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QIDVTFIGTATTLIRCGNITVLTDPNFLHRGQRAYLGYGLWSKRRRAPGLTPEELPPIDAIVLSHMHGDH WDRVAERSLDRELPVITTHEAAKALHRKGFTEAVGLSTWDPFVLTKDGETLTVTAMPGRHAPTPVSRLLP PVMGSMLDFDSGGGSSRRRVYISGDTLLIDELDEIPVRFNAIDAGVLHLGGTRLPFGDRLPVGLTVTMDG RQGAETVERLHLPRVIPVHFDDYRVFASPLADFHREMSRRGLADRVVTVERGQTVSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2585 | - | - | 100% (268) | protein Pfam: Lactamase_B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0930 | - | 2e-05 | 23.94% (259) | hypothetical protein Mb0930 |
| M. tuberculosis H37Rv | Rv0906 | - | 2e-05 | 23.94% (259) | hypothetical protein Rv0906 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4624 | - | 4e-05 | 23.02% (265) | hypothetical protein MMAR_4624 |
| M. avium 104 | MAV_1029 | - | 8e-08 | 24.22% (256) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_6233 | - | 1e-102 | 64.18% (268) | hypothetical protein MSMEG_6233 |
| M. thermoresistible (build 8) | TH_0095 | - | 4e-06 | 23.39% (248) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0235 | - | 2e-05 | 23.02% (265) | hypothetical protein MUL_0235 |
| M. vanbaalenii PYR-1 | Mvan_4991 | - | 6e-05 | 22.01% (268) | hypothetical protein Mvan_4991 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0930|M.bovis_AF2122/97 -MVR---RALRLAAGTASLAAGTWLLRALHGTPAALGADAASIRAVSEQS
Rv0906|M.tuberculosis_H37Rv -MVR---RALRLAAGTASLAAGTWLLRALHGTPAALGADAASIRAVSEQS
MMAR_4624|M.marinum_M -MVG---RALRLAAGTASLAAGGWLMRALHGAPAALGADPAAIEAASDGS
MUL_0235|M.ulcerans_Agy99 -MVG---RALRLAAGTASLAAGGWLMRALRGAPAALGADPAAIEAASDGS
MAV_1029|M.avium_104 --MR---GTLRLVAGTASLAAGGWLVRALHGAPDALGADPASIAAVTSGS
TH_0095|M.thermoresistible__bu -MSRSWLGLMRQAAGVATVLGGGWLIRALRGAPAAVGADRRDIRPVAQRS
Mvan_4991|M.vanbaalenii_PYR-1 MEVR---TALRFGFGTASLFAGGWVLRALQGTPAALGATPPEIAPVARRS
Mflv_2585|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6233|M.smegmatis_MC2_155 --------------------------------------------------
Mb0930|M.bovis_AF2122/97 PNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAPIPLASPN
Rv0906|M.tuberculosis_H37Rv PNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAPIPLASPN
MMAR_4624|M.marinum_M PNYRDGVFVNLDPASVFTLNREEMRLLAWELLANRGGSRPAKPIPLAAPQ
MUL_0235|M.ulcerans_Agy99 PYYRDGVFVNLDPASVFTLNREEMRLLAWELLANRGGSRPAKPIPLAAPQ
MAV_1029|M.avium_104 PHFRDGAFVNLEPASEIKMDREQLRLIAWELIANRGGSRPPAAIPLASPG
TH_0095|M.thermoresistible__bu PNYRDGAFVNLDPASMISLDRQQQWVLAREFLDGRAATRPAAPIPLVTPN
Mvan_4991|M.vanbaalenii_PYR-1 PHYQDGKFVNLEPPSGITMDRDLQRMLLRDLANFASQGTPPGPIPLADPP
Mflv_2585|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6233|M.smegmatis_MC2_155 --------------------------------------------------
Mb0930|M.bovis_AF2122/97 IYRG--DASRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVG---
Rv0906|M.tuberculosis_H37Rv IYRG--DASRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVG---
MMAR_4624|M.marinum_M VYQG--DASRLAVSWFGHSTAMVEIDGYRVLTDPVWSDRCSPSDLVG---
MUL_0235|M.ulcerans_Agy99 VYQG--DASRLAVSWFGHSTAMVEIDGYRVLTDPVWSDRCSPSDLVG---
MAV_1029|M.avium_104 VVDA--DPSRLAVSWFGHSTALLEIDGYRVLTDPVWSERCSPSDIVG---
TH_0095|M.thermoresistible__bu PADHGVGAADLAVRWYGHSTAMVEVDGYRVLTDPIWSRRCSPSALVG---
Mvan_4991|M.vanbaalenii_PYR-1 VVDP--TPAPAAASWYGHSSTLIEVDGYRVLADPVWSNRCSPSRAVG---
Mflv_2585|M.gilvum_PYR-GCK --------MQIDVTFIGTATTLIRCGNITVLTDPNFLHRGQRAYLGYGLW
MSMEG_6233|M.smegmatis_MC2_155 ----------MDITFVGNATTLISAGEVTLLTDPNFLHQGQHAYLGYGLM
: * ::::: . :*:** : : . :
Mb0930|M.bovis_AF2122/97 PQRLHPPPVQLAALPAVDAVVISHDHYDHLDIDTVVALVGMQRAPFLVPL
Rv0906|M.tuberculosis_H37Rv PQRLHPPPVQLAALPAVDAVVISHDHYDHLDIDTVVALVGMQRAPFLVPL
MMAR_4624|M.marinum_M PQRLHPPPVQLDGLPAVDAVVISHDHYDHLDIDTVIALVRSQRAPFFVPL
MUL_0235|M.ulcerans_Agy99 PQRLHPPPVQLDGLPAVDAVVISHDHYDHLDIDTVIALVRSQRAPFFVPL
MAV_1029|M.avium_104 PQRLHPPPIQLEGLPAVDAVVISHDHYDHLDIDTVRALARTQRAPFFVPL
TH_0095|M.thermoresistible__bu PRRLHEPPTPLEALPAVDAVLISHDHYDHLDMDTVVRLARTQRAPFLVPL
Mvan_4991|M.vanbaalenii_PYR-1 PQRMHDVPVLIEALPAVDAVIISHDHYDHLDIDTIVALAHTQRAPFVVPL
Mflv_2585|M.gilvum_PYR-GCK SKRRRAPGLTPEELPPIDAIVLSHMHGDHWDRVAERSLDRELPVITTHEA
MSMEG_6233|M.smegmatis_MC2_155 SKRLRDPAYSIDELPPLDAVVLSHMHGDHWDRVAQAGLDHALPILTTPHA
.:* : **.:**:::** * ** * : *
Mb0930|M.bovis_AF2122/97 GVGAHLRSWGVPQDRIVELDWNQSAQVDELTVVCVPARHFSG---RFLSR
Rv0906|M.tuberculosis_H37Rv GVGAHLRSWGVPQDRIVELDWNQSAQVDELTVVCVPARHFSG---RFLSR
MMAR_4624|M.marinum_M GVGAHLRSWGVPEDRIIELDWHQSAQVGELSVICMPARHFSG---RFMSR
MUL_0235|M.ulcerans_Agy99 GVGAHLRSWGVPEDRIIEFDWHQSAQVGELSVICMPARHFSG---RFMSR
MAV_1029|M.avium_104 GVGAHLRRWGIPEQRIVELDWHQSGKVDELTVTCVPARHFSG---RFLDR
TH_0095|M.thermoresistible__bu GVGAHLRTWRIPEHRIVELDWYESRRIGDLRITCTPARHFSG---RLFAR
Mvan_4991|M.vanbaalenii_PYR-1 GIGAHLRKWGIPESRIVELDWNEAHRIGDLTLICTPARHFSG---RLFAR
Mflv_2585|M.gilvum_PYR-GCK AKALHRKGFTEAVGLSTWDPFVLTKDGETLTVTAMPGRHAPTPVSRLLPP
MSMEG_6233|M.smegmatis_MC2_155 AKRLSHRGFEAAVPMTTWQTHTVTKGATTVTVTSLPGRHAPAPVHRVLPP
. : : . : : : . *.** . *.:
Mb0930|M.bovis_AF2122/97 NTTLWASWAFVG----PNHRAYFGGDTGYTKSFTQIGADHGPFDLTLLPI
Rv0906|M.tuberculosis_H37Rv NTTLWASWAFVG----PNHRAYFGGDTGYTKSFTQIGADHGPFDLTLLPI
MMAR_4624|M.marinum_M NNTLWASWAFVG----PTHRAYFGGDTGYTKSFAEIGADHGPFDLTLMPI
MUL_0235|M.ulcerans_Agy99 NNTLWASWAFVG----PTHRAYFGGDTGYTKSFAEIGADHGPFDLTLMPI
MAV_1029|M.avium_104 NTTLWASWALAG----PTHRAYFGGDTGYTKTFAQTGAEHGPFDLTLLPI
TH_0095|M.thermoresistible__bu NTTLWASWVIAG----PRHRAFFGGDTGYTKSFTEIGVDHGPFDLTLLPI
Mvan_4991|M.vanbaalenii_PYR-1 DSTLWSSWVVTG----PTHKAFFGGDTGYTKSFAEIGAEHGPFDLTLLPI
Mflv_2585|M.gilvum_PYR-GCK VMGSMLDFDSGG--GSSRRRVYISGDTLLIDELDEIPVRFNAIDAGVLHL
MSMEG_6233|M.smegmatis_MC2_155 VMGSMIEVTEGGSDGGATRRLYISGDTLFVEELDEIPARFTSIDAGILHL
. * . :: ::.*** . : : . . .:* :: :
Mb0930|M.bovis_AF2122/97 G----AYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHP
Rv0906|M.tuberculosis_H37Rv G----AYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHP
MMAR_4624|M.marinum_M G----AYNTGWPDIHMNPEEAVRAHLDVSDTGSGLLVPIHWGTFRLAPHP
MUL_0235|M.ulcerans_Agy99 G----AYSTGWPDIHMNPEEAVRAHLDVSDTGSGLLVPIHWGTFRLAPHP
MAV_1029|M.avium_104 G----AYNTAWPDVHMNPEEAVRAHRDVTN--DGLLVPIHWGTFRLAPHP
TH_0095|M.thermoresistible__bu G----AYHPAWPDIHMNPEEAVRAHLDMAEADSGLLVPIHWATFRLAPHP
Mvan_4991|M.vanbaalenii_PYR-1 G----AYHPAFADIHMNPEEAVRAHLDLADVDNSLMVPIHWATFRLAPHP
Mflv_2585|M.gilvum_PYR-GCK GGTRLPFGDRLPVGLTVTMDGRQGAETVERLHLPRVIPVHFDDYRVFASP
MSMEG_6233|M.smegmatis_MC2_155 GGTRLPFGRHLPFGLTVTMDGRQGADLAELLEPGKVIPVHFDDYGVFASP
* .: . . :. :. ::*:*: : : . *
Mb0930|M.bovis_AF2122/97 WGEPVERLLAAAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL----
Rv0906|M.tuberculosis_H37Rv WGEPVERLLAAAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL----
MMAR_4624|M.marinum_M WAEPVERLLKAAESDQVQVAVPLPGQRIDPAGPLRFNPWWRL----
MUL_0235|M.ulcerans_Agy99 WAEPVERLLKAAESDQVQVAVPLPGQGVDPAGPLRFNPWWRL----
MAV_1029|M.avium_104 WAEPVERLLAAAEPAKVKVAVPVPGQRIDPAAPQKPDPWWRL----
TH_0095|M.thermoresistible__bu WSEPVERLLAAADPARVPVAVPRPGERVDRDSAGASDQWWRPADGR
Mvan_4991|M.vanbaalenii_PYR-1 WAEPAERLLTAADAERVRVAVPMPGQRVVPES--TFDPWWRF----
Mflv_2585|M.gilvum_PYR-GCK LADFHREMSRRGLADRVVTVER--GQTVSL----------------
MSMEG_6233|M.smegmatis_MC2_155 LSDFHEEMARRGMGERVVELGR--GESVTV----------------
.: ..: . :* *: :