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AARRRAGQFVRNPAVGVAAVLTPLVLAGAVGASAPTHTPTRDAAVLPLAAVAPSADERAGISVVAVAKAP APLRTVAGTAASGPTPPTILNAPGTLRIPSVNLAAYRNAETMMAAAYPGCGVSWNLLAGIGRIESMHSYG GATDSRGTAVRPIYGPTLDGTLPGNEVIVESRSADRVVYARAMGPMQFLPGTWSRYAADGDGDGKADVQN IYDAALGAARYLCSGGLNLRNQADVMAAILRYNNSMSYAQNVLSWAAAYATGVVPLELPPITGSVPELEA ATTATLTAHLDRRAGLGPGLPLNATGLPANDPLALIPLMERTDVASQINTGLPGFGAGQTLGPLPGPMPA AAPQPVAPPPTWVPPWVQQPAPQKPAQCAVFCIQDLPAAPAPAPGPVPAGPLGLQPAAPLPVAPPATPGP QPGPAPGPAPGPAPGPVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2206 | - | - | 100% (439) | lytic transglycosylase, catalytic |
| M. gilvum PYR-GCK | Mflv_1953 | - | 8e-31 | 45.20% (177) | putative lipoprotein LpqU |
| M. gilvum PYR-GCK | Mflv_2804 | - | 1e-28 | 34.78% (253) | putative lipoprotein LpqU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1262c | - | 1e-116 | 53.32% (437) | hypothetical protein Mb1262c |
| M. tuberculosis H37Rv | Rv1230c | - | 1e-117 | 53.55% (437) | hypothetical protein Rv1230c |
| M. leprae Br4923 | MLBr_00048 | - | 3e-07 | 28.29% (152) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_1367c | - | 1e-98 | 48.87% (442) | hypothetical protein MAB_1367c |
| M. marinum M | MMAR_4211 | - | 1e-122 | 54.75% (453) | membrane protein |
| M. avium 104 | MAV_1369 | - | 1e-120 | 55.42% (424) | hypothetical protein MAV_1369 |
| M. smegmatis MC2 155 | MSMEG_5067 | - | 1e-157 | 63.55% (439) | secreted protein |
| M. thermoresistible (build 8) | TH_4644 | - | 1e-111 | 63.46% (312) | PUTATIVE secreted protein |
| M. ulcerans Agy99 | MUL_4514 | - | 1e-123 | 54.35% (460) | membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4490 | - | 0.0 | 78.48% (446) | lytic transglycosylase, catalytic |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2206|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4490|M.vanbaalenii_PYR-1 -------------------------------------MHIRG----GAAL
MSMEG_5067|M.smegmatis_MC2_155 -------------------------------------MRIGG----GAAI
Mb1262c|M.bovis_AF2122/97 -------------------------------------MHIGGRWGARPAV
Rv1230c|M.tuberculosis_H37Rv -------------------------------------MHIGGRWGARPAV
MMAR_4211|M.marinum_M -------------------------------------MRIGGRWVAHPAV
MUL_4514|M.ulcerans_Agy99 -------------------------------------MRIGGRWVAHPAV
MAV_1369|M.avium_104 --------------------------------------------------
TH_4644|M.thermoresistible__bu --------------------------------------------------
MAB_1367c|M.abscessus_ATCC_199 -----------------------------------MELPHWVATSVNHAR
MLBr_00048|M.leprae_Br4923 MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVA
Mflv_2206|M.gilvum_PYR-GCK MAARRRAGQFVRNPAVGVAAVLTPLVLAGAVGASAP---THTPTRDAAVL
Mvan_4490|M.vanbaalenii_PYR-1 VTARQRTGHFIRMPAFGVAAVLTPLVLAGAVGAAAPS--TTTPTRDSAVM
MSMEG_5067|M.smegmatis_MC2_155 QAARHRAGRFMRTPMVG-AAALAPLILAGAVGASAP---PHHGSSDAAVT
Mb1262c|M.bovis_AF2122/97 AAVRRGACRLTRAPAFG-VAAIAPLVFASAVGGAAPVFPGRTAPVHAVIT
Rv1230c|M.tuberculosis_H37Rv AAVRRGACRLTRAPAFG-VAAIAPLVFASAVGSAAPVFPGRTAPVHAVIT
MMAR_4211|M.marinum_M ASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATAPASYGKTPAVRAAIT
MUL_4514|M.ulcerans_Agy99 ASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATAPASYGKTPAVRAAIT
MAV_1369|M.avium_104 --------------------MITPLVFAGAVSATGPSLPVRTPPVHAAVT
TH_4644|M.thermoresistible__bu ----------LNRPAFG-LAVITPLVFAGAVGGSGPLQFPHES--DTAVT
MAB_1367c|M.abscessus_ATCC_199 GAASRIRGNSASVPWLR-VGGLSALTVVGFAVAASSAQVSGQAVVPVPVP
MLBr_00048|M.leprae_Br4923 SPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAP
:..: . . . . .
Mflv_2206|M.gilvum_PYR-GCK PLAAVAPS----------ADERAGISVVAVAKAPAPLRTVAGTAASGPTP
Mvan_4490|M.vanbaalenii_PYR-1 PLAAVAPS----------ADDRSGPSVVAVAKAPAPLRTVASTATA-PPP
MSMEG_5067|M.smegmatis_MC2_155 PLAAVQPQ----------ID-HDGPAVVAAAKAPTKFHIATTTAVSAPPP
Mb1262c|M.bovis_AF2122/97 PVAAVAAS----------GIDLSGPVVIAMKRPPTSFRVAVA-TIPAPPP
Rv1230c|M.tuberculosis_H37Rv PVAAVAAS----------GIDLSGPVVIAMKRPPTSFRVAVA-TISAPPP
MMAR_4211|M.marinum_M PVAAVAPSP---------AIDLSGPSIVAVERPPTNFHIAAG-TTAAPPP
MUL_4514|M.ulcerans_Agy99 PVAAVAPSP---------AIDLSGPSIVAVERPPTNFHIAAG-TTAAPPP
MAV_1369|M.avium_104 PVAAVSPT----------FPDLTGPAVVAIDRGPTAFHVAEP-ALSAPPP
TH_4644|M.thermoresistible__bu PLAAVSPE----------PVDRSGPTVVALQKKPAPFHFVES-TVAAPPP
MAB_1367c|M.abscessus_ATCC_199 MVSAATPQ-----------AEVGELNLVTVVRPPTQYRIAPS-AAIAPPP
MLBr_00048|M.leprae_Br4923 PRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATP
:.. . . .. . ..*
Mflv_2206|M.gilvum_PYR-GCK PTILNAPGTLRIPSVNLAAYRNAETMMAAAYP--------------GCGV
Mvan_4490|M.vanbaalenii_PYR-1 PMILNSPGTLRIPSMALAAYRNAETTMAAAQP--------------GCGL
MSMEG_5067|M.smegmatis_MC2_155 AVVVNSPGALGIPGMALNAYRNAERMMAAAYP--------------GCGV
Mb1262c|M.bovis_AF2122/97 PMIVNSPGALGIPAMALSAYRNAELKMAAAAP--------------GCGV
Rv1230c|M.tuberculosis_H37Rv PMIVNSPGALGIPAMALSAYRNAELKMAAAAP--------------GCGV
MMAR_4211|M.marinum_M ARVVNAPGALGIPIMALTAYRNAEQKMATAAP--------------ACGI
MUL_4514|M.ulcerans_Agy99 ARVVNAPGALGIPIMALTAYRNAEQKMATAAP--------------ACGI
MAV_1369|M.avium_104 AAIVNAPGALGIPSIALAAYRNAEQKMAVAAP--------------GCGV
TH_4644|M.thermoresistible__bu AAVVNTPGTLGIPAMALRAYRNAERMMAHAQP--------------ECGV
MAB_1367c|M.abscessus_ATCC_199 PGIVMAPGGLGIPKIALEAYQNAEKMMAKAAP--------------GCGV
MLBr_00048|M.leprae_Br4923 MPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRP
: * * . . * *
Mflv_2206|M.gilvum_PYR-GCK SWNLLAGIGRIESMHSYGGATDSRGTAVRPIYGPTLDGTLPGNEVIVE--
Mvan_4490|M.vanbaalenii_PYR-1 SWNLLAGIGRIESMHAYGGATDSRGTAVRPIYGPALDGTLPGNEVIVQ--
MSMEG_5067|M.smegmatis_MC2_155 SWNLLAGIGRIESMHANGGQTDARGTAVRPIYGPALDGTLPGNEIIVQ--
Mb1262c|M.bovis_AF2122/97 SWNLLAGIGRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ--
Rv1230c|M.tuberculosis_H37Rv SWNLLAGIGRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ--
MMAR_4211|M.marinum_M SWNLLAGIGRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ--
MUL_4514|M.ulcerans_Agy99 SWNLLAGIGRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ--
MAV_1369|M.avium_104 SWNLLAGIGRIESGHAGGGAVDARGTAITPIYGPSLDGTLPGNEVIIQ--
TH_4644|M.thermoresistible__bu SWNLLAGIGRIESMHAYGGATDANGTAIRPILGPLLDGSLPGNEIIVQ--
MAB_1367c|M.abscessus_ATCC_199 SWNLLAGIGRIESGHANNGATDVKGRVVRPIYGPSLDGTLPGNEVIVDHE
MLBr_00048|M.leprae_Br4923 SANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAE
* * : .* * . . *: .* : :
Mflv_2206|M.gilvum_PYR-GCK -SRSADRVVYARAMGPMQFLPGTWSRYAA---DGDGDGKADVQNIYDAAL
Mvan_4490|M.vanbaalenii_PYR-1 -SRAADRVVYARAMGPMQFLPGTWSRYAS---DGDGDGKADVQNLFDATL
MSMEG_5067|M.smegmatis_MC2_155 -SAQAGRVTYARAMGPMQFLPGTWARYAS---DGDGDGKADVQNLFDASL
Mb1262c|M.bovis_AF2122/97 -SSVGNRVTYARAMGPMQFLPGTWARYAT---DGDDDGVADPQNLFDSTL
Rv1230c|M.tuberculosis_H37Rv -SSVGNRVTYARAMGPMQFLPGTWARYAT---DGDDDGVADPQNLFDSTL
MMAR_4211|M.marinum_M -SKVGNRVTYARAMGPMQFLPGTWARYAS---DGDSDGVPDPQNIFDSTL
MUL_4514|M.ulcerans_Agy99 -SKVGNRVTYARAMGPMQFLPGTWARYAS---DGDSDGVPDPQNIFDSTL
MAV_1369|M.avium_104 -SAAGNRVTYARAMGPMQFLPGTWARYAS---DGKGDGVADPQNLFDSTL
TH_4644|M.thermoresistible__bu -SRTADRVTYARALGPMQFLPGTWARFAS---DGDGDGKADVQNLFDSTL
MAB_1367c|M.abscessus_ATCC_199 QSRTQGAQVYVRAMGPMQFLPSTWNHYAS---DGDGDGKADPQNVFDASL
MLBr_00048|M.leprae_Br4923 PAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRG
: :. * .: * * . * . .::
Mflv_2206|M.gilvum_PYR-GCK GAARYLCSGGLNLRNQAD-----VMAAILRYNNSMSYAQNVLSWAAAYAT
Mvan_4490|M.vanbaalenii_PYR-1 AAARYLCSGGMNLRNQPD-----VIAAILRYNNSMAYTQNVLSWAAAYAT
MSMEG_5067|M.smegmatis_MC2_155 AAARYLCSGGLNLRDQSQ-----VMTAILRYNNSIAYARNVLGWAAAYAT
Mb1262c|M.bovis_AF2122/97 AAARYLCSGGLNLRDPAQ-----VMAALLRYNNSMPYAQNVLGWAAGYAT
Rv1230c|M.tuberculosis_H37Rv AAARYLCSGGLNLRDPAQ-----VMAALLRYNNSMPYAQNVLGWAAGYAT
MMAR_4211|M.marinum_M AAARYLCSGGLNLRDPGQ-----VMAAILRYNNSMPYAQNVLGWAAAYAT
MUL_4514|M.ulcerans_Agy99 AAARYLCSGGLNLRDPGQ-----VMAAILRYNNSMPYAQNVLGWAAAYAT
MAV_1369|M.avium_104 AAARYLCSGGLNLRDQSQ-----VLTAILRYNNSMPYAQNVLGWAAAYAT
TH_4644|M.thermoresistible__bu AAARYLCSGGMNLRDPSH-----VMQALLRYNNSVAYAHNVMGWAAAYAT
MAB_1367c|M.abscessus_ATCC_199 AAARYLCSGGLNLRDRSQ-----TMSAILRYNNSVAYAQNVLAWAAGYAT
MLBr_00048|M.leprae_Br4923 WRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAGK
:** . : : :* .* .::. .. ..
Mflv_2206|M.gilvum_PYR-GCK GVVPLELPPITGSVPELEAATTATLTAHLDRRA--GLGPGLPLNATGLPA
Mvan_4490|M.vanbaalenii_PYR-1 GVVPVDLPPITGEVPALGTIG----DSHLDRPE--GIGPGLPLNATGLPA
MSMEG_5067|M.smegmatis_MC2_155 GVVPVDLPPITGEIPALG-------DSHLERKE--GLGPGLPVNALGLPP
Mb1262c|M.bovis_AF2122/97 GVFPVDLPPITGPPPPLG-------DAHLENPE--GLGPGLPINVNGLTA
Rv1230c|M.tuberculosis_H37Rv GVFPVDLPPITGPPPPLG-------DAHLENPE--GLGPGLPINVNGLTA
MMAR_4211|M.marinum_M GVLPVDLPPITGPPPPIG-------DAHLEHPE--GLGPNLPLNANGLGP
MUL_4514|M.ulcerans_Agy99 GVLPVDLPPITGPPPPIG-------DAHLEHPE--GLGPNLPLNANGLEP
MAV_1369|M.avium_104 GVVPVDLPPMTGPPPPLG-------DAHLEHPE--GLGPNLPMNINGLPL
TH_4644|M.thermoresistible__bu GVHPVDLPPLTGPVPSLN--------SHVSGYD--GLGPGSPLNAMGLSP
MAB_1367c|M.abscessus_ATCC_199 GVLPLNLPPLTAADVAPER------KAHLGGGESRGLGPGSVTDVAGLSP
MLBr_00048|M.leprae_Br4923 TTVTVTLGSMFARVRNDRILVVDADTSCGNLAD--RAGRFSEANIADLLA
. .: * .: . : * : .*
Mflv_2206|M.gilvum_PYR-GCK NDPLALIPLMERT-----------------DVASQINTGLPGFGAGQTLG
Mvan_4490|M.vanbaalenii_PYR-1 NDPLSLIPLMTRT-----------------DVASQINTNLPGFVPGQTLG
MSMEG_5067|M.smegmatis_MC2_155 DDPLALIPVLDSN-----------------VTATRVPAANLGFAPNQVLG
Mb1262c|M.bovis_AF2122/97 DGPMAHLPLIDLTP---------------RQAALNPPPMFPWMAPDPS--
Rv1230c|M.tuberculosis_H37Rv DGPMAHLPLIDLTP---------------RQAALNPPPMFPWMAPDPS--
MMAR_4211|M.marinum_M ADPLSHMPLIDFAP---------------PQMPAPPPPMFPWMQPTPQPL
MUL_4514|M.ulcerans_Agy99 ADPLSHMPLIDFAP---------------PQMPAPPPPMFPWMQPTPQPL
MAV_1369|M.avium_104 DDPLARVPLIDLSS---------------PALGS-PQPMFPWMTPTPQQA
TH_4644|M.thermoresistible__bu GDPLAVLPLIDGXXXLDLLDRSALHDLRLDIDILVNNAGVQHVDPVTEFP
MAB_1367c|M.abscessus_ATCC_199 NDPLAQLPIVNPLT----------------PDRAVIAALPGAVPPAPEAP
MLBr_00048|M.leprae_Br4923 DKDVKSYNDIRTHTSVN-----------AVNLEVLPAAEYSTAQHALSGE
: : .
Mflv_2206|M.gilvum_PYR-GCK --PLPGPMPA--AAPQPVAPPP-TWVPP------------WVQQP-APQK
Mvan_4490|M.vanbaalenii_PYR-1 --PLPGPAPAPLAVPEPVAPPPPAWVPP------------WMQQ---PQQ
MSMEG_5067|M.smegmatis_MC2_155 --PLPGPAEAVPTAPAAPPEPP-RWIPP------------WEQP----PR
Mb1262c|M.bovis_AF2122/97 -APMPGCTLICIGSHGPPVGAP-PFPPT------------APPPPFLPAA
Rv1230c|M.tuberculosis_H37Rv -APMPGCTLICIGSHGPPVGAP-PFPPT------------APPPPFLPAA
MMAR_4211|M.marinum_M -APQPGCTLICVTNPPEAVPPPAPMPFG------------LMPPPPAPAA
MUL_4514|M.ulcerans_Agy99 -APQPGCTLICVTNPPEAVPPPAPMPFG------------LMPPPPAPAA
MAV_1369|M.avium_104 PTQVPGCTVICISSQGSPPAGP-PPPFG------------APPPFAPPPS
TH_4644|M.thermoresistible__bu PDQFRDMLTLMVEAPFLLIRAALPYMFERGFGRIVNISSVHGLRASEYKA
MAB_1367c|M.abscessus_ATCC_199 ----QAPCMLFCAPPPPPAEPFNPFAPQ--------------------PP
MLBr_00048|M.leprae_Br4923 DWNFAAATVSKYYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAA
Mflv_2206|M.gilvum_PYR-GCK PAQCAVFCIQDLPAAPAPAPGPVPAGPL---------GLQPAAPLPVAPP
Mvan_4490|M.vanbaalenii_PYR-1 QPECAVFCIKDLPPA-APAPAPAPAGPL---------GLTPAPGPAPLLP
MSMEG_5067|M.smegmatis_MC2_155 QPECVVFCLGEQAPP-APAPGPPPAAP------------TPGPAPGPAPG
Mb1262c|M.bovis_AF2122/97 PPPPDPLA--------GPPGD-----------------------AGLAPP
Rv1230c|M.tuberculosis_H37Rv PPPPDPLA--------GPPGD-----------------------AGLAPP
MMAR_4211|M.marinum_M PPPPDPLAPLGAPPVGGPPAAPAPAPAG-----------PAPAPAGPAPA
MUL_4514|M.ulcerans_Agy99 PPPPDPLAPLGVPPVGGPPAAPAPAPAGPPVPGGPAPAGPAPAPAGPAPA
MAV_1369|M.avium_104 GPPPFAPPPPDAGPVPAPPAGPAPQAAP-------------APPAGAAPQ
TH_4644|M.thermoresistible__bu AYVTAKHALEGLSKVTALEGGPHGVTSNCVNPGYVRTPLVTRQIADQARA
MAB_1367c|M.abscessus_ATCC_199 AEPFNPFAPNQAPQPFNPFAPPPP-----------------PVELGPAPG
MLBr_00048|M.leprae_Br4923 RQAAIALDWLRHNGYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQ
Mflv_2206|M.gilvum_PYR-GCK A----------------------TPGPQPGPAPG---PAPGPAPGPVA--
Mvan_4490|M.vanbaalenii_PYR-1 A----------------------GPPPPPAPALPGMPPAPGPAPGPVG--
MSMEG_5067|M.smegmatis_MC2_155 P----------------------APAPAPAPVLG---PAPGPAPESP---
Mb1262c|M.bovis_AF2122/97 ------------------------APAPAG--------------------
Rv1230c|M.tuberculosis_H37Rv ------------------------APAPAG--------------------
MMAR_4211|M.marinum_M P----------------------GAPVPAGPAPTPTPSGPAPGEPVLTPV
MUL_4514|M.ulcerans_Agy99 P----------------------GAPAPAGPAPTPTPSGPAPGEPVLTPV
MAV_1369|M.avium_104 A----------------------PSPKSAGPTPN-APKKPGPA-------
TH_4644|M.thermoresistible__bu HGISEGEVLEQILLKESAIKRLIEPDEVASLVGWLASPDAGMVTGASYTM
MAB_1367c|M.abscessus_ATCC_199 P-----------------------APAPAAPRP-----------------
MLBr_00048|M.leprae_Br4923 PG--------------RVVVLPWDKHIAAGTEIRLDRLDPLYRRRILELA
..
Mflv_2206|M.gilvum_PYR-GCK -------------
Mvan_4490|M.vanbaalenii_PYR-1 -------------
MSMEG_5067|M.smegmatis_MC2_155 -------------
Mb1262c|M.bovis_AF2122/97 -------------
Rv1230c|M.tuberculosis_H37Rv -------------
MMAR_4211|M.marinum_M H------------
MUL_4514|M.ulcerans_Agy99 H------------
MAV_1369|M.avium_104 -------------
TH_4644|M.thermoresistible__bu DGGWSAR------
MAB_1367c|M.abscessus_ATCC_199 -------------
MLBr_00048|M.leprae_Br4923 AALSDDFERAGRH