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SAALRGEKILITGATGKIAFPIARLLAPHNDVWGAARLRDPADRDRLTAAGVTPVALDLGTGDVSPLPDD FTYVFHAAVDPGQGEWSRAVETNAQRSGELLHHCRTAKGFVLCSTGSIYGYQRGRPLTEDDPPGVPLRAN YSFSKVAAEAVCTWVSRHFDIPLTIIRICSTYGPEGGAAADRLDAILARRPIRLHPDRPNNYNPIYEDDY VALGIRAMQVARTPPQVVNWAGSETVSVEEYCAYLGELVGIEPVFEYTADAHTPLWPDVTRMHEVLGRTK VPWREGFRRMTAARHPELTLSDTCTTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2455 | - | - | 100% (308) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_1028 | - | 1e-09 | 27.41% (270) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 5e-05 | 26.38% (235) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 5e-05 | 26.38% (235) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-06 | 27.47% (233) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 6e-05 | 25.54% (231) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_2896 | - | 2e-61 | 42.09% (297) | nucleoside-diphosphate-sugar epimerase WcaG-like protein |
| M. avium 104 | MAV_0921 | - | 1e-143 | 79.53% (298) | hypothetical protein MAV_0921 |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 1e-07 | 26.92% (312) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_4464 | - | 1e-07 | 27.48% (222) | PUTATIVE NAD-dependent epimerase/dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 9e-05 | 26.04% (192) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_5808 | - | 5e-09 | 26.69% (266) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3658c|M.bovis_AF2122/97 ---------------------------MRALVTGAAGFIGSTLVDRLLAD
Rv3634c|M.tuberculosis_H37Rv ---------------------------MRALVTGAAGFIGSTLVDRLLAD
MUL_4210|M.ulcerans_Agy99 ---------------------------MRALVTGAAGFIGSTLVDRLLAD
MLBr_00204|M.leprae_Br4923 ----------------------MYGEPVRALVTGAAGFIGSTLVDRLLAD
MAB_0503|M.abscessus_ATCC_1997 ---------------------------MRAMVTGAAGFIGSTLVDRLLAD
MSMEG_6142|M.smegmatis_MC2_155 -------------------------MAVRTLVTGAAGFIGSTLVDRLLAD
TH_4464|M.thermoresistible__bu -------------------------MALTVAVTGPTGEIGMAAVEALERD
Mvan_5808|M.vanbaalenii_PYR-1 -------------------------MSLRVAVTGPTGEIGISTISALEAH
Mflv_2455|M.gilvum_PYR-GCK --------------------MSAALRGEKILITGATGKIAFPIARLLAPH
MAV_0921|M.avium_104 MAFRVAPGLCSKRDIKYFTLGGPLLEAEKILITGATGKIAFPIARALAAA
MMAR_2896|M.marinum_M ------------------------MRDSKILITGVTGQVASPVARALAAA
:** :* :. . *
Mb3658c|M.bovis_AF2122/97 GHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRPEV
Rv3634c|M.tuberculosis_H37Rv GHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRPEV
MUL_4210|M.ulcerans_Agy99 GHTVVGLDNFATGRATNLEHLVDNLAHVFVEADIVDADLQAIFEQHRPEV
MLBr_00204|M.leprae_Br4923 GHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDEHRPEV
MAB_0503|M.abscessus_ATCC_1997 GHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLDAVVAEYSPEV
MSMEG_6142|M.smegmatis_MC2_155 GHGVVGLDDLSSGRAENLHSAENSDKFEFVKADIVDADLTGLLAEFKPEV
TH_4464|M.thermoresistible__bu -PAVGRIVGMARRPFDAAAHG--WTKTEYRQGDILDREAVDALVAPADVV
Mvan_5808|M.vanbaalenii_PYR-1 -PAVAEIIGMARRPFDTSEHG--WTKTTYRQGDILDRDAVEALVADTDVV
Mflv_2455|M.gilvum_PYR-GCK -NDVWGAARLRDPADR---DRLTAAGVTPVALDLGTGDVSPLPDDFTYVF
MAV_0921|M.avium_104 GNEVWGVARLKDPAAR---EKLVAAGVKPVALDVGAGDFSGLPEDFSYVL
MMAR_2896|M.marinum_M -NEVWGIARFTDATAR---ADLEQAGIRCQAVNLAAGDFTEIPSDFDYVL
* : :: : .
Mb3658c|M.bovis_AF2122/97 VFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGG
Rv3634c|M.tuberculosis_H37Rv VFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGG
MUL_4210|M.ulcerans_Agy99 IFHLAAQIDVRHSVADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGG
MLBr_00204|M.leprae_Br4923 VFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGG
MAB_0503|M.abscessus_ATCC_1997 IFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAGVRKIVHTSSGG
MSMEG_6142|M.smegmatis_MC2_155 IFHLAAQISVKRSVDDPPFDATVNVVGTVRLAEAARLAGVRKVVHTSSGG
TH_4464|M.thermoresistible__bu VHLAFIIMGSRAESERVNLTGTRNVFQAVVDHHARTGRPRRLVYTSSVAA
Mvan_5808|M.vanbaalenii_PYR-1 VHLAFIIMGSREESARVNLEGTRNVFEAAVAG----PRVRRLVYTSSVAA
Mflv_2455|M.gilvum_PYR-GCK HAAVDPGQGEWSRAVETNAQRSGELLHHCRTAKG---------FVLCSTG
MAV_0921|M.avium_104 HAAVDTGAGDWNRCLETNAQRSGELLYHCRAAKG---------FVFCSTG
MMAR_2896|M.marinum_M NFAVAK-SGNWDKDLGANAESVGLLMAHCRAAKA---------FLHCSSA
. :. . .
Mb3658c|M.bovis_AF2122/97 SIYGTPPEYPTPETAP-----TDPASPYAAGKVAGEIYLNTFRHLYGLDC
Rv3634c|M.tuberculosis_H37Rv SIYGTPPEYPTPETAP-----TDPASPYAAGKVAGEIYLNTFRHLYGLDC
MUL_4210|M.ulcerans_Agy99 SIYGTPPQYPTSERVP-----TDPASPYAAGKVAGEIYLNTFRHLYGLEC
MLBr_00204|M.leprae_Br4923 SIYGTPSQYPTPETVP-----TDPTSPYAAGKVAGEIYLNTFRHLCGLDC
MAB_0503|M.abscessus_ATCC_1997 SIYGTPKQIPTSETVP-----TDPHSPYAAGKVAGEIYLNTFRHLYGLEC
MSMEG_6142|M.smegmatis_MC2_155 SVYGTPPAYPTSEDMP-----VNPASPYAAGKVAGEVYLNMYRNLYDLDC
TH_4464|M.thermoresistible__bu YGYHSDNPVPITESVAPR---GSPEHYYSAQKAACEALLAEITDGSGVEV
Mvan_5808|M.vanbaalenii_PYR-1 YGYHSDNPVPITEDVPPR---GSPEHYYSEQKAACEALLADVTAGSALEV
Mflv_2455|M.gilvum_PYR-GCK SIYGYQRGRPLTEDDPPG---VPLRANYSFSKVAAEAVCTWVSRHFDIPL
MAV_0921|M.avium_104 SVYAYQGRRPLTESDPPG---VPLRANYSISKVAAEAVCTWVARHFQIPL
MMAR_2896|M.marinum_M AVYDPPDNELRTENAALGDNHKFLFPTYSISKIAGEVVVRSMARVLELPA
* .* . *: * * * :
Mb3658c|M.bovis_AF2122/97 SHIAPANVYGPRQDPHGEAG-------VVAIFAQALLSGKPTRVFGDGTN
Rv3634c|M.tuberculosis_H37Rv SHIAPANVYGPRQDPHGEAG-------VVAIFAQALLSGKPTRVFGDGTN
MUL_4210|M.ulcerans_Agy99 SHIAPANVYGPRQDPHGEAG-------VVAIFAQALLSGKPTKVFGDGTN
MLBr_00204|M.leprae_Br4923 SHIAPANVYGPRQDPYGEAG-------VVAIFVQALLSDRPTKVFGDGTH
MAB_0503|M.abscessus_ATCC_1997 SHIAPANVYGPRQDPHGEAG-------VVAIFAQALLSGRSTKVFGDGGN
MSMEG_6142|M.smegmatis_MC2_155 SHIAPANVYGPRQDPHGEAG-------VVAIFSEALLAGRTTKIFGDGSD
TH_4464|M.thermoresistible__bu YVLRPCIVAGPRAPALADAMPWNQLPKPVKRITQALPLLRPP--FPDPGT
Mvan_5808|M.vanbaalenii_PYR-1 YVLRPCIVAGPKATALADAMPWNQLPGPVRRLAHALPLLKPP--FPDPGT
Mflv_2455|M.gilvum_PYR-GCK TIIRICSTYGPEGG-------------AAADRLDAILARRPIRLHPDRPN
MAV_0921|M.avium_104 TIIRICSTYGPQGG-------------APADRLEAMLAGKPIRLHPDKPN
MMAR_2896|M.marinum_M TIARLNVPYGNNGG-------------WPFFHMEMMLAGIPIPVPPGGPA
* . . : . .
Mb3658c|M.bovis_AF2122/97 TRDYVFVDDVVDAFVRVSADVGGGL-RFNIGTG------------KETSD
Rv3634c|M.tuberculosis_H37Rv TRDYVFVDDVVDAFVRVSADVGGGL-RFNIGTG------------KETSD
MUL_4210|M.ulcerans_Agy99 TRDYVFVDDVVDAFVKAGSDVGGGQ-RFNIGTG------------VETSD
MLBr_00204|M.leprae_Br4923 TRDYVFVDDVVDAFIKASGDAGGGQ-RFNIGTG------------IETSD
MAB_0503|M.abscessus_ATCC_1997 TRDYVFVDDVVEAFVRASGPDGGGQ-RFNVGTG------------VETSD
MSMEG_6142|M.smegmatis_MC2_155 TRDYVFVDDVVDAFVRAGGPAGGGQ-RFNVGTG------------VETST
TH_4464|M.thermoresistible__bu PLQLVHHDDVAEAIRLAATTTSAPPGAYNIAADGVLSMSQVASALGARPI
Mvan_5808|M.vanbaalenii_PYR-1 PVQLVHHDDVASAIVAAVTTTSAQPGAYNIAGDGVLSMSAVGEALGARPV
Mflv_2455|M.gilvum_PYR-GCK NYNPIYEDDYVALGIRAMQVARTPPQVVNWAGS------------ETVSV
MAV_0921|M.avium_104 NYNPIYEDDYVELGIRAMEVAATPPVVVNWAGS------------ETVSV
MMAR_2896|M.marinum_M RYNPIHEDDIIATIPKLFAAASVPATTVNWAGD------------QIVSL
: :. ** * . . .
Mb3658c|M.bovis_AF2122/97 RQLHSAVAAAVGGPDDPEFHPPRLGDLKRS----CLDIGLAERVLGWRPQ
Rv3634c|M.tuberculosis_H37Rv RQLHSAVAAAVGGPDDPEFHPPRLGDLKRS----CLDIGLAERVLGWRPQ
MUL_4210|M.ulcerans_Agy99 RQLHSAVAAAVGGPDDPEFHPPRLGDLKRS----CLDISRAEEVLGWRPQ
MLBr_00204|M.leprae_Br4923 RQLHTAVSAAVGGPDDPEFHPPRLGDLKRS----CLDIGLATTVLGWSPQ
MAB_0503|M.abscessus_ATCC_1997 RQLHSLVAAAAGAPDDPEFHPPRLGDLRQS----CLDVGLAKRVLGWEPR
MSMEG_6142|M.smegmatis_MC2_155 RELHTAIAGAVGAPDEPEFHPPRLGDLRRS----RLDNTRAREVLGWQPQ
TH_4464|M.thermoresistible__bu RVPRAAMTATSELVARLPFIPSTLEWLHVGRTSVVMDVDKAKRLLGWTPT
Mvan_5808|M.vanbaalenii_PYR-1 RVPHGAATATSEVIARLPFVPSILEWLHAGRTSVVMDTTKARDQLGWRPN
Mflv_2455|M.gilvum_PYR-GCK EEYCAYLGELVGI--EPVFEYTADAHTPLW-----PDVTRMHEVLG-RTK
MAV_0921|M.avium_104 EEYCTFMGQLIGV--EPKFEYTERAHTPLW-----PDVTRMHEVLG-RTK
MMAR_2896|M.marinum_M QDWCGYLGTLIGK--EPVFQESDSALRPNP-----VDVTRMHELIG-NTA
. * . * :* .
Mb3658c|M.bovis_AF2122/97 IELADGVRRTVEYFRHKHTD--------
Rv3634c|M.tuberculosis_H37Rv IELADGVRRTVEYFRHKHTD--------
MUL_4210|M.ulcerans_Agy99 VELADGVRRTVDYFRRTHGS--------
MLBr_00204|M.leprae_Br4923 VQLDDGVRRTVEYFRAAQRS--------
MAB_0503|M.abscessus_ATCC_1997 VPLADGIRRTVDFFRS------------
MSMEG_6142|M.smegmatis_MC2_155 VALAEGIAKTVEFFRNKSQ---------
TH_4464|M.thermoresistible__bu HTAADTLAALAARPT-------------
Mvan_5808|M.vanbaalenii_PYR-1 FSAAETLSALASSIGND-----------
Mflv_2455|M.gilvum_PYR-GCK VPWREGFRRMTAARHPELTLSDTCTTS-
MAV_0921|M.avium_104 VPWREGFRRMIEARHPEITLRQADPATS
MMAR_2896|M.marinum_M VDWHDGMRRLVAKFHPEAPGL-------
: .