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AGIHRQRPGADHLAAATDTPAVPLGNDVWMSPGVSNSYAVATDDGRVIINAGLVFEGYLRKKAFADIAGP TRTIVITQGHADHWGAVNELREPDAQVVMHRNYRYWRDDNSLLMGYRVPKTAFAFQKFSDAVMEHLKAID TSSIDFSFPEPTVTFDQHHEFDVGGRRFELAWTPGGETTDSLVAWLPEDRILFTGNLFGPLFGHVPNLMT IRGDRYRDPVLYIESLNTVLDYHPDTLITGHFDPIVGADRIAEEVTAMRDAMQAVHDRTAELMNSGADVH TAMREVKIPDHLDVGEGYGKTSWNVRAIWEMYAGWFRHQSTTELFGVSPNSIAVDVVAAAGVEPLLDAAR AHLAAARPVEALHLTDLVLAANPGNPAGREVAIDAHEALLARTENFWERAWFTKSINELRNTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3482 | - | - | 100% (414) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1201 | - | 4e-14 | 26.67% (270) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3788c | - | 5e-15 | 27.50% (280) | putative hydrolase |
| M. tuberculosis H37Rv | Rv3762c | - | 4e-15 | 27.50% (280) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1312 | - | 2e-14 | 25.67% (261) | Beta-lactamase-like |
| M. marinum M | MMAR_5289 | - | 1e-111 | 48.78% (410) | hydrolase |
| M. avium 104 | MAV_4176 | - | 0.0 | 76.13% (419) | metallo-beta-lactamase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6339 | - | 1e-13 | 25.19% (270) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1659 | - | 3e-17 | 27.76% (263) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_4362 | - | 1e-109 | 47.80% (410) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_5606 | - | 8e-14 | 26.02% (269) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3788c|M.bovis_AF2122/97 MPMEHKPPTAVIQAAHGEH--SLPLHDTTDFDDADRGFIAALSPCVIKAA
Rv3762c|M.tuberculosis_H37Rv MPMEHKPPTAVIQAAHGEH--SLPLHDTTDFDDADRGFIAALSPCVIKAA
Mvan_5606|M.vanbaalenii_PYR-1 --MDSKPPTATIEAAHREHLATLPFDDTRDFADADRGFIAAQQPCVIKAA
MSMEG_6339|M.smegmatis_MC2_155 --MESNPPSAVVEAAHREHLTTLPFGDRRDFDDADRGFIAALEPCVITAD
TH_1659|M.thermoresistible__bu --MEPRPPTDSVEAAHRDHLRTLPFDDTTDFDDADRGFIAALEPGVVTAG
MAB_1312|M.abscessus_ATCC_1997 -MAEQTQPTSRILEQNAAAAQELPFANTADQEDADRGFIAALEPGVVRDD
Mflv_3482|M.gilvum_PYR-GCK ------------------------------------------MAGIHRQR
MAV_4176|M.avium_104 ------------------------------------------MAGIHRER
MMAR_5289|M.marinum_M -----------------------------------------MFQPVYRSR
MUL_4362|M.ulcerans_Agy99 -----------------------------------MKETTAMFEPVYRSR
:
Mb3788c|M.bovis_AF2122/97 DGRVVWDNDAYSFLDG-AAPTSVHPSLWRQSQLTAKQGLYQVVPGIYQVR
Rv3762c|M.tuberculosis_H37Rv DGRVVWDNDAYSFLDG-AAPTSVHPSLWRQSQLTAKQGLYQVVPGIYQVR
Mvan_5606|M.vanbaalenii_PYR-1 DGRVVWDNDVYAFLTG-DAPTTVHPSLWRQSTLAAKQGLYRVVEGIYQVR
MSMEG_6339|M.smegmatis_MC2_155 DGRLVWDNDSYRFLDSEQAPASVHPSLWRQSRLCAKQGLYEVVDGIYQVR
TH_1659|M.thermoresistible__bu DGRVVWDNDAYAFLAG-EPPTSVHPSLWRQSRLCAEQGLYRVVDGVYQVR
MAB_1312|M.abscessus_ATCC_1997 SGKVVWDNDSYAFLQG-ACPGSVHPSLWRQCGLNIRQGLYHVTEGIYQVR
Mflv_3482|M.gilvum_PYR-GCK PG-----ADHLAAATD-TPAVPLGNDVWMSP-------------------
MAV_4176|M.avium_104 PG-----AGDLAAATG-APATPLGDDVWMSP-------------------
MMAR_5289|M.marinum_M PG-----ADAMRPAAA-ERAEQLAPGLWCSP-------------------
MUL_4362|M.ulcerans_Agy99 PG-----ADAMRPAAA-ERAEQIAPGLWCSP-------------------
* . . : .:* .
Mb3788c|M.bovis_AF2122/97 GFDISNISFVEGDTGLIVIDPLVSTEVAAAALDLYRAHRGADRPVVAVIY
Rv3762c|M.tuberculosis_H37Rv GFDISNISFVEGDTGLIVIDPLVSTEVAAAALDLYRAHRGADRPVVAVIY
Mvan_5606|M.vanbaalenii_PYR-1 GFDLSNITFVEGDTGIIVIDPLVSTEVAAAALALYREHRG-DREVRAVIY
MSMEG_6339|M.smegmatis_MC2_155 GLDLSNITFVEGDSGVIVIDPLISTETAAAALALYRAHRG-DRRVTAVIY
TH_1659|M.thermoresistible__bu GLDLSNVTFVEGDTGVIVIDPLISTETAAAALALYRRHRG-DRAVRAVIH
MAB_1312|M.abscessus_ATCC_1997 GLDISNMTLVEGERGVIVIDPLVSVETAAAGLALYRHHRG-DRPVTGLIY
Mflv_3482|M.gilvum_PYR-GCK --GVSNSYAVATDDGRVIINAGLVFEGYLRKKAFADIAG----PTRTIVI
MAV_4176|M.avium_104 --GVSNSYAVATDDGRVIVNTGLVFEGPLHRKAFADIPG----PARAIIV
MMAR_5289|M.marinum_M --GLSNSYLLTTADGRVVVNTGMGFEGPVHRANFDAVDCS---PVRYIIL
MUL_4362|M.ulcerans_Agy99 --GLSNSYLLTTADGRVVVNTGMGFEGPVHRANFYAVDCS---PVRYIIL
.:** : * ::::. : * : . ::
Mb3788c|M.bovis_AF2122/97 THSHVDHFGGVLGGTTQADVDAGKVAVLAPEGFTAHAVQENIYAGSAMMR
Rv3762c|M.tuberculosis_H37Rv THSHVDHFGGVLGVTTQADVDAGKVAVLAPEGFTAHAVQENIYAGSAMMR
Mvan_5606|M.vanbaalenii_PYR-1 THSHVDHFGGVLGVTSQADVDAGRVAVLAPEGFTAHAVQENVYAGTAMTR
MSMEG_6339|M.smegmatis_MC2_155 THSHVDHFGGVLGVTTQADVDAGRVVVIAPEHFTTHAVQENVYAGTAMAR
TH_1659|M.thermoresistible__bu THSHVDHFGGVLGVTTPADVESGRVAVIAPEGFVEHAVAENVYAGTAMAR
MAB_1312|M.abscessus_ATCC_1997 THSHVDHFGGALGVTSPEDVATGRCPVLAPAGLLEHAVAENVYAGPAMTR
Mflv_3482|M.gilvum_PYR-GCK TQGHADHWGAVNELRE-------PDAQVVMHRNYRYWRDDNSLLMGYRVP
MAV_4176|M.avium_104 TQGHADHWGGVNALRDGADDGDDRGTDIVMHRNYRYCRDDNALLMGYRVP
MMAR_5289|M.marinum_M TQGHVDHVGGLDSVRD-------PETKVVAQANWTLWRDDNERLIPYRAS
MUL_4362|M.ulcerans_Agy99 TQGHVDHVGGLDSVRD-------PETKVVAQANWTLWRDDNERLIPYRAS
*:.*.** *. :. :*
Mb3788c|M.bovis_AF2122/97 RAGYMYGTVLARGLRGHVGCGLGQTLSTGEVSLVVPTVDITETGETHTID
Rv3762c|M.tuberculosis_H37Rv RAGYMYGTVLARGLRGHVGCGLGQTLSTGEVSLVVPTVDITETGETHTID
Mvan_5606|M.vanbaalenii_PYR-1 RAAYMYGTVLERGPKGQVGCGLGQTPSTGEVAIIVPTVDIRETGETHTID
MSMEG_6339|M.smegmatis_MC2_155 RAAYMYGAALARGPLGQVGCGLGQVPSTGEVALIVPTLDIRETGEIHSID
TH_1659|M.thermoresistible__bu RASYMYGTMLEVGPRGQVGCGLGQRTSTGEVGMIVPTLDIRHTGEHHTVD
MAB_1312|M.abscessus_ATCC_1997 RAVYMYGAFLPRGPLGQVGAGLGQTNSLGTVTLIPPTVDITHTGQEETVD
Mflv_3482|M.gilvum_PYR-GCK KTAFAFQK-FSDAVMEHLKA--IDTSSID-FSFPEPTVTFDQH-HEFDVG
MAV_4176|M.avium_104 KTSFAFQK-FSDAMLEHFKT--IDPAALD-FTFPEPTVTFDQR-MNLRVG
MMAR_5289|M.marinum_M RSAFAFKDTLSAGIQAIQRR--LGTTRLAGQSVPNVDLDFADT-LVLEVG
MUL_4362|M.ulcerans_Agy99 RSAFAFKDTLSAGIQAIQRR--LGTTRLAGQSVPNVDLDFADT-LVLEVG
:: : : : . . : : . :.
Mb3788c|M.bovis_AF2122/97 GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
Rv3762c|M.tuberculosis_H37Rv GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
Mvan_5606|M.vanbaalenii_PYR-1 GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
MSMEG_6339|M.smegmatis_MC2_155 GVDIEFQMAPGTEAPAEMHFYFPKFRALCMAENAT---HNLHNLLTLRGA
TH_1659|M.thermoresistible__bu GIEIEFQMTPNSEAPAEMHFFFPRYRALCMAENAT---HNLHNLLTLRGA
MAB_1312|M.abscessus_ATCC_1997 GVRMVFQLTPGTEAPAEMNFHFPERRALCMAENAT---HTLHNLLTLRGA
Mflv_3482|M.gilvum_PYR-GCK GRRFELAWTPGGETTDSLVAWLPEDRILFTGNLFGPLFGHVPNLMTIRGD
MAV_4176|M.avium_104 GRAFELAWTPGGETTDALVVWLPEERILFTGNLFGPLFGHVPNLMTIRGD
MMAR_5289|M.marinum_M GRRMELVSVPGGETTDSLVVWLPEERICLCGNTFGPLFGHIPNLVTMRGD
MUL_4362|M.ulcerans_Agy99 GRRMELVSVPGGETTDSLVVWLPEERICLCGNTFGPLFGHIPNLVTMRGD
* : : .*. *:. : :*. * .: : **:*:**
Mb3788c|M.bovis_AF2122/97 LVRDPRAWSGYLTEAIDTFADRTDVVFASHHWPTWGREKIVEFLSQQRDM
Rv3762c|M.tuberculosis_H37Rv LVRDPRAWSGYLTEAIDTFADRTDVVFASHHWPTWGREKIVEFLSQQRDM
Mvan_5606|M.vanbaalenii_PYR-1 LVRDPHGWAGYLTEAIDTFADRADVVFASHHWPTWGKDRIVEFLSLQRDL
MSMEG_6339|M.smegmatis_MC2_155 LVRDPHGWAGYLTEAIDSFADRTDVVFASHHWPTWGRDNIVEYLSLQRDL
TH_1659|M.thermoresistible__bu LVRDPHAWANYLTEAIDLFAHRSEVAFASHHWPTWGTDRIVEYLSLQRDL
MAB_1312|M.abscessus_ATCC_1997 LVRDPHVWARYITEAINLYARDSDVVFASHHWPTWGTERLVEYLALQRDL
Mflv_3482|M.gilvum_PYR-GCK RYRDPVLYIESLNTVLDYHP---DTLITGHFDPIVGADRIAEEVTAMRDA
MAV_4176|M.avium_104 RYRDPILYIESLNTVLEFGP---QRLITGHFAPIEGADRIAEEVTAMRDA
MMAR_5289|M.marinum_M RYRDALAAIASIERVRALRP---EILVTGHFDPITGAELIYCELTRLRDA
MUL_4362|M.ulcerans_Agy99 RYRDALAAIASIERVRALRP---EILVTGHFDPMTGAELIYCELTRLRDA
**. : . . : .:.*. * * : : :: **
Mb3788c|M.bovis_AF2122/97 HSYLHDQTLRLLNQGYTGVEIAEMFQLPPALQRAWHTHGYYGSVSHNVKA
Rv3762c|M.tuberculosis_H37Rv YSYLHDQTLRLLNQGYTGVEIAEMFQLPPALQRAWHTHGYYGSVSHNVKA
Mvan_5606|M.vanbaalenii_PYR-1 YAYLHDQTLRQLNQGFTGIEIAEAFAMPPALERAWHARGYYGSVSHNVKA
MSMEG_6339|M.smegmatis_MC2_155 YAYLHDQTLRLINQGHTGIEIAEQFELPPALQAAWHTHGYYGSVSHNVKA
TH_1659|M.thermoresistible__bu YAYLHDQTLRLLNRGHTGIEIAEQLTLPPALERAWHTRGYYGSVSHNVKA
MAB_1312|M.abscessus_ATCC_1997 YAYLHDQTLRMLNQGLVGSEIAEDLQLPPAIAGAWHTRGYYGSVSHNVKA
Mflv_3482|M.gilvum_PYR-GCK MQAVHDRTAELMNSGADVHTAMREVKIP----DHLDVGEGYGKTSWNVRA
MAV_4176|M.avium_104 MRAVHDRTAELMNSGADLYTAMREVRVP----ERFDIGEGYGKTSWNVRA
MMAR_5289|M.marinum_M ITYVHDQTVAGMNAGKDVETLMREIVLP----AEYDVGQGYGTVAWDVRA
MUL_4362|M.ulcerans_Agy99 ITYVHDQTVAGMNAGKNVETLMREIVLP----AEYDVGQGYGTVAWDVRA
:**:* :* * . . :* . **..: :*:*
Mb3788c|M.bovis_AF2122/97 IYQRYMGWFDG-NPGWLWPHPPEALAPRYVDALGGIDRVLELAREAFDAG
Rv3762c|M.tuberculosis_H37Rv IYQRYMGWFDG-NPGWLWPHPPEALAPRYVDALGGIDRVLELAREAFDAG
Mvan_5606|M.vanbaalenii_PYR-1 VYQRYMGWFDG-NPARLWPHPPEAIGPRYVAAMGGIDRVVELAKGAFDEG
MSMEG_6339|M.smegmatis_MC2_155 VYQRYMGWFDG-NPGRLWQHPPEALGPRYVDAMGGIDRVVELARRAFDSG
TH_1659|M.thermoresistible__bu IYQRYMGWFDG-NPARLWPHPPEASGPRYVAAMGGADRVVELARQAFDDG
MAB_1312|M.abscessus_ATCC_1997 IYQRYMGWFDG-NPAHLWEHPPVENARRHVEFMGGAQEVLRKARIAFEQG
Mflv_3482|M.gilvum_PYR-GCK IWEMYAGWFRHQSTTELFGVSPNSIAVDVVAAAG-VEPLLDAARAHLAAA
MAV_4176|M.avium_104 IWEMYTGWFRHRSTTELYGVPPDSVAADLVDAAG-AETLSEAARAHLDAG
MMAR_5289|M.marinum_M IWENYSGWFHHRSTTELYPVGFDAVAADVVDLAG-ADAIVDRARAHLVSG
MUL_4362|M.ulcerans_Agy99 IWENYSGWFHHRSTTELYPVGFDAVAADVVDLAG-ADAIVDRARAHLVSG
::: * *** .. *: . * * : : *: : .
Mb3788c|M.bovis_AF2122/97 DFRWAATLLDHAVFADSEHAAARGLYADTLEQLAYGAECATWRNFFLTGA
Rv3762c|M.tuberculosis_H37Rv DFRWAATLLDHAVFADSEHAAARGLYADTLEQLAYGAECATWRNFFLTGA
Mvan_5606|M.vanbaalenii_PYR-1 DFRWAATLLDHAMFTDENHAGARALYADTLEQLAYGAETATWRNFFLGGA
MSMEG_6339|M.smegmatis_MC2_155 DYRWAATLLDHAVFTDEHHRGARALYAEVLEQLAYGAENAVWRNFFLGGA
TH_1659|M.thermoresistible__bu DFRWAATLLDHVVFTDANHAGARELHADTLEQLGYGSENATWRNFFLSGA
MAB_1312|M.abscessus_ATCC_1997 DYRWVAQVLNYVIFADPANDAAKALQANCFEQLGYGAENATWRNFYLMGA
Mflv_3482|M.gilvum_PYR-GCK RPVEALHLTDLVLAANPGNPAGREVAIDAHEALLARTENFWERAWFTKSI
MAV_4176|M.avium_104 RPVQALHLTDLVLAAEPAHARARAVAADAHEALLTGTENFWEKAWLTKSI
MMAR_5289|M.marinum_M RPVQAIHLAELIERDHPG---AREVLRQAHENLLACSTNFWESAWLERQI
MUL_4362|M.ulcerans_Agy99 RPVQAIHLAELIERDHPG---AREVLRQADENLLACSTNFWESAWLERQI
. : : . .: : : * * : :
Mb3788c|M.bovis_AF2122/97 AELRDGNPGSSGQVPAPTFFAQLTPDQIFDVLAISINGPRAWDLDLAIDF
Rv3762c|M.tuberculosis_H37Rv AELRDGNPGSSGQVPAPTFFAQLTPDQIFDVLAISINGPRAWDLDLAIDF
Mvan_5606|M.vanbaalenii_PYR-1 TELRVGNFGTPTQTTSTSMVAQLTPEQMFDVLAISVNGPRAWDLDLAVDV
MSMEG_6339|M.smegmatis_MC2_155 TELRDGKFGTPTAPSSPTLLAQLTPEQIFDAVAINVNGPRAWDLDLAIDV
TH_1659|M.thermoresistible__bu AELRHGNFGTGTGTASPAMLAQLRPEQIFDSLAINVDGPRAWDLDLAIDI
MAB_1312|M.abscessus_ATCC_1997 YELRHGSVGTPVSIGSPSMMAALSVDQIFDALSLRVNGPKAWDERFVSDW
Mflv_3482|M.gilvum_PYR-GCK NELRNTR-------------------------------------------
MAV_4176|M.avium_104 RELRDPE-------------------------------------------
MMAR_5289|M.marinum_M ASHS----------------------------------------------
MUL_4362|M.ulcerans_Agy99 ASHS----------------------------------------------
.
Mb3788c|M.bovis_AF2122/97 TFTEPD----------------VNYRLTLRNGVLIHRKLPADPATANATV
Rv3762c|M.tuberculosis_H37Rv TFTEPD----------------VNYRLTLRNGVLIHRKLPADPATANATV
Mvan_5606|M.vanbaalenii_PYR-1 TFLTAASRESGTAASRGSGTAATNYRLTLRNGVLVYRAAAADEASAHVTI
MSMEG_6339|M.smegmatis_MC2_155 TFADTG----------------DTYRLTLRNGVLVHRRTEPDPSSAHASV
TH_1659|M.thermoresistible__bu TFADPN-----------FTDTDVNHRLTLRHGVLVHRRAPADG-RAGARV
MAB_1312|M.abscessus_ATCC_1997 RFTDED----------------RVHRVELRNGVLVHYDLPETANAPQPAV
Mflv_3482|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4176|M.avium_104 --------------------------------------------------
MMAR_5289|M.marinum_M --------------------------------------------------
MUL_4362|M.ulcerans_Agy99 --------------------------------------------------
Mb3788c|M.bovis_AF2122/97 TVGDKVRLVAAALGDISSPG-------FEVFGDRTVLQTFLSVLDRPDSA
Rv3762c|M.tuberculosis_H37Rv TVGDKVRLVAAALGDISSPG-------FEVFGDRTVLQTFLSVLDRPDSA
Mvan_5606|M.vanbaalenii_PYR-1 RLANKLRLLTLAAGDTTSPG-------LEIAGDAEVLTALVSVLDKPDPS
MSMEG_6339|M.smegmatis_MC2_155 TVADRMRLLTFFIGDTAMPG-------LQVTGAPDVLQSFLRVLDRPDPN
TH_1659|M.thermoresistible__bu RVAGTGRLLALTAGDVSSPG-------LQITGDLQVLQALLDVLDRPDPA
MAB_1312|M.abscessus_ATCC_1997 AFTLTRTGLVKLLLAGEDPGRLFASGEITVEGDASGFARLVSVLDEPDPG
Mflv_3482|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4176|M.avium_104 --------------------------------------------------
MMAR_5289|M.marinum_M --------------------------------------------------
MUL_4362|M.ulcerans_Agy99 --------------------------------------------------
Mb3788c|M.bovis_AF2122/97 FNIVTP
Rv3762c|M.tuberculosis_H37Rv FNIVTP
Mvan_5606|M.vanbaalenii_PYR-1 FNIITP
MSMEG_6339|M.smegmatis_MC2_155 FSIVTP
TH_1659|M.thermoresistible__bu FDIVTP
MAB_1312|M.abscessus_ATCC_1997 FAIVTP
Mflv_3482|M.gilvum_PYR-GCK ------
MAV_4176|M.avium_104 ------
MMAR_5289|M.marinum_M ------
MUL_4362|M.ulcerans_Agy99 ------