For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RCLTSLLTLCALMSTLMLSPSGIAAAEHDGAPDGDNKDIPSLVAAVAEANQRVADVGANIQIKQEGVNKA LVEIATARDILADAQREVAASEQGLADSQVAIDAAQQRFDQFAASMYMNGPSGALPLANGPEEILAGAST QQSLIISFQKVRDDLVRRQTDHANKLSTATAARARAEGAAAEAQRRQDDAVAALQEAQQTFAAWQDEINR LAAERDSAQARLGAARPVAGTATAPTVPQPGAAQAPGDQWDRSDSLPADNSGAGLWDTTLPMVPSANVAG DPVAIINAILKIMATSVQLTADMGRKFLTKLGILSPAAAAADPGITNGRIPSLNGRQASEFVIRRAMSQL GVPYSWGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYNAGRKVPSSQMRRGDLIF YGPNASQHESMYLGDGMMLEAPYTGSVVKISPVRTSGMTPYVTRLIEY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2839 | - | - | 100% (469) | NLP/P60 protein |
| M. gilvum PYR-GCK | Mflv_0895 | - | 0.0 | 75.27% (469) | NLP/P60 protein |
| M. gilvum PYR-GCK | Mflv_3663 | - | e-141 | 60.09% (441) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1513 | - | 1e-134 | 54.41% (465) | invasion protein |
| M. tuberculosis H37Rv | Rv1477 | - | 1e-134 | 54.41% (465) | invasion protein |
| M. leprae Br4923 | MLBr_01812 | - | 1e-130 | 53.56% (463) | putative exported p60 protein homologue |
| M. abscessus ATCC 19977 | MAB_2728c | - | 1e-111 | 46.50% (471) | invasion protein Inv1 |
| M. marinum M | MMAR_2284 | iipA | 1e-131 | 54.88% (441) | invasion and intracellular persistence protein, IipA |
| M. avium 104 | MAV_3301 | - | 1e-129 | 53.45% (464) | invasion protein |
| M. smegmatis MC2 155 | MSMEG_3145 | - | 1e-143 | 57.51% (473) | secreted cell wall-associated hydrolase |
| M. thermoresistible (build 8) | TH_0436 | - | 1e-130 | 54.53% (453) | Possible inv protein |
| M. ulcerans Agy99 | MUL_1486 | - | 1e-130 | 54.42% (441) | cell wall-associated hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3656 | - | 0.0 | 74.84% (469) | NLP/P60 protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2839|M.gilvum_PYR-GCK --------------MRCLTSLLTLCALMSTLMLSPSGIAAAEHDGAPDGD
Mvan_3656|M.vanbaalenii_PYR-1 --------------MRRLTSLLIAGVLASMLVLHTSGVATAGHGSEPDGD
MMAR_2284|M.marinum_M MRRTR--RSSASRSAARLVRPAIPSVVSVALLVSVPAVVNADS------R
MUL_1486|M.ulcerans_Agy99 MRRTR--RSSASRSAARLVRPAIPSVVSVALLVTVPAVANADS------R
Mb1513|M.bovis_AF2122/97 MRRNR--RGSPARPAARFVRPAIPSALSVALLVCTPGLATADP------Q
Rv1477|M.tuberculosis_H37Rv MRRNR--RGSPARPAARFVRPAIPSALSVALLVCTPGLATADP------Q
MLBr_01812|M.leprae_Br4923 MKRPR--RGSVSRPTARFVRPAIPSLVSAALLVSLPVLATADP------D
MAV_3301|M.avium_104 ----------------------MPSVLSVALLICTPGLAQADP------A
MSMEG_3145|M.smegmatis_MC2_155 MRRTV--RALATRVHGRVCAVPLVVGMLLATALYGGGPAAADPA-----A
TH_0436|M.thermoresistible__bu --------------------------MALATTINCGSVAVADPG-----D
MAB_2728c|M.abscessus_ATCC_199 MKRTVNDRFAVRGKRTVATALMVPPLLVAGLMMFPTTVAVTSA------E
: : . :
Mflv_2839|M.gilvum_PYR-GCK NKDIPSLVAAVAEANQRVADVGANIQIKQEGVNKALVEIATARDILADAQ
Mvan_3656|M.vanbaalenii_PYR-1 SETVAGLVAAVAEVNQHVADIGADIQHMQESVNRALVELATAREAVSEAH
MMAR_2284|M.marinum_M TDSIAALIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAE
MUL_1486|M.ulcerans_Agy99 TDSIAALIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAE
Mb1513|M.bovis_AF2122/97 TDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAE
Rv1477|M.tuberculosis_H37Rv TDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAE
MLBr_01812|M.leprae_Br4923 GDNLGTLIADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAE
MAV_3301|M.avium_104 ADNLAALIANVAKANQRLQNLSAEIQTEQESVNKALVDVETARDNAAAAQ
MSMEG_3145|M.smegmatis_MC2_155 PDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQ
TH_0436|M.thermoresistible__bu PNEVATLVAAVANVNQKLQELGAAVQQKKESVNKALVDLQEARDAAEAAQ
MAB_2728c|M.abscessus_ATCC_199 PNDMASLITQLADTNQQIEQLTADVQTQQESINKGLVDLQAARDNAASAA
. : *:: :* .:*:: :: :: :: :*:.:* : **: *
Mflv_2839|M.gilvum_PYR-GCK REVAASEQGLADSQVAIDAAQQRFDQFAASMYMNGPSGALPLANGPEEIL
Mvan_3656|M.vanbaalenii_PYR-1 RRLADSEKALADSQTAIDATQQRFDEFAASTYMNGPSRSLPLASSPEDIL
MMAR_2284|M.marinum_M HELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEII
MUL_1486|M.ulcerans_Agy99 HELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEII
Mb1513|M.bovis_AF2122/97 DDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEII
Rv1477|M.tuberculosis_H37Rv DDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEII
MLBr_01812|M.leprae_Br4923 HDCEVSQQSVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDII
MAV_3301|M.avium_104 HDLEASQQAVKDANAAIAGAQRRFDTFAAAAYMNGPSNSYLTARNPDDII
MSMEG_3145|M.smegmatis_MC2_155 RELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIV
TH_0436|M.thermoresistible__bu AELKAAQESVETANTAIEDAQKRFDTFAAATYVNGPSVSYLTASDPADVL
MAB_2728c|M.abscessus_ATCC_199 AQVAEGQRAVDAANGAIEEAQGKFDRMAAATYMAGPSTSYLTATNPDDVV
.:..: :: ** :* :** :**: *: *** : * .* :::
Mflv_2839|M.gilvum_PYR-GCK AGASTQQSLIISFQKVRDDLVRRQTDHANKLSTATAARARAEGAAAEAQR
Mvan_3656|M.vanbaalenii_PYR-1 SAASTQQTYLLAFGRVKDDLRRSQTERANRLSAAKQARLDADAAAAEAQR
MMAR_2284|M.marinum_M AAATAAKTLAASAQTVMANLERARTRQVNKESASRLAKQKADKAAEEAKT
MUL_1486|M.ulcerans_Agy99 AAATAAKTLAASAQTVMANLERARTRQVNKESASRLAEQKADKAAEDAKT
Mb1513|M.bovis_AF2122/97 ATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKA
Rv1477|M.tuberculosis_H37Rv ATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKA
MLBr_01812|M.leprae_Br4923 ATATAARTLTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKA
MAV_3301|M.avium_104 ATEAAAKTLTASSQTVMAKLQQARTEQVNRESAARLAKQNADKAAADAKA
MSMEG_3145|M.smegmatis_MC2_155 NTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAES
TH_0436|M.thermoresistible__bu DTAVAGQVLATSAQQVMKNLQQARTEQVNKESLARLAKQRADEKLAAAQA
MAB_2728c|M.abscessus_ATCC_199 RLASVTKSVEASSQTVMDNLRRARTEQVNKQSQARAIQEKADQAAADAQQ
. : : * .* : :* :.* * : . *: *:
Mflv_2839|M.gilvum_PYR-GCK RQDDAVAALQEAQQTFAAWQDEINRLAAERDSAQARLGAAR--PVAGTAT
Mvan_3656|M.vanbaalenii_PYR-1 RQDGAVAELVAAQRAFTNQQSDLTRLAAERDSAQTRLTTAR--PVAATTR
MMAR_2284|M.marinum_M SQDAAVTALTDTQRKFDQQREEVNRLAAERDEAEAKLQAAR--LVAWSSA
MUL_1486|M.ulcerans_Agy99 SQDAAVTALTDTQRKFDQQREEVNRLAAERDEAEAKLQAAR--LVAWSSA
Mb1513|M.bovis_AF2122/97 SQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAAR--LVAWSSE
Rv1477|M.tuberculosis_H37Rv SQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAAR--LVAWSSE
MLBr_01812|M.leprae_Br4923 SMDAAVAALTASKRKFDEQRDEVNRLAAERDEAQARLEVAQ--IAAATWV
MAV_3301|M.avium_104 SQDAAVAALTNSRQKFDEQREQMIRLATERDQAQAKLEAAK--RQLSTPG
MSMEG_3145|M.smegmatis_MC2_155 SQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVR--KVSATGN
TH_0436|M.thermoresistible__bu SQEAAVNALTEAQETFGAQQAELQKLTAEREAAQAKLNEVR--TMSAATA
MAB_2728c|M.abscessus_ATCC_199 QQDDLVSAMKDVQKKLEAQRGVAADLTAKKKSAEAQLAAARGPAYAASTA
: * : :. : : *:::: *::.* .: :
Mflv_2839|M.gilvum_PYR-GCK APTVPQPGAAQAPG----------DQWDRS-----DSLPADNSGAG----
Mvan_3656|M.vanbaalenii_PYR-1 QPTAAQPGTPVPPS----------GQWDRS-----SPAPADSSGTG----
MMAR_2284|M.marinum_M ----GAEGPPPG------------AMWDPG----ARPGNGRRWDG-----
MUL_1486|M.ulcerans_Agy99 ----GAEGPPPG------------AMWDPG----ARPGNGRRWDG-----
Mb1513|M.bovis_AF2122/97 ----GGQGAPPF------------RMWDPG----SGPAGGRAWDGL----
Rv1477|M.tuberculosis_H37Rv ----GGQGAPPF------------RMWDPG----SGPAGGRAWDGL----
MLBr_01812|M.leprae_Br4923 PG-MGGHGTPPFG-----------DRWEPGSPASAGPAGGRKWDG-----
MAV_3301|M.avium_104 ------SG----------------DRWETGSAGAPAPSAGRQWDGA----
MSMEG_3145|M.smegmatis_MC2_155 AAPAAAPAAAPAPAAAPAPVPNSAPAPVPG-AQPNPQAAAGNWDRAPSGP
TH_0436|M.thermoresistible__bu GATSGANGSAPA------------AAPTPG-AASGTQDPARNWDRAPGGP
MAB_2728c|M.abscessus_ATCC_199 TARVINPSAAIAGNG---------NEWTEG------PAPVSSGGQ-----
. . .
Mflv_2839|M.gilvum_PYR-GCK --------LWDTTLPMVPSANVAGDPVAIINAILKIMATSVQLTADMGRK
Mvan_3656|M.vanbaalenii_PYR-1 --------QWDTTLPMVPSANVAGDPIAIINAVLKIMATSLQLTADMGRN
MMAR_2284|M.marinum_M ---------WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGRN
MUL_1486|M.ulcerans_Agy99 ---------WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGQN
Mb1513|M.bovis_AF2122/97 ---------WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRK
Rv1477|M.tuberculosis_H37Rv ---------WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRK
MLBr_01812|M.leprae_Br4923 ---------WDPTLPQVPSANVPGDPIAVINQVLGYAATSTQVTASMGRN
MAV_3301|M.avium_104 ---------WDPTLPMIPSANVPGDPIAVINQVLGISATSTQVTAGLGRN
MSMEG_3145|M.smegmatis_MC2_155 ASSGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRS
TH_0436|M.thermoresistible__bu VVPYGDPSQWDLTLPAIPSAFVSGDPIAIINASLQIAATSAQVTADLGRR
MAB_2728c|M.abscessus_ATCC_199 ---------WDTTLPMIASANVPTDPTQTINMVLGIGNTAANVGQSA---
** *** :.** :. ** :* * *: :: .
Mflv_2839|M.gilvum_PYR-GCK FLTKLGILSPAAAAADPG---ITNGRIPSLNGRQASEFVIRRAMSQLGVP
Mvan_3656|M.vanbaalenii_PYR-1 FLTKLGILSPATAAADPG---ITNGRIPRLYGRQASEFVIRRAMSQLGVP
MMAR_2284|M.marinum_M FLQQLGILKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVP
MUL_1486|M.ulcerans_Agy99 FLQQLGILKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVP
Mb1513|M.bovis_AF2122/97 FLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVP
Rv1477|M.tuberculosis_H37Rv FLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVP
MLBr_01812|M.leprae_Br4923 FLQQLGILKPNDTGITNAPIGSTQGRIPRVYGRQASEYVIRRGISQIGVP
MAV_3301|M.avium_104 FLQQLGILKPDDTGITNAAPGGVGARIPRVYGRQATEYVIRRGMSQIGVP
MSMEG_3145|M.smegmatis_MC2_155 FLQKLGIL-PTPTGFTN-------GAIPRVYGREAVEYVIRRGMSQIGVP
TH_0436|M.thermoresistible__bu FLQRLGLV-PTPTGYTNE------GGIPRVYGRQATEYVIQRAMSQIGVP
MAB_2728c|M.abscessus_ATCC_199 VCGVIGIFCPKAAPAAAAS-GEGGEYLPKVYGRENVERVIARAGSAMGTP
. :*:. * : :* : **: * ** *. : :*.*
Mflv_2839|M.gilvum_PYR-GCK YSWGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYN
Mvan_3656|M.vanbaalenii_PYR-1 YSWGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYN
MMAR_2284|M.marinum_M YSWGGGNAAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYN
MUL_1486|M.ulcerans_Agy99 YSWGGGNAAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYN
Mb1513|M.bovis_AF2122/97 YSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYN
Rv1477|M.tuberculosis_H37Rv YSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYN
MLBr_01812|M.leprae_Br4923 YSWGGGNAAGPSRGIDSGAGITGFDCSGLVLYSFAGVGIRLPHYSGSQYN
MAV_3301|M.avium_104 YSWGGGNAAGPSKGIDSGANIVGFDCSGLVLYSFAGVGIKLPHYSGSQYN
MSMEG_3145|M.smegmatis_MC2_155 YSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYN
TH_0436|M.thermoresistible__bu YSWGGGNAAGPSRGIDSGANTVGFDCSGLVLYAFAGVGIKLPHYSGAQYN
MAB_2728c|M.abscessus_ATCC_199 YSWGGGSYNGPTRGIDSGAGTVGYDCSGLMMYGFAAVGIRLRHYTGYQYN
******. **::***.**. .*:*****::* **.***:* **:* ***
Mflv_2839|M.gilvum_PYR-GCK AGRKVPSSQMRRGDLIFYGPNASQHESMYLGDGMMLEAPYTGSVVKISPV
Mvan_3656|M.vanbaalenii_PYR-1 AGRKVPSSQMQRGDLIFYGPNASQHEAMYLGDGMMIEAPYTGSVVKISPV
MMAR_2284|M.marinum_M LGRKIPTSQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPV
MUL_1486|M.ulcerans_Agy99 LGRKIPTSQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPV
Mb1513|M.bovis_AF2122/97 LGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPV
Rv1477|M.tuberculosis_H37Rv LGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPV
MLBr_01812|M.leprae_Br4923 LGRKIPSAQMRRGDVIFYGPGGSQHVTIYLGHGQMLEAPDIGLRVRVAPV
MAV_3301|M.avium_104 LGRKIPSSQMRRGDVIFYGPGGSQHVTIYLGDGQMLEAPDIGLKVRVAPV
MSMEG_3145|M.smegmatis_MC2_155 AGRKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPV
TH_0436|M.thermoresistible__bu LGRKIPSAQMRRGDVIFYGPGGSQHVTIYLGNGQMIEAPYTGSHVKISPV
MAB_2728c|M.abscessus_ATCC_199 SGRKVPSAQMKRGDMIFYGPNASQHVALYLGNGQMLEAPNTGDVVKVSPV
***:*::**:***:*****..*** ::***.* *:*** * *:::**
Mflv_2839|M.gilvum_PYR-GCK RTSGMTPYVTRLIEY
Mvan_3656|M.vanbaalenii_PYR-1 RSSGMTPYVTRLIEY
MMAR_2284|M.marinum_M RTSGMTPFVVRYIEY
MUL_1486|M.ulcerans_Agy99 RTSGMTPFVVRYIEY
Mb1513|M.bovis_AF2122/97 RTAGMTPYVVRYIEY
Rv1477|M.tuberculosis_H37Rv RTAGMTPYVVRYIEY
MLBr_01812|M.leprae_Br4923 RTSGMTPYVVRYIEY
MAV_3301|M.avium_104 RTSGMTPYVVRYIEW
MSMEG_3145|M.smegmatis_MC2_155 RTSGMTPYVTRLIEY
TH_0436|M.thermoresistible__bu RTSGMTPYVVRYIEW
MAB_2728c|M.abscessus_ATCC_199 RTSGMTPYVTRMIEW
*::****:*.* **: