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THERPPFPERREPPQVIRRDPNRRPPWPPNPPTPARRPIPPPHRARAVPPPPPPRRPPPPRPPAPRPPPP RPPAPRPPAPVAAAPRKPRRVRRWFRIALACLLLIAVAGVAVGAWIDSSLSRLPALTDYAGRPPAGAGTT WLLVGSDGREGLTPEQQAELTTGGDLGASRTDTILLVHLPGIGSSTPATMVSIPRDSYVPIPEYGSDKIN AAFSLGGPPLLAQTVEQATGLRIDHYAEVGFGGFAGMVDAVGGVTVCPAEPINDPLAGIDLPAGCQELDG RNALGYVRSRATARADLDRMANQRQFMSALIERASSPAVLLNPLRWYPLASAAADTVAVDDGDHVWDLAR LGWALRGDVTTVTVPIGEFTENSAGSIVVWDSETAQRLFAALASDSPVPADVLEAGNR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1142 | - | - | 100% (409) | cell envelope-related transcriptional attenuator |
| M. gilvum PYR-GCK | Mflv_4737 | - | 1e-35 | 34.60% (289) | cell envelope-related transcriptional attenuator |
| M. gilvum PYR-GCK | Mflv_1666 | - | 3e-34 | 31.65% (417) | cell envelope-related transcriptional attenuator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3870 | - | 3e-39 | 66.39% (119) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv3840 | - | 4e-39 | 66.39% (119) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00750 | - | 3e-35 | 33.14% (341) | hypothetical protein MLBr_00750 |
| M. abscessus ATCC 19977 | MAB_0128c | - | 1e-110 | 62.05% (303) | transcriptional regulator |
| M. marinum M | MMAR_5392 | - | 1e-138 | 62.16% (407) | transcriptional regulatory protein |
| M. avium 104 | MAV_0185 | - | 1e-119 | 67.10% (307) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6421 | - | 1e-158 | 66.98% (421) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3471 | - | 1e-35 | 35.62% (320) | PUTATIVE cell envelope-related transcriptional attenuator |
| M. ulcerans Agy99 | MUL_5013 | - | 1e-135 | 61.18% (407) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5665 | - | 1e-147 | 81.64% (305) | cell envelope-related transcriptional attenuator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 MAQRNRPQGHRPGPPAGARRRPRRPRPRRADRVTRARVLRRGPHPGPECR
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M --------------------------------------------------
MUL_5013|M.ulcerans_Agy99 --------------------------------------------------
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 RRTRRVVRHVVAHPGAARLGLCQRVGRGDHRRGFPAHPPAPTRHQPHAGV
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M --------------------------------------------------
MUL_5013|M.ulcerans_Agy99 --------------------------------------------------
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK ---------------------------------------MTHERPPFPER
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 GALGAAARGLPPLPGLQRGPGQSGDGPGVRLRVAAHRAAVAADHRPHSDR
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M --------------------------------------------------
MUL_5013|M.ulcerans_Agy99 --------------------------------------------------
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK R-------------------------------------------------
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 RGRVRRVCPVGATSRLVAVAATYIAEMNGFTPADGDRDPRMRRPGTPRPS
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M --------------------------------------------------
MUL_5013|M.ulcerans_Agy99 --------------------------------------------------
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK -EPPQVIRRDPNRRPPWPP---NPPTPARRPIPPPHRARAVPPPPPPRRP
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 GEPSQFIRRDPNYRPPQPPPRPAPPPPARRVPPPPPRQAPPPPPRRPAAP
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M ---MNGDRPAQFRRPQPPIPPQSEPSQVIRRDTLPLRRPAEPTGTPPHQP
MUL_5013|M.ulcerans_Agy99 ---MNGDRPAQFRRPQPPIPPQSEPSQVIRRDTLPLRRPAEPSGAPPRQP
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK PPPRPPAPRPP---------PPR-------------PPAPRPPAPVAAAP
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 PPAPPPPGRSPGQSPGQSSRPPRQFPPPPTRRKTSTPTAAAQSAPPAPTV
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M TSAPPPPRPATG--------------PVGPRRRRRTPAPAPPPRPAAPKA
MUL_5013|M.ulcerans_Agy99 TSAPPPPKPATG--------------PVGPRRRRRTPTPAPPPRPAAPKA
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 --------------------------------------------------
TH_3471|M.thermoresistible__bu --------------------------------------------------
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK RKPRRVRRW----FRIALACLLLIAVAGVAVGAWIDSSLSRLPALTDYAG
Mvan_5665|M.vanbaalenii_PYR-1 ---------------------MLLAAGTVAAGVWIDSALTRISALTDYSD
MSMEG_6421|M.smegmatis_MC2_155 RKPRRRRRW----GRIVLALLMIAVLAGAGAMIWVDTSLQRIPALAGYPE
MAB_0128c|M.abscessus_ATCC_199 -----------------MTLMLLGFCGVIGTALWLDGRLHHVDALKDYPD
MMAR_5392|M.marinum_M RRKKTKRRWGKIVALSLLTAVLLAGAGILGGALWLDTALHREPVLRDYAD
MUL_5013|M.ulcerans_Agy99 RRKKTERRWGKIVALSLLTAVLLAGAGILGGALWLDTALHREPVLRDYAD
MAV_0185|M.avium_104 ------------MASALLVVLLLAGVGLGAGVAWFDTKLHREPVLADYPG
MLBr_00750|M.leprae_Br4923 ---MPVQRVVRAVVTALTLAIVLGTGITWTSFRSFEDGIFHMSAP--SLG
TH_3471|M.thermoresistible__bu ----VPARLIRALAVATAVVIVLSTGVAWSRIRAFEAGISQISSP--LLG
Mb3870|M.bovis_AF2122/97 -----------MAGCIQR--------------FSHVRCLG----------
Rv3840|M.tuberculosis_H37Rv -----------MAGCIQR--------------FSHVRCLG----------
Mflv_1142|M.gilvum_PYR-GCK RPPAGAGTTWLLVGSDGREGLT----PEQQAELTTGGDLGASRTDTILLV
Mvan_5665|M.vanbaalenii_PYR-1 RPAQGEGTTWLLVGSDGREGLT----PEQQAELATGGDLGASRTDTILVV
MSMEG_6421|M.smegmatis_MC2_155 RPAAGRGTTWLLVGSDSREGLT----PEQQASLTTGGDLGTGRTDTILLV
MAB_0128c|M.abscessus_ATCC_199 RPATGSGTNWLLVGSDSRQGLT----PDQETQLATGGDIGDGRTDTILLV
MMAR_5392|M.marinum_M RPGPGRGTNWLIVGSDSRQGLT----TEQQRELTTGGDPGDGRTDTILLV
MUL_5013|M.ulcerans_Agy99 RPGPGRGTNWLIVGSDSRQGLT----TEQQQELTTGGDPGDGRTDTILLV
MAV_0185|M.avium_104 RPEPGRGSNWLIVGSDSRQGLS----AEQQQQLATGGDIGDGRTDTILLV
MLBr_00750|M.leprae_Br4923 KGGNDGAIDILLVGLDSRTDAYGNPLSAEELATLRAGDEEATNTDTIILI
TH_3471|M.thermoresistible__bu QGGEDGAVDILLVGMDSRTDAHGNPLSAEELAALRAGNDVATNTDTIVLV
:.* *
Mb3870|M.bovis_AF2122/97 --PGLASDNPTTLISIPRDSYVPIPGHGRDKINAAFALG-----------
Rv3840|M.tuberculosis_H37Rv --PGLASDNPTTLISIPRDSYVPIPGHGRDKINAAFALG-----------
Mflv_1142|M.gilvum_PYR-GCK HLPGIGSSTPATMVSIPRDSYVPIPEYGSDKINAAFSLG-----------
Mvan_5665|M.vanbaalenii_PYR-1 HLPGLGSATPATMVSIPRDSYVSIPEYGSDKINAAFSVG-----------
MSMEG_6421|M.smegmatis_MC2_155 HIPALGSSTPATMVSIPRDSYVEIPGYGEDKINAAFALG-----------
MAB_0128c|M.abscessus_ATCC_199 HIPAFYDGGAATMVSLPRDSYVSIPENGSNKLNAAYSLG-----------
MMAR_5392|M.marinum_M HLAGLGSSTPTALVSIPRDSYVPVPGYGRDKINAAFAIG-----------
MUL_5013|M.ulcerans_Agy99 HLAGLGSSTPTALVSIPRDSYVPVRGYGRDKINAAFAIG-----------
MAV_0185|M.avium_104 HLPGVGSGVAPTMVSIPRDSYVPIPEHGKDKINAAFAMG-----------
MLBr_00750|M.leprae_Br4923 RIPNNGKS--ATAISIPRDSYVQAPGLGKAKINGVYGQTREAKRASLVRT
TH_3471|M.thermoresistible__bu RIPNNGRS--ATAISIPRDSYVEAPGRGKMKINGVYGEVKFETMKQLVEV
. .: :*:****** * *:*..:.
Mb3870|M.bovis_AF2122/97 ---------------GGRLLTQTVELATGLHLDHYAEVGFSEFADLVDAF
Rv3840|M.tuberculosis_H37Rv ---------------GGRLLTQTVELATGLHLDHYAEVGFSEFADLVDAF
Mflv_1142|M.gilvum_PYR-GCK ---------------GPPLLAQTVEQATGLRIDHYAEVGFGGFAGMVDAV
Mvan_5665|M.vanbaalenii_PYR-1 ---------------GPRLLARTVELATGLRIDHYAEIGFGGFAELVDAV
MSMEG_6421|M.smegmatis_MC2_155 ---------------GAPLLAQTVESATGLRLDHYAEIGFGGFASLVDAV
MAB_0128c|M.abscessus_ATCC_199 ---------------GPALLTRTVEEATGLRIDHYAEIGFNGFASVVDAI
MMAR_5392|M.marinum_M ---------------GAPLLVQTVEQATGLRIDHYAEIGFGGFAELVDAL
MUL_5013|M.ulcerans_Agy99 ---------------GAPLLVQTVEQATGLRIDHYAEIGFGGFAELVDAL
MAV_0185|M.avium_104 ---------------GATLLVRTVEQATGLRIAHYAEIGFGGFAALVDAL
MLBr_00750|M.leprae_Br4923 -GDSAEDAAAQGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIVDAL
TH_3471|M.thermoresistible__bu QGMDPEVAEPLAVQDARGALIETVAELTGVTVDHYAEIGLLGFALITDAL
. * .** **: : ****:*: ** :.**.
Mb3870|M.bovis_AF2122/97 ------------DPLAGVDLPAGCQTLDGRAALGYVRTR-ATPRADLE--
Rv3840|M.tuberculosis_H37Rv ------------DPLAGVDLPAGCQTLDGRAALGYVRTR-ATPRADLE--
Mflv_1142|M.gilvum_PYR-GCK GGVTVCPAEPINDPLAGIDLPAGCQELDGRNALGYVRSR-ATARADLDRM
Mvan_5665|M.vanbaalenii_PYR-1 GGVTMCPEAPISDPLAGIDLPAGCQRLDGRTALGYVRSR-ATARADLDRM
MSMEG_6421|M.smegmatis_MC2_155 GGVTVCPAEPISDPLAGIDLPAGCQELDGRTALGFVRTR-ATARADLDRM
MAB_0128c|M.abscessus_ATCC_199 GGVSMCLDEPIQDPLAGIDLTPGCQILNGPSALGYVRSR-ATPRADLDRM
MMAR_5392|M.marinum_M GGVRMCLTEPIGDPLAGIDLAPGCQQLDGRSALGYVRSR-ATPRADLDRM
MUL_5013|M.ulcerans_Agy99 GGVRMCLTEPIGDPLAGIDLAPGCQQLDGRSALGYVRSR-ATPRADLDRM
MAV_0185|M.avium_104 GGVRVCPQAPMHDPLAGLDLPAGCQTLDGRNALAYVRSR-DTPRADLDRM
MLBr_00750|M.leprae_Br4923 GGVDVCLKDAVFEPMSGADFPAGRQKLNGPQALSFVRQRHELPRGDLDRV
TH_3471|M.thermoresistible__bu GGVEVCLKNPVYEPLSGADFPAGWQRLDGAQALSFVRQRQDLPRGDLDRV
:*::* *:..* * *:* **.:** * .*.**:
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK ANQRQFMSALIERASSPAVLLNPLRWYPLASAAADTVAVDDGDHVWDLAR
Mvan_5665|M.vanbaalenii_PYR-1 ANQRQFMSALVDRAASPTVLLNPLKWYPMARAAADTVTVNDGDHIWDLAR
MSMEG_6421|M.smegmatis_MC2_155 IHQREFMSGLLHRAASPAVWLNPLRWSPMMRAATGTLAVDEDAHVWNLAR
MAB_0128c|M.abscessus_ATCC_199 THQRAFMSALFHRVSSPAVWANPFRWYPVATSTADAITLAEGDHSWNLAQ
MMAR_5392|M.marinum_M INQRQFMSALLRRAESPAVWLNPWRWYSVPRAAAAALTVDQGAHVFDLAR
MUL_5013|M.ulcerans_Agy99 INQRQFMSALLRRAENPAVWLNPWRWYSVPRAAAAALTVDQGAHVFDLAR
MAV_0185|M.avium_104 VNQRQFVAALLHRAASPAVWLNPWRWYAAPRAVADSLTVDRADHAWDLAR
MLBr_00750|M.leprae_Br4923 VRQQAVMASLVHRVISGQTLSNPSTIKHLEQAIQRSVVISSGWNLMDFLK
TH_3471|M.thermoresistible__bu TRQQTVMASLAREVISSKTLSSPATLDRLQRAIQRSVVLSDGWDVMEFVE
Mb3870|M.bovis_AF2122/97 ----------------------------------------------GSDV
Rv3840|M.tuberculosis_H37Rv ----------------------------------------------GSDV
Mflv_1142|M.gilvum_PYR-GCK LGWALRGDVTTVT----VPIGEFTENSAGSIVVWDSETAQRLFAALASDS
Mvan_5665|M.vanbaalenii_PYR-1 LAWALRGDIVNVT----VPIGEFTENGSGSIVVWDSEAAQRLFGALASDT
MSMEG_6421|M.smegmatis_MC2_155 LAWSLRGDPVTMT----VPIGEFGSNGSGDVVMWDSDAAPRLFEALRTDA
MAB_0128c|M.abscessus_ATCC_199 LGWALAGSVQNLT----MPIGSFSENWAGDIVTWDQDASSRLFDALRTGQ
MMAR_5392|M.marinum_M LGWALHGHPTALT----VPIGEFTTTDVGSVVVWNHDAAAEMFDALASDT
MUL_5013|M.ulcerans_Agy99 LGWALHGHPTALA----VPIGEFTTTDVGSVVVWNHDAAAEMFDALASDT
MAV_0185|M.avium_104 LGWALHGSPATVT----VPIGEFTSGDAGSVVVWDHARAARLFDALSSDG
MLBr_00750|M.leprae_Br4923 QLQSLADRKVAFATIPVLDETGWSDDGMQSVVRVDPHQVQNFVSGLLHNQ
TH_3471|M.thermoresistible__bu QLQGLAAGNIAFATIPIVREDGWSDDGMQSVVRVDPQQVRDWVSSLLEEQ
Mb3870|M.bovis_AF2122/97 P-------------VPAAAFETQP--------------------------
Rv3840|M.tuberculosis_H37Rv P-------------VPAAAFETQP--------------------------
Mflv_1142|M.gilvum_PYR-GCK P-------------VPADVLEAGNR-------------------------
Mvan_5665|M.vanbaalenii_PYR-1 P-------------VPQDVLDAANP-------------------------
MSMEG_6421|M.smegmatis_MC2_155 P-------------VPPDVLENAVN-------------------------
MAB_0128c|M.abscessus_ATCC_199 Q-------------IPADLLPDPATPTP----------------------
MMAR_5392|M.marinum_M P-------------IPADAFDGPP--------------------------
MUL_5013|M.ulcerans_Agy99 P-------------IPADAFDGPP--------------------------
MAV_0185|M.avium_104 Q-------------LPAGSTDEQQPSS-----------------------
MLBr_00750|M.leprae_Br4923 AQDKTDELAYTPAKITANVANDTDINGLAAAVSDILTTKGFIAGSVANNQ
TH_3471|M.thermoresistible__bu DEGKTEEIAYSRDKTTVEVLNGTDINGLAAAVSHVLTSNGFSPGPVGNAE
.
Mb3870|M.bovis_AF2122/97 --------------------------------------------------
Rv3840|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5665|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0128c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5392|M.marinum_M --------------------------------------------------
MUL_5013|M.ulcerans_Agy99 --------------------------------------------------
MAV_0185|M.avium_104 --------------------------------------------------
MLBr_00750|M.leprae_Br4923 GSHVKSSQVRAAKSDDLGAQKVSKELGGLPIVVDGSIPAGSVLVILANDY
TH_3471|M.thermoresistible__bu DGPADRTEVRVAKQDDRGAREVADQLGDLPIVEDRTVAPGFVRVVLADDY
Mb3870|M.bovis_AF2122/97 -------------------------------------------------
Rv3840|M.tuberculosis_H37Rv -------------------------------------------------
Mflv_1142|M.gilvum_PYR-GCK -------------------------------------------------
Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------
MSMEG_6421|M.smegmatis_MC2_155 -------------------------------------------------
MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------
MMAR_5392|M.marinum_M -------------------------------------------------
MUL_5013|M.ulcerans_Agy99 -------------------------------------------------
MAV_0185|M.avium_104 -------------------------------------------------
MLBr_00750|M.leprae_Br4923 TGPGSGLFGNGSIASDYASNPGASADPNIPVPSP--ILTAGSDQPECIN
TH_3471|M.thermoresistible__bu TGPGSGLDGTDPTVTTLQQSSATVGQTVEAAPPPPQIITAGADDPKCVN