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ASALLVVLLLAGVGLGAGVAWFDTKLHREPVLADYPGRPEPGRGSNWLIVGSDSRQGLSAEQQQQLATGG DIGDGRTDTILLVHLPGVGSGVAPTMVSIPRDSYVPIPEHGKDKINAAFAMGGATLLVRTVEQATGLRIA HYAEIGFGGFAALVDALGGVRVCPQAPMHDPLAGLDLPAGCQTLDGRNALAYVRSRDTPRADLDRMVNQR QFVAALLHRAASPAVWLNPWRWYAAPRAVADSLTVDRADHAWDLARLGWALHGSPATVTVPIGEFTSGDA GSVVVWDHARAARLFDALSSDGQLPAGSTDEQQPSS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_0185 | - | - | 100% (317) | transcriptional regulator |
M. avium 104 | MAV_4232 | - | 6e-38 | 34.29% (347) | cell envelope-related function transcriptional attenuator |
M. avium 104 | MAV_0769 | - | 9e-28 | 33.88% (304) | LytR/CpsA/Psr family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3295 | - | 6e-39 | 36.21% (301) | hypothetical protein Mb3295 |
M. gilvum PYR-GCK | Mflv_1142 | - | 1e-120 | 67.10% (307) | cell envelope-related transcriptional attenuator |
M. tuberculosis H37Rv | Rv3267 | - | 6e-39 | 36.21% (301) | hypothetical protein Rv3267 |
M. leprae Br4923 | MLBr_00750 | - | 6e-38 | 35.16% (310) | hypothetical protein MLBr_00750 |
M. abscessus ATCC 19977 | MAB_0128c | - | 1e-107 | 59.60% (302) | transcriptional regulator |
M. marinum M | MMAR_5392 | - | 1e-131 | 71.70% (311) | transcriptional regulatory protein |
M. smegmatis MC2 155 | MSMEG_6421 | - | 1e-113 | 64.05% (306) | transcriptional regulator |
M. thermoresistible (build 8) | TH_3471 | - | 2e-36 | 35.03% (314) | PUTATIVE cell envelope-related transcriptional attenuator |
M. ulcerans Agy99 | MUL_5013 | - | 1e-129 | 71.06% (311) | transcriptional regulatory protein |
M. vanbaalenii PYR-1 | Mvan_5665 | - | 1e-112 | 65.15% (307) | cell envelope-related transcriptional attenuator |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 MAQRNRPQGHRPGPPAGARRRPRRPRPRRADRVTRARVLRRGPHPGPECR MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 -------------------------------------------------- Rv3267|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00750|M.leprae_Br4923 -------------------------------------------------- TH_3471|M.thermoresistible__bu -------------------------------------------------- MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 RRTRRVVRHVVAHPGAARLGLCQRVGRGDHRRGFPAHPPAPTRHQPHAGV MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 -------------------------------------------------- Rv3267|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00750|M.leprae_Br4923 -------------------------------------------------- TH_3471|M.thermoresistible__bu -------------------------------------------------- MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK ---------------------------------------MTHERPPFPER Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 GALGAAARGLPPLPGLQRGPGQSGDGPGVRLRVAAHRAAVAADHRPHSDR MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 -------------------------------------------------- Rv3267|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00750|M.leprae_Br4923 -------------------------------------------------- TH_3471|M.thermoresistible__bu -------------------------------------------------- MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK R------------------------------------------------- Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 RGRVRRVCPVGATSRLVAVAATYIAEMNGFTPADGDRDPRMRRPGTPRPS MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 -------------------------------------------------- Rv3267|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00750|M.leprae_Br4923 -------------------------------------------------- TH_3471|M.thermoresistible__bu -------------------------------------------------- MMAR_5392|M.marinum_M ---MNGDRPAQFRRPQPPIPPQSEPSQVIRRDTLPLRRPAEPTGTPPHQP MUL_5013|M.ulcerans_Agy99 ---MNGDRPAQFRRPQPPIPPQSEPSQVIRRDTLPLRRPAEPSGAPPRQP MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK -EPPQVIRRDPNRRPPWPP---NPPTPARRPIPPPHRARAVPPPPPPRRP Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 GEPSQFIRRDPNYRPPQPPPRPAPPPPARRVPPPPPRQAPPPPPRRPAAP MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 -------------------------------------------------- Rv3267|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00750|M.leprae_Br4923 -------------------------------------------------- TH_3471|M.thermoresistible__bu -------------------------------------------------- MMAR_5392|M.marinum_M TSAPPPPRPATG--------------PVGPRRRRRTPAPAPPPRPAAPKA MUL_5013|M.ulcerans_Agy99 TSAPPPPKPATG--------------PVGPRRRRRTPTPAPPPRPAAPKA MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK PPPRPPAPRPP---------PPR-------------PPAPRPPAPVAAAP Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 PPAPPPPGRSPGQSPGQSSRPPRQFPPPPTRRKTSTPTAAAQSAPPAPTV MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 ----------------------------------------------MMSA Rv3267|M.tuberculosis_H37Rv ----------------------------------------------MMSA MLBr_00750|M.leprae_Br4923 -----------------------------------------------MPV TH_3471|M.thermoresistible__bu ------------------------------------------------VP MMAR_5392|M.marinum_M RRKKTKRRWGKIVALSLLTAVLLAGAGILGGALWLDTALHREPVLRDYAD MUL_5013|M.ulcerans_Agy99 RRKKTERRWGKIVALSLLTAVLLAGAGILGGALWLDTALHREPVLRDYAD MAV_0185|M.avium_104 ------------MASALLVVLLLAGVGLGAGVAWFDTKLHREPVLADYPG Mflv_1142|M.gilvum_PYR-GCK RKPRRVRRWFR-IALACLLLIAVAGVAVG---AWIDSSLSRLPALTDYAG Mvan_5665|M.vanbaalenii_PYR-1 ------------------MLLAAGTVAAG---VWIDSALTRISALTDYSD MSMEG_6421|M.smegmatis_MC2_155 RKPRRRRRWGR-IVLALLMIAVLAGAGAM---IWVDTSLQRIPALAGYPE MAB_0128c|M.abscessus_ATCC_199 -----------------MTLMLLGFCGVIGTALWLDGRLHHVDALKDYPD Mb3295|M.bovis_AF2122/97 QRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAP--SLG Rv3267|M.tuberculosis_H37Rv QRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAP--SLG MLBr_00750|M.leprae_Br4923 QRVVR------AVVTALTLAIVLGTGITWTSFRSFEDGIFHMSAP--SLG TH_3471|M.thermoresistible__bu ARLIR------ALAVATAVVIVLSTGVAWSRIRAFEAGISQISSP--LLG . .: : : MMAR_5392|M.marinum_M RPGPGRGTNWLIVGSDSR-----QGLTTEQQRELTTGGDPGDGRTDTILL MUL_5013|M.ulcerans_Agy99 RPGPGRGTNWLIVGSDSR-----QGLTTEQQQELTTGGDPGDGRTDTILL MAV_0185|M.avium_104 RPEPGRGSNWLIVGSDSR-----QGLSAEQQQQLATGGDIGDGRTDTILL Mflv_1142|M.gilvum_PYR-GCK RPPAGAGTTWLLVGSDGR-----EGLTPEQQAELTTGGDLGASRTDTILL Mvan_5665|M.vanbaalenii_PYR-1 RPAQGEGTTWLLVGSDGR-----EGLTPEQQAELATGGDLGASRTDTILV MSMEG_6421|M.smegmatis_MC2_155 RPAAGRGTTWLLVGSDSR-----EGLTPEQQASLTTGGDLGTGRTDTILL MAB_0128c|M.abscessus_ATCC_199 RPATGSGTNWLLVGSDSR-----QGLTPDQETQLATGGDIGDGRTDTILL Mb3295|M.bovis_AF2122/97 HGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATN-TDTIIL Rv3267|M.tuberculosis_H37Rv HGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATN-TDTIIL MLBr_00750|M.leprae_Br4923 KGGNDGAIDILLVGLDSRTDAYGNPLSAEELATLRAGDEEATN-TDTIIL TH_3471|M.thermoresistible__bu QGGEDGAVDILLVGMDSRTDAHGNPLSAEELAALRAGNDVATN-TDTIVL : . . *:** *.* : *:.:: * :*.: . . ****:: MMAR_5392|M.marinum_M VHLAGLGSSTPTALVSIPRDSYVPVPGYGRDKINAAFAIGG--------- MUL_5013|M.ulcerans_Agy99 VHLAGLGSSTPTALVSIPRDSYVPVRGYGRDKINAAFAIGG--------- MAV_0185|M.avium_104 VHLPGVGSGVAPTMVSIPRDSYVPIPEHGKDKINAAFAMGG--------- Mflv_1142|M.gilvum_PYR-GCK VHLPGIGSSTPATMVSIPRDSYVPIPEYGSDKINAAFSLGG--------- Mvan_5665|M.vanbaalenii_PYR-1 VHLPGLGSATPATMVSIPRDSYVSIPEYGSDKINAAFSVGG--------- MSMEG_6421|M.smegmatis_MC2_155 VHIPALGSSTPATMVSIPRDSYVEIPGYGEDKINAAFALGG--------- MAB_0128c|M.abscessus_ATCC_199 VHIPAFYDGGAATMVSLPRDSYVSIPENGSNKLNAAYSLGG--------- Mb3295|M.bovis_AF2122/97 IRVP--NNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTR-ETKRAGLV Rv3267|M.tuberculosis_H37Rv IRVP--NNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTR-ETKRAGLV MLBr_00750|M.leprae_Br4923 IRIP--NNGKSATAISIPRDSYVQAPGLGKAKINGVYGQTR-EAKRASLV TH_3471|M.thermoresistible__bu VRIP--NNGRSATAISIPRDSYVEAPGRGKMKINGVYGEVKFETMKQLVE :::. .. ..: :*:****** * *:*..:. MMAR_5392|M.marinum_M -----------------APLLVQTVEQATGLRIDHYAEIGFGGFAELVDA MUL_5013|M.ulcerans_Agy99 -----------------APLLVQTVEQATGLRIDHYAEIGFGGFAELVDA MAV_0185|M.avium_104 -----------------ATLLVRTVEQATGLRIAHYAEIGFGGFAALVDA Mflv_1142|M.gilvum_PYR-GCK -----------------PPLLAQTVEQATGLRIDHYAEVGFGGFAGMVDA Mvan_5665|M.vanbaalenii_PYR-1 -----------------PRLLARTVELATGLRIDHYAEIGFGGFAELVDA MSMEG_6421|M.smegmatis_MC2_155 -----------------APLLAQTVESATGLRLDHYAEIGFGGFASLVDA MAB_0128c|M.abscessus_ATCC_199 -----------------PALLTRTVEEATGLRIDHYAEIGFNGFASVVDA Mb3295|M.bovis_AF2122/97 QAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADA Rv3267|M.tuberculosis_H37Rv QAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADA MLBr_00750|M.leprae_Br4923 RTGDSAEDAAAQGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIVDA TH_3471|M.thermoresistible__bu VQGMDPEVAEPLAVQDARGALIETVAELTGVTVDHYAEIGLLGFALITDA * .** **: : ****:*: *** :.** MMAR_5392|M.marinum_M LGGVRMCLTEPIGDPLAGIDLAPGCQQLDGRSALGYVRSR-ATPRADLDR MUL_5013|M.ulcerans_Agy99 LGGVRMCLTEPIGDPLAGIDLAPGCQQLDGRSALGYVRSR-ATPRADLDR MAV_0185|M.avium_104 LGGVRVCPQAPMHDPLAGLDLPAGCQTLDGRNALAYVRSR-DTPRADLDR Mflv_1142|M.gilvum_PYR-GCK VGGVTVCPAEPINDPLAGIDLPAGCQELDGRNALGYVRSR-ATARADLDR Mvan_5665|M.vanbaalenii_PYR-1 VGGVTMCPEAPISDPLAGIDLPAGCQRLDGRTALGYVRSR-ATARADLDR MSMEG_6421|M.smegmatis_MC2_155 VGGVTVCPAEPISDPLAGIDLPAGCQELDGRTALGFVRTR-ATARADLDR MAB_0128c|M.abscessus_ATCC_199 IGGVSMCLDEPIQDPLAGIDLTPGCQILNGPSALGYVRSR-ATPRADLDR Mb3295|M.bovis_AF2122/97 LGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDR Rv3267|M.tuberculosis_H37Rv LGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDR MLBr_00750|M.leprae_Br4923 LGGVDVCLKDAVFEPMSGADFPAGRQKLNGPQALSFVRQRHELPRGDLDR TH_3471|M.thermoresistible__bu LGGVEVCLKNPVYEPLSGADFPAGWQRLDGAQALSFVRQRQDLPRGDLDR :*** :* .: :*::* *:..* * *:* **.:** * .*.**** MMAR_5392|M.marinum_M MINQRQFMSALLRRAESPAVWLNPWRWYSVPRAAAAALTVDQGAHVFDLA MUL_5013|M.ulcerans_Agy99 MINQRQFMSALLRRAENPAVWLNPWRWYSVPRAAAAALTVDQGAHVFDLA MAV_0185|M.avium_104 MVNQRQFVAALLHRAASPAVWLNPWRWYAAPRAVADSLTVDRADHAWDLA Mflv_1142|M.gilvum_PYR-GCK MANQRQFMSALIERASSPAVLLNPLRWYPLASAAADTVAVDDGDHVWDLA Mvan_5665|M.vanbaalenii_PYR-1 MANQRQFMSALVDRAASPTVLLNPLKWYPMARAAADTVTVNDGDHIWDLA MSMEG_6421|M.smegmatis_MC2_155 MIHQREFMSGLLHRAASPAVWLNPLRWSPMMRAATGTLAVDEDAHVWNLA MAB_0128c|M.abscessus_ATCC_199 MTHQRAFMSALFHRVSSPAVWANPFRWYPVATSTADAITLAEGDHSWNLA Mb3295|M.bovis_AF2122/97 VVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFV Rv3267|M.tuberculosis_H37Rv VVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFV MLBr_00750|M.leprae_Br4923 VVRQQAVMASLVHRVISGQTLSNPSTIKHLEQAIQRSVVISSGWNLMDFL TH_3471|M.thermoresistible__bu VTRQQTVMASLAREVISSKTLSSPATLDRLQRAIQRSVVLSDGWDVMEFV : .*: .::.* .. . . .* : ::.: . :: MMAR_5392|M.marinum_M RLGWALHG-HPTALTVPIG---EFTTTDVGSVVVWNHDAAAEMFDALASD MUL_5013|M.ulcerans_Agy99 RLGWALHG-HPTALAVPIG---EFTTTDVGSVVVWNHDAAAEMFDALASD MAV_0185|M.avium_104 RLGWALHG-SPATVTVPIG---EFTSGDAGSVVVWDHARAARLFDALSSD Mflv_1142|M.gilvum_PYR-GCK RLGWALRG-DVTTVTVPIG---EFTENSAGSIVVWDSETAQRLFAALASD Mvan_5665|M.vanbaalenii_PYR-1 RLAWALRG-DIVNVTVPIG---EFTENGSGSIVVWDSEAAQRLFGALASD MSMEG_6421|M.smegmatis_MC2_155 RLAWSLRG-DPVTMTVPIG---EFGSNGSGDVVMWDSDAAPRLFEALRTD MAB_0128c|M.abscessus_ATCC_199 QLGWALAG-SVQNLTMPIG---SFSENWAGDIVTWDQDASSRLFDALRTG Mb3295|M.bovis_AF2122/97 RQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHE Rv3267|M.tuberculosis_H37Rv RQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHE MLBr_00750|M.leprae_Br4923 KQLQSLADRKVAFATIPVLDETGWSDDGMQSVVRVDPHQVQNFVSGLLHN TH_3471|M.thermoresistible__bu EQLQGLAAGNIAFATIPIVREDGWSDDGMQSVVRVDPQQVRDWVSSLLEE . * ::*: : .:* : . .* MMAR_5392|M.marinum_M T-------------PIPADAFDGPP------------------------- MUL_5013|M.ulcerans_Agy99 T-------------PIPADAFDGPP------------------------- MAV_0185|M.avium_104 G-------------QLPAGSTDEQQPSS---------------------- Mflv_1142|M.gilvum_PYR-GCK S-------------PVPADVLEAGNR------------------------ Mvan_5665|M.vanbaalenii_PYR-1 T-------------PVPQDVLDAANP------------------------ MSMEG_6421|M.smegmatis_MC2_155 A-------------PVPPDVLENAVN------------------------ MAB_0128c|M.abscessus_ATCC_199 Q-------------QIPADLLPDPATPTP--------------------- Mb3295|M.bovis_AF2122/97 QDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNN Rv3267|M.tuberculosis_H37Rv QDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNN MLBr_00750|M.leprae_Br4923 QAQDKTDELAYTPAKITANVANDTDINGLAAAVSDILTTKGFIAGSVANN TH_3471|M.thermoresistible__bu QDEGKTEEIAYSRDKTTVEVLNGTDINGLAAAVSHVLTSNGFSPGPVGNA . MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 DGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLAND Rv3267|M.tuberculosis_H37Rv DGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLAND MLBr_00750|M.leprae_Br4923 QGSHVKSSQVRAAKSDDLGAQKVSKELGGLPIVVDGSIPAGSVLVILAND TH_3471|M.thermoresistible__bu EDGPADRTEVRVAKQDDRGAREVADQLGDLPIVEDRTVAPGFVRVVLADD MMAR_5392|M.marinum_M -------------------------------------------------- MUL_5013|M.ulcerans_Agy99 -------------------------------------------------- MAV_0185|M.avium_104 -------------------------------------------------- Mflv_1142|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5665|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6421|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0128c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3295|M.bovis_AF2122/97 YSGPGSGLGGSDPNGVVSPARAFNLG-SADDTTPPPSPILTAGSDAPECI Rv3267|M.tuberculosis_H37Rv YSGPGSGLGGSDPNGVVSPARAFNLG-SADDTTPPPSPILTAGSDAPECI MLBr_00750|M.leprae_Br4923 YTGPGSGLFG---NGSIASDYASNPGASADPNIPVPSPILTAGSDQPECI TH_3471|M.thermoresistible__bu YTGPGSGLDGTDPTVTTLQQSSATVG-QTVEAAPPPPQIITAGADDPKCV MMAR_5392|M.marinum_M - MUL_5013|M.ulcerans_Agy99 - MAV_0185|M.avium_104 - Mflv_1142|M.gilvum_PYR-GCK - Mvan_5665|M.vanbaalenii_PYR-1 - MSMEG_6421|M.smegmatis_MC2_155 - MAB_0128c|M.abscessus_ATCC_199 - Mb3295|M.bovis_AF2122/97 N Rv3267|M.tuberculosis_H37Rv N MLBr_00750|M.leprae_Br4923 N TH_3471|M.thermoresistible__bu N