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MTSRDAAAETAFGPMVLAAIEHNEPPDRRLVDDDLAESFLPNRFRLLVRCARVAAVRRAVIAAADRSGPG LWASIACRKRYIDERLSDPLNDTDAVVVLGAGLDTRSCRIARHSTMPVFEVDQQINVDRKQAVLRRTLGE VPSSVRLVGVDLERGQVMPALRAQGYDTRARTFFSRAPLTPFPDAVRATLTQLDGAAEGSKLIFSYIRQD FIDGTDLYGARSVYRRFRQRRAVWKSGLVPEHVGELLADHGWRLVEQAGPSYYRDTYIRPTGRPLAASPL EWTVFAER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3997 | - | - | 100% (288) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_5024 | - | 1e-07 | 28.44% (225) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_5025 | - | 6e-07 | 34.53% (139) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2772 | - | 1e-85 | 54.17% (288) | hypothetical protein Mb2772 |
| M. tuberculosis H37Rv | Rv2751 | - | 1e-85 | 54.17% (288) | hypothetical protein Rv2751 |
| M. leprae Br4923 | MLBr_02640 | - | 2e-06 | 26.36% (220) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3082 | - | 1e-71 | 48.59% (284) | hypothetical protein MAB_3082 |
| M. marinum M | MMAR_1964 | - | 3e-82 | 51.39% (288) | O-methyltransferase |
| M. avium 104 | MAV_3642 | - | 4e-79 | 53.62% (276) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1501 | - | 2e-56 | 42.76% (283) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_4502 | - | 1e-08 | 28.23% (209) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_3393 | - | 4e-83 | 51.74% (288) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2390 | - | 1e-121 | 74.14% (290) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3997|M.gilvum_PYR-GCK -----MTSRDAAAETAFG---PMVLAAIEHNEPPDRRLVDDDLAESFLPN
Mvan_2390|M.vanbaalenii_PYR-1 -----MTARDAAAQTAFG---PMVLAAIEQNEPPLQRLVHDDLAESFLPG
Mb2772|M.bovis_AF2122/97 ------MARNPAAQTAFG---PMVLAAVEQNEPPGRRLVDDDLADLFLPR
Rv2751|M.tuberculosis_H37Rv ------MARNPAAQTAFG---PMVLAAVEQNEPPGRRLVDDDLADLFLPR
MMAR_1964|M.marinum_M ------MTRNPAAQTAFG---PMVLSAVEQNEPAEHRLVDDDLADLFLPR
MUL_3393|M.ulcerans_Agy99 ------MTRNPAAQTAFG---PMVLSAVEQNEPAEHRLVDDDLADLFLPR
MAV_3642|M.avium_104 ----------------------MVLAAVEQNEPPGRRLVDDDFAELFLPA
MAB_3082|M.abscessus_ATCC_1997 -----MPQSNPAAQTAFG---PMAITAVEQHEPAAARIVDDDLAAHILPR
MSMEG_1501|M.smegmatis_MC2_155 -----------MERTAVG---PTLIVAIDQYD--ERTLVPDPWAVRILPR
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
: :: * * ::.
Mflv_3997|M.gilvum_PYR-GCK RFRLLVRCARVAAVRRAVIAAADRSGPGLWASI----ACRKRYIDERLS-
Mvan_2390|M.vanbaalenii_PYR-1 RLRLLVRLTRVAALRRAAATVTDRSGPGLWASI----ACRKRYIDERLS-
Mb2772|M.bovis_AF2122/97 PLRWLAGATRSAVLRRLLISASEWSGRGLWANL----ACRKRFIGDKLD-
Rv2751|M.tuberculosis_H37Rv PLRWLAGATRSAVLRRLLISASEWSGRGLWANL----ACRKRFIGDKLD-
MMAR_1964|M.marinum_M PLRWLVSATRPAGIRRLFIRWSEWSGSGLWVNL----TCRKRFIGDKLG-
MUL_3393|M.ulcerans_Agy99 PLRWLVSATRPAGIRRLFIRWSEWSGSGLWVNL----TCRKRFIGDRLG-
MAV_3642|M.avium_104 PLRWLVGATRFAPVRHLMIRGSEFTGPGLWANL----ACRKRFIADKLK-
MAB_3082|M.abscessus_ATCC_1997 GLRWFVRATAWAPLRHWLIRLTERGGQGAWSLF----VCRKRYIDDQLA-
MSMEG_1501|M.smegmatis_MC2_155 RWRVPAVLSRFKVVRNAMIAATENSVRGGWASL----LCRKRYIDDVLAG
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
: . : *..:: :
Mflv_3997|M.gilvum_PYR-GCK -DPLNDTDAVVVLGAGLDTRSCRIARHSTMPVFEVDQQINVDRKQAVLRR
Mvan_2390|M.vanbaalenii_PYR-1 -DPLNDTDAVVVLGAGLDTRACRIARHGDLPVFEVDRPVNVDRKAAVLHR
Mb2772|M.bovis_AF2122/97 -EALGDIDAVVILGAGLDTRAYRLTRRVRMPVFEVDLPVNIARKAKTVRR
Rv2751|M.tuberculosis_H37Rv -EALGDIDAVVILGAGLDTRAYRLTRRVRMPVFEVDLPVNIARKAKTVRR
MMAR_1964|M.marinum_M -EALDDIDAVAILGAGLDTRAYRLTRKVRIPIFEVDLPVNIARKAKTVRR
MUL_3393|M.ulcerans_Agy99 -EALDDVDAVAILGAGLDTRAYRLTRKMRIPIFEVDLPVNIARKAKTVRR
MAV_3642|M.avium_104 -ESLDDINAVVILGAGLDTRAYLLTRRVRIPVFEVDLPVNVARKFKTVRR
MAB_3082|M.abscessus_ATCC_1997 -ASS--IDAVVDLGAGLDTRGCRVARAAPTPVFEVDQAVNIAIKQQAVKR
MSMEG_1501|M.smegmatis_MC2_155 AASGGGLDAVVILGAGYDTRAHRVLQLSDVPVWEVDLPDNIAAKTAALQR
MLBr_02640|M.leprae_Br4923 -AVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAE
TH_4502|M.thermoresistible__bu -AAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATLAA
.. *.:* *:*. : ::*:* : * .:
Mflv_3997|M.gilvum_PYR-GCK TLGEVPSSVRLVGVDLERGQVMPALRAQGYDTRARTFFSRAPLTPF--PD
Mvan_2390|M.vanbaalenii_PYR-1 VFGAVPASVHLVPVDLEEDPLIPALESHGYRPEQRTFFIWEGVTQYLSPE
Mb2772|M.bovis_AF2122/97 VLGELPLSVRLVALDFEHDDLLTALAEHGYRTEYRVFFVCEGVTQYLTER
Rv2751|M.tuberculosis_H37Rv VLGELPLSVRLVALDFEHDDLLTALAEHGYRTEYRVFFVCEGVTQYLTER
MMAR_1964|M.marinum_M VLGELPLSVRLVALDFEHDDLLTALAEHGYLTDFRVFFICEGVTQYLTEE
MUL_3393|M.ulcerans_Agy99 VLGELPLSVRLVALDFEHDDLLTALAEHGYLTDFRVFFICEDVTQYLTEE
MAV_3642|M.avium_104 VLGELPLSVRLVALDLEHDDLLTALAEHGYRTDYRVFFICEGVTQYLSEA
MAB_3082|M.abscessus_ATCC_1997 ALGAVPASLHLVPVDFQRDELAEELRRAGHDTAHRTFFIWEGVTQYIPET
MSMEG_1501|M.smegmatis_MC2_155 CFGPMPANVTPVSVDLEHGDLIGSLTGAGFDTGMRTAFVWESVTMYLTEP
MLBr_02640|M.leprae_Br4923 HGVTPTADRREVPIDLR-QDWPPALRSAGFDPSARTAWLAEGLLMYLPAT
TH_4502|M.thermoresistible__bu HGVQPAADRREVAVDLR-HDWPKALRAKGFDPQQRTAWLAEGLLMYLPAD
. . * :*:. * *. . *. : : :
Mflv_3997|M.gilvum_PYR-GCK AVRATLTQLDGAAE-GSKLIFS-------YIRQDFIDGTDLYGARSVYRR
Mvan_2390|M.vanbaalenii_PYR-1 AVHATLAQLAGAAP-GSKLVFT-------YIRQDFIDGTNLYGADAVYRR
Mb2772|M.bovis_AF2122/97 AVRRTLEGLRAAAP-GSRMVFT-------YVRRDFIDGTNRYGTRTLYHT
Rv2751|M.tuberculosis_H37Rv AVRRTLEGLRAAAP-GSRMVFT-------YVRRDFIDGTNRYGTRTLYHT
MMAR_1964|M.marinum_M TVRRTLEGLRAAAP-GSRLVFT-------YVRRDFIDGTNRYGTRTLYRS
MUL_3393|M.ulcerans_Agy99 TVRRTLEGLRAAAP-GSRLVFT-------YVRRDFIDGTNRYGTRTLYRS
MAV_3642|M.avium_104 TVRRTLDGLRAAAP-GSRLVFT-------YVRSDFIDGTNRYGTRTLYRN
MAB_3082|M.abscessus_ATCC_1997 AVRATLAYLGTAAT-GSRLAFT-------YVQRDFIDGSNLYGNSMLYKR
MSMEG_1501|M.smegmatis_MC2_155 VVRRTLQATSACAA-GSHLVFT-------HFRKDFVDGVSLYGAQKARER
MLBr_02640|M.leprae_Br4923 AQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALGFEQ
TH_4502|M.thermoresistible__bu AQDRLFENITALSAPGSRLAVETAAEEPVDRREQMRARMERIASQFGLEK
. : : **:: . : :: . .
Mflv_3997|M.gilvum_PYR-GCK FRQRRAVWKSGLVPEHVGELLADHGWRLVEQAGPSYYRDTYIRP-----T
Mvan_2390|M.vanbaalenii_PYR-1 FRKRSQVWRSGVVPEQVGELLAGHGWRLVEQAGPSYFRDTYIRP-----T
Mb2772|M.bovis_AF2122/97 VRQRRQLWHFGLDPEEVAGFLADYGWRLTEQAGPEELVQRYVEP-----T
Rv2751|M.tuberculosis_H37Rv VRQRRQLWHFGLDPEEVAGFLADYGWRLTEQAGPEELVQRYVEP-----T
MMAR_1964|M.marinum_M VRQRRQLWHFGLLPDEVPEFLAEYGWRLVEQAGPDELVQRYVEP-----A
MUL_3393|M.ulcerans_Agy99 VRQRRQLWHFGLLPDEVPEFLAEYGWRLVEQAGPDELVQRYVEP-----A
MAV_3642|M.avium_104 VRQRRQLWHFGLQPGEVADFLAEYGWRLVEQAGPDELMQRYVVP-----T
MAB_3082|M.abscessus_ATCC_1997 FRVRSQVWMFGLTPGTVGPLLAEYGWQVLEDVSGPEYQRRYLIP-----A
MSMEG_1501|M.smegmatis_MC2_155 FADKLHLWRYGIDPEDVAGVLAEYGWRETEQAGASEYRKRYLAP-----A
MLBr_02640|M.leprae_Br4923 AVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRW-------
TH_4502|M.thermoresistible__bu ALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDRFVAAAMPP
: . * * :**: .
Mflv_3997|M.gilvum_PYR-GCK GRPLAASPLEWTVFAER-------
Mvan_2390|M.vanbaalenii_PYR-1 GREVSASPVEWTVLAER-------
Mb2772|M.bovis_AF2122/97 GRNLNASQIEWSAYAEKSEPVTPR
Rv2751|M.tuberculosis_H37Rv GRNLNASQIEWSAYAEKSEPVTPR
MMAR_1964|M.marinum_M GRKLNASQIEWSAYAEKL------
MUL_3393|M.ulcerans_Agy99 GRKLNASQIEWSAYAEKL------
MAV_3642|M.avium_104 GRKLKASQLEWSAYAEKT------
MAB_3082|M.abscessus_ATCC_1997 GRTLSTTELERTVLAEKI------
MSMEG_1501|M.smegmatis_MC2_155 GRSDPLSEIERAVWAQR-------
MLBr_02640|M.leprae_Br4923 GDGVPMAD-DKDAFAEFVTAHRL-
TH_4502|M.thermoresistible__bu GDDADAADLDDTAFSKFVTAERPS
* : : . ::