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RTFIDFDDAPVFAVPTASGVREGVLLDGPQGWGEFSPPADADDELAARWLTAAMEPSTVGWPDAVRGRVP VSGEATARVVVADVDDAVSRIAALGSVDLVELVCRTPRDASEVRRRVQVPVAVDAAVAAEDPQCADIVVL RAGPLGGVRRALRRAERLGLPAVVAFTGTTSVGLAADVALAAVLPDLPFAVGPVPEWLHDNDVVSAARSL VPSDGFLPAAPMPAGPDPERLARFRVTDPATTARWRDLLHRAAALL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3261 | - | - | 100% (257) | hypothetical protein Mflv_3261 |
| M. gilvum PYR-GCK | Mflv_5268 | - | 1e-27 | 32.37% (278) | O-succinylbenzoate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0568 | menC | 2e-27 | 32.43% (296) | O-succinylbenzoate synthase |
| M. tuberculosis H37Rv | Rv0553 | menC | 2e-27 | 32.43% (296) | O-succinylbenzoate synthase |
| M. leprae Br4923 | MLBr_02268 | - | 2e-26 | 30.41% (296) | O-succinylbenzoate synthase |
| M. abscessus ATCC 19977 | MAB_3935c | - | 3e-24 | 31.54% (298) | O-succinylbenzoate synthase |
| M. marinum M | MMAR_0899 | menC | 3e-25 | 32.10% (271) | muconate cycloisomerase, MenC |
| M. avium 104 | MAV_4590 | - | 4e-24 | 31.10% (299) | O-succinylbenzoate synthase |
| M. smegmatis MC2 155 | MSMEG_3481 | - | 9e-54 | 40.85% (328) | O-succinylbenzoate synthase |
| M. thermoresistible (build 8) | TH_2569 | - | 9e-39 | 53.99% (163) | PUTATIVE O-succinylbenzoate synthase |
| M. ulcerans Agy99 | MUL_0652 | menC | 9e-26 | 32.10% (271) | O-succinylbenzoate synthase |
| M. vanbaalenii PYR-1 | Mvan_2978 | - | 1e-114 | 79.46% (258) | O-succinylbenzoate-CoA synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0899|M.marinum_M -------------MIPGPATLPDLLDRLHVVALPMRVRFRGITTREVALI
MUL_0652|M.ulcerans_Agy99 -------------MIPGPATLPDLLDRLQVVALPMRVRFRGITTREVALI
MAV_4590|M.avium_104 -------------MIP---PLQDLLDRLHVVALPMRVRFRGITTREVALI
Mb0568|M.bovis_AF2122/97 -------------MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALI
Rv0553|M.tuberculosis_H37Rv -------------MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALI
MLBr_02268|M.leprae_Br4923 -------------MIP---TLTELLDRLHVVALPMRVRFRGITTREVALI
MAB_3935c|M.abscessus_ATCC_199 ------------MELP---VLDDVLDRLHVVALPMRVRFRGITTREVALI
Mflv_3261|M.gilvum_PYR-GCK ------------------MRTFIDFDDAPVFAVPTAS-----GVREGVLL
Mvan_2978|M.vanbaalenii_PYR-1 ------------------MRTFIDFDDAPVFAVPTAT-----GVREGALL
MSMEG_3481|M.smegmatis_MC2_155 MRGNTARCAVPMGYRHELVQTLIDFERAPAFAIALTDPVGDATVREGLLV
TH_2569|M.thermoresistible__bu --------------------------------------------------
MMAR_0899|M.marinum_M EGPSGWGEFGAFLEYQPPE----AAAWLASAIDAAYGQPPPVRRGRIPIN
MUL_0652|M.ulcerans_Agy99 EGPSGWGEFGAFLEYQPPE----AAAWLASAIDAAYGQPPPVRRGRIPIN
MAV_4590|M.avium_104 DGPAGWGEFGAFVEYGPPE----AAHWLASAVESAYRPAPPVRRDRIPIN
Mb0568|M.bovis_AF2122/97 EGPAGWGEFGAFVEYQSAQ----ACAWLASAIETAYCAPPPVRRDRVPIN
Rv0553|M.tuberculosis_H37Rv EGPAGWGEFGAFVEYQSAQ----ACAWLASAIETAYCAPPPVRRDRVPIN
MLBr_02268|M.leprae_Br4923 DGPAGWGEFGAFLEYQPLE----ASAWLVAGIEAAYGEPPEGRRDRIPIN
MAB_3935c|M.abscessus_ATCC_199 DGPAGWGEFGAFPEYQPAE----ASAWLSAAIEAAYRALPTPRRDRIPVN
Mflv_3261|M.gilvum_PYR-GCK DGPQGWGEFSPP---ADAD-DELAARWLTAAMEPSTVGWPDAVRGRVPVS
Mvan_2978|M.vanbaalenii_PYR-1 DGPQGWGEFSPP---ADAD-DELAARWLTAAMEPSTVGWPDAVRGRVPVT
MSMEG_3481|M.smegmatis_MC2_155 EGPQGWGEFSPPGAGAEADGDAALVRWLTAAIEPGTVGWPDPVRGRVPVA
TH_2569|M.thermoresistible__bu --------------------------------------------------
MMAR_0899|M.marinum_M ATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVNAVRALVP
MUL_0652|M.ulcerans_Agy99 ATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVNAVRALVP
MAV_4590|M.avium_104 ATVPAVPAAAVPDVLARFPGARTAKVKVAEPGQTLADDVARVNAVRDLVP
Mb0568|M.bovis_AF2122/97 ATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVP
Rv0553|M.tuberculosis_H37Rv ATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVP
MLBr_02268|M.leprae_Br4923 ATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVNAVRELVE
MAB_3935c|M.abscessus_ATCC_199 ATVPAVTAADVPEVLSRFPGAQTAKVKVAEPGQTLDEDVARVEAVRARIR
Mflv_3261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2978|M.vanbaalenii_PYR-1 D-------------------------------------------------
MSMEG_3481|M.smegmatis_MC2_155 VSVPVVDVRRAREIVDGSPCRTATVEVGAGGLDDDTARVAAVREVLGPEG
TH_2569|M.thermoresistible__bu --------------------------------------------------
MMAR_0899|M.marinum_M TVRVDANGGWSVDQAAQAAVALTADG-PLEYLEQPCATVGELAELRRR--
MUL_0652|M.ulcerans_Agy99 TVRVDANGGWSVDQAAQAAVALTADG-PLEYLEQPCATVGELAELRRR--
MAV_4590|M.avium_104 TVRVDANGGWSVDEAARAARALSADG-PLEYLEQPCATVGELAELRRRPD
Mb0568|M.bovis_AF2122/97 MVRVDANGGWGVAEAVAAAAALTADG-PLEYLEQPCATVAELAELRRR--
Rv0553|M.tuberculosis_H37Rv MVRVDANGGWGVAEAVAAAAALTADG-PLEYLEQPCATVAELAELRRR--
MLBr_02268|M.leprae_Br4923 TVRVDANGGWSVEAAAQAAVALTADG-PLEYLEQPCATVAELAALRRR--
MAB_3935c|M.abscessus_ATCC_199 TVRVDANGGWTVAQAVHALTALTRDG-ALEYAEQPCATVEELAELRRR--
Mflv_3261|M.gilvum_PYR-GCK ---GEATARVVVADVDDAVSRIAALG-SVDLVELVCRTPRDASEVRRR--
Mvan_2978|M.vanbaalenii_PYR-1 ---GAARAVIEVDNVDAAVARITRSD-AVELVELVCRSAADAGAVRQR--
MSMEG_3481|M.smegmatis_MC2_155 ALRCDARGRWDAQTARTAVAALDAAAGGLEFVERPCATLDDLVRLRKE--
TH_2569|M.thermoresistible__bu -----------VQTAVAVIRELTRAAGELEFVEQPCRTAAELAEVRRR--
. . . : :: * * : : :*:.
MMAR_0899|M.marinum_M -IEVPIAADEAIRKAEDPLAVVR----AGAADVAVLKVAPLGGVWALLDI
MUL_0652|M.ulcerans_Agy99 -IEVPIAADEAIRKAEDPLAVVR----AGAADVAVLKVAPLGGVWALLDI
MAV_4590|M.avium_104 MPDVPIAADESIRKADDPLAVVR----ARAADIAVLKVAPLGGISALLEI
Mb0568|M.bovis_AF2122/97 -VDVPIAADESIRKAEDPLAVVR----AQAADIAVLKVAPLGGISALLDI
Rv0553|M.tuberculosis_H37Rv -VDVPIAADESIRKAEDPLAVVR----AQAADIAVLKVAPLGGISALLDI
MLBr_02268|M.leprae_Br4923 -VDIPIAADESIRKADDPLAVVR----SHAADVAVLKVAPLGGIASFLAI
MAB_3935c|M.abscessus_ATCC_199 LPGVPIAADESIRRASDPLRVAQ----ARAADIAVLKVAPLGGVHALLEI
Mflv_3261|M.gilvum_PYR-GCK -VQVPVAVDAAVAAE--DPQC---------ADIVVLRAGPLGGVRRALRR
Mvan_2978|M.vanbaalenii_PYR-1 -VDVPVAVDAELLAQ--DPRC---------ADIAILRCGPLGGVRRALRR
MSMEG_3481|M.smegmatis_MC2_155 -IDVRIAAHATMRDTLSDPAVPVDPRLREAADVVVLACGPLGGARRALRV
TH_2569|M.thermoresistible__bu -VDVPIAADAALQH----PGV----RWAEIADVAVLRCGPLGGVRRSLRV
: :*.. : **:.:* .**** *
MMAR_0899|M.marinum_M AAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVEDVA
MUL_0652|M.ulcerans_Agy99 AAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVEDVA
MAV_4590|M.avium_104 AARIDIPVVISSALDSAVGIAAGLTAAAALPVLGHACGLGTGGLFVEDVA
Mb0568|M.bovis_AF2122/97 AARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVA
Rv0553|M.tuberculosis_H37Rv AARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVA
MLBr_02268|M.leprae_Br4923 AAQIDIPVVVSSALDSVVGITAGLIAAAALPELDYACGLGTGRLFVADVA
MAB_3935c|M.abscessus_ATCC_199 AARIGMPAVISSALDSAVGIGIGLRAAAALPELDHACGLGTGGFFLADVA
Mflv_3261|M.gilvum_PYR-GCK AERLGLPAVVAFTGTTSVGLAADVALAAVLPDLPFAVGPVPEWLHDNDVV
Mvan_2978|M.vanbaalenii_PYR-1 AERLGLPALVNFTGATSIGLAADVALAAALPDLPFACGPVPEWLTHADVV
MSMEG_3481|M.smegmatis_MC2_155 AESSGLPCVVTSMWETTIGLAAGLAVAGALPELPFACQLGTRPLLTGDLV
TH_2569|M.thermoresistible__bu AESTGLPCVVASTAETSVGQAAGVALAGALPELRFACALGSAGELAGDLV
* :* :: : :* .: *..** * .* . *:.
MMAR_0899|M.marinum_M EPAI----PVDGALAPQRVV--PDPARLRALGAA-PDRRQWWIDRIKACY
MUL_0652|M.ulcerans_Agy99 EPAI----PVDGALAPQRVA--PDPARLRALGAA-PDRRQWWIDRIKACY
MAV_4590|M.avium_104 DVAA----PVDGALPVGPVT--PDPARLRALAAP-PQRRQWWIDRVTACH
Mb0568|M.bovis_AF2122/97 EPAA----PVDGFLAVARTT--PDPARLQALGAP-PQRRQWWIDRVKACY
Rv0553|M.tuberculosis_H37Rv EPAA----PVDGFLAVARTT--PDPARLQALGAP-PQRRQWWIDRVKACY
MLBr_02268|M.leprae_Br4923 EPML----PVDGFLPVGPVT--PDPARLQALGTP-PARRQWWIDRVKTCY
MAB_3935c|M.abscessus_ATCC_199 DVPP----VVDGHLPVTSCT--PDPARLAALAVP-ADRLDRWRRRVADCH
Mflv_3261|M.gilvum_PYR-GCK SAAR-SLVPSDGFLPAAPMPAGPDPERLARFRVTDPATTARWRDLLHRAA
Mvan_2978|M.vanbaalenii_PYR-1 SDSR-TLVPVDGFLPAAPMPAGPDPGRLARFTVTDAATVGRWRDLLHRAA
MSMEG_3481|M.smegmatis_MC2_155 AASRSLVADADGCLPVAPMPPAPQPELLEQFAMADPARVAWWRERLRAAI
TH_2569|M.thermoresistible__bu SGPR-VLRPVDGHLPVAPMPPGPDPELLERFAITDPDRIAWWRERLRVAR
** *. *:* * : . . * : .
MMAR_0899|M.marinum_M PLLYRRSGD----------
MUL_0652|M.ulcerans_Agy99 PLLYRRSGD----------
MAV_4590|M.avium_104 GLLVPSSG-----------
Mb0568|M.bovis_AF2122/97 SLLVPSFG-----------
Rv0553|M.tuberculosis_H37Rv SLLVPSFG-----------
MLBr_02268|M.leprae_Br4923 SLLVPCAGDQSGLRRPRDR
MAB_3935c|M.abscessus_ATCC_199 ALLNR--------------
Mflv_3261|M.gilvum_PYR-GCK ALL----------------
Mvan_2978|M.vanbaalenii_PYR-1 ALI----------------
MSMEG_3481|M.smegmatis_MC2_155 SAS----------------
TH_2569|M.thermoresistible__bu S------------------