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KETTAMFEPVYRSRPGADAMRPAAAERAEQIAPGLWCSPGLSNSYLLTTADGRVVVNTGMGFEGPVHRAN FYAVDCSPVRYIILTQGHVDHVGGLDSVRDPETKVVAQANWTLWRDDNERLIPYRASRSAFAFKDTLSAG IQAIQRRLGTTRLAGQSVPNVDLDFADTLVLEVGGRRMELVSVPGGETTDSLVVWLPEERICLCGNTFGP LFGHIPNLVTMRGDRYRDALAAIASIERVRALRPEILVTGHFDPMTGAELIYCELTRLRDAITYVHDQTV AGMNAGKNVETLMREIVLPAEYDVGQGYGTVAWDVRAIWENYSGWFHHRSTTELYPVGFDAVAADVVDLA GADAIVDRARAHLVSGRPVQAIHLAELIERDHPGAREVLRQADENLLACSTNFWESAWLERQIASHS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4362 | - | - | 100% (418) | hydrolase |
| M. ulcerans Agy99 | MUL_4388 | - | 3e-17 | 26.02% (415) | hydrolase |
| M. ulcerans Agy99 | MUL_3429 | - | 4e-14 | 26.73% (333) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3788c | - | 1e-17 | 26.21% (412) | putative hydrolase |
| M. gilvum PYR-GCK | Mflv_3482 | - | 1e-109 | 47.80% (410) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv3762c | - | 5e-18 | 26.21% (412) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1312 | - | 5e-15 | 26.62% (308) | Beta-lactamase-like |
| M. marinum M | MMAR_5289 | - | 0.0 | 98.54% (412) | hydrolase |
| M. avium 104 | MAV_0336 | - | 0.0 | 83.01% (412) | metallo-beta-lactamase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6339 | - | 9e-16 | 26.20% (355) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1659 | - | 7e-17 | 26.97% (356) | POSSIBLE HYDROLASE |
| M. vanbaalenii PYR-1 | Mvan_5606 | - | 3e-16 | 26.12% (356) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3788c|M.bovis_AF2122/97 MPMEHKPPTAVIQAAHGEH--SLPLHDTTDFDDADRGFIAALSPCVIKAA
Rv3762c|M.tuberculosis_H37Rv MPMEHKPPTAVIQAAHGEH--SLPLHDTTDFDDADRGFIAALSPCVIKAA
Mvan_5606|M.vanbaalenii_PYR-1 --MDSKPPTATIEAAHREHLATLPFDDTRDFADADRGFIAAQQPCVIKAA
MSMEG_6339|M.smegmatis_MC2_155 --MESNPPSAVVEAAHREHLTTLPFGDRRDFDDADRGFIAALEPCVITAD
TH_1659|M.thermoresistible__bu --MEPRPPTDSVEAAHRDHLRTLPFDDTTDFDDADRGFIAALEPGVVTAG
MAB_1312|M.abscessus_ATCC_1997 -MAEQTQPTSRILEQNAAAAQELPFANTADQEDADRGFIAALEPGVVRDD
MUL_4362|M.ulcerans_Agy99 ----MKETTAMFEPVYRSR----PGADAMRPAAAER--------------
MMAR_5289|M.marinum_M ----------MFQPVYRSR----PGADAMRPAAAER--------------
MAV_0336|M.avium_104 ----------MPEPVYRSR----PGAEAMRPASAER--------------
Mflv_3482|M.gilvum_PYR-GCK -----------MAGIHRQR----PGADHLAAATDTP--------------
* :
Mb3788c|M.bovis_AF2122/97 DGRVVWDNDAYSFLDG-AAPTSVHPSLWRQSQLTAKQGLYQVVPGIYQVR
Rv3762c|M.tuberculosis_H37Rv DGRVVWDNDAYSFLDG-AAPTSVHPSLWRQSQLTAKQGLYQVVPGIYQVR
Mvan_5606|M.vanbaalenii_PYR-1 DGRVVWDNDVYAFLTG-DAPTTVHPSLWRQSTLAAKQGLYRVVEGIYQVR
MSMEG_6339|M.smegmatis_MC2_155 DGRLVWDNDSYRFLDSEQAPASVHPSLWRQSRLCAKQGLYEVVDGIYQVR
TH_1659|M.thermoresistible__bu DGRVVWDNDAYAFLAG-EPPTSVHPSLWRQSRLCAEQGLYRVVDGVYQVR
MAB_1312|M.abscessus_ATCC_1997 SGKVVWDNDSYAFLQG-ACPGSVHPSLWRQCGLNIRQGLYHVTEGIYQVR
MUL_4362|M.ulcerans_Agy99 -------------------AEQIAPGLWCSP-------------------
MMAR_5289|M.marinum_M -------------------AEQLAPGLWCSP-------------------
MAV_0336|M.avium_104 -------------------ADPIAPGLWCSP-------------------
Mflv_3482|M.gilvum_PYR-GCK -------------------AVPLGNDVWMSP-------------------
. : .:* .
Mb3788c|M.bovis_AF2122/97 GFDISNISFVEGDTGLIVIDPLVSTEVAAAALDLYRAHRGADRPVVAVIY
Rv3762c|M.tuberculosis_H37Rv GFDISNISFVEGDTGLIVIDPLVSTEVAAAALDLYRAHRGADRPVVAVIY
Mvan_5606|M.vanbaalenii_PYR-1 GFDLSNITFVEGDTGIIVIDPLVSTEVAAAALALYREHRG-DREVRAVIY
MSMEG_6339|M.smegmatis_MC2_155 GLDLSNITFVEGDSGVIVIDPLISTETAAAALALYRAHRG-DRRVTAVIY
TH_1659|M.thermoresistible__bu GLDLSNVTFVEGDTGVIVIDPLISTETAAAALALYRRHRG-DRAVRAVIH
MAB_1312|M.abscessus_ATCC_1997 GLDISNMTLVEGERGVIVIDPLVSVETAAAGLALYRHHRG-DRPVTGLIY
MUL_4362|M.ulcerans_Agy99 --GLSNSYLLTTADGRVVVNTGMGFEGPVHRANFYAVDCS---PVRYIIL
MMAR_5289|M.marinum_M --GLSNSYLLTTADGRVVVNTGMGFEGPVHRANFDAVDCS---PVRYIIL
MAV_0336|M.avium_104 --GLSNSYLLTTAEGRVIVNTGMGFEGPVHRANFDAVDSS---PVRYIVF
Mflv_3482|M.gilvum_PYR-GCK --GVSNSYAVATDDGRVIINAGLVFEGYLRKKAFADIAG----PTRTIVI
.:** : * ::::. : * : . ::
Mb3788c|M.bovis_AF2122/97 THSHVDHFGGVLGGTTQADVDAGKVAVLAPEGFTAHAVQENIYAGSAMMR
Rv3762c|M.tuberculosis_H37Rv THSHVDHFGGVLGVTTQADVDAGKVAVLAPEGFTAHAVQENIYAGSAMMR
Mvan_5606|M.vanbaalenii_PYR-1 THSHVDHFGGVLGVTSQADVDAGRVAVLAPEGFTAHAVQENVYAGTAMTR
MSMEG_6339|M.smegmatis_MC2_155 THSHVDHFGGVLGVTTQADVDAGRVVVIAPEHFTTHAVQENVYAGTAMAR
TH_1659|M.thermoresistible__bu THSHVDHFGGVLGVTTPADVESGRVAVIAPEGFVEHAVAENVYAGTAMAR
MAB_1312|M.abscessus_ATCC_1997 THSHVDHFGGALGVTSPEDVATGRCPVLAPAGLLEHAVAENVYAGPAMTR
MUL_4362|M.ulcerans_Agy99 TQGHVDHVGGLDSVRDPE-------TKVVAQANWTLWRDDNERLIPYRAS
MMAR_5289|M.marinum_M TQGHVDHVGGLDSVRDPE-------TKVVAQANWTLWRDDNERLIPYRAS
MAV_0336|M.avium_104 TQGHVDHVGGLDSVRDPD-------TVVVAQANWTMWRDDNERLIPYRAS
Mflv_3482|M.gilvum_PYR-GCK TQGHADHWGAVNELREPD-------AQVVMHRNYRYWRDDNSLLMGYRVP
*:.*.** *. :. :*
Mb3788c|M.bovis_AF2122/97 RAGYMYGTVLARGLRGHVGCGLGQTLSTGEVSLVVPTVDITETGETHTID
Rv3762c|M.tuberculosis_H37Rv RAGYMYGTVLARGLRGHVGCGLGQTLSTGEVSLVVPTVDITETGETHTID
Mvan_5606|M.vanbaalenii_PYR-1 RAAYMYGTVLERGPKGQVGCGLGQTPSTGEVAIIVPTVDIRETGETHTID
MSMEG_6339|M.smegmatis_MC2_155 RAAYMYGAALARGPLGQVGCGLGQVPSTGEVALIVPTLDIRETGEIHSID
TH_1659|M.thermoresistible__bu RASYMYGTMLEVGPRGQVGCGLGQRTSTGEVGMIVPTLDIRHTGEHHTVD
MAB_1312|M.abscessus_ATCC_1997 RAVYMYGAFLPRGPLGQVGAGLGQTNSLGTVTLIPPTVDITHTGQEETVD
MUL_4362|M.ulcerans_Agy99 RSAFAFKDTLSAGIQAIQRR--LGTTRLAGQSVPNVDLDFADT-LVLEVG
MMAR_5289|M.marinum_M RSAFAFKDTLSAGIQAIQRR--LGTTRLAGQSVPNVDLDFADT-LVLEVG
MAV_0336|M.avium_104 RSAFAFKDTLAGGIKAIQRR--LGTTRLPGQSVPVVDLDFEDT-LTLELG
Mflv_3482|M.gilvum_PYR-GCK KTAFAFQK-FSDAVMEHLKA--IDTSSID-FSFPEPTVTFDQH-HEFDVG
:: : : : . . : : . :.
Mb3788c|M.bovis_AF2122/97 GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
Rv3762c|M.tuberculosis_H37Rv GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
Mvan_5606|M.vanbaalenii_PYR-1 GVEIEFQMAPGTEAPAEMHFYFPRFRALCMAENAT---HNLHNLLTLRGA
MSMEG_6339|M.smegmatis_MC2_155 GVDIEFQMAPGTEAPAEMHFYFPKFRALCMAENAT---HNLHNLLTLRGA
TH_1659|M.thermoresistible__bu GIEIEFQMTPNSEAPAEMHFFFPRYRALCMAENAT---HNLHNLLTLRGA
MAB_1312|M.abscessus_ATCC_1997 GVRMVFQLTPGTEAPAEMNFHFPERRALCMAENAT---HTLHNLLTLRGA
MUL_4362|M.ulcerans_Agy99 GRRMELVSVPGGETTDSLVVWLPEERICLCGNTFGPLFGHIPNLVTMRGD
MMAR_5289|M.marinum_M GRRMELVSVPGGETTDSLVVWLPEERICLCGNTFGPLFGHIPNLVTMRGD
MAV_0336|M.avium_104 GRRMELISVPGGETTDSLVVWLPDERICLCGNTFGPLFGHIPNLVTMRGD
Mflv_3482|M.gilvum_PYR-GCK GRRFELAWTPGGETTDSLVAWLPEDRILFTGNLFGPLFGHVPNLMTIRGD
* : : .*. *:. .: :* * .: : **:*:**
Mb3788c|M.bovis_AF2122/97 LVRDPRAWSGYLTEAIDTFADRTDVVFASHHWPTWGREKIVEFLSQQRDM
Rv3762c|M.tuberculosis_H37Rv LVRDPRAWSGYLTEAIDTFADRTDVVFASHHWPTWGREKIVEFLSQQRDM
Mvan_5606|M.vanbaalenii_PYR-1 LVRDPHGWAGYLTEAIDTFADRADVVFASHHWPTWGKDRIVEFLSLQRDL
MSMEG_6339|M.smegmatis_MC2_155 LVRDPHGWAGYLTEAIDSFADRTDVVFASHHWPTWGRDNIVEYLSLQRDL
TH_1659|M.thermoresistible__bu LVRDPHAWANYLTEAIDLFAHRSEVAFASHHWPTWGTDRIVEYLSLQRDL
MAB_1312|M.abscessus_ATCC_1997 LVRDPHVWARYITEAINLYARDSDVVFASHHWPTWGTERLVEYLALQRDL
MUL_4362|M.ulcerans_Agy99 RYRDA---LAAIASIERVRALRPEILVTGHFDPMTGAELIYCELTRLRDA
MMAR_5289|M.marinum_M RYRDA---LAAIASIERVRALRPEILVTGHFDPITGAELIYCELTRLRDA
MAV_0336|M.avium_104 RYRDA---LTAIASVERVRGLRAELLVTGHFEPIAGADRIDEELTRLRDA
Mflv_3482|M.gilvum_PYR-GCK RYRDP---VLYIESLNTVLDYHPDTLITGHFDPIVGADRIAEEVTAMRDA
**. : . .: .:.*. * * : : :: **
Mb3788c|M.bovis_AF2122/97 HSYLHDQTLRLLNQGYTGVEIAEMFQLPPALQRAWHTHGYYGSVSHNVKA
Rv3762c|M.tuberculosis_H37Rv YSYLHDQTLRLLNQGYTGVEIAEMFQLPPALQRAWHTHGYYGSVSHNVKA
Mvan_5606|M.vanbaalenii_PYR-1 YAYLHDQTLRQLNQGFTGIEIAEAFAMPPALERAWHARGYYGSVSHNVKA
MSMEG_6339|M.smegmatis_MC2_155 YAYLHDQTLRLINQGHTGIEIAEQFELPPALQAAWHTHGYYGSVSHNVKA
TH_1659|M.thermoresistible__bu YAYLHDQTLRLLNRGHTGIEIAEQLTLPPALERAWHTRGYYGSVSHNVKA
MAB_1312|M.abscessus_ATCC_1997 YAYLHDQTLRMLNQGLVGSEIAEDLQLPPAIAGAWHTRGYYGSVSHNVKA
MUL_4362|M.ulcerans_Agy99 ITYVHDQTVAGMNAGKNVETLMREIVLP----AEYDVGQGYGTVAWDVRA
MMAR_5289|M.marinum_M ITYVHDQTVAGMNAGKDVETLMREIVLP----AEYDVGQGYGTVAWDVRA
MAV_0336|M.avium_104 LGYLHDQTVAGMNAGKDVRTLMREITLP----TEYEVGQGYGKVSWDVRA
Mflv_3482|M.gilvum_PYR-GCK MQAVHDRTAELMNSGADVHTAMREVKIP----DHLDVGEGYGKTSWNVRA
:**:* :* * . . :* .. **..: :*:*
Mb3788c|M.bovis_AF2122/97 IYQRYMGWFDGNPGWLWPHPPEALAPRYVDALGGIDRVLELAREAFDAGD
Rv3762c|M.tuberculosis_H37Rv IYQRYMGWFDGNPGWLWPHPPEALAPRYVDALGGIDRVLELAREAFDAGD
Mvan_5606|M.vanbaalenii_PYR-1 VYQRYMGWFDGNPARLWPHPPEAIGPRYVAAMGGIDRVVELAKGAFDEGD
MSMEG_6339|M.smegmatis_MC2_155 VYQRYMGWFDGNPGRLWQHPPEALGPRYVDAMGGIDRVVELARRAFDSGD
TH_1659|M.thermoresistible__bu IYQRYMGWFDGNPARLWPHPPEASGPRYVAAMGGADRVVELARQAFDDGD
MAB_1312|M.abscessus_ATCC_1997 IYQRYMGWFDGNPAHLWEHPPVENARRHVEFMGGAQEVLRKARIAFEQGD
MUL_4362|M.ulcerans_Agy99 IWENYSGWFHHRSTTELYPVGFDAVAADVVDLAGADAIVDRARAHLVSGR
MMAR_5289|M.marinum_M IWENYSGWFHHRSTTELYPVGFDAVAADVVDLAGADAIVDRARAHLVSGR
MAV_0336|M.avium_104 IWENYSGWFHHESTTELYPVGFDAVAHDVVELAGADALLDRARAHLAADR
Mflv_3482|M.gilvum_PYR-GCK IWEMYAGWFRHQSTTELFGVSPNSIAVDVVAAAGVEPLLDAARAHLAAAR
::: * *** .. * .* : :: *: :
Mb3788c|M.bovis_AF2122/97 FRWAATLLDHAVFADSEHAAARGLYADTLEQLAYGAECATWRNFFLTGAA
Rv3762c|M.tuberculosis_H37Rv FRWAATLLDHAVFADSEHAAARGLYADTLEQLAYGAECATWRNFFLTGAA
Mvan_5606|M.vanbaalenii_PYR-1 FRWAATLLDHAMFTDENHAGARALYADTLEQLAYGAETATWRNFFLGGAT
MSMEG_6339|M.smegmatis_MC2_155 YRWAATLLDHAVFTDEHHRGARALYAEVLEQLAYGAENAVWRNFFLGGAT
TH_1659|M.thermoresistible__bu FRWAATLLDHVVFTDANHAGARELHADTLEQLGYGSENATWRNFFLSGAA
MAB_1312|M.abscessus_ATCC_1997 YRWVAQVLNYVIFADPANDAAKALQANCFEQLGYGAENATWRNFYLMGAY
MUL_4362|M.ulcerans_Agy99 PVQAIHLAELIERDHPG---AREVLRQADENLLACSTNFWESAWLERQIA
MMAR_5289|M.marinum_M PVQAIHLAELIERDHPG---AREVLRQAHENLLACSTNFWESAWLERQIA
MAV_0336|M.avium_104 ALHAIHLAQLLPAEHSG---AREVLRQAHEKLLASSTNFWESAWLRHQIA
Mflv_3482|M.gilvum_PYR-GCK PVEALHLTDLVLAANPGNPAGREVAIDAHEALLARTENFWERAWFTKSIN
. : : . .: : : * * : :
Mb3788c|M.bovis_AF2122/97 ELRDGNPGSSGQVPAPTFFAQLTPDQIFDVLAISINGPRAWDLDLAIDFT
Rv3762c|M.tuberculosis_H37Rv ELRDGNPGSSGQVPAPTFFAQLTPDQIFDVLAISINGPRAWDLDLAIDFT
Mvan_5606|M.vanbaalenii_PYR-1 ELRVGNFGTPTQTTSTSMVAQLTPEQMFDVLAISVNGPRAWDLDLAVDVT
MSMEG_6339|M.smegmatis_MC2_155 ELRDGKFGTPTAPSSPTLLAQLTPEQIFDAVAINVNGPRAWDLDLAIDVT
TH_1659|M.thermoresistible__bu ELRHGNFGTGTGTASPAMLAQLRPEQIFDSLAINVDGPRAWDLDLAIDIT
MAB_1312|M.abscessus_ATCC_1997 ELRHGSVGTPVSIGSPSMMAALSVDQIFDALSLRVNGPKAWDERFVSDWR
MUL_4362|M.ulcerans_Agy99 SHS-----------------------------------------------
MMAR_5289|M.marinum_M SHS-----------------------------------------------
MAV_0336|M.avium_104 RNS-----------------------------------------------
Mflv_3482|M.gilvum_PYR-GCK ELRNTR--------------------------------------------
Mb3788c|M.bovis_AF2122/97 FTEPD----------------VNYRLTLRNGVLIHRKLPADPATANATVT
Rv3762c|M.tuberculosis_H37Rv FTEPD----------------VNYRLTLRNGVLIHRKLPADPATANATVT
Mvan_5606|M.vanbaalenii_PYR-1 FLTAASRESGTAASRGSGTAATNYRLTLRNGVLVYRAAAADEASAHVTIR
MSMEG_6339|M.smegmatis_MC2_155 FADTG----------------DTYRLTLRNGVLVHRRTEPDPSSAHASVT
TH_1659|M.thermoresistible__bu FADPN-----------FTDTDVNHRLTLRHGVLVHRRAPADG-RAGARVR
MAB_1312|M.abscessus_ATCC_1997 FTDED----------------RVHRVELRNGVLVHYDLPETANAPQPAVA
MUL_4362|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5289|M.marinum_M --------------------------------------------------
MAV_0336|M.avium_104 --------------------------------------------------
Mflv_3482|M.gilvum_PYR-GCK --------------------------------------------------
Mb3788c|M.bovis_AF2122/97 VGDKVRLVAAALGDISSPG-------FEVFGDRTVLQTFLSVLDRPDSAF
Rv3762c|M.tuberculosis_H37Rv VGDKVRLVAAALGDISSPG-------FEVFGDRTVLQTFLSVLDRPDSAF
Mvan_5606|M.vanbaalenii_PYR-1 LANKLRLLTLAAGDTTSPG-------LEIAGDAEVLTALVSVLDKPDPSF
MSMEG_6339|M.smegmatis_MC2_155 VADRMRLLTFFIGDTAMPG-------LQVTGAPDVLQSFLRVLDRPDPNF
TH_1659|M.thermoresistible__bu VAGTGRLLALTAGDVSSPG-------LQITGDLQVLQALLDVLDRPDPAF
MAB_1312|M.abscessus_ATCC_1997 FTLTRTGLVKLLLAGEDPGRLFASGEITVEGDASGFARLVSVLDEPDPGF
MUL_4362|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5289|M.marinum_M --------------------------------------------------
MAV_0336|M.avium_104 --------------------------------------------------
Mflv_3482|M.gilvum_PYR-GCK --------------------------------------------------
Mb3788c|M.bovis_AF2122/97 NIVTP
Rv3762c|M.tuberculosis_H37Rv NIVTP
Mvan_5606|M.vanbaalenii_PYR-1 NIITP
MSMEG_6339|M.smegmatis_MC2_155 SIVTP
TH_1659|M.thermoresistible__bu DIVTP
MAB_1312|M.abscessus_ATCC_1997 AIVTP
MUL_4362|M.ulcerans_Agy99 -----
MMAR_5289|M.marinum_M -----
MAV_0336|M.avium_104 -----
Mflv_3482|M.gilvum_PYR-GCK -----