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VSQPLHTSHIDLTVDGDQRSLDVDNRLTLLDALREKLGATAPKKGCDHGQCGSCTVLVDGRRVTSCLTFA VAADGMRVTTAAGLGDADTLHPVAQAFQDEDAFQCGYCTPGQICSAVGMLDEVKSGAPSFVSDDLDAPPE LTADEIRERMSGNLCRCAAYPNIVAAIGRAADR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0282 | - | - | 100% (173) | 2Fe-2S iron-sulfur cluster binding domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1570 | - | 2e-33 | 42.01% (169) | 2Fe-2S iron-sulfur cluster binding domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0381c | - | 2e-24 | 36.81% (163) | carbon monoxyde dehydrogenase small subunit |
| M. tuberculosis H37Rv | Rv0374c | - | 2e-24 | 36.81% (163) | carbon monoxyde dehydrogenase small subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2925c | - | 2e-17 | 34.07% (135) | xanthine dehydrogenase family protein |
| M. marinum M | MMAR_0834 | coxS_1 | 7e-46 | 53.53% (170) | carbon monoxyde dehydrogenase (small chain), CoxS_1 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0686 | - | 1e-81 | 83.82% (173) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1272 | - | 8e-38 | 44.97% (169) | PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL CHAIN) |
| M. ulcerans Agy99 | MUL_4578 | coxS_1 | 5e-46 | 53.53% (170) | carbon monoxyde dehydrogenase (small chain), CoxS_1 |
| M. vanbaalenii PYR-1 | Mvan_2076 | - | 7e-48 | 56.47% (170) | 2Fe-2S iron-sulfur cluster binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0381c|M.bovis_AF2122/97 --------------------------------------------MQVNMT
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------MQVNMT
Mflv_0282|M.gilvum_PYR-GCK MSQ-------------------------------------PLHTSHIDLT
MSMEG_0686|M.smegmatis_MC2_155 MSQ-------------------------------------PDHTSHVTLE
Mvan_2076|M.vanbaalenii_PYR-1 MTTGR-----------------------------TDVTVPPPPTRRIELT
MMAR_0834|M.marinum_M MDDGLGLRVNRRTFVGTSVAVGGAVAAVTAIPGSERVHQGDGHTAVVRLQ
MUL_4578|M.ulcerans_Agy99 MDDGLGLRVNRRTFVGTSVAVGGAVAAVTAIPGSERVHQGDGHTAVVRLQ
TH_1272|M.thermoresistible__bu -----------------------------------------VHDHQVELT
MAB_2925c|M.abscessus_ATCC_199 ------------------------------------------------MK
:
Mb0381c|M.bovis_AF2122/97 VNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNCGTCVVEVDGVPV
Rv0374c|M.tuberculosis_H37Rv VNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNCGTCVVEVDGVPV
Mflv_0282|M.gilvum_PYR-GCK VDGDQRSLDVDNRLTLLDALREKLGATAPKKGCDHGQCGSCTVLVDGRRV
MSMEG_0686|M.smegmatis_MC2_155 VDGARRELTVDNRVTLLDALREHLQVTAPKKGCDHGQCGSCTVLLDGRRV
Mvan_2076|M.vanbaalenii_PYR-1 VNGVTRTVETDVRSTLLDLLREGLALTGTKKGCDHGLCGACTVEVDHERV
MMAR_0834|M.marinum_M INGEHREIAVDNRTSLLDMLRERAGLPGTKKGCDQGACGSCTVLVDGRRI
MUL_4578|M.ulcerans_Agy99 INGEHREIAVDNRTSLLDMLRERAGLPGTKKGCDQGACGSCTVLVDGRRI
TH_1272|M.thermoresistible__bu VNGQRTSAPVESRLTLADFLRERCGLTGTHLGCEHGACGACTVIMDGAAV
MAB_2925c|M.abscessus_ATCC_199 VNGKLIDASPRPGQCLRTFLREHG-HVEVKKGCDAGDCGACTVLVDGASQ
::* * **: : **: . **:*.* :*
Mb0381c|M.bovis_AF2122/97 KSCTMLAVMASGHSIRTVEGLAG---PDGQLDPVQEGFMRCHGLQCGFCT
Rv0374c|M.tuberculosis_H37Rv KSCTMLAVMASGHSIRTVEGLAG---PDGQLDPVQEGFMRCHGLQCGFCT
Mflv_0282|M.gilvum_PYR-GCK TSCLTFAVAADGMRVTTAAGLG----DADTLHPVAQAFQDEDAFQCGYCT
MSMEG_0686|M.smegmatis_MC2_155 TTCLTFAVAADGARITTAAGLG----LNDELHPVAQAFCDEDAFQCGYCT
Mvan_2076|M.vanbaalenii_PYR-1 LSCLTLAVSIDGAAVGTVEGFA----DGEHLDPLQQAFVDHDGFQCGYCT
MMAR_0834|M.marinum_M NSCLALAVMHDGAQITTIEGLTGSAGPDGRLHPLQQAFIDEDALQCGYCT
MUL_4578|M.ulcerans_Agy99 NSCLALAVMHDGAQITTIEGLTGSAGPDGRLHPLQQAFIDEDALQCGYCT
TH_1272|M.thermoresistible__bu RSCLVFAVQADGSEVTTVEGIAS---PDGELSPVQQAMRDCHGLQCGFCT
MAB_2925c|M.abscessus_ATCC_199 HSCIVPAHRVTDAEIHTVRSLAG----EHDLHPMQRGFIDHAGFQCGFCT
:* * . : * .: * *: ..: .:***:**
Mb0381c|M.bovis_AF2122/97 PGMLITARALLDRNPDP---------------------DEQTIREAISGQ
Rv0374c|M.tuberculosis_H37Rv PGMLITARALLDRNPDP---------------------DEQTIREAISGQ
Mflv_0282|M.gilvum_PYR-GCK PGQICSAVGMLDEVKSG---APSFVSDD---LDAPPELTADEIRERMSGN
MSMEG_0686|M.smegmatis_MC2_155 PGQICSAVGMLDEVKAG---APSFVADD---LDAPPVLSEREIRERMSGN
Mvan_2076|M.vanbaalenii_PYR-1 PGQLCSARAMLREHARGDLSAASFDPADRDVVDGPQHLSENEIRERMAGN
MMAR_0834|M.marinum_M PGQIMSGVACIAEGHAG---------------------SPAEIREWMSGN
MUL_4578|M.ulcerans_Agy99 PGQIMSGVACIAEGHAG---------------------SPAEIREWMSGN
TH_1272|M.thermoresistible__bu PGFVTTITAMLQENPDP---------------------TDEEIREGLSGN
MAB_2925c|M.abscessus_ATCC_199 AGMVLTAATLTGDQTED-------------------------LGNALKGN
.* : : : : : *:
Mb0381c|M.bovis_AF2122/97 ICRCTGYTTIVRSIQWAAAHQTVKAQS-----------------------
Rv0374c|M.tuberculosis_H37Rv ICRCTGYTTIVRSIQWAAAHQTVKAQS-----------------------
Mflv_0282|M.gilvum_PYR-GCK LCRCAAYPNIVAAIGRAADR------------------------------
MSMEG_0686|M.smegmatis_MC2_155 LCRCAAYPNIVAAIERAANR------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 ICRCGAYANIVAAISAVHGAS-----------------------------
MMAR_0834|M.marinum_M LCRCGAYPNIVKAVASVARDD-----------------------------
MUL_4578|M.ulcerans_Agy99 LCRCGAYPNIVKAVASVARDD-----------------------------
TH_1272|M.thermoresistible__bu FCRCTGYQGIIKAVRQAAEAMRA---------------------------
MAB_2925c|M.abscessus_ATCC_199 LCRCTGYRPIRDAVCGVVPPRGSVSAPAAARVVTGTEPYTMDELPAGVGH
:*** .* * :: .
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 VAVLGSPHPSARITRIDTDRARLLPGVRAVLCYRDDPGVPFSTARHHERT
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 DDPDDTLVFDRVLRFAGQRVAAVVADTPAIAHRALEHIDVEYEVLPAVFD
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 PEMAQLPGAHLVHGDKGLGARIADPARNLVAEVHGEVGDVAAALARARES
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 GAVVTGSWQTARVQHVHLETHGSVGWQDERGRYVLRTSSQVPFLVRDELC
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 HVFGLAREQVRVFAPRVGGGFGAKQEMLTEDLVLLAVRVTGAPVVYEFTR
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 SDQFTIAPCRHPMRVNVTAAADGDGVLTALAVDVLSDAGAYGNHSVGVMF
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 HGCNESMAQYRCANKRVDAQAVYTNNIPSGAFRGYGLGQVLFGIESALDE
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 LARNLGIDPFEFRRRNVIVPGDSFVSWEVEEDDLAFGSYGLDQCLDLAQD
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 ALARGAADPARNGSDLPAGWKVGEGMAIAMIATVPPRGHVADARAELDAR
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 GRYRISVGSAEFGNGTTTVHAQLAAGVLGCAPDQVYIHQADTDAVSHDTG
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 AFGSAGTTVAGLAVYRAAELLRDQIIRFAATKLAVPQSRCVLEPDGVRAG
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 ADLLGLTEIAASAPEPLSAVGHHEGTPRSVAFNVQAFRVAVRPQTGTVRI
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 LQSVQTADAGVVVNPQQCRGQVEGGVAQAIGSALYEEILVHDGFVSTTAL
Mb0381c|M.bovis_AF2122/97 --------------------------------------------------
Rv0374c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0282|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0686|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0834|M.marinum_M --------------------------------------------------
MUL_4578|M.ulcerans_Agy99 --------------------------------------------------
TH_1272|M.thermoresistible__bu --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199 RNYHIPRLVDVPDTEVYFADTYDTFGPLGAKSMSESPYNPVAPALANAIR
Mb0381c|M.bovis_AF2122/97 ------------------------------
Rv0374c|M.tuberculosis_H37Rv ------------------------------
Mflv_0282|M.gilvum_PYR-GCK ------------------------------
MSMEG_0686|M.smegmatis_MC2_155 ------------------------------
Mvan_2076|M.vanbaalenii_PYR-1 ------------------------------
MMAR_0834|M.marinum_M ------------------------------
MUL_4578|M.ulcerans_Agy99 ------------------------------
TH_1272|M.thermoresistible__bu ------------------------------
MAB_2925c|M.abscessus_ATCC_199 DAVGVRVYRLPMNAARVWRVINDSGGGESS