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PKVAPSTQAHAATSPGCEMLVAVTNCPVPATVETVEANPTTTAGVVDSSPTHDAWTITALPTPTAIAVAV RLPPNRCAAYRLALAIATPTRFEHTERTQPAGPPPTKKKDAHARNTTQMGTVTSVAVNATAIPPSTPMLN VNADRESILPHPRSRRRLRPVLPGPPTTLGSWCFRRVTPAFRPASGPDRFVRKRDIPAPRTDRHRQLGCI SGHRRTREQPRVHAVAMSRRDPAHQRHIAVLVYDGVRALDLAGPTEVFEIAREMGCGYTTGLYSTANSPT VRCASGMTVHATAASELTNADTLLVPGGDDPARSAAPWLSKVLRAQLNDVRRIAALGTGCFALAAAGILD GRRTTTHWRHLDAFAARHPTAVLDRESAFTRDGPVWTSAGASAGVDLALALVGEDHGAAVAQEIAKELVL PGRRMEGHPQLSVAARTPRPKHPEIDRLLVTISVDPAGDYELDSVAAHLGISARHLARLFKAQVGVTLRQ YVHEVRLENAVGLVLAGESFHAAARRSGLHGGARVRDHLAGRLRVDARGAEAVSVHAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1009 | - | - | 100% (549) | AraC family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1008 | - | 4e-46 | 36.91% (298) | Fis family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_5267 | - | 5e-34 | 31.63% (313) | AraC family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0053 | - | 1e-07 | 31.68% (161) | hypothetical protein Mb0053 |
| M. tuberculosis H37Rv | Rv0052 | - | 1e-07 | 31.68% (161) | hypothetical protein Rv0052 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4754 | - | 2e-48 | 38.24% (306) | AraC family transcriptional regulator |
| M. marinum M | MMAR_2855 | - | 2e-40 | 38.15% (270) | transcriptional regulatory protein |
| M. avium 104 | MAV_4981 | - | 3e-47 | 35.94% (320) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_3488 | - | 7e-50 | 37.06% (286) | transcriptional regulator, AraC family protein |
| M. thermoresistible (build 8) | TH_3120 | - | 2e-22 | 29.64% (307) | PUTATIVE transcriptional regulator, AraC family with |
| M. ulcerans Agy99 | MUL_2902 | - | 1e-38 | 37.41% (270) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5828 | - | 1e-111 | 63.96% (308) | AraC family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1009|M.gilvum_PYR-GCK MPKVAPSTQAHAATSPGCEMLVAVTNCPVPATVETVEANPTTTAGVVDSS
Mvan_5828|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2855|M.marinum_M --------------------------------------------------
MUL_2902|M.ulcerans_Agy99 --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
MSMEG_3488|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4754|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
Mb0053|M.bovis_AF2122/97 --------------------------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1009|M.gilvum_PYR-GCK PTHDAWTITALPTPTAIAVAVRLPPNRCAAYRLALAIATPTRFEHTERTQ
Mvan_5828|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2855|M.marinum_M --------------------------------------------------
MUL_2902|M.ulcerans_Agy99 --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
MSMEG_3488|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4754|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
Mb0053|M.bovis_AF2122/97 --------------------------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1009|M.gilvum_PYR-GCK PAGPPPTKKKDAHARNTTQMGTVTSVAVNATAIPPSTPMLNVNADRESIL
Mvan_5828|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2855|M.marinum_M --------------------------------------------------
MUL_2902|M.ulcerans_Agy99 --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
MSMEG_3488|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4754|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
Mb0053|M.bovis_AF2122/97 --------------------------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1009|M.gilvum_PYR-GCK PHPRSRRRLRPVLPGPPTTLGSWCFRRVTPAFRPASGPDRFVRKRDIPAP
Mvan_5828|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2855|M.marinum_M --------------------------------------------------
MUL_2902|M.ulcerans_Agy99 --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
MSMEG_3488|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4754|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
Mb0053|M.bovis_AF2122/97 --------------------------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1009|M.gilvum_PYR-GCK RTDRHRQLGCISGHRRTREQPRVHAVAMSRRDPAHQRHIAVLVYDGVRAL
Mvan_5828|M.vanbaalenii_PYR-1 ---------------------------MSIPTDGRSRHIAMVVFDGVRTL
MMAR_2855|M.marinum_M ----------------------------MAR------KVVIVGFPGVQPL
MUL_2902|M.ulcerans_Agy99 ----------------------------MAR------KVVTVGFPGVQPL
MAV_4981|M.avium_104 ----------------------------MADSSATPRVVVIVVFDDVTML
MSMEG_3488|M.smegmatis_MC2_155 ----------------------------MAHAPNR-RTVVIVVFDGMKLL
MAB_4754|M.abscessus_ATCC_1997 ----------------------------MSD----ERLITIVVFDGMKLL
TH_3120|M.thermoresistible__bu --------------------------------------VAALVLDGLAIF
Mb0053|M.bovis_AF2122/97 ------------------------------------MPSFDVVFVGHRRG
Rv0052|M.tuberculosis_H37Rv ------------------------------------MPSFDVVFVGHRRG
: .
Mflv_1009|M.gilvum_PYR-GCK DLAGPTEVFEIAREMGCGYTTGLYST--ANSPTVRCASGMTVHATAAS-E
Mvan_5828|M.vanbaalenii_PYR-1 DLTGPLEVFDVAQALGCRYSIGLYSS--SGATSVRCSSGLSIDAAPASVA
MMAR_2855|M.marinum_M DVVGPFEVFAGASLLSEGGYDVALAS--IDERPVATGIGLEFMTTRLPDP
MUL_2902|M.ulcerans_Agy99 DVVGPFEVFAGASLLSEGGYDVALAS--IDERPVATGIGLEFMTTRLPDP
MAV_4981|M.avium_104 DVAGAGEVFAEANRFG-ADYLLKIAS--VDGRDVTTSIGTRLGVTDAVSS
MSMEG_3488|M.smegmatis_MC2_155 DVAGPAEVFAEANRFG-ADYVLKIAS--VDGADVTTSVGTRFPVDQTISD
MAB_4754|M.abscessus_ATCC_1997 DLAGPAEVFAEANRFG-ANYRLVVAS--VDGRDVSTSIGSPFSVTETIDS
TH_3120|M.thermoresistible__bu EFGVICEVFGVDRTDDGVPPVDFTVCGPRAGQPVRTSFGATLTPDSGLDG
Mb0053|M.bovis_AF2122/97 EVRSDNAMLG-------------------------------LLCDAAFDE
Rv0052|M.tuberculosis_H37Rv EVRSDNAMLG-------------------------------LLCDAAFDE
:. :: .
Mflv_1009|M.gilvum_PYR-GCK LTNADTLLVPGGDDPARSAAP-WLSKVLRAQLNDVRRIAALGTGCFALAA
Mvan_5828|M.vanbaalenii_PYR-1 ASEVDTLLVPGGECLVAGGVPAHLRRAIRALAPGARRIASICAGSFALAA
MMAR_2855|M.marinum_M SAPVDTVVLPGGGGVDAARDNVALMDWVKAAAGTARRVVTVCTGTFLAAE
MUL_2902|M.ulcerans_Agy99 SAPVDTVVLPGGGGVDAARDNVALMDWVKAAAGTARRVVTVCTGTFLAAE
MAV_4981|M.avium_104 IESADTVLVAGSDNLPRRPIDPELVEAVKSVADRTRRLASICTGSFILGQ
MSMEG_3488|M.smegmatis_MC2_155 IEHADTVLVSGGDDLVGRPIDPQLVAAVRELAGRTRRLASICTGTFILAT
MAB_4754|M.abscessus_ATCC_1997 IECADTVLVAGGDVLIGSPLNPTLVAALAQLQARCRRIASICTGAFLLAQ
TH_3120|M.thermoresistible__bu LAGADLVAIP---AIRQDDYLPEALDAVRAAADAGAIILTVCSGAFLAGA
Mb0053|M.bovis_AF2122/97 LTRPDVVIFPGGIGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAA
Rv0052|M.tuberculosis_H37Rv LTRPDVVIFPGGIGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAA
* : .. : :: :* : .
Mflv_1009|M.gilvum_PYR-GCK AGILDGRRTTTHWRHLDAFAARHPTAVLDRESAFTRDG-PVWTSAGASAG
Mvan_5828|M.vanbaalenii_PYR-1 AGVLDGRRATTHWRHLDTFARRYPSTRVERESVYTRDG-ETWTSSGGTAG
MMAR_2855|M.marinum_M AGLLDGCRATTHWAFADRLAREFPAVDVDPDPIFIRSSPKVWTAAGVTAG
MUL_2902|M.ulcerans_Agy99 AGLLDGCRATTHWAFADRLAREFPAVDVDPDPIFIRSSPKVWTAAGVTAG
MAV_4981|M.avium_104 AGLLDGRRATTHWHDVRLFARAFPEITVEPDALFVCDG-DVFTSAGISSG
MSMEG_3488|M.smegmatis_MC2_155 AGLLAGRRATTHWRHAGLLQRAYRDVSVEPDAIFVRDG-DIYTSAGVSAG
MAB_4754|M.abscessus_ATCC_1997 AGMLDHRRATTHWRHTGLLQRAFPNVTVEPDAIFVRDA-NVFTSAGVSAG
TH_3120|M.thermoresistible__bu AGLLDGRPCTTHWGLTEELARRYPTARVDRNVLYVDDG-DLITSAGTAAG
Mb0053|M.bovis_AF2122/97 AGLLNGLTATTHWRVQDLFNSLGARYVPQRVVEHLPER--VITAAGVSSG
Rv0052|M.tuberculosis_H37Rv AGLLNGLTATTHWRVQDLFNSLGARYVPQRVVEHLPER--VITAAGVSSG
**:* **** : : . . *::* ::*
Mflv_1009|M.gilvum_PYR-GCK VDLALALVGEDHGAAVAQEIAKELVLPGRRMEGHPQLSVAARTPRPKHPE
Mvan_5828|M.vanbaalenii_PYR-1 IDLALALVGDDFGAAVAQEISKEMVVLGRRMEGHPQISAAARTPRPKHPE
MMAR_2855|M.marinum_M IDLALALVEGDHGTEIAQTVARWLVLYLRRPGGQTQFAAPVWMPRAKRPS
MUL_2902|M.ulcerans_Agy99 IDLALALVEGDHGTEIAQTVARWLVLYLRRPCGQTQFAAPVWMPRAKRPS
MAV_4981|M.avium_104 IDLALALVEMDYGTELVRAVARWLVVYLKRAGGQSQFSALVEAEPPPRSP
MSMEG_3488|M.smegmatis_MC2_155 IDLALALVELDHGSELVREVARSLVVYLKRAGGQSQFSTLIESDAPQQSA
MAB_4754|M.abscessus_ATCC_1997 IDLALALVEDDHGSEMVRDVARSLVVYLKRAGGQSQFSVFVESALPTGSA
TH_3120|M.thermoresistible__bu IDACLHLVRRELGSEVTNTIARHMVVPPQRDGGQRQFIDQPIPVRHSEG-
Mb0053|M.bovis_AF2122/97 IDMGLRLVELLVSREAAEAS------------------------------
Rv0052|M.tuberculosis_H37Rv IDMGLRLVELLVSREAAEAS------------------------------
:* * ** . ..
Mflv_1009|M.gilvum_PYR-GCK IDRLLVTISVDPAGDYELDSVAAHLGISARHLARLFKAQVGVTLRQYVHE
Mvan_5828|M.vanbaalenii_PYR-1 LERLMATVVVNPAGHYELETVAAQLGLSPRHLARLFKAQVGVTLREYVNE
MMAR_2855|M.marinum_M IRDVQEAIEAQPGGPHSIEELAHRAAMSPRHFTRVFTGEVGEAPRQYVER
MUL_2902|M.ulcerans_Agy99 IRDVQEAIEAQPGGPHSIEELAHRAAMSPRHFTRVFTGEVGEAPGRYVER
MAV_4981|M.avium_104 LRKVTAAISADPAADHSVKSLSARASLSTRQLTRLFQSELGTTPARYVEM
MSMEG_3488|M.smegmatis_MC2_155 LRRVTEAIAADPAADHSVRSLAKVAALSTRQLTRLFQSELGTTPARFVEM
MAB_4754|M.abscessus_ATCC_1997 LRPATDAIAADPAADHSVAKLAARAALSARQLTRLFHSELGTTPARYVEL
TH_3120|M.thermoresistible__bu FAPHLDWILSNLDKTHTVASLARRANMSPRTFARRFVEETGRTPMQWVTD
Mb0053|M.bovis_AF2122/97 ----QLMIEYDPQPPVDAGSLAKASPATHRLALEFYQHRL----------
Rv0052|M.tuberculosis_H37Rv ----QLMIEYDPQPPVDAGSLAKASPATHRLALEFYQHRL----------
: : :: : * . : .
Mflv_1009|M.gilvum_PYR-GCK VRLENAVGLVLAGE-SFHAAARRSGLHGGARVRDHLAGRLRVDARGAEAV
Mvan_5828|M.vanbaalenii_PYR-1 VRLENAVALVLAGE-SFHAAAQRSGLRSGARVRDHLIAR-RTPA------
MMAR_2855|M.marinum_M VRTEAARRQLEETEDTVVAIAARCGFGTAETMRRNFIRRVGISPDQYRKA
MUL_2902|M.ulcerans_Agy99 VRTEAARRQLEETEDTVVAIAARCGFGTAETMRRNFIRRVGISPDQYRKA
MAV_4981|M.avium_104 VRIDAARAALDAGR-SVAESARLAGFGSAETLRRVFVEHLGLSPKAYRDR
MSMEG_3488|M.smegmatis_MC2_155 VRIDAARAALDAGM-SVSDTARQAGFGSPETLRRVFVTHLGVSPKAYRDR
MAB_4754|M.abscessus_ATCC_1997 VRIDAARGALDAGS-TVTEAARIAGFGSAETLRRAFVSELGVSPKAYRER
TH_3120|M.thermoresistible__bu QRVLYARRLLEETDLDIHRIAARCGFGSTTLLRHHFRRVIGVTPSDYRRR
Mb0053|M.bovis_AF2122/97 --------------------------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1009|M.gilvum_PYR-GCK SVHAG--------------
Mvan_5828|M.vanbaalenii_PYR-1 -------------------
MMAR_2855|M.marinum_M FA-----------------
MUL_2902|M.ulcerans_Agy99 FA-----------------
MAV_4981|M.avium_104 FRTAARG------------
MSMEG_3488|M.smegmatis_MC2_155 FRTAARN------------
MAB_4754|M.abscessus_ATCC_1997 FRTAAR-------------
TH_3120|M.thermoresistible__bu FACGSTTSGSTESGAEVTD
Mb0053|M.bovis_AF2122/97 -------------------
Rv0052|M.tuberculosis_H37Rv -------------------