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TDQHSTPVGPQPVDEPPKKSSRAGRNLPAAIAVGVLLGGGLIAILIFAPYLWLALLSAAVAMATYEVSSR LGEAGYRIPFVPLLVGGQATLWLTWPFGPSGALGGFAATVVVCMIWRLVGHGLNHAPQNYTRDIGATVFL ATWVPLFASFGALLIYPDDGANRVFCLMLGVVFSDIGGYVAGVLFGRHTMAPAISPKKSWEGLAGSLLFG VTASVLAVVFLLDKPWWAGVALGLMLVITGTLGDLVESQFKRDLGIKDMSNLLPGHGGMMDRIDAALPSA VATWIVLTLLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4122 | - | - | 100% (292) | phosphatidate cytidylyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2905c | cdsA | 4e-99 | 59.86% (284) | integral membrane phosphatidate cytidylyltransferase CdsA |
| M. tuberculosis H37Rv | Rv2881c | cdsA | 4e-99 | 59.86% (284) | integral membrane phosphatidate cytidylyltransferase CdsA |
| M. leprae Br4923 | MLBr_01589 | - | 1e-100 | 59.93% (297) | putative phosphatidate cytidylyltransferase |
| M. abscessus ATCC 19977 | MAB_3186c | - | 1e-108 | 64.48% (290) | phosphatidate cytidylyltransferase (CdsA) |
| M. marinum M | MMAR_1828 | cdsA | 7e-99 | 57.67% (300) | integral membrane phosphatidate cytidylyltransferase CdsA |
| M. avium 104 | MAV_3731 | cdsA | 2e-99 | 62.99% (281) | phosphatidate cytidylyltransferase |
| M. smegmatis MC2 155 | MSMEG_2543 | cdsA | 1e-125 | 73.29% (292) | phosphatidate cytidylyltransferase |
| M. thermoresistible (build 8) | TH_0273 | cdsA | 1e-123 | 73.22% (295) | PROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE |
| M. ulcerans Agy99 | MUL_2076 | cdsA | 1e-98 | 57.33% (300) | integral membrane phosphatidate cytidylyltransferase CdsA |
| M. vanbaalenii PYR-1 | Mvan_2222 | - | 1e-131 | 76.71% (292) | phosphatidate cytidylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4122|M.gilvum_PYR-GCK --MTDQHSTPVGPQPVD---------EPPKKSSRAGRNLPAAIAVGVLLG
TH_0273|M.thermoresistible__bu -------------VPAD---------ET-QKVGRAGRNLPAAIAVGVLLG
MSMEG_2543|M.smegmatis_MC2_155 --MTDQQASLVASKPVG---------EPQKKQSRAGRNLPAAIGVGVGLG
Mvan_2222|M.vanbaalenii_PYR-1 --MTDQHSTPVISKPVN---------EPPKKASRAGRNLPAAIAVGVALG
MAB_3186c|M.abscessus_ATCC_199 --MGDTDAAPAPGSSPA---------PPAGAKSRAGRNLPAAIGVGVALA
Mb2905c|M.bovis_AF2122/97 MTTNDAGTGNPAEQPARGAKQ-----QPATETSRAGRDLRAAIVVGLSIG
Rv2881c|M.tuberculosis_H37Rv MTTNDAGTGNPAEQPARGAKQ-----QPATETSRAGRDLRAAIVVGLSIG
MMAR_1828|M.marinum_M MANTDATTGTPADEPVQ---------EPPKKASRAGRDLPAAIAVGLSIG
MUL_2076|M.ulcerans_Agy99 MANTDATTGTPADEPVQ---------EPPKKASRAGRDLPAAIAVGLSIG
MLBr_01589|M.leprae_Br4923 MASTDPGTGTPLDESVPGIKR--AMRQSTKNTPRAGRNLPAAIAVGLSIG
MAV_3731|M.avium_104 MATSDPGAGDEPEHAVENTTEGAAGQRAKKKTSRAGRDLRAAIAVGAGIG
. . ****:* *** ** :.
Mflv_4122|M.gilvum_PYR-GCK GGLIAILIFAPYLWLALLSAAVAMATYEVSSRLGEAGYRIPFVPLLVGGQ
TH_0273|M.thermoresistible__bu GGLIAVLVWAPYVWLGVLAVAIAIATREVTARLREAGYQIPLVPLLLGGQ
MSMEG_2543|M.smegmatis_MC2_155 GGVIAILLFAPLVWVGVVAAAMAVATHEVVRRLRTGGFSIPVVPLLIGGQ
Mvan_2222|M.vanbaalenii_PYR-1 AMLIVVLLFAPKVWVGVVSVAIAIATHEVVRRLREGGYSIPVVPLLVGGQ
MAB_3186c|M.abscessus_ATCC_199 ALIIFSLLYQKEIWVGIISVFLGIAMWEVTKRLRQADISVPFIPLFFGGQ
Mb2905c|M.bovis_AF2122/97 LVLIAVLVFVPRVWVAIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQ
Rv2881c|M.tuberculosis_H37Rv LVLIAVLVFVPRVWVAIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQ
MMAR_1828|M.marinum_M LFLVATLVFAPRGWVAICAFAMVVATHEVVRRLREAGYLIPVVPLLIGGQ
MUL_2076|M.ulcerans_Agy99 LFLVATLVFAPRGWVAICAFAMVVATHEVVRRLREAGYLIPVVPLLIGGQ
MLBr_01589|M.leprae_Br4923 GVLVATLVFAPRIWVVLCAGAIFVASHEVVRRLREAGYVIPAIPLLIGGQ
MAV_3731|M.avium_104 AVLIVTLVFAPRFWVPIVAMAILVASHEVVRRLREAGYVIPVIPLLAGGQ
:: *:: *: : : :* ** ** .. :* :**: ***
Mflv_4122|M.gilvum_PYR-GCK ATLWLTWPFGPSGALGGFAATVVVCMIWRLVGHG-------------LN-
TH_0273|M.thermoresistible__bu ATLWLTWPFGAAGALGGFAGMVVTCMIWRLIAQGRAAAPVRTSADPDLSG
MSMEG_2543|M.smegmatis_MC2_155 AMVWLTLPFGPAGALGGFGATVVLCLIWRLLSGG-------------LT-
Mvan_2222|M.vanbaalenii_PYR-1 AMIWLTWPFGAAGALGAFGGTVVVCMIWRLVSGG-------------LS-
MAB_3186c|M.abscessus_ATCC_199 AMIWLTWPWGTAGSVGAFAATVVVCMIWRLLSQG-------------LG-
Mb2905c|M.bovis_AF2122/97 AAVWLTWPFGAVGALAGFGGMVVVCMIWRLFMQDSVTRPTTG-------G
Rv2881c|M.tuberculosis_H37Rv AAVWLTWPFGAVGALAGFGGMVVVCMIWRLFMQDSVTRPTTG-------G
MMAR_1828|M.marinum_M LTVWLSWPYGVRGVLAGFGAMIVVCMFWRLFMQDNRPHDGAGS-----DG
MUL_2076|M.ulcerans_Agy99 LTVWLSWPYGVRGVLAGFGAMIVVCMFWRLFMQDNLPHDGAGS-----DG
MLBr_01589|M.leprae_Br4923 FTVWLTWPYRTVGALAGFGATVVVCMIWRLVMHDNSKQHESREA----LA
MAV_3731|M.avium_104 LTVWLTWPFHAAGALAGFGVTVVACLFWRLFMQDNRKRPEP-------FA
:**: *: * :..*. :* *::***. .
Mflv_4122|M.gilvum_PYR-GCK -HAPQNYTRDIGATVFLATWVPLFASFGALLIYPDDGANRVFCLMLGVVF
TH_0273|M.thermoresistible__bu QPGPTNYLRDIAATIFLATWVPLFAGFGALLIYPDDGPARVFSFMLAVVC
MSMEG_2543|M.smegmatis_MC2_155 -AAPVNYLRDVSVTVFLAAWIPLFGAFGALLIYPDDGAGRVFCLMLGVVA
Mvan_2222|M.vanbaalenii_PYR-1 -DAPQNYLRDMSTTVFLATWVPLFASFGVLLIYPDDGAGRVFCLMLGVVA
MAB_3186c|M.abscessus_ATCC_199 -SQPVNYLRDVAITVFVAAWIPLFASFGALLVYPDNGAEQVFCLMLGVTF
Mb2905c|M.bovis_AF2122/97 APSPGNYLSDVSATVFLAVWVPLFCSFGAMLVYPENGSGWVFCMMIAVIA
Rv2881c|M.tuberculosis_H37Rv APSPGNYLSDVSATVFLAVWVPLFCSFGAMLVYPENGSGWVFCMMIAVIA
MMAR_1828|M.marinum_M VPASGTYLRDTSATVFLAVWVVLFGSFAAMLVYPPNGTGWVFCVMIAIIA
MUL_2076|M.ulcerans_Agy99 VPASGTYLRDTSTTVFLAVWVVLFGSFAAMLVYPPNGTGWVFCVMIAIIA
MLBr_01589|M.leprae_Br4923 GPPVSNYLRDASATVFLAAWVPLFASFAALLVYPKDGAGRVFCLMIAVVA
MAV_3731|M.avium_104 GSPSANYLRDASATVFLACWVPLFASFAALLVYPADGAGRVFCLMITVVA
.* * . *:*:* *: ** .*..:*:** :*. **..*: :
Mflv_4122|M.gilvum_PYR-GCK SDIGGYVAGVLFGRHTMAPAISPKKSWEGLAGSLLFGVTASVLAVVFLLD
TH_0273|M.thermoresistible__bu SDIGGYTAGVLFGRHPMVPAISPKKSWEGFAGSMVFGTTAAVLAVVFLMD
MSMEG_2543|M.smegmatis_MC2_155 SDVGGYTAGVLFGKHPMVPAISPKKSWEGLAGSLVLGIVVSVLAVTFLLD
Mvan_2222|M.vanbaalenii_PYR-1 SDVGGYTAGVLFGKHPMAPAISPKKSWEGLAGSLVLGVVVSSLAVQFLTD
MAB_3186c|M.abscessus_ATCC_199 SDIGGYAAGVLFGKHPMAPAISPKKSWEGLAGSLVVGTTASTLAVTFLLG
Mb2905c|M.bovis_AF2122/97 SDVGGYAVGVLFGKHPMVPTISPKKSWEGFAGSLVCGITATIITATFLVG
Rv2881c|M.tuberculosis_H37Rv SDVGGYAVGVLFGKHPMVPTISPKKSWEGFAGSLVCGITATIITATFLVG
MMAR_1828|M.marinum_M SDVGGYTVGVLFGKHPMVPAISPKKSWEGFVGSLFCGIVATTITATFLAH
MUL_2076|M.ulcerans_Agy99 SDVGGYTVGVLFGKHPMVPTISPKKSWEGFAGSLFCGIVATTITATFLAH
MLBr_01589|M.leprae_Br4923 SDVGGYTVGVLFGKHPLVPRISPNKSWEGFAGSLVCGTTATILTATFLAG
MAV_3731|M.avium_104 SDVGGYAVGVLFGKHPMVPAISPKKSWEGLAGSLVLGITAATLAATFLAG
**:***..*****:*.:.* ***:*****:.**:. * ..: ::. **
Mflv_4122|M.gilvum_PYR-GCK KPWWAGVALGLMLVITGTLGDLVESQFKRDLGIKDMSNLLPGHGGMMDRI
TH_0273|M.thermoresistible__bu KPWWAGAALGVLLVITATLGDLVESQFKRDLGIKDMGSLLPGHGGLMDRI
MSMEG_2543|M.smegmatis_MC2_155 KPAWVGVPLGIMLVITGTLGDLVESQVKRDLGIKDMGTLLPGHGGLMDRI
Mvan_2222|M.vanbaalenii_PYR-1 NPWWIGIPLGLMLVITGTLGDLVESQVKRDLGIKDMGTLLPGHGGLMDRL
MAB_3186c|M.abscessus_ATCC_199 HHPFVGIALGVMLVITGTLGDLVESQVKRDLGIKDMGTLLPGHGGIMDRL
Mb2905c|M.bovis_AF2122/97 KTPWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
Rv2881c|M.tuberculosis_H37Rv KTPWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
MMAR_1828|M.marinum_M EPPWVGALLGVLFVLTTTLGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
MUL_2076|M.ulcerans_Agy99 EPPWVGALLGVLFVLTTTLGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
MLBr_01589|M.leprae_Br4923 KTPWVGALLSFVLVLTCTLGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
MAV_3731|M.avium_104 KAPWVGALLGVVLVFTCTLGDLVESQVKRDLGIKDMGRLLPGHGGLMDRL
. : * *..::*:* :********.*********. *******:***:
Mflv_4122|M.gilvum_PYR-GCK DAALPSAVATWIVLTLLA
TH_0273|M.thermoresistible__bu DGMLPSAVATWIVLSLLA
MSMEG_2543|M.smegmatis_MC2_155 DSVLPSAVATWIVLTLLA
Mvan_2222|M.vanbaalenii_PYR-1 DSILPSAVATWIVLSLLA
MAB_3186c|M.abscessus_ATCC_199 DSLLPSAVATWIVLTLFI
Mb2905c|M.bovis_AF2122/97 DGILPSAVAAWIVLTLLP
Rv2881c|M.tuberculosis_H37Rv DGILPSAVAAWIVLTLLP
MMAR_1828|M.marinum_M DGVLPSAVAAWIVMSLLT
MUL_2076|M.ulcerans_Agy99 DGVLPSAVAAWIVMSLLT
MLBr_01589|M.leprae_Br4923 DGVLPSAVVAWTMLTLLP
MAV_3731|M.avium_104 DGVLPSAVAAWTVLTLVP
*. *****.:* :::*.