For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGVRHRLRQAVCGAAAACLVAVTAIGDVHADPASDALATLNDLSQQAVQSREALTSAQRDADVKFAEQAA ADDRHRADRAALDAANAELDPLQNAVDRMAAMDYTSGRNGQGAAVLTASSPQNLIDRLSLQRTVGARMAE NMKAYRAARERAVVAAQASEKSSADARAAAEHAEVVRAELQAKLGELLRQIAAAEAQYAALTPQQQAIVD AAPPPAAAPAPPILALPGIPPGDVAPPPAAPILDIPEALPMGVAVEAGLQPNAILAARAVSHQFPQIAEI GGVRPDSKPWHPSGLAIDIMIPNHGSPEGIALGDQIMAYAMANAARFGLQDVIWRGTYYTPAGPQASGYG HFDHVHITVMPRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0505 | - | - | 100% (364) | hypothetical protein Mflv_0505 |
| M. gilvum PYR-GCK | Mflv_2959 | - | 3e-51 | 42.91% (282) | NLP/P60 protein |
| M. gilvum PYR-GCK | Mflv_0888 | - | 3e-43 | 43.86% (228) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2213c | - | 2e-50 | 49.17% (242) | hypothetical protein Mb2213c |
| M. tuberculosis H37Rv | Rv2190c | - | 2e-50 | 49.17% (242) | hypothetical protein Rv2190c |
| M. leprae Br4923 | MLBr_00885 | - | 8e-45 | 48.80% (209) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1974 | - | 3e-37 | 42.19% (256) | hypothetical protein MAB_1974 |
| M. marinum M | MMAR_3234 | - | 5e-48 | 45.11% (266) | hypothetical protein MMAR_3234 |
| M. avium 104 | MAV_2304 | - | 2e-45 | 46.41% (237) | NLP/P60 family protein |
| M. smegmatis MC2 155 | MSMEG_6821 | - | 1e-132 | 64.85% (367) | NLP/P60 family protein |
| M. thermoresistible (build 8) | TH_1403 | - | 1e-114 | 61.45% (345) | NLP/P60 family protein |
| M. ulcerans Agy99 | MUL_3545 | - | 8e-46 | 47.08% (240) | hypothetical protein MUL_3545 |
| M. vanbaalenii PYR-1 | Mvan_5924 | - | 1e-154 | 76.22% (370) | hypothetical protein Mvan_5924 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2213c|M.bovis_AF2122/97 ------MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAAN-VLADPADDA
Rv2190c|M.tuberculosis_H37Rv ------MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAAN-VLADPADDA
MMAR_3234|M.marinum_M ------MRLDCRQLTARVIRRSAIGSLASFTALSGFVAAG-AMADPAEDA
MUL_3545|M.ulcerans_Agy99 ------MRLDCRQLTARVIRRSAIGSLASFTALSGFVAAG-AMADQAEDA
MAV_2304|M.avium_104 --------------------------------------------------
MLBr_00885|M.leprae_Br4923 ------MRLGCKHPVVRLIAHFVVGTLVGFAVLSRFFVAT-AMADPAEDA
MAB_1974|M.abscessus_ATCC_1997 MSVGRLLRNHSDRLTPSPLRRAMLAVTAAALVGGVFTGAQTATADPNNDA
Mflv_0505|M.gilvum_PYR-GCK -----------MTGVRHRLRQAVCGAAAACLVAV--TAIGDVHADPASDA
Mvan_5924|M.vanbaalenii_PYR-1 -----------MTAVRQLLRRAAYGSAAAVLVLA--VSMGDVNADPAADA
MSMEG_6821|M.smegmatis_MC2_155 -----------MTGVRRSLRRAACGFVATFLVLT--FTIGAVQADPAADA
TH_1403|M.thermoresistible__bu -------------------------------VLT--LSMGQVQADPAADA
Mb2213c|M.bovis_AF2122/97 LAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAAR
Rv2190c|M.tuberculosis_H37Rv LAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAAR
MMAR_3234|M.marinum_M LAKLNELSRQAEQTTEAMHSAELDLGAKLAAQQAAENKLTDDQAALDAAK
MUL_3545|M.ulcerans_Agy99 LAKLNELSRQAEQTTEAMHSAELELGAKLAAQQAAENKLTDDQAALDATK
MAV_2304|M.avium_104 MAKLNELSRQAEQTTEAMHSAQLDLNEKLAAQRAAEKKHDDDQAAVDAAK
MLBr_00885|M.leprae_Br4923 LAKLNELSRQAEQTTEAVHSAQLDLTEKLAAQRAADKKYTDDQAALADAQ
MAB_1974|M.abscessus_ATCC_1997 VKKLNELSRQAEATSEAANTAKIDLDAKLAAQRDAEKTVLADEAVAKAAR
Mflv_0505|M.gilvum_PYR-GCK LATLNDLSQQAVQSREALTSAQRDADVKFAEQAAADDRHRADRAALDAAN
Mvan_5924|M.vanbaalenii_PYR-1 LSKLNDLSAQAVQTREAVTAAQRDADARLAEQTAAEDRHRADLAAVDAAN
MSMEG_6821|M.smegmatis_MC2_155 IAKVQELSQQAIKAREAVTAAQRDADARQAEQAAAEERHRVDQEALAAAN
TH_1403|M.thermoresistible__bu MARLDELSRQALQSREEVTAAQREVDAKLAEQSAAEERHRADQEALAAAN
: :::** ** : * :*: : : * * *:. : . :.
Mb2213c|M.bovis_AF2122/97 ARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAH
Rv2190c|M.tuberculosis_H37Rv ARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAH
MMAR_3234|M.marinum_M GQLASFQTAVNKVAAAAYMGGRANGMDTILTAPSPQLLIDGLSMQRVMAH
MUL_3545|M.ulcerans_Agy99 GQLASFQTAVNKVAAAAYMGGRANGMDTILTAPSPQLLIDGLSMQRVMVH
MAV_2304|M.avium_104 AHLASYQNAVNNLAAATYMGGRVDGMEAILTAGSPQGLIDKLAVQRLMAT
MLBr_00885|M.leprae_Br4923 VRLATFQAAVNKLAAATYMSGRINGMTALLTAYSPQQLINKLALQRVLGV
MAB_1974|M.abscessus_ATCC_1997 MAVSTYQVDVNKAMVAAYMGGTTSGYGAVLTSNSPQNLIDQLSVQRTVGG
Mflv_0505|M.gilvum_PYR-GCK AELDPLQNAVDRMAAMDYTSGRNGQGAAVLTASSPQNLIDRLSLQRTVGA
Mvan_5924|M.vanbaalenii_PYR-1 AQLAPLQDVANRVAAMTYMSGRDGPMAAVLTAASPQQLIDRLSLQRVVAA
MSMEG_6821|M.smegmatis_MC2_155 SQLAPHQAAADRLAAMTYMSGRTGQMAAVLTATSPQQLIDQLALERTVAA
TH_1403|M.thermoresistible__bu IRLQPHQEAVNKVAAMTYMGGSTDPISATLTATAPQQLIDRLAIQRMVTV
: . * .:. . * .* : **: :** **: *:::* :
Mb2213c|M.bovis_AF2122/97 QMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQ
Rv2190c|M.tuberculosis_H37Rv QMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQ
MMAR_3234|M.marinum_M QMATQMSGFRTAREQAAKAEQASEKSAADAKSAAEQAAAVRANLQHKQSQ
MUL_3545|M.ulcerans_Agy99 QMATQMSGFRTAREQTAKAEQASEKSAADAKSAAEQAAAVRANLQHKQSQ
MAV_2304|M.avium_104 QMASQMKSYRIAGEQAAKAERESAKSAADAKSAAEQAAAVRASLQSKQSQ
MLBr_00885|M.leprae_Br4923 QMATQMAGYRDAGEQAVKAEQTSAKSAADAKHAADQAAVVRAGLQSKQSK
MAB_1974|M.abscessus_ATCC_1997 EMRSRMDSYRAAQTSADEAEQRSRDAAEAARVAAEQAKNVRASLQAKQSQ
Mflv_0505|M.gilvum_PYR-GCK RMAENMKAYRAARERAVVAAQASEKSSADARAAAEHAEVVRAELQAKLGE
Mvan_5924|M.vanbaalenii_PYR-1 TTADQMKEYRSTRERAAAAAAASERSAADARAAAERAAAVRADLQAKWSE
MSMEG_6821|M.smegmatis_MC2_155 EIAAQMKGYQEARDRALAAAAASEKSAADARAKAEQADAVRADLQAKWKD
TH_1403|M.thermoresistible__bu QITERLASFRAERERAAGAARASERSAAEARAAAERAAAEKEQLQAKWKD
.: :: : * : :: *: *::* : ** * .
Mb2213c|M.bovis_AF2122/97 LQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPG-APPAALPPG-A
Rv2190c|M.tuberculosis_H37Rv LQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPG-APPAALPPG-A
MMAR_3234|M.marinum_M LQVQIAVVKSQYLALTPDQRTALADPGQVPAGLPGAPG-PAPEGTPPGGP
MUL_3545|M.ulcerans_Agy99 LQVQIAVVKSQYLALTPDQRTALVDPGQVPAGLPGAPG-PAPEGTPPGGP
MAV_2304|M.avium_104 LQVQIAVVKSQYMSLTADQRTALANPGPAVPAAATAPGAPAPEAAPPG-T
MLBr_00885|M.leprae_Br4923 LQLQIAVVKSHYLSLSPRQRTTLAEPGPVPAVAT-LPG-----AASAGVS
MAB_1974|M.abscessus_ATCC_1997 LQVQIAVVKSQYNTLSPGQRAQLAAPAPVPPPPAAEPG-------EAGDA
Mflv_0505|M.gilvum_PYR-GCK LLRQIAAAEAQYAALTPQQQAIVD--AAPPPAAAPAP----PILALPGIP
Mvan_5924|M.vanbaalenii_PYR-1 LLRQIAAAEAQYAALTPQQQAVVDNAVPPPPLAAPAPQ-DPAIVAMPGLP
MSMEG_6821|M.smegmatis_MC2_155 LLSQISAAEAQYAALTPQQQAVVDNTPPPSAPVDPAI----VAMPGP-AP
TH_1403|M.thermoresistible__bu LLRQIAAAEAQYAALTPEQQQMVVNAAAP--------------VPGAGSP
* **:..:::* :*:. :: : . .
Mb2213c|M.bovis_AF2122/97 PPGDGPAPGVAPPP--GGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYA
Rv2190c|M.tuberculosis_H37Rv PPGDGPAPGVAPPP--GGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYA
MMAR_3234|M.marinum_M PPAGAPVPGEAPPP--GGVSAMPFTPPDGAGGDRAAVVQAALTQVGTPYA
MUL_3545|M.ulcerans_Agy99 PPAGAPVPGEAPPPGAGGVSAMPFTPPDGAGGDRAAVVQAALTQVGTPYA
MAV_2304|M.avium_104 PPG-GPGPGEAPPP--GGAPGMAPGGGGVGGGDRATVVQAALTQVGSPYV
MLBr_00885|M.leprae_Br4923 PPP------DAAPP--GGLLGVAP-APFAGGGDRAAVVQAALTQIGSPYA
MAB_1974|M.abscessus_ATCC_1997 PEPLMQAAAAAPAP--------EAAIGGGGSPAGAGAVAAALTRIGAPYS
Mflv_0505|M.gilvum_PYR-GCK PGDVAPPP-AAPILDIPEALPMGVAVEAGLQPNAILAARAVSHQFPQIAE
Mvan_5924|M.vanbaalenii_PYR-1 PGDIAPPPLAAAIADIPEALPMGVASEVGLQPNAILAARAVSRQFPQIAN
MSMEG_6821|M.smegmatis_MC2_155 GEDPAARNLLAIPGDIPEALPVGVANETGLQPATVYVARVISMRYPQIAE
TH_1403|M.thermoresistible__bu LELAAARADLNL-----ESLPVGVAPEAGLQPNTVLVARAISARFPQIAE
.. . :
Mb2213c|M.bovis_AF2122/97 WGGAAPGG--FDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPG
Rv2190c|M.tuberculosis_H37Rv WGGAAPGG--FDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPG
MMAR_3234|M.marinum_M WGGAAPGG--FDCSGLVMWAFQQAGIALPHSSQALAHGGQPVSLSDLQPG
MUL_3545|M.ulcerans_Agy99 WGGAAPGG--FDCSGLVMWAFQQAGIALPHSSQALAHEGQPVSLSDLQPG
MAV_2304|M.avium_104 WGGAAPGG--FDCSGLVMWAFQQAGISLPHSSQALAHGGQPVSLSDLQPG
MLBr_00885|M.leprae_Br4923 WGGAAPGG--FDCSGLVMWAYQQAGIALPHSSQALARGGQPVSLSELQPG
MAB_1974|M.abscessus_ATCC_1997 WGGSGPNA--FDCSGLVMWAYGQQGVSLPHSSQALARGGTPVSLSELQPG
Mflv_0505|M.gilvum_PYR-GCK IGGVRPDSKPWHPSGLAIDIMIPN----HGSPEGIALG-DQIMAYAMANA
Mvan_5924|M.vanbaalenii_PYR-1 IGGVRPDSKPWHPSGLAIDIMIPN----SDSPEGIALG-DQIMAYAMANA
MSMEG_6821|M.smegmatis_MC2_155 IGGVRPDSKPWHPSGLAIDVMIPN----PSSPEGIALG-NEIRDFVLSNA
TH_1403|M.thermoresistible__bu IGGVRPDSLPWHPSGLAIDVMIPN----HHSPEGIALG-DEIMAFVLSNA
** *.. :. ***.: *.:.:* : : .
Mb2213c|M.bovis_AF2122/97 DVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY
Rv2190c|M.tuberculosis_H37Rv DVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY
MMAR_3234|M.marinum_M DVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMNSSGPIYDARRY
MUL_3545|M.ulcerans_Agy99 DVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMNSSGPIYDARRY
MAV_2304|M.avium_104 DVLTFYSDASHAGIYIGDGMMIHSSTYGVPVRVVPMNSSGPIYDARRY
MLBr_00885|M.leprae_Br4923 DVLTFYSDASHAGIYVGDGMMIHSSTYGVPVRVVPMNSSGPIYDARRY
MAB_1974|M.abscessus_ATCC_1997 DVINFYGDASHTGIYVGNGMMVHASTYGVPVAVVPITSSGPIYNARRY
Mflv_0505|M.gilvum_PYR-GCK ARFGLQDVIWRGTYYTPAGPQASGYGHFDHVHITVMPRR---------
Mvan_5924|M.vanbaalenii_PYR-1 ARFGLQDVIWRGTYYTPAGPQGSGYGHYDHVHITVTPRR---------
MSMEG_6821|M.smegmatis_MC2_155 GRFKLQDVIWRGTYYTPSGPQASGYGHFDHVHVTTLRR----------
TH_1403|M.thermoresistible__bu ARFGVQDVIWRGTYYTPSGPQGSGYGHFDHVHVTTLPGR---------
: . . : * * . : * :.