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VRIGGGAAIQAARHRAGRFMRTPMVGAAALAPLILAGAVGASAPPHHGSSDAAVTPLAAVQPQIDHDGPA VVAAAKAPTKFHIATTTAVSAPPPAVVVNSPGALGIPGMALNAYRNAERMMAAAYPGCGVSWNLLAGIGR IESMHANGGQTDARGTAVRPIYGPALDGTLPGNEIIVQSAQAGRVTYARAMGPMQFLPGTWARYASDGDG DGKADVQNLFDASLAAARYLCSGGLNLRDQSQVMTAILRYNNSIAYARNVLGWAAAYATGVVPVDLPPIT GEIPALGDSHLERKEGLGPGLPVNALGLPPDDPLALIPVLDSNVTATRVPAANLGFAPNQVLGPLPGPAE AVPTAPAAPPEPPRWIPPWEQPPRQPECVVFCLGEQAPPAPAPGPPPAAPTPGPAPGPAPGPAPAPAPAP VLGPAPGPAPESP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5067 | - | - | 100% (433) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_5416 | - | 4e-29 | 39.19% (222) | LpqU protein |
| M. smegmatis MC2 155 | MSMEG_5700 | - | 3e-13 | 27.42% (310) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1262c | - | 1e-135 | 58.62% (435) | hypothetical protein Mb1262c |
| M. gilvum PYR-GCK | Mflv_2206 | - | 1e-157 | 63.55% (439) | lytic transglycosylase, catalytic |
| M. tuberculosis H37Rv | Rv1230c | - | 1e-136 | 58.85% (435) | hypothetical protein Rv1230c |
| M. leprae Br4923 | MLBr_00568 | - | 4e-07 | 40.45% (89) | hypothetical protein MLBr_00568 |
| M. abscessus ATCC 19977 | MAB_1367c | - | 1e-107 | 51.71% (439) | hypothetical protein MAB_1367c |
| M. marinum M | MMAR_4211 | - | 1e-139 | 60.99% (464) | membrane protein |
| M. avium 104 | MAV_1369 | - | 1e-135 | 60.89% (427) | hypothetical protein MAV_1369 |
| M. thermoresistible (build 8) | TH_4644 | - | 1e-123 | 70.92% (306) | PUTATIVE secreted protein |
| M. ulcerans Agy99 | MUL_4514 | - | 1e-142 | 59.70% (474) | membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4490 | - | 1e-165 | 67.71% (446) | lytic transglycosylase, catalytic |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2206|M.gilvum_PYR-GCK ---------------MAARRRAGQFVRNPAVGVAAVLTPLVLAGAVGASA
Mvan_4490|M.vanbaalenii_PYR-1 --MHIRG----GAALVTARQRTGHFIRMPAFGVAAVLTPLVLAGAVGAAA
MSMEG_5067|M.smegmatis_MC2_155 --MRIGG----GAAIQAARHRAGRFMRTPMVG-AAALAPLILAGAVGASA
Mb1262c|M.bovis_AF2122/97 --MHIGGRWGARPAVAAVRRGACRLTRAPAFG-VAAIAPLVFASAVGGAA
Rv1230c|M.tuberculosis_H37Rv --MHIGGRWGARPAVAAVRRGACRLTRAPAFG-VAAIAPLVFASAVGSAA
MMAR_4211|M.marinum_M --MRIGGRWVAHPAVASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATA
MUL_4514|M.ulcerans_Agy99 --MRIGGRWVAHPAVASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATA
MAV_1369|M.avium_104 -----------------------------------MITPLVFAGAVSATG
MAB_1367c|M.abscessus_ATCC_199 MELPHWVATSVNHARGAASRIRGNSASVPWLR-VGGLSALTVVGFAVAAS
TH_4644|M.thermoresistible__bu -------------------------LNRPAFG-LAVITPLVFAGAVGGSG
MLBr_00568|M.leprae_Br4923 --------------------------------------------------
Mflv_2206|M.gilvum_PYR-GCK P---THTPTRDAAVLPLAAVAPS-ADERAGISVVAVAKAPAPLRTVAGTA
Mvan_4490|M.vanbaalenii_PYR-1 PS--TTTPTRDSAVMPLAAVAPS-ADDRSGPSVVAVAKAPAPLRTVASTA
MSMEG_5067|M.smegmatis_MC2_155 P---PHHGSSDAAVTPLAAVQPQ-ID-HDGPAVVAAAKAPTKFHIATTTA
Mb1262c|M.bovis_AF2122/97 PVFPGRTAPVHAVITPVAAVAAS-GIDLSGPVVIAMKRPPTSFRVAVA-T
Rv1230c|M.tuberculosis_H37Rv PVFPGRTAPVHAVITPVAAVAAS-GIDLSGPVVIAMKRPPTSFRVAVA-T
MMAR_4211|M.marinum_M PASYGKTPAVRAAITPVAAVAPSPAIDLSGPSIVAVERPPTNFHIAAG-T
MUL_4514|M.ulcerans_Agy99 PASYGKTPAVRAAITPVAAVAPSPAIDLSGPSIVAVERPPTNFHIAAG-T
MAV_1369|M.avium_104 PSLPVRTPPVHAAVTPVAAVSPT-FPDLTGPAVVAIDRGPTAFHVAEP-A
MAB_1367c|M.abscessus_ATCC_199 SAQVSGQAVVPVPVPMVSAATPQ--AEVGELNLVTVVRPPTQYRIAPS-A
TH_4644|M.thermoresistible__bu PLQFPHES--DTAVTPLAAVSPE-PVDRSGPTVVALQKKPAPFHFVES-T
MLBr_00568|M.leprae_Br4923 -----------------MKVFDR---------------------------
.
Mflv_2206|M.gilvum_PYR-GCK ASGPTPPTILNAPGTLRIPSVNLAAYRNAETMMAAAYPGCGVSWNLLAGI
Mvan_4490|M.vanbaalenii_PYR-1 TA-PPPPMILNSPGTLRIPSMALAAYRNAETTMAAAQPGCGLSWNLLAGI
MSMEG_5067|M.smegmatis_MC2_155 VSAPPPAVVVNSPGALGIPGMALNAYRNAERMMAAAYPGCGVSWNLLAGI
Mb1262c|M.bovis_AF2122/97 IPAPPPPMIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGI
Rv1230c|M.tuberculosis_H37Rv ISAPPPPMIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGI
MMAR_4211|M.marinum_M TAAPPPARVVNAPGALGIPIMALTAYRNAEQKMATAAPACGISWNLLAGI
MUL_4514|M.ulcerans_Agy99 TAAPPPARVVNAPGALGIPIMALTAYRNAEQKMATAAPACGISWNLLAGI
MAV_1369|M.avium_104 LSAPPPAAIVNAPGALGIPSIALAAYRNAEQKMAVAAPGCGVSWNLLAGI
MAB_1367c|M.abscessus_ATCC_199 AIAPPPPGIVMAPGGLGIPKIALEAYQNAEKMMAKAAPGCGVSWNLLAGI
TH_4644|M.thermoresistible__bu VAAPPPAAVVNTPGTLGIPAMALRAYRNAERMMAHAQPECGVSWNLLAGI
MLBr_00568|M.leprae_Br4923 ----FNTAILVSAGLCGAALAFSPSAAAAPLSMPTGGPTC---IEQMAGL
. :: :.* . : * *. . * * : :**:
Mflv_2206|M.gilvum_PYR-GCK GRIESMHSYGGATDSRGTAVRPIYGPTLDGTLPGNEVIVE---SRSADRV
Mvan_4490|M.vanbaalenii_PYR-1 GRIESMHAYGGATDSRGTAVRPIYGPALDGTLPGNEVIVQ---SRAADRV
MSMEG_5067|M.smegmatis_MC2_155 GRIESMHANGGQTDARGTAVRPIYGPALDGTLPGNEIIVQ---SAQAGRV
Mb1262c|M.bovis_AF2122/97 GRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ---SSVGNRV
Rv1230c|M.tuberculosis_H37Rv GRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ---SSVGNRV
MMAR_4211|M.marinum_M GRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ---SKVGNRV
MUL_4514|M.ulcerans_Agy99 GRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ---SKVGNRV
MAV_1369|M.avium_104 GRIESGHAGGGAVDARGTAITPIYGPSLDGTLPGNEVIIQ---SAAGNRV
MAB_1367c|M.abscessus_ATCC_199 GRIESGHANNGATDVKGRVVRPIYGPSLDGTLPGNEVIVDHEQSRTQGAQ
TH_4644|M.thermoresistible__bu GRIESMHAYGGATDANGTAIRPILGPLLDGSLPGNEIIVQ---SRTADRV
MLBr_00568|M.leprae_Br4923 GAVP-------------AAVPAVLPGPVAGAVPSVPVVPS---------G
* : .: .: : *::*. :: .
Mflv_2206|M.gilvum_PYR-GCK VYARAMGPMQFLPGTWSRYAADGDGDGKADVQNIYDAALGAARYLCSGGL
Mvan_4490|M.vanbaalenii_PYR-1 VYARAMGPMQFLPGTWSRYASDGDGDGKADVQNLFDATLAAARYLCSGGM
MSMEG_5067|M.smegmatis_MC2_155 TYARAMGPMQFLPGTWARYASDGDGDGKADVQNLFDASLAAARYLCSGGL
Mb1262c|M.bovis_AF2122/97 TYARAMGPMQFLPGTWARYATDGDDDGVADPQNLFDSTLAAARYLCSGGL
Rv1230c|M.tuberculosis_H37Rv TYARAMGPMQFLPGTWARYATDGDDDGVADPQNLFDSTLAAARYLCSGGL
MMAR_4211|M.marinum_M TYARAMGPMQFLPGTWARYASDGDSDGVPDPQNIFDSTLAAARYLCSGGL
MUL_4514|M.ulcerans_Agy99 TYARAMGPMQFLPGTWARYASDGDSDGVPDPQNIFDSTLAAARYLCSGGL
MAV_1369|M.avium_104 TYARAMGPMQFLPGTWARYASDGKGDGVADPQNLFDSTLAAARYLCSGGL
MAB_1367c|M.abscessus_ATCC_199 VYVRAMGPMQFLPSTWNHYASDGDGDGKADPQNVFDASLAAARYLCSGGL
TH_4644|M.thermoresistible__bu TYARALGPMQFLPGTWARFASDGDGDGKADVQNLFDSTLAAARYLCSGGM
MLBr_00568|M.leprae_Br4923 GFPPVVPPGGFPP------------------------------VVPPGGF
: .: * * * : .**:
Mflv_2206|M.gilvum_PYR-GCK NLRNQADVMAAILRYNNSMSYAQNVLSWAAAYATGVVPLELPPITGSVPE
Mvan_4490|M.vanbaalenii_PYR-1 NLRNQPDVIAAILRYNNSMAYTQNVLSWAAAYATGVVPVDLPPITGEVPA
MSMEG_5067|M.smegmatis_MC2_155 NLRDQSQVMTAILRYNNSIAYARNVLGWAAAYATGVVPVDLPPITGEIPA
Mb1262c|M.bovis_AF2122/97 NLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPVDLPPITGPPPP
Rv1230c|M.tuberculosis_H37Rv NLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPVDLPPITGPPPP
MMAR_4211|M.marinum_M NLRDPGQVMAAILRYNNSMPYAQNVLGWAAAYATGVLPVDLPPITGPPPP
MUL_4514|M.ulcerans_Agy99 NLRDPGQVMAAILRYNNSMPYAQNVLGWAAAYATGVLPVDLPPITGPPPP
MAV_1369|M.avium_104 NLRDQSQVLTAILRYNNSMPYAQNVLGWAAAYATGVVPVDLPPMTGPPPP
MAB_1367c|M.abscessus_ATCC_199 NLRDRSQTMSAILRYNNSVAYAQNVLAWAAGYATGVLPLNLPPLTAADVA
TH_4644|M.thermoresistible__bu NLRDPSHVMQALLRYNNSVAYAHNVMGWAAAYATGVHPVDLPPLTGPVPS
MLBr_00568|M.leprae_Br4923 LPVVPPGGFPPVVPPG----------GFPPVVPPGVAPAVGPLLAEDSAA
: .:: . .:.. ..** * * ::
Mflv_2206|M.gilvum_PYR-GCK LEAATTATLTAHLDRRA--GLGPGLPLNATGLPANDPLALIPLMERT---
Mvan_4490|M.vanbaalenii_PYR-1 LGTIG----DSHLDRPE--GIGPGLPLNATGLPANDPLSLIPLMTRT---
MSMEG_5067|M.smegmatis_MC2_155 LG-------DSHLERKE--GLGPGLPVNALGLPPDDPLALIPVLDSN---
Mb1262c|M.bovis_AF2122/97 LG-------DAHLENPE--GLGPGLPINVNGLTADGPMAHLPLIDLTP--
Rv1230c|M.tuberculosis_H37Rv LG-------DAHLENPE--GLGPGLPINVNGLTADGPMAHLPLIDLTP--
MMAR_4211|M.marinum_M IG-------DAHLEHPE--GLGPNLPLNANGLGPADPLSHMPLIDFAP--
MUL_4514|M.ulcerans_Agy99 IG-------DAHLEHPE--GLGPNLPLNANGLEPADPLSHMPLIDFAP--
MAV_1369|M.avium_104 LG-------DAHLEHPE--GLGPNLPMNINGLPLDDPLARVPLIDLSS--
MAB_1367c|M.abscessus_ATCC_199 PER------KAHLGGGESRGLGPGSVTDVAGLSPNDPLAQLPIVNPL---
TH_4644|M.thermoresistible__bu LN--------SHVSGYD--GLGPGSPLNAMGLSPGDPLAVLPLIDGXXXL
MLBr_00568|M.leprae_Br4923 LG---------------------SGILAGKGVPTASPQAALSGLVVLP--
. *: .* : :. :
Mflv_2206|M.gilvum_PYR-GCK -----------------------------------------------DVA
Mvan_4490|M.vanbaalenii_PYR-1 -----------------------------------------------DVA
MSMEG_5067|M.smegmatis_MC2_155 -----------------------------------------------VTA
Mb1262c|M.bovis_AF2122/97 ----------------------------------------------RQAA
Rv1230c|M.tuberculosis_H37Rv ----------------------------------------------RQAA
MMAR_4211|M.marinum_M ----------------------------------------------PQMP
MUL_4514|M.ulcerans_Agy99 ----------------------------------------------PQMP
MAV_1369|M.avium_104 ----------------------------------------------PALG
MAB_1367c|M.abscessus_ATCC_199 -----------------------------------------------TPD
TH_4644|M.thermoresistible__bu DLLDRSALHDLRLDIDILVNNAGVQHVDPVTEFPPDQFRDMLTLMVEAPF
MLBr_00568|M.leprae_Br4923 --------------------------------------------------
Mflv_2206|M.gilvum_PYR-GCK SQINTGLPGFGAGQTLG--PLPGPMPA--AAPQPVAPPP-TWVPPWVQQP
Mvan_4490|M.vanbaalenii_PYR-1 SQINTNLPGFVPGQTLG--PLPGPAPAPLAVPEPVAPPPPAWVPPWMQQ-
MSMEG_5067|M.smegmatis_MC2_155 TRVPAANLGFAPNQVLG--PLPGPAEAVPTAPAAPPEPP-RWIPPWEQP-
Mb1262c|M.bovis_AF2122/97 LNPPPMFPWMAPDPS---APMPGCTLICIGSHGPPVGAP-PFPPTAPPPP
Rv1230c|M.tuberculosis_H37Rv LNPPPMFPWMAPDPS---APMPGCTLICIGSHGPPVGAP-PFPPTAPPPP
MMAR_4211|M.marinum_M APPPPMFPWMQPTPQPL-APQPGCTLICVTNPPEAVPPPAPMPFGLMPPP
MUL_4514|M.ulcerans_Agy99 APPPPMFPWMQPTPQPL-APQPGCTLICVTNPPEAVPPPAPMPFGLMPPP
MAV_1369|M.avium_104 S-PQPMFPWMTPTPQQAPTQVPGCTVICISSQGSPPAGP-PPPFGAPPPF
MAB_1367c|M.abscessus_ATCC_199 RAVIAALPGAVPPAP----EAPQAPCMLFCAPPPPPAEP--FNPFAPQP-
TH_4644|M.thermoresistible__bu LLIRAALPYMFERGFGRIVNISSVHGLRASEYKAAYVTAKHALEGLSKVT
MLBr_00568|M.leprae_Br4923 -----GPPASVEAPPAAAPVVAAATPLLCCGEAAPPVR------------
.
Mflv_2206|M.gilvum_PYR-GCK -APQKPAQCAVFCIQDLPAAPAPAPGPVPAGPLGL---------QPAAPL
Mvan_4490|M.vanbaalenii_PYR-1 --PQQQPECAVFCIKDLPPA-APAPAPAPAGPLGL---------TPAPGP
MSMEG_5067|M.smegmatis_MC2_155 ---PRQPECVVFCLGEQAPP-APAPGPPPAAPT------------PGPAP
Mb1262c|M.bovis_AF2122/97 FLPAAPPPPDPLA--------GPPGD-----------------------A
Rv1230c|M.tuberculosis_H37Rv FLPAAPPPPDPLA--------GPPGD-----------------------A
MMAR_4211|M.marinum_M PAPAAPPPPDPLAPLGAPPVGGPPAAPAPAPAG-----------PAPAPA
MUL_4514|M.ulcerans_Agy99 PAPAAPPPPDPLAPLGVPPVGGPPAAPAPAPAGPPVPGGPAPAGPAPAPA
MAV_1369|M.avium_104 APPPSGPPPFAPPPPDAGPVPAPPAGPAPQAAP-------------APPA
MAB_1367c|M.abscessus_ATCC_199 --PAEPFNP-----------FAPNQAPQP--------------------F
TH_4644|M.thermoresistible__bu ALEGGPHGVTSNCVNPGYVRTPLVTRQIADQARAHGISEGEVLEQILLKE
MLBr_00568|M.leprae_Br4923 --------------------------------------------------
Mflv_2206|M.gilvum_PYR-GCK PVAPPATPGPQPGPAPG---PAPGPAPGPVA----------
Mvan_4490|M.vanbaalenii_PYR-1 APLLPAGPPPPPAPALPGMPPAPGPAPGPVG----------
MSMEG_5067|M.smegmatis_MC2_155 GPAPGPAPAPAPAPVLG---PAPGPAPESP-----------
Mb1262c|M.bovis_AF2122/97 GLAPP--APAPAG----------------------------
Rv1230c|M.tuberculosis_H37Rv GLAPP--APAPAG----------------------------
MMAR_4211|M.marinum_M GPAPAPGAPVPAGPAPTPTPSGPAPGEPVLTPVH-------
MUL_4514|M.ulcerans_Agy99 GPAPAPGAPAPAGPAPTPTPSGPAPGEPVLTPVH-------
MAV_1369|M.avium_104 GAAPQAPSPKSAGPTPN-APKKPGPA---------------
MAB_1367c|M.abscessus_ATCC_199 NPFAPPPPPVELGPAPG---PAPAPAAPRP-----------
TH_4644|M.thermoresistible__bu SAIKRLIEPDEVASLVGWLASPDAGMVTGASYTMDGGWSAR
MLBr_00568|M.leprae_Br4923 -----------------------------------------