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LGGIQGRQTRLWRVVAVFAATGAMALSGCSSSSESPSDEGSPTAVAPAEKVDAIANTVPESIKSTGTLVV GVNVPYAPNEFKDPEGKLVGFDVDLMNAIAGTLGLTPEYKEADFAKIIPSIQGGTFDVGMSSFTDSKERE EQVDFVTYFSAGTAWAQPAGGDINPEDACGKKVAVQATTVQETDELPARSKKCVDEGKPAIEIIPFDSQD AATNAVVLGQADAMSADSPVTLYAIKQTNGKLEQAGETFDSAPYGWPVEKGSPLAQSLLQALQHLIDNGK YQEIAANWGLEEGMIDKPVINGAIS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3583 | - | - | 100% (306) | extracellular solute-binding protein |
| M. gilvum PYR-GCK | Mflv_5237 | - | 3e-85 | 53.63% (289) | protein kinase |
| M. gilvum PYR-GCK | Mflv_3164 | - | 2e-17 | 30.74% (231) | polar amino acid ABC transporter, inner membrane subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0419c | glnH | 1e-10 | 23.66% (262) | glutamine-binding lipoprotein |
| M. tuberculosis H37Rv | Rv0411c | glnH | 1e-10 | 23.66% (262) | glutamine-binding lipoprotein |
| M. leprae Br4923 | MLBr_00303 | glnH | 3e-10 | 23.28% (262) | putative glutamine-binding protein |
| M. abscessus ATCC 19977 | MAB_4236c | - | 3e-24 | 28.52% (305) | amino acid ABC transporter substrate-binding protein |
| M. marinum M | MMAR_0061 | glnQ | 4e-11 | 28.82% (170) | ABC transporter permease protein GlnQ |
| M. avium 104 | MAV_0059 | - | 1e-12 | 27.27% (264) | amino acid ABC transporter, permease protein, |
| M. smegmatis MC2 155 | MSMEG_3235 | - | 1e-134 | 77.29% (295) | ABC-type amino acid transport system, secreted component |
| M. thermoresistible (build 8) | TH_0053 | - | 8e-78 | 58.70% (230) | ABC-type amino acid transport system, secreted component |
| M. ulcerans Agy99 | MUL_2809 | glnH | 1e-10 | 24.33% (263) | glutamine-binding lipoprotein GlnH |
| M. vanbaalenii PYR-1 | Mvan_2832 | - | 1e-156 | 87.91% (306) | extracellular solute-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0419c|M.bovis_AF2122/97 -----MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTP
Rv0411c|M.tuberculosis_H37Rv -----MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTP
MUL_2809|M.ulcerans_Agy99 -----MRRLPGLRRAASALAVLALVITLDGCGHSEPLKVESTPTLPLPTP
MLBr_00303|M.leprae_Br4923 ----MMTRQFKIQRACS---VLATAMMLAACGHAELLTVASMPTLPPPTP
Mflv_3583|M.gilvum_PYR-GCK ---------MLGGIQGRQTRLWRVVAVFAATGAMALSGCSSS--------
Mvan_2832|M.vanbaalenii_PYR-1 ---------MVAGIQDRRTRIWRVAAVFAAVGALALSGCSSS--------
MSMEG_3235|M.smegmatis_MC2_155 --------------------MWRFAVVLAASGALTLSACASG--------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M ----------MLAVSATILIVLG--LALAAPALADHNQCAPAGV------
MAV_0059|M.avium_104 MGRRGTRRGKLLALTATVLMVCGSSALLAPPAAADRNQCAPAGP------
MAB_4236c|M.abscessus_ATCC_199 ---------------------MRFLTVLVCTALTVLAGCAEG--------
Mb0419c|M.bovis_AF2122/97 VGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLI
Rv0411c|M.tuberculosis_H37Rv VGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLI
MUL_2809|M.ulcerans_Agy99 VGMEVMPPEPPLPADSSSQDCDPTASLRPFPTKAEADAAVADIRARGRLI
MLBr_00303|M.leprae_Br4923 VGMEQVPPELLLPQDNTEEDCDPTASLRPFPTKAEADAAVAEIRARGRLI
Mflv_3583|M.gilvum_PYR-GCK -------------SESPSDEGSPTAVAPAEKVDAIANTVPESIKSTGTLV
Mvan_2832|M.vanbaalenii_PYR-1 -------------SEEPVEEGSPTAAAPAEKVDAIANTVPEAIKSTGKLI
MSMEG_3235|M.smegmatis_MC2_155 -------------EGGGESSPESTQAASGAKVDEIANTLPEDIKSSGKLI
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M --DSAMVLPADLSSATTAGSDEDVQTTAGVVPLSSVNIGDLGLGTPGVLT
MAV_0059|M.avium_104 --KSAAVLPENLTRGGSMS-QPDEHTTPTVEPLSSVRIDTLGLGTPGVLT
MAB_4236c|M.abscessus_ATCC_199 ----------AAPGSSSFNLSPDQDRVRVAKVDAIAAEVPEGIRKRGTLV
Mb0419c|M.bovis_AF2122/97 VG-LDIGSNLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSA
Rv0411c|M.tuberculosis_H37Rv VG-LDIGSNLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSA
MUL_2809|M.ulcerans_Agy99 VG-LDIGSNLFSFRDPITGEITGFDVDIASEVARDIFGGPTHVEYRILSA
MLBr_00303|M.leprae_Br4923 VG-LEIGSNLFSFRDPITGEITGFDIDIAGEVARDIFGTPSHMEYRILST
Mflv_3583|M.gilvum_PYR-GCK VG-VNVPYAPNEFKDPE-GKLVGFDVDLMNAIAGTLGLTP---EYKEADF
Mvan_2832|M.vanbaalenii_PYR-1 VG-VNIPYAPNEFKDES-GKIVGFDVDLMNAIAGTLGLTP---EYREADF
MSMEG_3235|M.smegmatis_MC2_155 VG-VNIPYAPNEFKDPS-GKIVGFDVDLMNAVAATLGLTP---EYREADF
TH_0053|M.thermoresistible__bu -----VPYKPNEFKNAA-GEIVGFDVDLMNAVARTLGLAP---EYRELPF
MMAR_0061|M.marinum_M AG-TLSDAPPNTCINST-GQFTGFDNELLRAIAAKLGLQVR---FVGTDF
MAV_0059|M.avium_104 VG-TLSGAPPNVCITPT-GQYSGFDNQLLRAIAGKLGLQVR---FVGTDF
MAB_4236c|M.abscessus_ATCC_199 VTGDANSSPPLRFYADDDKTMIGIETDIAYLVADILGLRVD---LRSADW
*:: :: :* :
Mb0419c|M.bovis_AF2122/97 AERVTALQKSQVDIVVKTMSITCERRKLVNFSTVYLDANQRILAPRDSPI
Rv0411c|M.tuberculosis_H37Rv AERVTALQKSQVDIVVKTMSITCERRKLVNFSTVYLDANQRILAPRDSPI
MUL_2809|M.ulcerans_Agy99 AERITALQSSQVDVVVKTMTITCERRKLVNFSTVYLDANQRILTSRDSPI
MLBr_00303|M.leprae_Br4923 AARITALQKSEVDIIVKTMTITCKRRKLVNFSTVYLDAKQRILAPRDSPI
Mflv_3583|M.gilvum_PYR-GCK AKIIPSIQGGTFDVGMSSFTDSKEREEQVDFVTYFSAG--TAWAQPAGGD
Mvan_2832|M.vanbaalenii_PYR-1 AKIIPSIQGGTFNVGMSSFTDSKEREQQVDFVTYFSAG--TLWAQPAGGQ
MSMEG_3235|M.smegmatis_MC2_155 AKIIPSIQGGTFNVGMSSFTDTKEREQSVDFVTYFSAG--SLWAQRVGGG
TH_0053|M.thermoresistible__bu EAILPSVRAGDVHVGMASLTVTPERSAGADFVTYFQAG--TLWAQPAGGA
MMAR_0061|M.marinum_M SGLLAQVAARRFDVGSASVKLTEARRRTVAFTNGYDFGYYSLVVPPGSAI
MAV_0059|M.avium_104 AGLLAQVASRRFDVGSSSIKATDERRQTVAFTNGYDFGYYALVVPPGSAI
MAB_4236c|M.abscessus_ATCC_199 AQNFVKVDSGEVDAFISNVTVTEERKEKFDFATYRLDNVTFEARRSLDWK
. : .. ... : * * . .
Mb0419c|M.bovis_AF2122/97 TKVSDLS-GKRVCVARGTT---------SLRRIREIAPPPVIVSVVNWAD
Rv0411c|M.tuberculosis_H37Rv TKVSDLS-GKRVCVARGTT---------SLRRIREIAPPPVIVSVVNWAD
MUL_2809|M.ulcerans_Agy99 FKVSDLS-GKRVCVARGTT---------SLRRIREIAPPPVIVSVVNWAD
MLBr_00303|M.leprae_Br4923 TKPSDLS-NKRVCMTRGTT---------SLHQVSEVVPPPIIVSAENWAD
Mflv_3583|M.gilvum_PYR-GCK INPEDAC-GKKVAVQATTVQETDELPARSKKCVDEGKPAIEIIPFDSQDA
Mvan_2832|M.vanbaalenii_PYR-1 IDPENAC-GKKVAVQATTVQETDELPARSKKCTDAGQPAIEIIAFDSQDA
MSMEG_3235|M.smegmatis_MC2_155 IDPENAC-GKKVAVQATTVQETDELPARSKKCTDAGQPAIEIVPFDGQDA
TH_0053|M.thermoresistible__bu VNPADAC-GLRVGVAYATIQESDEVPFKSEICTAAGKPPIDKVVYVSQDD
MMAR_0061|M.marinum_M TKFSDLAPGQRIGVVQGTV----------EESYVVNSLHLQPVKYPDFAT
MAV_0059|M.avium_104 KEFTDLAAGQRIGVVQGTV----------EESYVVDTLHLQPVKYPDFAT
MAB_4236c|M.abscessus_ATCC_199 VKGARDIAGKTIGVGSGTNQEALLVR-WNEENVAAGLPAADLKYFQQATG
. . : : *
Mb0419c|M.bovis_AF2122/97 CLVALQQREIDAVSTDDTILAGLVEE-DPYLHIVGPDMADQPYG---VGI
Rv0411c|M.tuberculosis_H37Rv CLVALQQREIDAVSTDDTILAGLVEE-DPYLHIVGPDMADQPYG---VGI
MUL_2809|M.ulcerans_Agy99 CLVALQQREIDAVSTDDTILAGLVEE-DPYLHIVGPNMANQPYG---IGI
MLBr_00303|M.leprae_Br4923 CLVAMQQREIDAISTDDAILAGLVEE-DPYLHIVGPNMATQPYG---IGI
Mflv_3583|M.gilvum_PYR-GCK ATNAVVLGQADAMSADSPVTLYAIKQTNGKLEQAGETFDSAPYG---WPV
Mvan_2832|M.vanbaalenii_PYR-1 ATNAVVLGQADAMSADSPVTLYAIKQTNGKLVQAGEVFDSAPYG---WPV
MSMEG_3235|M.smegmatis_MC2_155 ATNAVVLGQVDAMSADSPVTLYAIKQSNGKLEKAGEVFDSAPYG---WPV
TH_0053|M.thermoresistible__bu LTEALMNGEIDAMSADSPVTGFAVKTSGGALQEAGEIFSPAPYG---WPV
MMAR_0061|M.marinum_M VYGNLKTHQIDAWVAPGNQAEAAIRPGDPAVLVANTFGAGDFVA---YVV
MAV_0059|M.avium_104 VYASLKTRQIDAWVAPAGQAATTIQPGDPAVVVANTISPGNFVA---YAV
MAB_4236c|M.abscessus_ATCC_199 YYLALASGRIDAYVGPNPSAVFHSEATGQTKLVGTFSGAGEALQGEIAVL
: . ** . . :
Mb0419c|M.bovis_AF2122/97 NLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD--
Rv0411c|M.tuberculosis_H37Rv NLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD--
MUL_2809|M.ulcerans_Agy99 NLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLSVLGPAPAPPRPRYVD--
MLBr_00303|M.leprae_Br4923 NLNNTTLVRFVNGTLERIRRDGTWITLYRKWLTVLGPAPAPPTPRYVD--
Mflv_3583|M.gilvum_PYR-GCK EKG-SPLAQSLLQALQHLIDNGKYQEIAANWGLEEGMIDKPVINGAIS--
Mvan_2832|M.vanbaalenii_PYR-1 EKG-SPLAQSLLQALEHLIETGKYKEIAANWGLEEGMIDKPVINGAVS--
MSMEG_3235|M.smegmatis_MC2_155 AKG-SPLAQSLQQALQHLIDNGEYEKIAANWGLEDGTIDKPAINGAVS--
TH_0053|M.thermoresistible__bu TRG-SPLAESLRQALEHLIATGEYRTIATMWGVEKGMIDRPEINAAAG--
MMAR_0061|M.marinum_M ARDNRPLLDALNSGLDAVIADGTWSQLYSKWVPRTLPPGWKPGSRAVAAP
MAV_0059|M.avium_104 AKDNKPLVDALNSGLDAVIADGTWSNLYSQWVPRTLPPGWKPGSQAVAPP
MAB_4236c|M.abscessus_ATCC_199 TKKDNGLVRAYADAINHAIADGTYRKVLQRWGLEDEAVAKSEINPRGLPR
* :: * : : *
Mb0419c|M.bovis_AF2122/97 --------------------------------------------------
Rv0411c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2809|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00303|M.leprae_Br4923 --------------------------------------------------
Mflv_3583|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2832|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M TLPDFAAIAAAHRHKPVGPAAPKSALTQLRDSFFDWDMYRQAIPTLFKTG
MAV_0059|M.avium_104 KLPDFAAIAASQHHKAVGPAAPKSTLAQLRDSFFDWDMYRQAIPTLLRTG
MAB_4236c|M.abscessus_ATCC_199 QG------------------------------------------------
Mb0419c|M.bovis_AF2122/97 --------------------------------------------------
Rv0411c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2809|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00303|M.leprae_Br4923 --------------------------------------------------
Mflv_3583|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2832|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M LPNTLILTLSASIIGLALGMALAIAGISHQRWLRWPARVYTDIFRGLPEV
MAV_0059|M.avium_104 LPNTLILTFSASVIGLVLGMVLAVAGISHARWLRWPARVYTDVFRGLPEV
MAB_4236c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0419c|M.bovis_AF2122/97 --------------------------------------------------
Rv0411c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2809|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00303|M.leprae_Br4923 --------------------------------------------------
Mflv_3583|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2832|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M VIILIIGLGVGPIVGGLTNNNPYPLGIAALGLMAGAYVGEILRSGIQSVD
MAV_0059|M.avium_104 VIILLIGLGIGPIVGGLTNNNPYPLGIAALGMMAAAYIGEILRSGIQSVD
MAB_4236c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0419c|M.bovis_AF2122/97 --------------------------------------------------
Rv0411c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2809|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00303|M.leprae_Br4923 --------------------------------------------------
Mflv_3583|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2832|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M PGQLEASRALGFSYSAAMRLVVVPQGVRRVLPALVNQFIALLKASALVYF
MAV_0059|M.avium_104 PGQLEASRALGFSYATAMRLVVVPQGVRRVLPALVNQFIALLKASALVYF
MAB_4236c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0419c|M.bovis_AF2122/97 --------------------------------------------------
Rv0411c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2809|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00303|M.leprae_Br4923 --------------------------------------------------
Mflv_3583|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2832|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0053|M.thermoresistible__bu --------------------------------------------------
MMAR_0061|M.marinum_M LGLIAQQRELFQVGRDLNAQTGNLSPLVAAGIFYLMLTVPLTHLVNYIDA
MAV_0059|M.avium_104 LGLVADQRELFQVGRDLNAETGNLSPLVAAGACYLILTVPLTHLVNMIDA
MAB_4236c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0419c|M.bovis_AF2122/97 ---------------------------
Rv0411c|M.tuberculosis_H37Rv ---------------------------
MUL_2809|M.ulcerans_Agy99 ---------------------------
MLBr_00303|M.leprae_Br4923 ---------------------------
Mflv_3583|M.gilvum_PYR-GCK ---------------------------
Mvan_2832|M.vanbaalenii_PYR-1 ---------------------------
MSMEG_3235|M.smegmatis_MC2_155 ---------------------------
TH_0053|M.thermoresistible__bu ---------------------------
MMAR_0061|M.marinum_M RLRRGRRRLDPEDPPGVVSSTIGEEMT
MAV_0059|M.avium_104 RLRRGRAAVDPEEPAEMLT--FGQEIT
MAB_4236c|M.abscessus_ATCC_199 ---------------------------