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TGIEADYLVVGAGAMGMAFVDTLLAETRDAGTTVVLVDENHQPGGHWNTVYPFVRLHQPSAYYGVNSEPL GDEEAIDRSGFNEGFFELASGHEVCAYYDHVMRNHLLPTGRLTYLPMTRYLGDNRIRTLDGAEQTVTVRR RTVDATYLLTVVQSMRSAPFSVADGVEVVAPNDLPRRAPHHDHYTVVGGGKTGMDCCLWLLRNGVPADAV RWVRPRDSWLLNRAHIQPGEQFAPQLRDAMAARMQAISEAASVEHLFTLLEDAEVLLRLDPSVWPTMYHC AIVSQRELEYLRRIEDVVRLGHIEHAEPDRVRLTGATIPATPSLYVDCTTQGLPRPPSVPVFDGDRITLQ SVRSCQQVFSSAFIAHAETTFSDDDTRNALCVPVVHPDAPIDWLRHMSEDNAASMRWIRDPELMTWLRTA RLNAARDLFPVFPPGKERVRDKAMGALAVALRKTNEELAALMAGAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2222 | - | - | 100% (467) | hypothetical protein Mflv_2222 |
| M. gilvum PYR-GCK | Mflv_4557 | - | 6e-05 | 34.43% (61) | hypothetical protein Mflv_4557 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2023 | - | 1e-147 | 55.27% (465) | hypothetical protein Mb2023 |
| M. tuberculosis H37Rv | Rv2000 | - | 1e-147 | 55.27% (465) | hypothetical protein Rv2000 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2976 | - | 1e-143 | 54.33% (462) | hypothetical protein MMAR_2976 |
| M. avium 104 | MAV_4416 | - | 1e-141 | 54.06% (468) | hypothetical protein MAV_4416 |
| M. smegmatis MC2 155 | MSMEG_2884 | - | 2e-06 | 37.88% (66) | cyclohexanone monooxygenase |
| M. thermoresistible (build 8) | TH_3566 | - | 6e-06 | 40.98% (61) | PUTATIVE cyclohexanone monooxygenase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2883 | - | 1e-05 | 39.39% (66) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2023|M.bovis_AF2122/97 ---------------MRPGFVGLGFGQWPVYVVRWPKLHLTPRQRKRVLH
Rv2000|M.tuberculosis_H37Rv ---------------MRPGFVGLGFGQWPVYVVRWPKLHLTPRQRKRVLH
MMAR_2976|M.marinum_M --------------------------------------------------
MAV_4416|M.avium_104 --------------------------------------------------
Mflv_2222|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2884|M.smegmatis_MC2_155 MTTDATVTADGTRLDADELRRNLRQADAGVLVAVLAQLTGDPAVVDRFAP
Mvan_2883|M.vanbaalenii_PYR-1 MTIGVTVAADEKTVDREELRTNLRRADAGVLVAVLAQLTGDPGVADRYAG
TH_3566|M.thermoresistible__bu MPTDPTVLSAETASHAEELRMYLRHADAGVLVAVLAQLTGDPGVVDRFGP
Mb2023|M.bovis_AF2122/97 RRRLLTDRPISLSQIPIRTGGPMNDPWPRPTQGP----------------
Rv2000|M.tuberculosis_H37Rv RRRLLTDRPISLSQIPIRTGGPMNDPWPRPTQGP----------------
MMAR_2976|M.marinum_M ----------------MREG--------EHVQAP----------------
MAV_4416|M.avium_104 --------------------------------------------------
Mflv_2222|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2884|M.smegmatis_MC2_155 GISHIPDPPEHIGVADDETLDQLVEAVVEAMNSPRPQSALPADDQDLFLR
Mvan_2883|M.vanbaalenii_PYR-1 KISFTPDPPEQVGATDPETHEGLVDDVIAALEGPRPPGALPFDDPGLFAR
TH_3566|M.thermoresistible__bu RIEHVPDPPEHVGVTDAATLDALVEAVVAAMGGDRPDHRLPPDDPQLFVR
Mb2023|M.bovis_AF2122/97 ------AKTIETDYLVIGAGAMGMAFTDTLITESG---------------
Rv2000|M.tuberculosis_H37Rv ------AKTIETDYLVIGAGAMGMAFTDTLITESG---------------
MMAR_2976|M.marinum_M ------AKAIEADYLVVGAGAMGMAFTDTLITESD---------------
MAV_4416|M.avium_104 ------MHTIEADYLVVGAGAMGMAFIDTLVTETAAS-------------
Mflv_2222|M.gilvum_PYR-GCK ------MTGIEADYLVVGAGAMGMAFVDTLLAETRDA-------------
MSMEG_2884|M.smegmatis_MC2_155 IAPLALGTPVGPEYAGLLLEQGGFHPSQPVLPRTAKLPPDFKVVIIGAGI
Mvan_2883|M.vanbaalenii_PYR-1 VAPLALGTAVGDEYVGLLLEQGGFHPSQPVLPRTAKLPQGFKVVIVGAGI
TH_3566|M.thermoresistible__bu IAPLALGTPVDTDYVGLLLEQGGFHPSQPVLPRTARLPADFSVTVIGAGM
: :* : *: :.::..:
Mb2023|M.bovis_AF2122/97 -------------ARVVMIDRACQPGGHWT-TAYPFVRLHQPSAYYGVNS
Rv2000|M.tuberculosis_H37Rv -------------ARVVMIDRACQPGGHWT-TAYPFVRLHQPSAYYGVNS
MMAR_2976|M.marinum_M -------------ARVVIVDRAHAPGGHWT-TAYPFVRLHQPSAYYGVNS
MAV_4416|M.avium_104 ------------QARVVVVDRHHAPGGHWT-IAYPFVRLHQPSAFYGVNS
Mflv_2222|M.gilvum_PYR-GCK ------------GTTVVLVDENHQPGGHWN-TVYPFVRLHQPSAYYGVNS
MSMEG_2884|M.smegmatis_MC2_155 AGMAAALELADAGVDFEIIDRNDEVGGTWYTTTYPGIGVDTPSAYYSLSR
Mvan_2883|M.vanbaalenii_PYR-1 AGMAAALECAAAGIDYEIIDRNDEVGGTWYTAVYPGIGVDTPSAYYSLSR
TH_3566|M.thermoresistible__bu AGMAAALELADAGIDYQIIDRNDDVGGTWCTTVYPGIGVDTPSAYYSLSR
::*. ** * .** : :. ***:*.:.
Mb2023|M.bovis_AF2122/97 RALGNN-TIDLVGWNQGLNELAPVGEICAYFDAVLQQQLLPTGRVDYFPM
Rv2000|M.tuberculosis_H37Rv RALGNN-TIDLVGWNQGLNELAPVGEICAYFDAVLQQQLLPTGRVDYFPM
MMAR_2976|M.marinum_M RPLGNN-TIDAVGWNQGLNELAPVGEICAYFDAVMQQQFLPTGRVEYFPM
MAV_4416|M.avium_104 LRLGGD-SIDQIGWNRGLYELATADEICAYYDRVMRTRLLPTGRVRYFPD
Mflv_2222|M.gilvum_PYR-GCK EPLGDEEAIDRSGFNEGFFELASGHEVCAYYDHVMRNHLLPTGRLTYLPM
MSMEG_2884|M.smegmatis_MC2_155 DVNGDW----TSYYPQGPEYQNYLRAVADKNGLRDRTRFGTEVTALHWDE
Mvan_2883|M.vanbaalenii_PYR-1 DINGDW----TSYYPQGAEYQRYLESVADKNALRDHIRFNTEVEALWWDE
TH_3566|M.thermoresistible__bu DINPDW----SSYYPNGAEYQQYLLSVADKHGLREHIRFGTEVTALRWDD
. : .* :. : :: .
Mb2023|M.bovis_AF2122/97 SEYLGDGRFRTLAGTEYVVTVNRRIVDATYLRAVVPSMRPAPYSVAPGVD
Rv2000|M.tuberculosis_H37Rv SEYLGDGRFRTLAGTEYVVTVNRRIVDATYLRAVVPSMRPAPYSVAPGVD
MMAR_2976|M.marinum_M SEYLGDGRFRTLGGAEHQVTVSRRIVDATYLRAVVPSMRPTPYPVAPGID
MAV_4416|M.avium_104 SEYRGDGRFRTSAGADHTVEVTRRIVDATYMHVSVPAMRPPPYTVGDGVD
Mflv_2222|M.gilvum_PYR-GCK TRYLGDNRIRTLDGAEQTVTVRRRTVDATYLLTVVQSMRSAPFSVADGVE
MSMEG_2884|M.smegmatis_MC2_155 QRAQWQVHTVGPDGRRDVGHANVVIPAAGYLNRPRWPDLEGRETFG-GIS
Mvan_2883|M.vanbaalenii_PYR-1 KRTMWEVRTVAPDGTRDVSYANVVVPAAGYLNRPRWPELAGRETFG-GVS
TH_3566|M.thermoresistible__bu DRDQWQVHTVGPDGTKQVSYANVVIPAAGYLNRPRWPEVEGRHTFT-GVS
. : : * . * *: . .. *:.
Mb2023|M.bovis_AF2122/97 CVAPNELPKLG-TRDRYVVVGAGKTGMDVCLWLLRN----DVCPDKLTWI
Rv2000|M.tuberculosis_H37Rv CVAPNELPKLG-TRDRYVVVGAGKTGMDVCLWLLRN----DVCPDKLTWI
MMAR_2976|M.marinum_M CIAPNDLPKFT-GKDRYVIVGAGKTAMDVCLWLLRN----SVDPGQLSWI
MAV_4416|M.avium_104 CVPPNELPRRP-GYQRYVVVGAGKTGIDTCLWLLGQ----GVEPDRLTWI
Mflv_2222|M.gilvum_PYR-GCK VVAPNDLPRRAPHHDHYTVVGGGKTGMDCCLWLLRN----GVPADAVRWV
MSMEG_2884|M.smegmatis_MC2_155 IHSAEWDPGLDLTGKKVAIIGAGCTAVQIVDACVDRVEHLTVFQRQPHWV
Mvan_2883|M.vanbaalenii_PYR-1 IHSAEWDPALSLRGKKVAIIGAGCTAVQIVDACVDEVEHLTVFQRQPHWV
TH_3566|M.thermoresistible__bu VHSAQWDPELDLTGKRVAVIGAGCTAVQIVDACVDQVAHLTVFQRQPHWV
..: * .: .::*.* *.:: : . * *:
Mb2023|M.bovis_AF2122/97 MPRD----------SWLIDRATLQPGPTFVRQFRESYGATLEAIGAAT--
Rv2000|M.tuberculosis_H37Rv MPRD----------SWLIDRATLQPGPTFVRQFRESYGATLEAIGAAT--
MMAR_2976|M.marinum_M KPRD----------AWLIDRATLQPGPTFIKQFRDSYGITLEAIGRAT--
MAV_4416|M.avium_104 MPRD----------SWLLDRATMQPGALFAEQIKHSFTAQLRAINEAG--
Mflv_2222|M.gilvum_PYR-GCK RPRD----------SWLLNRAHIQPGEQFAPQLRDAMAARMQAISEAA--
MSMEG_2884|M.smegmatis_MC2_155 APRKRLSDDVPEHRRWLNNHVPFHANWVRLKSFWGTADNNHPVILRDPEW
Mvan_2883|M.vanbaalenii_PYR-1 APRKRLTDDVPDHRRWLNAHVPFYANWIRLKSFWGTADNNYPVIVRDPEW
TH_3566|M.thermoresistible__bu APRKRLSDDVPEHRRWLNNHIPFYANWNRLKSFWGTADNNYPVILRDPQW
**. ** : : .. .: : .*
Mb2023|M.bovis_AF2122/97 STDDLFDRLETAGTLLRIDPSVRPSMY--RCATVSHLELEQLRRIRDIVR
Rv2000|M.tuberculosis_H37Rv STDDLFDRLETAGTLLRIDPSVRPSMY--RCATVSHLELEQLRRIRDIVR
MMAR_2976|M.marinum_M SIRDLFDRLEKAGTLLRLDPAVRPTMY--RCATVSQPEFDQLRRIEDVVR
MAV_4416|M.avium_104 SVAELFSRLEAAGLLLRIDPAVRPTMY--RCATVTRLELEQLRRITDVVR
Mflv_2222|M.gilvum_PYR-GCK SVEHLFTLLEDAEVLLRLDPSVWPTMY--HCAIVSQRELEYLRRIEDVVR
MSMEG_2884|M.smegmatis_MC2_155 AAEH-LSISKANDVLLQICLDYIDRTFGAGSELAAKVTPDFAPYGKRIIR
Mvan_2883|M.vanbaalenii_PYR-1 AAEH-LSISPANDVLLQMCLEYIDRVFGAGSELAKKVTPDFAPYGKRIIR
TH_3566|M.thermoresistible__bu AAEHPLSISKANDALLQLCLDYIDRTFGAGSELAAKVTPDFAPYGKRIIR
: . : **:: : . . : : ::*
Mb2023|M.bovis_AF2122/97 MGHVQRIEPTTIVLDGGSVPATPTALYIDCTADGAPQRPAKPVFDA----
Rv2000|M.tuberculosis_H37Rv MGHVQRIEPTTIVLDGGSVPATPTALYIDCTADGAPQRPAKPVFDA----
MMAR_2976|M.marinum_M MGHVQRIDSTEIVLDGGSVPCSASALYVDCTADGAPQRPAKPVFDG----
MAV_4416|M.avium_104 LGHVRSIEPGAMVLDGGAVAVDGRALYLDCTADGAEKRPATPIFTP----
Mflv_2222|M.gilvum_PYR-GCK LGHIEHAEPDRVRLTGATIPATP-SLYVDCTTQGLPRPPSVPVFDG----
MSMEG_2884|M.smegmatis_MC2_155 DPGGYYAALTKPHVDVEAAEPARVNEAGIVTQDGRQIDLDVIIYATGYHL
Mvan_2883|M.vanbaalenii_PYR-1 DPGGYYAALARDHVDVEASEPARVNERGIVTQDGRQIDLDVIIYATGYHL
TH_3566|M.thermoresistible__bu DPGGYYAALTRPHVNLEAAEPARINERGIVTQEGRQIDLDVIIYATGYYL
: : * :* ::
Mb2023|M.bovis_AF2122/97 DHLTLQAVRGCQQVFSAAFIAHVEFAYEDDAVK--NELCTPIPHPDCDLD
Rv2000|M.tuberculosis_H37Rv DHLTLQAVRGCQQVFSAAFIAHVEFAYEDDAVK--NELCTPIPHPDCDLD
MMAR_2976|M.marinum_M DHLTLQAVRGCQQVFSAAFTAHVELAYDGDEVK--NELCTPIPHPDSDLD
MAV_4416|M.avium_104 GRITLQSVRGCQQIFSAALIAHVEAGYGDDARR--NELCVPLPHPDTDVD
Mflv_2222|M.gilvum_PYR-GCK DRITLQSVRSCQQVFSSAFIAHAETTFSDDDTR--NALCVPVVHPDAPID
MSMEG_2884|M.smegmatis_MC2_155 DFLSTVDIRGRNGVRLSEFWGDSPSAYRGGLVPGFPNLFISSAPNYSPGH
Mvan_2883|M.vanbaalenii_PYR-1 DFLSTVDIRGRDGLELREVWGDSPSAYRGGLVPGFPNMFISSAPNYSPGH
TH_3566|M.thermoresistible__bu DFLSTVDIRGRDGVRLAEVWGDSPSAYRGGTVPGFPNMFVSSAPNYSPGH
. :: :*. : : . .. : .. : . .
Mb2023|M.bovis_AF2122/97 WMRLMHSDLGNFQRWLNDPDLTDWLSSARLN----LLADLLPPLS-HKPR
Rv2000|M.tuberculosis_H37Rv WMRLMHSDLGNFQRWLNDPDLTDWLSSARLN----LLADLLPPLS-HKPR
MMAR_2976|M.marinum_M WMRLTHSDLRNFQRWLDDVELTDWLSSARLN----LLADLLPPLS-HKPR
MAV_4416|M.avium_104 WLRLALADYTNQLRWFDDPELMTWLSGARLDLFGHLIGHLLPSAS-AKPR
Mflv_2222|M.gilvum_PYR-GCK WLRHMSEDNAASMRWIRDPELMTWLRTARLN----AARDLFPVFPPGKER
MSMEG_2884|M.smegmatis_MC2_155 GAGHNFGVEVMVHYVMECLQLMAIREATTLEVTEEAFTDYVRQIDEAMQN
Mvan_2883|M.vanbaalenii_PYR-1 GAGHNFGVEVMVHYVMECLQLMALRGAATLEVKPEAFDEYVRQIDDVMAQ
TH_3566|M.thermoresistible__bu GAGHNFGVEIMVHYVMECLQLMALRGARTIEVKPEAFTDYVRRVDEAMAD
: :* :: . .
Mb2023|M.bovis_AF2122/97 VRERVVSMFQKRLGTAGDQLAKLLDAA--TATTEQR----------
Rv2000|M.tuberculosis_H37Rv VRERVVSMFQKRLGTAGDQLAKLLDAA--TATTEQR----------
MMAR_2976|M.marinum_M VRDRVVSMFRSKLNIASEQLEKLLSDHGHDGASQQQ----------
MAV_4416|M.avium_104 VRARILGIAKSVFAATAARLGELLAAEAALAAS-------------
Mflv_2222|M.gilvum_PYR-GCK VRDKAMGALAVALRKTNEELAALMAGAS------------------
MSMEG_2884|M.smegmatis_MC2_155 TVWCHTPTAHTYYRSGGGRIVTAFPFRLIDVWQSHRAPIEEDLTLS
Mvan_2883|M.vanbaalenii_PYR-1 TVWCHTPTAHTYYRSGGGRIVTAFPFRLIEVWQSHRAPVEGDLELR
TH_3566|M.thermoresistible__bu TVWCHTPTAHTYYRSGSGRIVTAFPFRLIDMWQSHRAPIEDDFILR
. .: :