c|M.bovis_AF2122/97 SGLVYSSLPVVTFVVASSAAGLLPAIGFALSMAGLILLWRLLRRESARPV
Rv2693c|M.tuberculosis_H37Rv SGLVYSSLPVVTFVVASSAAGLLPAIGFALSMAGLILLWRLLRRESARPV
MMAR_2021|M.marinum_M SGLVYSSVPVVIFVAVSSIGGLLPAIGSALAAAGLVLLLRLIRRESTQPA
MUL_3331|M.ulcerans_Agy99 SGLVYSSVPVVIFVAVSSIGGLLPAIGSALAAAGLVLLLRLIRRESTQPA
MAV_3584|M.avium_104 SGVIYSSLPVVVFVIASSVSGLVAAIAAALGVAALVLLWRLVRRDSPQPA
MAB_2996c|M.abscessus_ATCC_199 QGIVYSSIPVIVFVVAVSVSSLIPAIISALVAATLVLIWRLVRRESVQPA
Mflv_4236|M.gilvum_PYR-GCK RGLVYTALPVTTFAAGNAIAGLMPALIAAVVAGALVMTVQLVRRESTRPA
Mvan_2125|M.vanbaalenii_PYR-1 RGLVYTALPVTTFAALNAVAGLTPALIAALGAGAIVLVLQLVRRESTRPA
*::*:::** *. .* .*: *: . :: :*:**:* :*.
MSMEG_2770|M.smegmatis_MC2_155 ISGFFAVGVSALIAYMVGESKGYFLLGIWSSLIYAVVFGISVLIRRPVVG
TH_2214|M.thermoresistible__bu ISGFFGVGVCVLIAYLMGESKGYFLLGIWMSLLWAAVFGVSVLIRRPVVG
Mb2712c|M.bovis_AF2122/97 VAGFCGVAVCALIAYLVGQSKGYFLLGIWMSLLWAVVFTLSILIRRPIVG
Rv2693c|M.tuberculosis_H37Rv VAGFCGVAVCALIAYLVGQSKGYFLLGIWMSLLWAVVFTLSILIRRPIVG
MMAR_2021|M.marinum_M VSGFFGVAGCALVAYLVGQSKGYFLLGIWMSLLWAVVFALSIVVRRPVVG
MUL_3331|M.ulcerans_Agy99 VSGFFGVAGCALVAYLVGQSKGYFLLGIWMSLLWAVVFALSIVVRRPVVG
MAV_3584|M.avium_104 ISGFFGVALCALIAYVVGESKGYFLLGIWMSLLWAVVVAASVLIRRPLVG
MAB_2996c|M.abscessus_ATCC_199 VSGFISVGISALIAYLLGEAKGYFLIGIWANFFWGTVFLVSVIIRRPIVG
Mflv_4236|M.gilvum_PYR-GCK MFGFAGVAAGAGFALVTGRAKDFYLPGIWMYLALAVLFTASVLARRPLIG
Mvan_2125|M.vanbaalenii_PYR-1 LFGFAGIAVGAGLALATGRAKDFYLPGIWMYLAMAVLFTGSIVVGRPLIG
: ** .:. . .* *.:*.::* *** : ..:. *:: **::*
MSMEG_2770|M.smegmatis_MC2_155 YIWGWVHTDDAGWRDVRKAVRAFDIATLTWVAVFGSRFVVQNHLYDADET
TH_2214|M.thermoresistible__bu YLWGWLSGHGAHWRGVRRAVLAFDIATLTWVLVFSSRFLVQRYLYDADET
Mb2712c|M.bovis_AF2122/97 YLWSWLSGRDRAWRDVSRAVFAFDVATLGWTLVFAARFIVQRHLYDADKT
Rv2693c|M.tuberculosis_H37Rv YLWSWLSGRDRAWRDVSRAVFAFDVATLGWTLVFAARFIVQRHLYDADKT
MMAR_2021|M.marinum_M FLWSWTSGRDQGWREVPRAVYAFDVATLGWTLVFAARFIVQRLLYDADKT
MUL_3331|M.ulcerans_Agy99 FLWSWTSGRDQGWREVPRAVYAFDVATLGWTLVFAARFIVQRLLYDADKT
MAV_3584|M.avium_104 YAWSWAGGRGDGWRSVPRAVYAFDVASLCWVLVFAARFVVQGLLYDADRT
MAB_2996c|M.abscessus_ATCC_199 YAYSWATGGDMSWRGNRRIVTAFDIATVSWIVLFAVRFVVQEWLYLAGNT
Mflv_4236|M.gilvum_PYR-GCK VVWAWMTGRDDTWRRTRRVRIAFDLVTLMMAAVSATRFAVQFYLYDTDQE
Mvan_2125|M.vanbaalenii_PYR-1 VVWAWMTGRDDTWRRTPRVRTAFVLVTLMMAAVSATRFAVQFYLYDTDQE
:.* . ** : ** :.:: : . ** ** ** :..
MSMEG_2770|M.smegmatis_MC2_155 TWLGVARIAMGWPLTAVAALVTYLAIRSAQRAVREHQAARHIDAATGSGS
TH_2214|M.thermoresistible__bu GWLGVARIAMGWPLTAVAALVTYLAIRTAQRALEHHRAA-----------
Mb2712c|M.bovis_AF2122/97 GWLGVARIGMGWPLTALAALATYAAIKAAQRAILASHDA--------AAV
Rv2693c|M.tuberculosis_H37Rv GWLGVARIGMGWPLTALAALATYAAIKAAQRAILASHDA--------AAV
MMAR_2021|M.marinum_M GWLGVARIGMGWPLTAVAALATYAAIKAARRAMPAADEP--------EAA
MUL_3331|M.ulcerans_Agy99 GWLGVARIGMGWPLTAVAALATYAAIKAARRAMPAADEP--------EAA
MAV_3584|M.avium_104 GWLAAARIGMGWPLTVLAALATYAAIKSAQRAIAAVELA--------SGA
MAB_2996c|M.abscessus_ATCC_199 AWLGGAKIAMGWPLTAVGALVTLLVIRYVRRHTDQAEDR-----------
Mflv_4236|M.gilvum_PYR-GCK GLLAVARIAMGWPVFLLTSTLIYLAIRTAMRTLPRGVPE-----------
Mvan_2125|M.vanbaalenii_PYR-1 GLLAVARIAMGWPIFLVTSTLIYLAIRTAMRTLPKGAEPA----------
*. *:*.****: : : .*: . *
MSMEG_2770|M.smegmatis_MC2_155 EPAAESGAEPHAG-
TH_2214|M.thermoresistible__bu ------GGAPASG-
Mb2712c|M.bovis_AF2122/97 GGAAEFDADAGRE-
Rv2693c|M.tuberculosis_H37Rv GGAAEFDADAGRE-
MMAR_2021|M.marinum_M -EVAAVDTEACREL
MUL_3331|M.ulcerans_Agy99 -EVAAVDTEACREL
MAV_3584|M.avium_104 AGE-----------
MAB_2996c|M.abscessus_ATCC_199 ----APESEPPA--
Mflv_4236|M.gilvum_PYR-GCK --------------
Mvan_2125|M.vanbaalenii_PYR-1 --------------