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VTERVRPWTDVVTLPMRNPVMFAKDMATIDVLSGGRLTLGVGIGAWDEDYVAAGSPTDRKRQRMDAAVAT MRKVWAQEPPVEGHHPVGPTPVQAAGIPLVAGVVGPKALARAAKWAVGVSDPANSLHFDAENLAAQRERV AQAWQAAGRTDKPHFSTPIWFALGPDPETQLRDHVREFWDQEVVATTGRLLPHGCDHRHAQLRAVCAPHG CERRARSGPRRAQAHPDNRRSRRNRSRPRRPRHLIGLQSCHRAHWPCARIRLHHRGCRQRRLPARQPAQR RPRSPGAPDRSRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3229 | - | - | 100% (293) | coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase-like protein |
| M. gilvum PYR-GCK | Mflv_2283 | - | 1e-33 | 43.33% (180) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_4839 | - | 4e-15 | 38.71% (124) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0978c | - | 4e-11 | 30.63% (160) | oxidoreductase |
| M. tuberculosis H37Rv | Rv0953c | - | 5e-11 | 30.63% (160) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 3e-11 | 33.59% (131) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3271 | - | 7e-35 | 43.02% (179) | hypothetical protein MAB_3271 |
| M. marinum M | MMAR_4128 | - | 3e-34 | 43.89% (180) | flavin-dependent oxidoreductase |
| M. avium 104 | MAV_1441 | - | 5e-31 | 41.53% (183) | hypothetical protein MAV_1441 |
| M. smegmatis MC2 155 | MSMEG_4967 | - | 1e-30 | 44.64% (168) | hypothetical protein MSMEG_4967 |
| M. thermoresistible (build 8) | TH_2001 | - | 2e-32 | 42.78% (180) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3991 | - | 1e-33 | 43.33% (180) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4383 | - | 3e-31 | 42.22% (180) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4128|M.marinum_M -------MTMPVMEPDLDANVLKTWARAVDEGPFSA--------------
MUL_3991|M.ulcerans_Agy99 ------------MEPDLDANVLKTWARAVDEGTFSA--------------
MAV_1441|M.avium_104 -------MTMPVMEPDLDATVLETWARTIDEGPFSS--------------
TH_2001|M.thermoresistible__bu -------MTMPVMEPDLDAATLRTWARAIDDGPFSA--------------
MSMEG_4967|M.smegmatis_MC2_155 -------MTLPVMEPQLDAATLRAWAHVIDGGPFSS--------------
Mvan_4383|M.vanbaalenii_PYR-1 ---------MPVMEPDLDRATLRSWAQLVDGGPFSS--------------
MAB_3271|M.abscessus_ATCC_1997 ---MDIGIALPFMCRDYTRESTITWARLADEGPFST--------------
Mb0978c|M.bovis_AF2122/97 ---MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQAAH
Rv0953c|M.tuberculosis_H37Rv ---MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQAAH
Mflv_3229|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAG--------------
MMAR_4128|M.marinum_M -----LCWGERIAFDNPDSLTLLGALAAWTDRVRLVTTVIVPQLHDPVML
MUL_3991|M.ulcerans_Agy99 -----LCWGERIAFDNPDSSTLLGALAAWTDRVRLVTTVIVPQLHDPVML
MAV_1441|M.avium_104 -----LCWGERIAFDNPDSLTLLGALAAWTERVRLLTTVIVPQLHDPVLL
TH_2001|M.thermoresistible__bu -----LCWGERIAFDNPDSLTLLGALAAWTDRVRLVTTVVVPQLHDPVLL
MSMEG_4967|M.smegmatis_MC2_155 -----LCWGERIAFDNPDSLTLLGALAAWTDRVRLVTTVIVPQLHDPVAL
Mvan_4383|M.vanbaalenii_PYR-1 -----LCWGERIAFDNPESLTLLGALAAWTDRVRLVTTVVIPQLHDPVML
MAB_3271|M.abscessus_ATCC_1997 -----ISSGERISYHNQDMWVTLAAAAAVTERVRILANVSVLPAHPVPLV
Mb0978c|M.bovis_AF2122/97 PTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITL
Rv0953c|M.tuberculosis_H37Rv PTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITL
Mflv_3229|M.gilvum_PYR-GCK ----------------------------MTERVRPWTDVVTLPMRNPVMF
MLBr_00348|M.leprae_Br4923 -----FDAVFTGEAWGSDAYTPLAWWGSSTQRVRLGTSVVQLSARTPTAC
*.*:* : * :
MMAR_4128|M.marinum_M AKALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGMATRVAVM
MUL_3991|M.ulcerans_Agy99 AEALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGMATRVAVM
MAV_1441|M.avium_104 AKGLATGDLLSGGRLSVGIGVGGRQEDYHAVGADPATQTMRGMAERVAVM
TH_2001|M.thermoresistible__bu AKGLATGDVLSGGRLTVGIGVGGRHEDYRAVGADPATQTMREMAERVAVM
MSMEG_4967|M.smegmatis_MC2_155 AKALATGDMLSGGRLTVGLGIGGREEDYRAVGADLSAQNRKGLADAVAVM
Mvan_4383|M.vanbaalenii_PYR-1 AKQLATGDMLCGGRLTVGIGVGGRHEDYRAVGVDPATQTMRQMAERVAVM
MAB_3271|M.abscessus_ATCC_1997 AKQAATLDVLSEGRFILGVGVGGREHDYRCLDASFGRRHQR-LDDQVAEL
Mb0978c|M.bovis_AF2122/97 AKSIATLDHLSHGRVSVGVGFGWNTDELVDHGVPPGR-RRTMLREYLEAM
Rv0953c|M.tuberculosis_H37Rv AKSIATLDHLSHGRVSVGVGFGWNTDELVDHGVPPGR-RRTMLREYLEAM
Mflv_3229|M.gilvum_PYR-GCK AKDMATIDVLSGGRLTLGVGIGAWDEDYVAAGSPTDRKRQR-MDAAVATM
MLBr_00348|M.leprae_Br4923 AMAALTLDHLSGGRHILGLGVSGPQVVEGWYGQPFPKPLSR-TREYIDIV
* * * *. ** :*:*.. . : :
MMAR_4128|M.marinum_M KRVWAGEQISES-------------VRPVG-----PLPVQPGGPPLLVGT
MUL_3991|M.ulcerans_Agy99 KRVWAGEQISES-------------VRPVG-----PLPVQPGGPPLLVGT
MAV_1441|M.avium_104 KRVWAGEKLTES-------------VRPVG-----PAPVQPGGPPLFVGS
TH_2001|M.thermoresistible__bu KRVWAGEKVTES-------------VLPVG-----PPPVQSGGPPLLVGT
MSMEG_4967|M.smegmatis_MC2_155 KRVWAGEKVTES-------------VLPVG-----PPPAQTGGPPLHIGT
Mvan_4383|M.vanbaalenii_PYR-1 KRVWAGEKVTES-------------TLPVG-----PPPVQPGGPELHVGT
MAB_3271|M.abscessus_ATCC_1997 RRLWRGEPPFEG-------------ADPVG-----PAPVQDGGPPVVAAA
Mb0978c|M.bovis_AF2122/97 RALWTQEEACYDGE-----------FVKFGPSWAWPKPVQPHIPVLVGAA
Rv0953c|M.tuberculosis_H37Rv RALWTQEEACYDGE-----------FVKFGPSWAWPKPVQPHIPVLVGAA
Mflv_3229|M.gilvum_PYR-GCK RKVWAQEPPVEG-------------HHPVG-----PTPVQAAGIPLVAGV
MLBr_00348|M.leprae_Br4923 RQVWAREAPVVSDGQHYPLPLTGAGATGLGKALKPITHPLRADIPIMLGA
: :* * . .* : .
MMAR_4128|M.marinum_M IGPKTLRSAAPWADGLAG--TTLDLDAAKQNELFDVARAAWAQAGKPKPH
MUL_3991|M.ulcerans_Agy99 IGPKTLRSAAPWADGLAG--TTLDLDVAKQNELFDVARAAWAQAGKPKPH
MAV_1441|M.avium_104 IGPKTIRSAAAWADGLAG--TTLDLDVAKQRELFDVTRDAWARAGKPAPH
TH_2001|M.thermoresistible__bu IGPKTVRSAAAWADGMAG--TTLDLDTGKQNELFDIARSAWAQAGKPAPH
MSMEG_4967|M.smegmatis_MC2_155 IGPKTVRDAAAWADGVAG--TTLDLDLGKQAELFQIARSAWAQEGKPKPH
Mvan_4383|M.vanbaalenii_PYR-1 LGPKTVRSAAAWADGLAG--ITMDLAVDKQGELFDVARDAWQQAGKGKPH
MAB_3271|M.abscessus_ATCC_1997 IGPKSLARAARWADGITG--FSVSGAPAELTYSADSARAAWQAAGHAEPP
Mb0978c|M.bovis_AF2122/97 GTEKNFKWIARSADGWIT--TPRDVDIDEP---VKLLQDIWAAAGRD---
Rv0953c|M.tuberculosis_H37Rv GTEKNFKWIARSADGWIT--TPRDVDIDEP---VKLLQDIWAAAGRD---
Mflv_3229|M.gilvum_PYR-GCK VGPKALARAAKWAVGVSDPANSLHFDAENLAAQRERVAQAWQAAGRTDKP
MLBr_00348|M.leprae_Br4923 EGPKNVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGARRSREDFE
* . * . * . . .:
MMAR_4128|M.marinum_M LATS-FWFAFGPQADARAQVHRHLRRYMNWIPAEYVDAMAPTTGWAGSED
MUL_3991|M.ulcerans_Agy99 LATS-FWFAFGPQADARAQVHRHLRRYMNWIPAEYVDAMAPTTGWAGSED
MAV_1441|M.avium_104 LITS-FWFAFGSARGAREQIHRHLRRYMNWIPADYVDAMAPTTGWAGDED
TH_2001|M.thermoresistible__bu LATS-FWFALGAADTARDQVHRHLRRYMNWIPVEFVDAMAPTTGFAGSED
MSMEG_4967|M.smegmatis_MC2_155 LATS-FWFALGEPEVARAQVHRHLLRYMNWIPAEYVDAMAPTTGWAGTED
Mvan_4383|M.vanbaalenii_PYR-1 LATS-FWFAIGDGDAPRAQVHRHLLRYMNWIPAEFVDALAPTTGFAGTAD
MAB_3271|M.abscessus_ATCC_1997 VLSSGCFYTLGIP-GAESELKQFTSEYLAIFGTQIAEN-VPKTLTNFDAD
Mb0978c|M.bovis_AF2122/97 ----------GLPQIVALDVKPVPDKLARWAELGVTEVLFGMP--DRSAD
Rv0953c|M.tuberculosis_H37Rv ----------GLPQIVALDVKPVPDKLARWAELGVTEVLFGMP--DRSAD
Mflv_3229|M.gilvum_PYR-GCK HFSTPIWFALGPD--PETQLRDHVREFWDQEVVATTGRLLPHGCDHRHAQ
MLBr_00348|M.leprae_Br4923 ICASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAE
:: . :
MMAR_4128|M.marinum_M E----LLAVLRRFEEVGTDEVQLIP----TSSDVEQLRRAIDVVTRFGTA
MUL_3991|M.ulcerans_Agy99 E----LLAVLRRFEEIGTDEVPLIP----TSSDVEQLRRAIDVVTRFGAA
MAV_1441|M.avium_104 E----LAEVLRKFAEIGADEVQLIP----TSSDVGQLRRAADVAARL---
TH_2001|M.thermoresistible__bu E----LHRVLRRFRDIGADEVHLIP----TSADVDQVRRAAEVVREFGEP
MSMEG_4967|M.smegmatis_MC2_155 D----LVELLGKFEDIGTDEIHLIP----TSANIDQLRRVAEAVQNFA--
Mvan_4383|M.vanbaalenii_PYR-1 D----LREVLQRFADIGTDEVHLIP----TSQDIDQVRRVAEVIDDFS--
MAB_3271|M.abscessus_ATCC_1997 A----LNRTLDGAEEAGLDEFILVP----GASDVAVIEATIELIQRR---
Mb0978c|M.bovis_AF2122/97 D----AAAYVERLAAKLACCV-----------------------------
Rv0953c|M.tuberculosis_H37Rv D----AAAYVERLAAKLACCV-----------------------------
Mflv_3229|M.gilvum_PYR-GCK LRAVCAPHGCERRARSGPRRAQAHPDNRRSRRNRSRPRRPRHLIGLQSCH
MLBr_00348|M.leprae_Br4923 VVD--EVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAA
MMAR_4128|M.marinum_M ------------------------------------------
MUL_3991|M.ulcerans_Agy99 ------------------------------------------
MAV_1441|M.avium_104 ------------------------------------------
TH_2001|M.thermoresistible__bu ------------------------------------------
MSMEG_4967|M.smegmatis_MC2_155 ------------------------------------------
Mvan_4383|M.vanbaalenii_PYR-1 ------------------------------------------
MAB_3271|M.abscessus_ATCC_1997 ------------------------------------------
Mb0978c|M.bovis_AF2122/97 ------------------------------------------
Rv0953c|M.tuberculosis_H37Rv ------------------------------------------
Mflv_3229|M.gilvum_PYR-GCK RAHWPCARIRLHHRGCRQRRLPARQPAQRRPRSPGAPDRSRR
MLBr_00348|M.leprae_Br4923 GVTMMMVSASSVEQVRDLAGLF--------------------