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GEFDDIATPDDVLRLAAQRTGLSDVDGDSWREGLAIVLDEVNNCPAFTETGRARIIDDATKALARRLQVH DYIQQHPEVLEVPVERPLVTLGMPRTGTTVISYLLAADPKRRSLLHWECLNPVPPATTDTLRSDPRCVAL LGEQKLILDMVKAAKMPIPHWEDADGPTECMFIHNQDFKGLSWDAFMATPRYAEWLLNDADMISAYEYQK RYLQVLQSKAPGTWSLKMPSHSVHIEALLTVFPDARLIWAHRDPYKATGSLGNLLTLPKSMVLNPEAMTT TEWGANLKDQMRQHVERPLRTRERIGDDRFFDMYYHEMMRDPMDVMRRLYDWAGDPLTPDTETRMQSWLA EHPQGLLGHSSYSLDQYGLSVEELTPVFAEYLGTFDIELEDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3480 | - | - | 100% (393) | hypothetical protein Mflv_3480 |
| M. gilvum PYR-GCK | Mflv_1831 | - | 5e-50 | 32.28% (378) | hypothetical protein Mflv_1831 |
| M. gilvum PYR-GCK | Mflv_4074 | - | 4e-48 | 32.99% (385) | hypothetical protein Mflv_4074 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3559c | - | 6e-35 | 29.31% (389) | hypothetical protein Mb3559c |
| M. tuberculosis H37Rv | Rv3529c | - | 7e-35 | 29.31% (389) | hypothetical protein Rv3529c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3968 | - | 3e-43 | 30.53% (380) | putative sulfotransferase |
| M. marinum M | MMAR_0220 | - | 3e-44 | 29.56% (389) | hypothetical protein MMAR_0220 |
| M. avium 104 | MAV_4174 | - | 1e-175 | 72.63% (391) | hypothetical protein MAV_4174 |
| M. smegmatis MC2 155 | MSMEG_5930 | - | 1e-30 | 27.46% (386) | hypothetical protein MSMEG_5930 |
| M. thermoresistible (build 8) | TH_0375 | - | 3e-31 | 27.95% (390) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4363 | - | 3e-35 | 28.03% (396) | hypothetical protein MUL_4363 |
| M. vanbaalenii PYR-1 | Mvan_2324 | - | 6e-56 | 34.30% (379) | hypothetical protein Mvan_2324 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3480|M.gilvum_PYR-GCK -------------------------------MGEFDDIATPDDVLRLAAQ
MAV_4174|M.avium_104 -------------------------------MSDFDNITTADDVFKLAAQ
Mvan_2324|M.vanbaalenii_PYR-1 -------------------------------------MASSDDLLRAARG
MMAR_0220|M.marinum_M -------------------------------MSMPQDRFKPERLIATACE
Mb3559c|M.bovis_AF2122/97 ----------------------------MTRRPDRKDVATVDELHASATK
Rv3529c|M.tuberculosis_H37Rv ----------------------------MTRRPDRKDVATVDELHASATK
MSMEG_5930|M.smegmatis_MC2_155 -------------------------------------MGTVEDLHASATK
TH_0375|M.thermoresistible__bu ----------------------------MTPR---TDVGTVEDLHASAVK
MAB_3968|M.abscessus_ATCC_1997 ----------------------------MRAGFKAARPWPIRALNRVGNP
MUL_4363|M.ulcerans_Agy99 MEPSSTDIADIDFDDLTRPVLTDVQRQVLQFTESRHVEFDIAALLAEAVD
: .
Mflv_3480|M.gilvum_PYR-GCK RTGLSDVDGDSWR---------------------EGLAIVLDEVNNCPAF
MAV_4174|M.avium_104 RTGLSEIDSDSWR---------------------EGLALIVDEVNTSPVF
Mvan_2324|M.vanbaalenii_PYR-1 SSGLDDFGDDAFR---------------------EGLDILVGALDREARL
MMAR_0220|M.marinum_M EAGSDDFGADGWQ---------------------DGLQRVTDALIHEARL
Mb3559c|M.bovis_AF2122/97 LVGLDDFGTDDDNYR-------------------EALGVLLDAYQGEAGL
Rv3529c|M.tuberculosis_H37Rv LVGLDDFGTDDDNYR-------------------EALGVLLDAYQGEAGL
MSMEG_5930|M.smegmatis_MC2_155 ATGLDDFGTDDDNYR-------------------EALGVLLESYQRDAHL
TH_0375|M.thermoresistible__bu ACGLEDFGSDDDNYK-------------------EALAVLLDSYQREADL
MAB_3968|M.abscessus_ATCC_1997 LTGIGAAPTLDTQWLRSAARRATGLEWVADAYLDDALEVLAASLRNDAKL
MUL_4363|M.ulcerans_Agy99 QAGVGDDLGDTDGFG-------------------NRLRAHVAAIEGDQGL
* : * :
Mflv_3480|M.gilvum_PYR-GCK TETGRARIIDDATKALARRLQVHDYIQQHPEVLEVPVERPLVTLGMPRTG
MAV_4174|M.avium_104 TPFGRQRVLDDATNALGRRLQVHAYIQDHPEVLDAPVERPLIVLGMPRTG
Mvan_2324|M.vanbaalenii_PYR-1 NARGEAFMYPRIVGHLRQRLQVEDWYRRHPEIDDERVDAPLFGLGLPRTG
MMAR_0220|M.marinum_M SAIGVEIAHLDLMRALRNRLGVIAWRRQHPEIATKAIDQPIVIVGQPRTG
Mb3559c|M.bovis_AF2122/97 TVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTG
Rv3529c|M.tuberculosis_H37Rv TVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTG
MSMEG_5930|M.smegmatis_MC2_155 TELGSKMSRFFLRNALVARLLSEASWKANPQYADVEIERPIFVTGLPRTG
TH_0375|M.thermoresistible__bu TELGSKMSRFFLRNALVARLVSEAAWKQYPQHADVVIERPIFVTGLPRTG
MAB_3968|M.abscessus_ATCC_1997 SFLGRKMVQVRLVGMLSTRLRLRELIRKNPGIAQLPVEPPIVIVGLQRTG
MUL_4363|M.ulcerans_Agy99 TQLTRSSLRQRVVRLLRNRLSLTDLIRRYPEIESIRIEKPFVVVGMPRSG
. * ** : * :. *:. * *:*
Mflv_3480|M.gilvum_PYR-GCK TTVISYLLAADPKRRSLLHWECLNPVPP--ATTDTLRSDPRCVALLGEQK
MAV_4174|M.avium_104 TTVISYLLDQDPARRSLLHWQCVHPIPP--ASTETLRTDPRCLALLDEQR
Mvan_2324|M.vanbaalenii_PYR-1 STALSFLLAQDPGIRYLHSWEAARPCPP--PSTVAG-DDPRIPPGVTEVP
MMAR_0220|M.marinum_M TTILYDLLAQDPDLRAPLTWEVDAPCPV--PAPETYLSDPRIAQTQASIE
Mb3559c|M.bovis_AF2122/97 TTALHRLLGADPAHQGLHMWLAEYPQPR--PPRETWESNPLYRQLDAQFT
Rv3529c|M.tuberculosis_H37Rv TTALHRLLGADPAHQGLHMWLAEYPQPR--PPRETWESNPLYRQLDAQFT
MSMEG_5930|M.smegmatis_MC2_155 TTVLHRLLTADPAHQGLEMWLAEFPQPR--PPRETWPDNPVYQQLAASFS
TH_0375|M.thermoresistible__bu TTALHRLLAADPAHQGLELWLAEFPQPR--PPRETWPDNPIYRQLEAQFT
MAB_3968|M.abscessus_ATCC_1997 TTLLHRLLAADPSAGSMSSWEGASPLPH--PEQPSGAPDLRIAQAAKDER
MUL_4363|M.ulcerans_Agy99 TTHLVNLLAADPRRRALPYWESQDPIPARGQGPDIFGVDPRYTRAKTEHD
:* : ** ** * * * : .
Mflv_3480|M.gilvum_PYR-GCK LILDMVKAAKMPIPHWEDADGPTECMFIHNQDFKGLSWDAFMATPRYAEW
MAV_4174|M.avium_104 KILDAVTRAKMPLPHWEDADGPTEDMFIHNQDFKGLSWDSFLPTDRYARW
Mvan_2324|M.vanbaalenii_PYR-1 ----AGSRHHVPS----DPDGPAECLDLMALDFTSQIFQAFAHIPSYSQW
MMAR_0220|M.marinum_M LSEQIIPGFLSFHP--MGAQVGQECVRITASEFTSMIYSVQYRLPSYYRW
Mb3559c|M.bovis_AF2122/97 QHHAENPGYTGLHF--MAAYELEECWQLLRQSLHSVSYEALAHVPSYADW
Rv3529c|M.tuberculosis_H37Rv QHHAENPGYTGLHF--MAAYELEECWQLLRQSLHSVSYEALAHVPSYADW
MSMEG_5930|M.smegmatis_MC2_155 QHHQENPDYTGLHF--MTADEVEECWQLLRQSLHSVSYETLAHLPTYANW
TH_0375|M.thermoresistible__bu KAHQENPDYTGLHF--MTAGEVEECWQLLRQSVHSVSYETLAHVPSYARW
MAB_3968|M.abscessus_ATCC_1997 SLRYLAPQFFAIHS--VEAEAPEEDVLLLDFALHSQMPEVMFHVPGYAKW
MUL_4363|M.ulcerans_Agy99 ALMATAPVVAAMHDR--FPEAIEEEVELLDLDLASYVLEWHARVPDWRDY
. * : . . . : :
Mflv_3480|M.gilvum_PYR-GCK LLNDADMISAYEYQKRYLQVLQSKAPG-TWSLKMPSHSVHIEALLTVFPD
MAV_4174|M.avium_104 LFDEADMSSTYEYQKRYLQVLQSTAPG-SWSLKMPSHSVHIEALLKVFPD
Mvan_2324|M.vanbaalenii_PYR-1 LVERADFTSTYTYQRRVLKLLQWGQPTRPWRLKSPAHVLSLDCLDAVFPD
MMAR_0220|M.marinum_M LLYEADHRGAYRFHRIFLQHLQSGVAG-QWLLKSPAHLWQLDALLAEYPD
Mb3559c|M.bovis_AF2122/97 LS-RQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPD
Rv3529c|M.tuberculosis_H37Rv LS-RQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPD
MSMEG_5930|M.smegmatis_MC2_155 LA-QQDWTRPYQRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALFATYPD
TH_0375|M.thermoresistible__bu LA-RQDWTKPYQRHRRNLQLIGLNDVEKRWVLKNPSHLFALDALFATYPD
MAB_3968|M.abscessus_ATCC_1997 LA-DQDMTPAYELHRLLLQVLQWQQPRGRWVLKTPAHLEHLDVLLRVYPG
MUL_4363|M.ulcerans_Agy99 YL-GLDQRRHYAYLKKVLQALTFLRGPQTWVLKRPQHCEQLGPLMATFPD
* * : *: : * ** * * : * :*.
Mflv_3480|M.gilvum_PYR-GCK ARLIWAHRDPYKATGSLGNLLTLPKSMVLNPEAMTTTEWGANLKDQMRQH
MAV_4174|M.avium_104 ARLIWAHRDPYKATGSLCNLWRLPQSLVMNTELLDQTEMGRLAMWQMRYH
Mvan_2324|M.vanbaalenii_PYR-1 ARFVMTHRDPTDVLLSVADVY--ADIVGGFSDHVDRRYLGELNTYQWSVG
MMAR_0220|M.marinum_M ALIVQTHRDPLNVISSIAALTHHLRRMASDESSIAECAAQCYEEIVVGLD
Mb3559c|M.bovis_AF2122/97 ALVVQTHRPVETIMASMCSLAQHTTEGWS--TKFVGAQIGADAMDTWSRG
Rv3529c|M.tuberculosis_H37Rv ALVVQTHRPVETIMASMCSLAQHTTEGWS--TKFVGAQIGADAMDTWSRG
MSMEG_5930|M.smegmatis_MC2_155 ALVIQCHRPAETIMASMCSLSAHTTAGWS--NTFVGAQIGADAMDTWARG
TH_0375|M.thermoresistible__bu ALVVQCHRPAETIMASMCSLSQHTTAGWS--NTFVGAQIGADAMETWTRG
MAB_3968|M.abscessus_ATCC_1997 AVVVWTHRDPAQTTASSSSMLAHYQALFS--DRVDHHELARYWLGKNAQI
MUL_4363|M.ulcerans_Agy99 ATVAFTHRDPVAVIQSTITMMAYSDRLRR--TSIDAGWLLDYWSDRVYPL
* . ** * : .
Mflv_3480|M.gilvum_PYR-GCK VERPLRTRERIGDDRFFDMYYHEMMRDPMDVMRRLYDWAGDPLTPDTETR
MAV_4174|M.avium_104 VDRPLRARERIGDERFFHMYYHEMMRDPMDVMRRIYEWADEPLTAETEAR
Mvan_2324|M.vanbaalenii_PYR-1 MGRAVAFREDGADHRFFDIDFRTMAQDPVGEVRALYAWLGDPVTVEFESG
MMAR_0220|M.marinum_M REMALRAGGALPAGQVIDVLYTDFINDPWSTIRGVYRKLGRELAPETEQR
Mb3559c|M.bovis_AF2122/97 LERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQA
Rv3529c|M.tuberculosis_H37Rv LERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQA
MSMEG_5930|M.smegmatis_MC2_155 LEAFTAERAKHDPAQFLDVDYDDFVADPLATVESVYRHFGMPYTDAARAA
TH_0375|M.thermoresistible__bu LRLFNEARANYDPAQFHDVEYADFVKDPIGTVEGIYRHFGLEFTDAARDA
MAB_3968|M.abscessus_ATCC_1997 IDRAIAVRAEHP-AAFVDINYTELLDDPIAAVQRIYHAADRRLSDDALTA
MUL_4363|M.ulcerans_Agy99 LWACVRDRDIVPPDRSIDIGFHQLNGNEMALLDELYRCSGVAITPKVRGL
.: : : : : :* . :
Mflv_3480|M.gilvum_PYR-GCK MQSWLAEHP-QGLLGHSSYSLDQYGLSVEELTPVFAEYLGTFDIELEDA-
MAV_4174|M.avium_104 MRNWLAHHP-QDRFALNAYRLDEYGLTVEALQPIFAEYLDTFDIELEGRP
Mvan_2324|M.vanbaalenii_PYR-1 MRGWWAHNA-QNREAKPTADPGAFGLDPGRIRPLFADYVAHARRWIGPRD
MMAR_0220|M.marinum_M MRDFLRAHP-GDG-GRGRYTWSDTGLDASVVRDRVRPYQDRYGVPTEQLR
Mb3559c|M.bovis_AF2122/97 MTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL------------
Rv3529c|M.tuberculosis_H37Rv MTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL------------
MSMEG_5930|M.smegmatis_MC2_155 VTEVYEASRRGPRAPKHTYSLADYGLTSEAVKERFTGL------------
TH_0375|M.thermoresistible__bu MTRLHTESQRGPRAPRHSYSLADYGLTAESVRDAFSGL------------
MAB_3968|M.abscessus_ATCC_1997 MRVSLQQNRQHKHG-EHRYSLAQFGLTIAEVDAAYRRYIDHFAIQTERGG
MUL_4363|M.ulcerans_Agy99 FQQYLDGNPRGKHGRVRYHLQRHFGSSAEQLRERFDFYFDRFDVRPE---
. * :
Mflv_3480|M.gilvum_PYR-GCK -----
MAV_4174|M.avium_104 -----
Mvan_2324|M.vanbaalenii_PYR-1 APEER
MMAR_0220|M.marinum_M -----
Mb3559c|M.bovis_AF2122/97 -----
Rv3529c|M.tuberculosis_H37Rv -----
MSMEG_5930|M.smegmatis_MC2_155 -----
TH_0375|M.thermoresistible__bu -----
MAB_3968|M.abscessus_ATCC_1997 VRGDR
MUL_4363|M.ulcerans_Agy99 -----