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AQETHDVTAYPKPTSGAPKFPALEAEVLQYWDSDDTFRASIAQRDGAPEFVFYDGPPFANGLPHYGHLLT GYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVQRQLGITDKAQIEQMGIEKFNDACRASVLKYTDEW RDYVTRQARWVDFDNDYKTLDIGFMESVIWVFKQLWDKGLAYEGNRVLPYCWNDETPLSSHELRMDDDVY QNRQDPALTVGFRISSGELEGAYLLVWTTTPWTLPSNQAVAVNPDVTYVVVESDGRRYVLAEARLAAYAR EFGEEPAVVATYRGADLLDVGYVPPFPYFMDSPNAFRVLPAEFVSTEDGTGLVHMSPAYGEDDMATAQAG GIDAVTPVDAKGRFDASVPDYAGQHVFDANPQIIRDLKNGTGAAATNGAVLLRHDSYEHSYPHCWRCRNP LIYRAVSSWFVKVTQFRDRMVELNQEITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPA YPRIDVYGSLDELERDFGVRPDNLHRPFIDELTRPNPDDPTGRSTMRRIEDVLDVWFDSGSMPYGQVHYP FENQQWFESHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFRTCVSHGIVLGNDGQKMSKSLRNYPDV SEVFDRDGSDAMRWFLMASPILRGGNLIVTEQGIREGVRQVLLPLWNAYTFLALYAPEKGTWRTDSTHVL DRYILAKLAQLRDDLTASLDVCDISQACDQLRQFTEALTNWYVRRSRSRFWDEDADAIDTLHTVLEVTGR LAAPLLPLITEVIWRGVTGERSVHLTDWPEAGVLPADPQLVADMDLVRDVASAGSSLRKAQKLRVRLPLL KLTVAVQDPGRLEPYRDLIADELNVKAVELTDDIAAHGRFELAVNARVAGPRIGRDVQAAIKAVKAGEAV VNDDGTLTAGPAVLLPEEFSSKLVAAEEAFTAALPGGAGLVVLDGTVTPELEAEGWAKDRIRELQELRKS TGLDVSDRISVVMSVPSTHQQWAQTHRDLIAGEILATSFEFGEPDGATEIGDGVRVAIAKA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3644 | ileS | - | 100% (1042) | isoleucyl-tRNA synthetase |
M. gilvum PYR-GCK | Mflv_2630 | valS | 2e-57 | 24.82% (999) | valyl-tRNA synthetase |
M. gilvum PYR-GCK | Mflv_1930 | - | 2e-06 | 22.99% (335) | methionyl-tRNA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1563 | ileS | 0.0 | 81.47% (1036) | isoleucyl-tRNA synthetase |
M. tuberculosis H37Rv | Rv1536 | ileS | 0.0 | 81.56% (1036) | isoleucyl-tRNA synthetase |
M. leprae Br4923 | MLBr_01195 | ileS | 0.0 | 78.39% (1055) | isoleucyl-tRNA synthetase |
M. abscessus ATCC 19977 | MAB_2705c | ileS | 0.0 | 77.42% (1054) | isoleucyl-tRNA synthetase |
M. marinum M | MMAR_2356 | ileS | 0.0 | 83.14% (1038) | isoleucyl-tRNA synthetase IleS |
M. avium 104 | MAV_3235 | ileS | 0.0 | 83.46% (1040) | isoleucyl-tRNA synthetase |
M. smegmatis MC2 155 | MSMEG_3169 | ileS | 0.0 | 85.59% (1041) | isoleucyl-tRNA synthetase |
M. thermoresistible (build 8) | TH_3715 | - | 0.0 | 83.41% (1055) | PUTATIVE Isoleucyl-tRNA synthetase |
M. ulcerans Agy99 | MUL_1532 | ileS | 0.0 | 82.56% (1038) | isoleucyl-tRNA synthetase |
M. vanbaalenii PYR-1 | Mvan_2769 | ileS | 0.0 | 87.44% (1051) | isoleucyl-tRNA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3644|M.gilvum_PYR-GCK --------------------MAQETHDVTAYP--------KPTSGAPKFP Mvan_2769|M.vanbaalenii_PYR-1 ---------------------------MTAYP--------KFTAGAPRFP MSMEG_3169|M.smegmatis_MC2_155 ---------------------------MTAYP--------KP--AAPNFP TH_3715|M.thermoresistible__bu VVPRRSRYPARCRPRVLKTWAQENREIVTAYP--------KPSPGAPNFP MMAR_2356|M.marinum_M -----------------MTD--------STYPRSNLG--ADHRGGSPDFP MUL_1532|M.ulcerans_Agy99 -----------------MTD--------STYPRSNLG--ADHRGGSPDFP Mb1563|M.bovis_AF2122/97 -----------------MTD--------NAYP--------KLAGGAPDLP Rv1536|M.tuberculosis_H37Rv -----------------MTD--------NAYP--------KLAGGAPDLP MLBr_01195|M.leprae_Br4923 -----------------MTN--------SAYPRTDLG--ADQRGGSPNFP MAV_3235|M.avium_104 -----------------MTDNLGFQADREAQPADSVQTYPKPAGGAPDFP MAB_2705c|M.abscessus_ATCC_199 ---------------------------MDAYPRTDLG--ADQRSGSPNLP : * . .:* :* Mflv_3644|M.gilvum_PYR-GCK ALEAEVLQYWDSDDTFRASIAQRDGAPEFVFYDGPPFANGLPHYGHLLTG Mvan_2769|M.vanbaalenii_PYR-1 ALEADVLSYWDTDDTFRASIARREGAPEYVFYDGPPFANGLPHYGHLLTG MSMEG_3169|M.smegmatis_MC2_155 ERELEVLDYWAKDDTFRASVERREGAEEYVFYDGPPFANGLPHYGHLLTG TH_3715|M.thermoresistible__bu ALEQEVLEYWSADDTFRASIERRADAPEYVFYDGPPFANGLPHYGHLLTG MMAR_2356|M.marinum_M ELETQVLDYWARDETFRASIERRDGAPEYVFYDGPPFANGLPHYGHLLTG MUL_1532|M.ulcerans_Agy99 ELETQVLDYWARDETFRASIERRDGAPEYVFYDGPPFANGLPHYGHLLTG Mb1563|M.bovis_AF2122/97 ALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTG Rv1536|M.tuberculosis_H37Rv ALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTG MLBr_01195|M.leprae_Br4923 ALEAQVLDYWSNDDTFRASIARCDDAPEYVFYDGPPFANGLPHYGHLLTG MAV_3235|M.avium_104 ALELEVLDYWARDDTFRASIARRDGAEEYVFYDGPPFANGLPHYGHLLTG MAB_2705c|M.abscessus_ATCC_199 ALEKQVLRYWDQDDTFRASIANRDGAPEYVFYDGPPFANGLPHYGHLLTG * :** ** *:*****: . .* *:********************* Mflv_3644|M.gilvum_PYR-GCK YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVQRQLGITDKAQIEQMG Mvan_2769|M.vanbaalenii_PYR-1 YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVQRQLGITDKAQIEEMG MSMEG_3169|M.smegmatis_MC2_155 YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVQRQLDITDKSQIEEMG TH_3715|M.thermoresistible__bu YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVQRQLGITDKAQIEQMG MMAR_2356|M.marinum_M YVKDIVPRYRTMRGFKVERRFGWDTHGLPAELEVERQLGITDKSQIDAMG MUL_1532|M.ulcerans_Agy99 YVKDIVPRYRTMRGFKVERRFGWDTHGLPAELEVERQLGITDKSQIDAMG Mb1563|M.bovis_AF2122/97 YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIEAMG Rv1536|M.tuberculosis_H37Rv YVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIEAMG MLBr_01195|M.leprae_Br4923 YVKDIVPRYRTMCGYKVERRFGWDTHGLPAELEVERQLGITDKSQIDAMG MAV_3235|M.avium_104 YVKDIVPRYRTMRGNKVERRFGWDTHGLPAELEVERQLGITDKSQIDDMG MAB_2705c|M.abscessus_ATCC_199 YVKDIVPRYQTMRGYQVDRRFGWDTHGLPAELEVERQLGITDKSQIDSMG *********:** * :*:****************:***.****:**: ** Mflv_3644|M.gilvum_PYR-GCK IEKFNDACRASVLKYTDEWRDYVTRQARWVDFDNDYKTLDIGFMESVIWV Mvan_2769|M.vanbaalenii_PYR-1 IEKFNDACRESVLKYTNEWREYVTRQARWVDFDNDYKTLDIGFMESVIWV MSMEG_3169|M.smegmatis_MC2_155 IEKFNDACRASVLKYTNEWQAYVTRQARWVDFDNDYKTLDLPFMESVIWA TH_3715|M.thermoresistible__bu IEKFNDACRASVLRYTKEWREYVTRQARWVDFDNDYKTLDLGYMESVIWA MMAR_2356|M.marinum_M IAAFNDACRASVLRYTDEWQQYVTRQARWVDFDNDYKTLDLGYMESVIWA MUL_1532|M.ulcerans_Agy99 IAAFNDACRASVLRYTDEWQQYVTRQARWVDFDNDYKTVDLGYMESVIWA Mb1563|M.bovis_AF2122/97 IAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWA Rv1536|M.tuberculosis_H37Rv IAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWA MLBr_01195|M.leprae_Br4923 IAAFNEACRKSVLRYTEEWQAYVTRQARWVDFDNDYKTLDLSYMESVIWA MAV_3235|M.avium_104 IAAFNDACRESVLRYTDEWRAYVTRQARWVDFDNDYKTLDLPYMESVIWA MAB_2705c|M.abscessus_ATCC_199 IAEFNDACRESVLRYTKEWREYVTRQARWVDFDNDYKTLDLTFMESVIWA * **:*** ***:**.**: *****************:*: :******. Mflv_3644|M.gilvum_PYR-GCK FKQLWDKGLAYEGNRVLPYCWNDETPLSSHELRMDDDVYQNRQDPALTVG Mvan_2769|M.vanbaalenii_PYR-1 FKQLWDKGLAYEGNRVLPYCWNDETPLSSHELRMDDDVYQNRQDPALTVG MSMEG_3169|M.smegmatis_MC2_155 FKQLWDKGLAYEGNRVLPYCWNDETPLSSHELRMDDDVYQSRQDPALTVG TH_3715|M.thermoresistible__bu FKQLWDKGLAYEGIRVLPYCWNDETPLSSHELRMDDDVYQSRQDPAITVG MMAR_2356|M.marinum_M FRQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPALTVG MUL_1532|M.ulcerans_Agy99 FRQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPALTVG Mb1563|M.bovis_AF2122/97 FKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVG Rv1536|M.tuberculosis_H37Rv FKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVG MLBr_01195|M.leprae_Br4923 FKQLWDKGLAYESYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTLG MAV_3235|M.avium_104 FKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPALTVG MAB_2705c|M.abscessus_ATCC_199 FKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVG *:**********. *******.******.***********.*****:*:* Mflv_3644|M.gilvum_PYR-GCK FRISSG--------------ELEGAYLLVWTTTPWTLPSNQAVAVNPDVT Mvan_2769|M.vanbaalenii_PYR-1 YRIVGGPADERSREERTAKSDLVGAYLLIWTTTPWTLPSNQAVAVNPEVT MSMEG_3169|M.smegmatis_MC2_155 FRIDEG--------------PLTDSYLLIWTTTPWTLPSNQAVAVGPDIT TH_3715|M.thermoresistible__bu FRVPDG--------------PLAGSHLLIWTTTPWTLPSNQAVAVHPDVT MMAR_2356|M.marinum_M FKVVDGEP----------QGELAGAYLLVWTTTPWTLPSNLAVAVHPDVT MUL_1532|M.ulcerans_Agy99 FKVVDGEP----------QGELAGAYLLVWTTTPWTLPSNLAVAVHPDVT Mb1563|M.bovis_AF2122/97 FKVVGGQP----------DNGLDGAYLLVWTTTPWTLPSNLAVAVSPDIT Rv1536|M.tuberculosis_H37Rv FKVVGGQP----------DNGLDGAYLLVWTTTPWTLPSNLAVAVSPDIT MLBr_01195|M.leprae_Br4923 FKVLGGD-----------DEDLVGAYLLVWTTTPWTLPSNLAVAVHPDVT MAV_3235|M.avium_104 FKVVGGE--------------LDGAHLLIWTTTPWTLPSNLAVAVHPEVT MAB_2705c|M.abscessus_ATCC_199 YRIAGNED--------SRWATLDGARLLIWTTTPWTLPSNLAVAVNPEVT ::: . * .: **:*********** **** *::* Mflv_3644|M.gilvum_PYR-GCK YVVVE--SDGRRYVLAEARLAAYAREFGEEPAVVATYRGADLLDVGYVPP Mvan_2769|M.vanbaalenii_PYR-1 YVVVE--ADGRRYVLAEARLGAYARELGEEPTVVATYTGRELLDLHYAPP MSMEG_3169|M.smegmatis_MC2_155 YVHVEG-ADGRRYLLAEARLGAYARELGEEPKVLATFTGRDLLGTHYVPP TH_3715|M.thermoresistible__bu YVQVAA-PDGRRYVLAEARLAAYARELGEEPEVLARFPGSELVETRYLPP MMAR_2356|M.marinum_M YVQVR--VGDRRLVLAEARLAAYTRELGEEPEVIGSYRGADLLGMRYLPP MUL_1532|M.ulcerans_Agy99 YVQVR--VGDRRLVLAEARLAAYTRELGEEPEVIGSYRGADLLGIRYLPP Mb1563|M.bovis_AF2122/97 YVQVQ--AGDRRFVLAEARLAAYARELGEEPVVLGTYRGAELLGTRYLPP Rv1536|M.tuberculosis_H37Rv YVQVQ--AGDRRFVLAEARLAAYARELGEEPVVLGTYRGAELLGTRYLPP MLBr_01195|M.leprae_Br4923 YVDVR--AGDRRFVLAQARLTAYARELGDEPEVLATYRGADLLGRHYLPP MAV_3235|M.avium_104 YVQVR--SGDRRFVLAQPRLAAYARELGPEPEILGSYRGAELLGTRYLPP MAB_2705c|M.abscessus_ATCC_199 YAVVKPEDSEDRYLLAQARVGAYARELGEEPTVLDTYTGAELLGLRYLPP *. * . * :**:.*: **:**:* ** :: : * :*: * ** Mflv_3644|M.gilvum_PYR-GCK FPYFMDSP--NAFRVLPAEFVSTEDGTGLVHMSPAYGEDDMATAQAGGID Mvan_2769|M.vanbaalenii_PYR-1 FPYFMDSP--NAFRVLPGEFVSTEDGTGLVHMSPAYGEDDMATAQAGGIE MSMEG_3169|M.smegmatis_MC2_155 FPYFMGSA--NAFQVLAGDFVSTEDGTGIVHMAPAYGEDDKATADAADIV TH_3715|M.thermoresistible__bu FTYFADAA--NSFRVLPADFVSTEDGTGIVHMAPAYGEDDMDVAKAADIT MMAR_2356|M.marinum_M FAYFMDSP--NAFAVLAGEFVTTEDGTGIVHMAPAYGEDDMAVTSPVGIE MUL_1532|M.ulcerans_Agy99 FAYFMDSP--NAFAVLAGEFVTTEDGTGIVHMAPAYGEDDMAVTSPVGIE Mb1563|M.bovis_AF2122/97 FAYFMDWP--NAFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIA Rv1536|M.tuberculosis_H37Rv FAYFMDWP--NAFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIA MLBr_01195|M.leprae_Br4923 FQYFYESAR-NAFQVLPGDFVTTDDGTGIVHIAPAYGEDDMATADKVGIV MAV_3235|M.avium_104 FPYFMDSP--NAFRVLAGEFVTTEDGTGIVHLAPAYGEDDMAVADAAGIA MAB_2705c|M.abscessus_ATCC_199 FPYFQQDASPNAFTVLSGDYVTTDDGTGIVHMAPAYGEEDKNVTDRAQIT * ** . *:* **..::*:*:****:**::*****:* .:. * Mflv_3644|M.gilvum_PYR-GCK AVTPVDAKGRFDASVPDYAGQHVFDANPQIIRDLKNGTGAAATNGAVLLR Mvan_2769|M.vanbaalenii_PYR-1 AVTPVDAKGRFDATVPDYAGQHVFDANPQIIRDLKNQSGPAQANGAVLLR MSMEG_3169|M.smegmatis_MC2_155 AVTPVDSKGRFDESVPDYVGQHVFEANPQIIRDLKNGDGSAGANGAVVLR TH_3715|M.thermoresistible__bu AVTPVDAKGCFDASVPDYQGRHVFDANPQIIRDLKNQAGPAGHNGAVLLR MMAR_2356|M.marinum_M PVTPVDAKGRFDSSVPDYQGQHVFDANAQIIRDLKNQSGPAAANGAVLIR MUL_1532|M.ulcerans_Agy99 PVTPVDAKGRFDSSVPDYQGQHVFDANAQIIRDLKNQSGPAAANGAVLIR Mb1563|M.bovis_AF2122/97 PVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGPAAVNGPVLIR Rv1536|M.tuberculosis_H37Rv PVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGPAAVNGPVLIR MLBr_01195|M.leprae_Br4923 PVTPVDSNGCFDATVPDYQGQHVFEANAQIIRDLKNQSGSAAVNGAVLLR MAV_3235|M.avium_104 PVTPVDSNGRFDAAVPDYQGLNVFDANPQIIRDLKNGSGAAAANAPVLLR MAB_2705c|M.abscessus_ATCC_199 PVTPVDSKGRFDATVPDYEGQQVFDANAQIIKDLKNGTGAAGLNGAVLLR .*****::* ** :*.** * :**:**.**::***. *.* *..*::* Mflv_3644|M.gilvum_PYR-GCK HDSYEHSYPHCWRCRNPLIYRAVSSWFVKVTQFRDRMVELNQEITWYPEH Mvan_2769|M.vanbaalenii_PYR-1 HDTYEHSYPHCWRCRNPLIYRAVSSWFIKVTQFRDRMVELNQEITWYPEH MSMEG_3169|M.smegmatis_MC2_155 HETYEHSYPHCWRCRNPLIYRAVSSWFVRVTEFRDRMVELNQQITWYPEH TH_3715|M.thermoresistible__bu HDTYEHSYPHCWRCRNPLIYRAVSSWFIKVTEFRDRMVELNQQITWYPGH MMAR_2356|M.marinum_M HETYEHPYPHCWRCRNPLIYRAVSSWFVTVTKFRERMVELNQQITWYPEH MUL_1532|M.ulcerans_Agy99 HETYEHPYPHCWRCRNPLIYRAVSSWFVTVTKFRERMVELNQQITWCPEH Mb1563|M.bovis_AF2122/97 HETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEH Rv1536|M.tuberculosis_H37Rv HETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEH MLBr_01195|M.leprae_Br4923 HETYEHPYPHCWRCRNPLIYRAVSSWFVAVTEFRDRMVELNQQITWYPEH MAV_3235|M.avium_104 HETYEHPYPHCWRCRNPLIYRAVSSWFVAVTRFRDRMVELNQQITWYPEH MAB_2705c|M.abscessus_ATCC_199 HETYDHSYPHCWRCRNPLIYRAVSSWFIKVTEFRDRMVQLNEQITWYPEH *::*:*.**************:*****: ** **:***:**::*** * * Mflv_3644|M.gilvum_PYR-GCK VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL Mvan_2769|M.vanbaalenii_PYR-1 VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL MSMEG_3169|M.smegmatis_MC2_155 VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL TH_3715|M.thermoresistible__bu VKDGQFGKWLANARDWSISRNRYWGTPIPVWVSDNPEYPRIDVYGSLDEL MMAR_2356|M.marinum_M VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL MUL_1532|M.ulcerans_Agy99 VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL Mb1563|M.bovis_AF2122/97 VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL Rv1536|M.tuberculosis_H37Rv VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL MLBr_01195|M.leprae_Br4923 VKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPDYPRIDVYGSLDEL MAV_3235|M.avium_104 VKDGQFGKWLAGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDEL MAB_2705c|M.abscessus_ATCC_199 VKHGQFGKWLEGARDWSVSRNRYWGSPIPVWKSDDPAYPRIDVYGSLDEL **.******* .*****:*******:***** **:* ************* Mflv_3644|M.gilvum_PYR-GCK ERDFGVRPDNLHRPFIDELTRPNPDDPTGRSTMRRIEDVLDVWFDSGSMP Mvan_2769|M.vanbaalenii_PYR-1 ERDFGVRPDNLHRPFIDELTRPNPDDPTGRSTMRRIEDVLDVWFDSGSMP MSMEG_3169|M.smegmatis_MC2_155 ERDFGVRPDNLHRPFIDQLTRPNPDDPTGKSTMRRIEDVLDVWFDSGSMP TH_3715|M.thermoresistible__bu ERDFGVRPTDLHRPYIDELTRPNPDDPTGKSTMRRIPDVLDVWFDSGSMP MMAR_2356|M.marinum_M ERDFGVRPTNLHRPYIDELTRPNPDDPTGQSTMRRIPDVLDVWFDSGSMP MUL_1532|M.ulcerans_Agy99 ERDFGVRPINLHRPYIDELTRPNPDDPTGQSTMRRIPDVLDVWFDSGSMP Mb1563|M.bovis_AF2122/97 ERDFGVRPANLHRPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMP Rv1536|M.tuberculosis_H37Rv ERDFGVRPANLHRPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMP MLBr_01195|M.leprae_Br4923 ERDFGVRPTNLHRPYIDELTRPNPDDPTGLSTMRRIPDVFDVWFDSGSMP MAV_3235|M.avium_104 ERDFGVRPDNLHRPYIDELTRPNPDDPSGRSTMRRIPDVLDVWFDSGSMP MAB_2705c|M.abscessus_ATCC_199 ERDFGVRPTNLHRPYIDELTRPNPDDPTGKSTMRRIPDIFDVWFDSGSMP ******** :****:**:*********:* ****** *::********** Mflv_3644|M.gilvum_PYR-GCK YGQVHYPFENQQWFE------------SHYPGDFIVEYIGQTRGWFYTLH Mvan_2769|M.vanbaalenii_PYR-1 YGQVHYPFENSDWFD------------SHFPGDFIVEYIGQTRGWFYTLH MSMEG_3169|M.smegmatis_MC2_155 YAQVHYPFENREWFDGASGEE------AHFPGDFIVEYIGQTRGWFYTLH TH_3715|M.thermoresistible__bu FAQVHYPFENADWFDGSDDQE------PHFPGDFIVEYIGQTRGWFYTLH MMAR_2356|M.marinum_M YAQVHYPFENGDWFLGGAAGDAG----AHYPGDFIVEYIGQTRGWFYTLH MUL_1532|M.ulcerans_Agy99 YAQVHYPFENGDWFLGGAAGDAG----AHYPGDFIVEYIGQTRGWFYTLH Mb1563|M.bovis_AF2122/97 YAQVHYPFENLDWFQG------------HYPGDFIVEYIGQTRGWFYTLH Rv1536|M.tuberculosis_H37Rv YAQVHYPFENLDWFQG------------HYPGDFIVEYIGQTRGWFYTLH MLBr_01195|M.leprae_Br4923 YAQVHYPFENDDWFDGFDSADSDKQVDAHYPGDFIVEYIGQARGWFYTLH MAV_3235|M.avium_104 YAQVHYPFENRDWFET------------HYPGDFIVEYIGQTRGWFYTLH MAB_2705c|M.abscessus_ATCC_199 YAQVHYPFENAEWFEK------------HFPADFIVEYIGQTRGWFYVMH :.******** :** *:*.*********:*****.:* Mflv_3644|M.gilvum_PYR-GCK VLATALFDRPAFRTCVSHGIVLGNDGQKMSKSLRNYPDVSEVFDRDGSDA Mvan_2769|M.vanbaalenii_PYR-1 ILATALFDRPAFRTCVSHGIVLGNDGQKMSKSLRNYPDVSEVFDRDGSDA MSMEG_3169|M.smegmatis_MC2_155 VLATALFDKPAFKTCVSHGIVLGNDGQKMSKSLRNYPDVSEVFDRDGSDA TH_3715|M.thermoresistible__bu ILATALFDKPAFKTCVAHGIVLGNDGQKMSKSLRNYPDVTEVFDRDGSDA MMAR_2356|M.marinum_M VLATALFDRPAFKTCVAHGIVLGSDGQKMSKSLRNYPDVAEVFHRDGSDA MUL_1532|M.ulcerans_Agy99 VLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVAEVFHRDGSDA Mb1563|M.bovis_AF2122/97 VLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDA Rv1536|M.tuberculosis_H37Rv VLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDA MLBr_01195|M.leprae_Br4923 VLATALFDRPAFKTCIAHGVVLGSNGQKMSKSLRNYPDVTEIFDRDGSDA MAV_3235|M.avium_104 VLATALFDRPAFKTCVAHGIVLGSDGQKMSKSLRNYPDVSEVFDRDGSDA MAB_2705c|M.abscessus_ATCC_199 VLATALFDRPAFRTCVSHGIVLGNDGQKMSKSLRNYPDVNEVFDRDGSDA :*******:***:**::**:*** :************** *:*.****** Mflv_3644|M.gilvum_PYR-GCK MRWFLMASPILRGGNLIVTEQGIREGVRQVLLPLWNAYTFLALYAPEKGT Mvan_2769|M.vanbaalenii_PYR-1 MRWFLMASPILRGGNLIVTEQGIREGVRQVLLPLWNAYTFLALYAPSKGT MSMEG_3169|M.smegmatis_MC2_155 MRWFLMASPILRGGNLIVTEQGIREGVRQVLLPLWNAYSFLALYAPEKGT TH_3715|M.thermoresistible__bu MRWFLMASPILRGGNLIVTEQGIRDGVRQVQLPLWNAYTFLALYAPKKGA MMAR_2356|M.marinum_M MRWFLMASPILRGGNLIVTEQGIREGVRQVLLPFWNAYSFLALYAPKVGT MUL_1532|M.ulcerans_Agy99 MRWFLMASPILRGGNLIVTEQGIREGVRQVLLPFWNAYSFLALYAPKVGT Mb1563|M.bovis_AF2122/97 MRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYAPKVGT Rv1536|M.tuberculosis_H37Rv MRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYAPKVGT MLBr_01195|M.leprae_Br4923 MRWFLMASPILRGGNLIITEPGIREGMRQVLLPLWNAYSFLALYAPKIGT MAV_3235|M.avium_104 MRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPFWNAYSFLALYAPKVGT MAB_2705c|M.abscessus_ATCC_199 MRWFLMASPILRGGNLIVTEQGIREGVRQVILPLWNAWSFLQLYAPKPGT *****************:** ***:*:*** **:**:::** ****. *: Mflv_3644|M.gilvum_PYR-GCK WRTDSTHVLDRYILAKLAQLRDDLTASLDVCDISQACDQLRQFTEALTNW Mvan_2769|M.vanbaalenii_PYR-1 WRTDSEHVLDRYILAKLAVLRDDLTASLDVCDISQACDQLRQFTEALTNW MSMEG_3169|M.smegmatis_MC2_155 WRTDSKNVLDRYILAKLAQLRDDLTSALDVCDISGACDELRQFAESLTNW TH_3715|M.thermoresistible__bu WRTDSRHVLDRYILAKLAALRDDLTDAMEVCDISGACEQLRQFIEALTNW MMAR_2356|M.marinum_M WRTDSDHVLDRYILAKLAVLRDDLTQAMEVCDISGACEQLRQFTEALTNW MUL_1532|M.ulcerans_Agy99 WRTDSDHVLDRYILAKLAVLRDDLTQAMEVCDISGACEQLRQFTEALTNW Mb1563|M.bovis_AF2122/97 WRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNW Rv1536|M.tuberculosis_H37Rv WRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNW MLBr_01195|M.leprae_Br4923 WHTDVSHVLDRYILAKLAVLRDDLSQAMEVCDISGACEQLRQFTEPLTNW MAV_3235|M.avium_104 WRTDSTQVLDRYILAKLAELRDDLTREMDACDISRACEQLRQFTEALTNW MAB_2705c|M.abscessus_ATCC_199 WRTDSKQVLDRYILAKLAQLRDDLTTSMDDCDVSVACEQLRQFTDALTNW *:.* :*********** *****: :: *:. **:.**** :.**** Mflv_3644|M.gilvum_PYR-GCK YVRRSRSRFWDEDADAIDTLHTVLEVTGRLAAPLLPLITEVIWRGVTGER Mvan_2769|M.vanbaalenii_PYR-1 YVRRSRSRFWEEDADAIDTLHTVLEVTSRLAAPLLPLITEVIWRGVTGER MSMEG_3169|M.smegmatis_MC2_155 YVRRSRSRFWDEDPDAIDTLHTVLEVTCRLAAPLLPLATEVIWRGLTGER TH_3715|M.thermoresistible__bu YVRRSRSRFWDEDPDAIDTLHTVLEVTGRLAAPLLPMTTEVIWRGITGER MMAR_2356|M.marinum_M YVRRSRSRFWQEDVDAIDTLHTVLEITARLAAPLLPLVTEVIWRGLTGER MUL_1532|M.ulcerans_Agy99 YVRRSRSRFWQEDVDAIDTLHTVLEMTARLAAPLLPLVTEVIWRGLTGER Mb1563|M.bovis_AF2122/97 YVRRSRSRFWAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRER Rv1536|M.tuberculosis_H37Rv YVRRSRSRFWAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRER MLBr_01195|M.leprae_Br4923 YLRRSRARFWDEDVDAIDTLHTVLEVTARLAAPLLPLITEIIWRSVTGGR MAV_3235|M.avium_104 YVRRSRSRFWSEDADAIDTLHTVLEVTARLAAPLLPSVTELVWRGLTGGR MAB_2705c|M.abscessus_ATCC_199 YVRRSRSRFWEEDADAIDTLHTVLETTCRLAAPLLPMTTEVIWRGLTGER *:****:*** ** *********** * ******** **::**.:* * Mflv_3644|M.gilvum_PYR-GCK SVHLTDWPEAGVLPADPQLVADMDLVRDVASAGSSLRKAQKLRVRLPLLK Mvan_2769|M.vanbaalenii_PYR-1 SVHLTDWPEAGAVPADPQLVADMDLVREVASAGSSLRKAKKLRVRLPLLK MSMEG_3169|M.smegmatis_MC2_155 SVHLTDWPEADVLPKDPDLVAAMDQVREVCSVGSSLRKAKKLRVRLPLPK TH_3715|M.thermoresistible__bu SVHLTDWPESGLLPSDPDLVEAMDQVRDVCSAASSLRKAKKLRVRLPLPK MMAR_2356|M.marinum_M SVHLTDWPQAGEVPADAELVAAMDQVREVCSAASSLRKAKKLRVRLPLPK MUL_1532|M.ulcerans_Agy99 SVHLTDWPQAGEVPADAELVAAMDQVREVCSAASSLRKAKKLRVRLPLPK Mb1563|M.bovis_AF2122/97 SVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPK Rv1536|M.tuberculosis_H37Rv SVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPK MLBr_01195|M.leprae_Br4923 SVHLTDWPQANQLPADPDLVAVMDQVRQVCSAASSLRKAKKLRVRLPLPK MAV_3235|M.avium_104 SVHLTDWPRSGELPADPGLVAAMDQVREVCSAASSLRKAKKLRVRLPLPK MAB_2705c|M.abscessus_ATCC_199 SVHLTDWVSESVLPADAALVAAMDEVRKVASTGSSLRKAKKLRVRLPLLK ******* . :* *. ** ** **.*.*..******:******** * Mflv_3644|M.gilvum_PYR-GCK LTVAVQDPGRLEPYRDLIADELNVKAVELTDDIAAHGRFELAVNARVAGP Mvan_2769|M.vanbaalenii_PYR-1 LTVAVEDPTRLEPYRELIADELNVKSVELTDDIAAHGRFELTVNARVAGP MSMEG_3169|M.smegmatis_MC2_155 LTVAVQDPDSLRPFADLIADELNVKAVELSDDVPAYGRFELAVNARVAGP TH_3715|M.thermoresistible__bu LTVGVDNPQRLEPFVDLIADELNVKSVELTDDIARYGRFELTVNARVAGP MMAR_2356|M.marinum_M LTVAVENPQALKPFTDLIADELNVKQVELTDAIGTYGRFELTVNARVAGP MUL_1532|M.ulcerans_Agy99 LTVAVENPQALKPFTDLIADELNVKQIELADAIGTYGRFELTVNARVAGP Mb1563|M.bovis_AF2122/97 LIVAVENPQLLRPFVDLIGDELNVKQVELTDAIDTYGRFELTVNARVAGP Rv1536|M.tuberculosis_H37Rv LIVAVENPQLLRPFVDLIGDELNVKQVELTDAIDTYGRFELTVNARVAGP MLBr_01195|M.leprae_Br4923 LVVAVYNSQRLKPYIDLIGDELNVKQIELTDAIDTYGRFEFTVNARVAGP MAV_3235|M.avium_104 LTVAVENPQHLAPFVDLIADELNVKSVELTDAIDTYGTFELTVNARVAGP MAB_2705c|M.abscessus_ATCC_199 LTVAVPDPKRLEPYTALIADELNVKSVELTDDIAAYGKFELTVNARVAGP * *.* :. * *: **.****** :**:* : :* **::******** Mflv_3644|M.gilvum_PYR-GCK RIGRDVQAAIKAVKAGEAVVNDDGTLTAGPAVLLPEEFSSKLVAAEE--- Mvan_2769|M.vanbaalenii_PYR-1 RIGKDVQAAIKAVKAGEAVVNADGTLTAGPAVLQPEEYSSRLVAADP--- MSMEG_3169|M.smegmatis_MC2_155 RIGKDVQAAIKAVKAGEGVVNPDGTLTAGPVVLQPEEYTSKLVAADP--- TH_3715|M.thermoresistible__bu RLGKDVQAAIKAVKAGEGVVNPDGTLTAGSVVLQPGEFSSRLVAADAPAD MMAR_2356|M.marinum_M RLGKDVQAAIKAVKAGEGVVNSDGTLTAGPAVLQPEEYSSRLVAADP--- MUL_1532|M.ulcerans_Agy99 RLGKDVQAAIKAVKAGEGVVNSDGILTAGPAVLQPEEYSSRLVAADP--- Mb1563|M.bovis_AF2122/97 RLGKDVQAAIKAVKAGDGVINPDGTLLAGPAVLTADEYNSRLVAADP--- Rv1536|M.tuberculosis_H37Rv RLGKDVQAAIKAVKAGDGVINPDGTLLAGPAVLTPDEYNSRLVAADP--- MLBr_01195|M.leprae_Br4923 RLGRDVQAAIKVVKAGEGVANPDGTLTAGPVVLQPDEYSSRLVAANP--- MAV_3235|M.avium_104 RLGKDVQAAIKAVKAGEGVVNADGTLTAGPAVLRPEEYSSRLVAADP--- MAB_2705c|M.abscessus_ATCC_199 RLGKDVQTVIRAVKSGDWAQQADGTVVAAGITLREGEFDSKLVAAEP--- *:*:***:.*:.**:*: . : ** : *. .* *: *:****: Mflv_3644|M.gilvum_PYR-GCK --AFTAALPGGAGLVVLDGTVTPELEAEGWAKDRIRELQELRKSTGLDVS Mvan_2769|M.vanbaalenii_PYR-1 --EWTAALPDGAGLVVLDGTVTPELEAEGWARDMIREIQEFRRQCELDIS MSMEG_3169|M.smegmatis_MC2_155 --EWTAALPDGAGLVVLDGTVTEELEAEGWAKDRIRELQELRKSTGLEVS TH_3715|M.thermoresistible__bu EDRATAALPEGAGLVVLDCTVTPELEAEGWAKDRIRELQELRKSTGLDIS MMAR_2356|M.marinum_M --EFTAALPGGAGLVVLDGTVTPELEAEGWAKDRIRELQELRKSTGLDVS MUL_1532|M.ulcerans_Agy99 --EFTAALPSGAGLVVLDGTVTPELEAEGWAKDRIRELQELRKSTGLDVS Mb1563|M.bovis_AF2122/97 --ESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVS Rv1536|M.tuberculosis_H37Rv --ESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVS MLBr_01195|M.leprae_Br4923 --EFTAELPDGSGLVVLDDTVTPELEAEGWAKDRIRELQELRKLIGLDVS MAV_3235|M.avium_104 --EFTAALPNGAGLVVLDGTVTPELEAEGWAKDRIRELQELRKSTGLDVS MAB_2705c|M.abscessus_ATCC_199 --DSTAALPEGGGLVILDDTVTEELEAEGWARDLIRELQDLRKSTGLEVS ** ** *.***:** *** ********:* ***:*::*: *::* Mflv_3644|M.gilvum_PYR-GCK DRISVVMSVPSTHQQWAQTHRDLIAGEILATSFEFG---------EPDGA Mvan_2769|M.vanbaalenii_PYR-1 DRILLELGVSELPEGWQEGLKDLIANEVLALELTINPELNLKLKVEPDDG MSMEG_3169|M.smegmatis_MC2_155 DRISVRISVPAEHEQWARTHRDLIAGEILATSFEFA---------EVTDG TH_3715|M.thermoresistible__bu DRISVVMSVPPQRQDWAERHRELIAGEILATSFEFGD--------PGESA MMAR_2356|M.marinum_M DRIQVLISVPGERAEWARTHRDLIAGEILATTFEFG---------EPDDG MUL_1532|M.ulcerans_Agy99 DRIQVLISVPGERAEWARTHRDLIAGEILATTFEFG---------EPDDG Mb1563|M.bovis_AF2122/97 DRIRVVMSVPAEREDWARTHRDLIAGEILATDFEFA---------DLADG Rv1536|M.tuberculosis_H37Rv DRIRVVMSVPAEREDWARTHRDLIAGEILATDFEFA---------DLADG MLBr_01195|M.leprae_Br4923 DRIRVLMSVPAERADWARVHRDFIAREILATSFEFG---------EPADS MAV_3235|M.avium_104 DRISVVMSVPAGRAEWAHTHRDLIAGEILATRFEFG---------EPADP MAB_2705c|M.abscessus_ATCC_199 DRIEVVLEVPAVHRAWAERHRELISGEILATTLDIAEAG----ADTRTPA *** : : *. * . :::*: *:** : : Mflv_3644|M.gilvum_PYR-GCK TEIGDGVRVAIAKA------------------------ Mvan_2769|M.vanbaalenii_PYR-1 LDAQSGVVQATDDPNVFVGRVGRGYPVRLERVVAPSVH MSMEG_3169|M.smegmatis_MC2_155 AEIGDGVRVEIAKV------------------------ TH_3715|M.thermoresistible__bu AEIGDGVRVAIAKAV----------------------- MMAR_2356|M.marinum_M VEIGDGVRVAIAKSGGAGVSGREQA------------- MUL_1532|M.ulcerans_Agy99 VEIGDGVRVAIAKSGGAGVSGREQA------------- Mb1563|M.bovis_AF2122/97 VAIGDGVRVSIEKT------------------------ Rv1536|M.tuberculosis_H37Rv VAIGDGVRVSIEKT------------------------ MLBr_01195|M.leprae_Br4923 VAIGDGVRVSLLKV------------------------ MAV_3235|M.avium_104 VAIGDGVRVSISKV------------------------ MAB_2705c|M.abscessus_ATCC_199 TALSDGVRVSLKKAAG---------------------- .** .