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MRQCWVTPAPTPQQMYPDPAKGSTVASDLLSQVVNSGPGSFLAKQLGVPQPEPLRRYKQGEPPLVGSLLI GGEGRVVEPLRAALADDYDVVANNLGGRWADSFGGLVYDATGITEPEGLKGLKGLYEFFTPLLRNLGHSG RVVVIGTTPEETGSIHERTVQRALEGFTRSLAKELRNGSTASLVYLSADAKPAATGLESTLRFLLSGKSA YVDGQVFHIGAADATPPADWDKPLDGKVAVVTGAARGIGATIAQVFARDGAKVIAVDVEGAVEALTETAT KVGGTALTLDVTAADAVDRITEHVREHYDGTLDILVNNAGITRDKLLANMDESRWDSVIAVNLLAPLRLA EELVGSGLIGDGGRIVGLSSMAGIAGNRGQTNYAATKAGMIGLTDALAPQFAEKNITINAVAPGFIETKM TEAIPLATREVGRRLNSLFQGGQPVDVAEAIAFFASPASNAVTGNTIRVCGQAMLGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0412 | fabG | - | 100% (477) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 3e-38 | 40.00% (245) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_3658 | - | 5e-32 | 37.13% (237) | 3-oxoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0248c | fabG | 0.0 | 80.53% (452) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv0242c | fabG | 0.0 | 80.53% (452) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 0.0 | 75.00% (452) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4443 | fabG | 0.0 | 72.63% (453) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. marinum M | MMAR_0503 | fabG | 0.0 | 79.69% (453) | 3-oxoacyl- |
| M. avium 104 | MAV_4916 | fabG | 0.0 | 81.46% (453) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_0372 | fabG | 0.0 | 82.12% (453) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_4166 | - | 0.0 | 80.48% (456) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_1166 | fabG | 0.0 | 79.47% (453) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_0259 | fabG | 0.0 | 91.42% (466) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0412|M.gilvum_PYR-GCK MRQCWVTPAPTPQQMYPDPAKGSTVASDLLSQVVNSGPGSFLAKQLGVPQ
Mvan_0259|M.vanbaalenii_PYR-1 MDATVLGNPITVDNDVPRSSKGSAVASDLLSQVVNSGPGSFLAKQLGVPQ
TH_4166|M.thermoresistible__bu ------------------------MATDLYSQIVHSTPGSFLARQLGIPQ
MSMEG_0372|M.smegmatis_MC2_155 ------------------------MASDLFSQVVNSGPGSFLAKQLGVPQ
MLBr_02565|M.leprae_Br4923 --------------------MAPKCSSDLFSQIVSSGPGSFVAKQLGVPR
MAV_4916|M.avium_104 --------------------MAPKVSSDLFSQIVNSGPGSFLAKQLGVPQ
Mb0248c|M.bovis_AF2122/97 --------------------MAPKRSSDLFSQVVNSGPGSFLARQLGVPQ
Rv0242c|M.tuberculosis_H37Rv --------------------MAPKRSSDLFSQVVNSGPGSFLARQLGVPQ
MMAR_0503|M.marinum_M --------------------MAPKLSSDLFSQVVNSGPGTFVAKQLGVPQ
MUL_1166|M.ulcerans_Agy99 --------------------MAPRLSSDLFSQVVNSGPGTFVAKQLGVPQ
MAB_4443|M.abscessus_ATCC_1997 --------------------MSPKLTDDLYALLVNSGPGNLLAGRLGIPQ
: ** : :* * **.::* :**:*:
Mflv_0412|M.gilvum_PYR-GCK PEPLRRYKQGEPPLVGSLLIGGE-----GRVVEPLRAALADDYDVVANNL
Mvan_0259|M.vanbaalenii_PYR-1 PEPLRRYKQGEPPLAGSLLIGGSGAAGGGRVVEPLRAALADDYDVVANNL
TH_4166|M.thermoresistible__bu PEPLRRYRPGEPPLAGSLLIGGD-----GRVVEPLRTALADDYQLVGNNL
MSMEG_0372|M.smegmatis_MC2_155 PETLRRYRPGDPPLAGSLLIGGS-----GRVAEPLRTALADDYNLVSNNI
MLBr_02565|M.leprae_Br4923 PETLRRYRPSDAPLCGSLLIGGD-----GRLVEPLRATLEKDYDLVSNNL
MAV_4916|M.avium_104 PETLRRYRPGDPPLAGSLLIGGE-----GRVVEPLRAALAKDYDLVGNNL
Mb0248c|M.bovis_AF2122/97 PETLRRYRAGEPPLTGSLLIGGA-----GRVVEPLRAALEKDYDLVGNNL
Rv0242c|M.tuberculosis_H37Rv PETLRRYRAGEPPLTGSLLIGGA-----GRVVEPLRAALEKDYDLVGNNL
MMAR_0503|M.marinum_M AETLRRYRPGDPPLAGSLLIGGE-----GRVAEPLRAALAKDYDQVSNNL
MUL_1166|M.ulcerans_Agy99 AETLRRYRPGDPPLAGSLLIGGE-----GRVAEPLRAALAKDYDQVSNNL
MAB_4443|M.abscessus_ATCC_1997 PEKLRRYKKGQPALAGPVLIGGE-----GRLAEPLRAALADDYEVVSNNL
.* ****: .:..* *.:**** **:.****::* .**: *.**:
Mflv_0412|M.gilvum_PYR-GCK GGRWADSFGGLVYDATGITEPEGLKGLKGLYEFFTPLLRNLGHSGRVVVI
Mvan_0259|M.vanbaalenii_PYR-1 GGRWADSFGGLVYDATAITEPE---GLKGLYQFFTPLMRNLGHSGRVVVI
TH_4166|M.thermoresistible__bu GGRWADKFGGLLFDATGITEPA---GLKALYEFFTPLLRNVGPCARIAVV
MSMEG_0372|M.smegmatis_MC2_155 GGRWADSFGGVVFDATGITEAE---GLKELYTFFTPLLRNLAPCARVVVV
MLBr_02565|M.leprae_Br4923 GGRWTDSFGGLVFDATGITAPA---ELKGLHNFFTPLLRNLGRCARVVVI
MAV_4916|M.avium_104 GGRWADRFGGLVFDATGITTPE---GLKGLYEFFTPLLRNLGHCARVVVV
Mb0248c|M.bovis_AF2122/97 GGRWADSFGGLVFDATGITEPA---GLKGLHEFFTPVLRNLGRCGRVVVV
Rv0242c|M.tuberculosis_H37Rv GGRWADSFGGLVFDATGITEPA---GLKGLHEFFTPVLRNLGRCGRVVVV
MMAR_0503|M.marinum_M GGRWADSFGGLVFDATGITDPA---GLKGLHDFFKPVLRNLGASARVVVV
MUL_1166|M.ulcerans_Agy99 GGRWADSFGGLVFDATGITDPA---GLKGLHDFFKPVLRNLGASARVVVV
MAB_4443|M.abscessus_ATCC_1997 GGRWADKFGALVFDATGITTPV---ELKALHEFFTPLLRNVGKSGRLLVI
****:* **.:::***.** . ** *: **.*::**:. ..*: *:
Mflv_0412|M.gilvum_PYR-GCK GTTPEETGSIHERTVQRALEGFTRSLAKELRNGSTASLVYLSADAKPAAT
Mvan_0259|M.vanbaalenii_PYR-1 GTTPEETGSVHERTAQRALEGFTRSLAKELRNGSTASLVYLSPDAKPAAT
TH_4166|M.thermoresistible__bu GTTPEETGSVNERIAQRALEGFTRSLAKEMRRGATVNLVYLSPEAKPAAT
MSMEG_0372|M.smegmatis_MC2_155 GTTPAEAGSVHAQVVQRALEGFTRSLGKELRRGATVSLVYLSADAKPGAT
MLBr_02565|M.leprae_Br4923 GTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVALVYLSPDAKPAAT
MAV_4916|M.avium_104 GTTPDAAAGTHERIAQRALEGFTRSLGKELRNGSTVALVYLSPAAKPAAT
Mb0248c|M.bovis_AF2122/97 GGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAAT
Rv0242c|M.tuberculosis_H37Rv GGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAAT
MMAR_0503|M.marinum_M GTTPDAIDNSHERIAQRALEGFTRSLAKELRRGSTAALVYLSPEAKPAAT
MUL_1166|M.ulcerans_Agy99 GTTPDAIDNSHERIAQRALEGFTRSLAKELRRASTAALVYLSPEAKPAAT
MAB_4443|M.abscessus_ATCC_1997 GTTPDKAATTDERIAQRALEGFTRSLAKEFSNGATVQLVYLHPDAKTGAT
* ** . : .*******:***.**: ..:*. **** . **..**
Mflv_0412|M.gilvum_PYR-GCK GLESTLRFLLSGKSAYVDGQVFHIGAADATPPADWDKPLDGKVAVVTGAA
Mvan_0259|M.vanbaalenii_PYR-1 GLESTLRFLLSGKSAYVDGQVFRVGAADATPPADWDRPLEGKVAVVTGAA
TH_4166|M.thermoresistible__bu GLESTIRFIMSAKSAYVDGQVFRVGPADSVPPADWDKPLDGKVAVVTGAA
MSMEG_0372|M.smegmatis_MC2_155 GLESTMRFILSAKSAYVDGQVFRVGAADSTPPADWDKPLDGKVAVVTGAA
MLBr_02565|M.leprae_Br4923 GLESTMRFILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAA
MAV_4916|M.avium_104 GLESTMRFILSAKSAYVDGQVFYVGEADSTPPADWERPLDGKVAIVTGAA
Mb0248c|M.bovis_AF2122/97 GLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAA
Rv0242c|M.tuberculosis_H37Rv GLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAA
MMAR_0503|M.marinum_M GLESTVRFILSAKSAYVDGQVFYVGAADSTPPADWDRPLEGKVAIVTGAA
MUL_1166|M.ulcerans_Agy99 GLESTVRFILSAKSAYVDGQVFYVGAADSTPPADWDRPLEGKVAIVTGAA
MAB_4443|M.abscessus_ATCC_1997 GLESTVRFILSAKSTYVDGQVFYVGADDSTAPADWDKPLAGKVAIVTGAA
*****:**::*.**:**:**** :* *:..*::*::** .***:*****
Mflv_0412|M.gilvum_PYR-GCK RGIGATIAQVFARDGAKVIAVDV---EGAVEALTETATKVGGTALTLDVT
Mvan_0259|M.vanbaalenii_PYR-1 RGIGATIAEVFARDGAKVIAVDV---EGAAEALAETATKVGGTALTLDVT
TH_4166|M.thermoresistible__bu RGIGATIAEVFARDGARVVAVDIGDAAGANDALAETAAKVNGTALVLDVT
MSMEG_0372|M.smegmatis_MC2_155 RGIGATIAEVFARDGATVVAIDV---DGAAEDLKRVADKVGGTALTLDVT
MLBr_02565|M.leprae_Br4923 RGIGAAIAEVVARDGARVVAIDV---ESAAEALDETANRVGGTTLSLDVT
MAV_4916|M.avium_104 RGIGATIAEVFARDGARVVAIDV---ESAAETLAETASRVGGTALWLDVT
Mb0248c|M.bovis_AF2122/97 RGIGATIAEVFARDGAHVVAIDV---ESAAENLAETASKVGGTALWLDVT
Rv0242c|M.tuberculosis_H37Rv RGIGATIAEVFARDGAHVVAIDV---ESAAENLAETASKVGGTALWLDVT
MMAR_0503|M.marinum_M RGIGQTIAEVFARDGASVVAIDV---ESAADALAETAASVGGTPLWLDVT
MUL_1166|M.ulcerans_Agy99 RGIGQTIAEVFARDGASVVAIDV---ESAADALAETAASVGGTPLWLDVT
MAB_4443|M.abscessus_ATCC_1997 RGIGETIAEVFARDGAAVVAIDM-----PSEELNELASRVGGTALALDVT
**** :**:*.***** *:*:*: . : * . * *.**.* ****
Mflv_0412|M.gilvum_PYR-GCK AADAVDRITEHVREHYDGTLDILVNNAGITRDKLLANMDESRWDSVIAVN
Mvan_0259|M.vanbaalenii_PYR-1 AADAVDRIAEHVREHYEGRLDILVNNAGITRDKLLANMDEARWDSVLAVN
TH_4166|M.thermoresistible__bu ADDAVDRITEHVREHYDGKVDILVNNAGITRDKLLVNMTEDRWDAVIAVN
MSMEG_0372|M.smegmatis_MC2_155 ADDAVDKITAHVTEHHGGKVDILVNNAGITRDKLLANMDEKRWDAVIAVN
MLBr_02565|M.leprae_Br4923 ADDAVDKITEHLHDYQGGHADILVNNAGITRDKLLANMDDCRWDAVLEVN
MAV_4916|M.avium_104 APDAVDKITEHLREHHGGHADILVNNAGITRDKLLANMDDARWDAVLAVN
Mb0248c|M.bovis_AF2122/97 ADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVN
Rv0242c|M.tuberculosis_H37Rv ADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVN
MMAR_0503|M.marinum_M ADDAVDKITEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDSVIAVN
MUL_1166|M.ulcerans_Agy99 ADDAVDKITEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDSVIAVN
MAB_4443|M.abscessus_ATCC_1997 SEDAVDTITAHLKEHHGGKADILVNNAGITRDKLLKNMDDARWDSVIAVN
: **** *: *: :: * *************** ** : ***:*: **
Mflv_0412|M.gilvum_PYR-GCK LLAPLRLAEELVGSGLIGDGGRIVGLSSMAGIAGNRGQTNYAATKAGMIG
Mvan_0259|M.vanbaalenii_PYR-1 LLAPLRLAEGLVASGLIGDGGRIIGLSSMAGIAGNRGQTNYAATKAGMIG
TH_4166|M.thermoresistible__bu LLAPQRLTEGLFGNGTLAEGGRVVGLSSMAGIAGNRGQTNYAATKAGMIG
MSMEG_0372|M.smegmatis_MC2_155 LLAPQRLTEGLVGNGTIGEGGRVIGLSSMAGIAGNRGQTNYATTKAGMIG
MLBr_02565|M.leprae_Br4923 LLAPQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNYATAKAGVIG
MAV_4916|M.avium_104 LLAPLRLTEGLVGNGSIGEGGRIVGLSSMAGIAGNRGQTNYATTKAGMIG
Mb0248c|M.bovis_AF2122/97 LLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIG
Rv0242c|M.tuberculosis_H37Rv LLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIG
MMAR_0503|M.marinum_M LLAPLRLTEGLVGNGSIGAGGRVIGLSSIAGIAGNRGQTNYGATKAGMIG
MUL_1166|M.ulcerans_Agy99 LLAPLRLTEGLVGNGSIGAGGRVIGLSSIAGIAGNRGQTNYGATKAGMIG
MAB_4443|M.abscessus_ATCC_1997 LLAPQRLTEGLIGNGTIGEGGRVIGLASIAGIAGNRGQTNYGATKAGMIG
**** **:* *...* :. ***:: *:*:************.::***:**
Mflv_0412|M.gilvum_PYR-GCK LTDALAPQFAEKNITINAVAPGFIETKMTEAIPLATREVGRRLNSLFQGG
Mvan_0259|M.vanbaalenii_PYR-1 LTDALAPQFAEKNITINAVAPGFIETKMTDAIPFATREVGRRLNSLFQGG
TH_4166|M.thermoresistible__bu LTDALAPVLAEKNITINAVAPGFIETKMTEAIPFATREVGRRLNSLYQGG
MSMEG_0372|M.smegmatis_MC2_155 LAEALAPVLADKGITINAVAPGFIETKMTEAIPLATREVGRRLNSLFQGG
MLBr_02565|M.leprae_Br4923 LTQALAPGLAEKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGG
MAV_4916|M.avium_104 LTQALAPELYDKGITINAVAPGFIETQMTAAIPLATREVGRRMNSLLQGG
Mb0248c|M.bovis_AF2122/97 ITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGG
Rv0242c|M.tuberculosis_H37Rv ITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGG
MMAR_0503|M.marinum_M IAQALAPSLAEKDITINAVAPGFIETKMTAAIPLATREVGRRLNSLLQGG
MUL_1166|M.ulcerans_Agy99 IAQALAPSLAEKDITINAVAPGFIETKMTAAIPLATREVGRRLNSLLQGG
MAB_4443|M.abscessus_ATCC_1997 ITQALAPSLAEKGITINAVAPGFIETKMTAAIPLANREVGRRINSLNQGG
:::**** : *.*************:** ***:*.******:*** ***
Mflv_0412|M.gilvum_PYR-GCK QPVDVAEAIAFFASPASNAVTGNTIRVCGQAMLGA
Mvan_0259|M.vanbaalenii_PYR-1 QPVDVAEAIAYFASPGSNAVSGNTIRVCGQAMLGA
TH_4166|M.thermoresistible__bu QPVDVAETIAYFANPASNAVTGNTIRVCGQAMLGA
MSMEG_0372|M.smegmatis_MC2_155 QPVDVAELIAYFASPASNAVTGNTIRVCGQAMLGA
MLBr_02565|M.leprae_Br4923 LPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA
MAV_4916|M.avium_104 QPVDVAETIAYFASPASNAVTGNVIRVCGQAMLGA
Mb0248c|M.bovis_AF2122/97 QPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
Rv0242c|M.tuberculosis_H37Rv QPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
MMAR_0503|M.marinum_M QPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
MUL_1166|M.ulcerans_Agy99 QPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
MAB_4443|M.abscessus_ATCC_1997 EPVDVAETIAYFASPASNAVTGNVVRVCGQSWLGA
****** **:** *.****:**.:*****: :**