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GTSLLGGVPVAENVPLAPLTTLRVGPVARRLVTCVTTDQIVDAVMAAGPEALILAGGSNVVLAGDAADLT VVRLANTRISVDGDVVRAEAGAGWDDVVAASLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEVADTIRR VRLLERGTGSVRWVSPEFLRFGYRTSVLKHSSQWVVLEVEFGLDAAGHSAPVRYRELATELAVEQGERTD PQRVRAAVLELRARKGMVLDAADHDTWSVGSFFTNPVVSRAEFERIAATVGSAVPNYPAEDGVKLAAGWL VEQAGFGKGYPGADAPARLSTKHALALTNRGTATTADVLALARTVRDGVKAAFGIELTPEPVLVGCSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0090 | murB | - | 100% (349) | UDP-N-acetylenolpyruvoylglucosamine reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0492 | murB | 1e-128 | 66.02% (362) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. tuberculosis H37Rv | Rv0482 | murB | 1e-128 | 66.02% (362) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. leprae Br4923 | MLBr_02447 | murB | 1e-128 | 66.20% (361) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. abscessus ATCC 19977 | MAB_4066c | - | 1e-119 | 63.32% (349) | UDP-N-acetylenolpyruvoylglucosamine reductase MurB |
| M. marinum M | MMAR_0808 | murB | 1e-130 | 67.69% (359) | UDP-N-acetylenolpyruvoylglucosamine reductase MurB |
| M. avium 104 | MAV_4668 | murB | 1e-129 | 65.93% (361) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. smegmatis MC2 155 | MSMEG_0928 | murB | 1e-142 | 73.61% (360) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. thermoresistible (build 8) | TH_0875 | - | 1e-147 | 76.27% (354) | PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB |
| M. ulcerans Agy99 | MUL_4552 | murB | 1e-130 | 67.41% (359) | UDP-N-acetylenolpyruvoylglucosamine reductase |
| M. vanbaalenii PYR-1 | Mvan_0823 | murB | 1e-162 | 83.19% (345) | UDP-N-acetylenolpyruvoylglucosamine reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0492|M.bovis_AF2122/97 ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA
Rv0482|M.tuberculosis_H37Rv ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA
MLBr_02447|M.leprae_Br4923 ---MKRSAVGSFFAGAHVAEAVSLAPLTTLRVGPVAQRVITCASTEQVVD
MAV_4668|M.avium_104 ---MKSSGAGAAFAGASVADAVPLAPLTTLRVGPTARRLITCASSEQVIA
MMAR_0808|M.marinum_M ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG
MUL_4552|M.ulcerans_Agy99 ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG
Mflv_0090|M.gilvum_PYR-GCK -------MGTSLLGGVPVAENVPLAPLTTLRVGPVARRLVTCVTTDQIVD
Mvan_0823|M.vanbaalenii_PYR-1 -----------MSGGVPFAEQVPLAPLTTLRVGPVARRLITCVATEQIGP
MSMEG_0928|M.smegmatis_MC2_155 -------MASSHVAGVEIAEAVPLAPLTTLRIGPVARRMLTCTSTEQLIG
TH_0875|M.thermoresistible__bu -------VVGSRVAGVPVAEGVPLAPLTTLRVGPVARRLIECTATDQVIG
MAB_4066c|M.abscessus_ATCC_199 MGLARTTRAEIEDLGAVVTEGAALAPLTTLRLGPVAATLIRCESTRQVTG
*. .:: ..********:** * :: * :: *:
Mb0492|M.bovis_AF2122/97 ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN
Rv0482|M.tuberculosis_H37Rv ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN
MLBr_02447|M.leprae_Br4923 VIRQLDAPAGGRGAGPLLIFAGGSNLVIADTLADLTAVRLANAGITIDGN
MAV_4668|M.avium_104 TLRRLDTERLAGQRDPVLVFAGGSNLVISDALSDLTAVRLANDGITVEGN
MMAR_0808|M.marinum_M VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTIDGN
MUL_4552|M.ulcerans_Agy99 VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTVDGN
Mflv_0090|M.gilvum_PYR-GCK AVMAAGPEAL--------ILAGGSNVVLAGDAADLTVVRLANTRISVDGD
Mvan_0823|M.vanbaalenii_PYR-1 AVRAAGPDAL--------ILAGGSNVVIADDLADLTVVRLANTGIVVDGA
MSMEG_0928|M.smegmatis_MC2_155 VLRALTADDE-----PLLILAGGSNVVLADDLTDLTVVRIANTEITVDGD
TH_0875|M.thermoresistible__bu VLRVLDADRTG----PMLVLAGGSNVVLADDLTDLTVVRLANDRISVDGH
MAB_4066c|M.abscessus_ATCC_199 TLAALDG-------HPALLLAGGSNVVLADDLADVTAVHIAAAGVTVDGS
.: ::*****:*:. :*:*.*::* : ::*
Mb0492|M.bovis_AF2122/97 LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
Rv0482|M.tuberculosis_H37Rv LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MLBr_02447|M.leprae_Br4923 LVRAEAGAVWDDVVVRAIEHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MAV_4668|M.avium_104 LVRAQAGAVWDDVVLTAIEHGLGGLECLSGIPGSAGATPIQNVGAYGAEV
MMAR_0808|M.marinum_M LVRAEAGAVWDEVVVAAIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV
MUL_4552|M.ulcerans_Agy99 LVRAEAGTVWDEVVVATIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV
Mflv_0090|M.gilvum_PYR-GCK VVRAEAGAGWDDVVAASLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
Mvan_0823|M.vanbaalenii_PYR-1 VVRAEAGAVWDDVVAASLTQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MSMEG_0928|M.smegmatis_MC2_155 RVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
TH_0875|M.thermoresistible__bu LVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MAB_4066c|M.abscessus_ATCC_199 LLRAEAGANWDEVVALSLRAGLGGLECLSGIPGTAGATPVQNVGAYGVEV
:**:**: :*:** :: *************:*****:*******.**
Mb0492|M.bovis_AF2122/97 SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE
Rv0482|M.tuberculosis_H37Rv SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE
MLBr_02447|M.leprae_Br4923 SDTITRVRLLERSSGSVRWVSACELRFGYRTSVFKQADPSGSQPPAVVLE
MAV_4668|M.avium_104 SDTLTRVRVLDRGSGQVRWVPGTELEFGYRTSVFKRRADDGLEIPSVVLE
MMAR_0808|M.marinum_M SDVITRVRLLDRSTGEVSWVPAADLSFGYRTSVLKQAD--GLALPAVVLE
MUL_4552|M.ulcerans_Agy99 SDVITRVRLLDRSTGDVSWVPAADLSFGYRTSVLKQAE--GLALPAVVLE
Mflv_0090|M.gilvum_PYR-GCK ADTIRRVRLLERGTGSVRWVSPEFLRFGYRTSVLKHSS------QWVVLE
Mvan_0823|M.vanbaalenii_PYR-1 SDTIRRVRLLDRSTGDDRWVNPDFLQFGYRTSILKKSS------AWVVLE
MSMEG_0928|M.smegmatis_MC2_155 ADTITRVRLLDRRTGEDRWATTEELRFGYRTSVLKHSD------AVIVLE
TH_0875|M.thermoresistible__bu ADTIRRVRLHDRRTGEDRWVAPEYLRFGYRSSILKHSD------TVVVLE
MAB_4066c|M.abscessus_ATCC_199 SSLLRRVRVLNRETGRVRWYGPDELRFGYRTSILKGTS------ARVVLE
:. : ***: :* :* * * ****:*::* :***
Mb0492|M.bovis_AF2122/97 VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV
Rv0482|M.tuberculosis_H37Rv VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV
MLBr_02447|M.leprae_Br4923 VEFKLDASGQSAPLHYGELVATLDATSGQRANPHAVREAVLALRVRKGMV
MAV_4668|M.avium_104 VEFALDASGRSAPVRYGELAAELEVPVGERADPRAVREAVLALRARKGMV
MMAR_0808|M.marinum_M VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRARKGMV
MUL_4552|M.ulcerans_Agy99 VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRTRKGMV
Mflv_0090|M.gilvum_PYR-GCK VEFGLDAAGHSAPVRYRELATELAVEQGERTDPQRVRAAVLELRARKGMV
Mvan_0823|M.vanbaalenii_PYR-1 VEFALDASGRSAPLRYGELAAELNAEPGERVDPAQVRAAVLSLRARKGMV
MSMEG_0928|M.smegmatis_MC2_155 VEFGLDAAGRSAPVRYRELATALGVEPGERTDPLRVRDAVLRLRTGKGMV
TH_0875|M.thermoresistible__bu VEFALDPAGRSAPIRYAELARTLDVATGERTDPARVREAVLALRAGKGML
MAB_4066c|M.abscessus_ATCC_199 VEFGLSTDGLSAPIRYPELAKELGVAQGDRTDASAVREAVLGLRRRKGMV
*** *.. * ***::* ** * *:* :. ** *** ** ***:
Mb0492|M.bovis_AF2122/97 LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY
Rv0482|M.tuberculosis_H37Rv LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY
MLBr_02447|M.leprae_Br4923 LD----AADHDTWSVGSFFTNPVVAPDVYRQLA----KMVDGP---VPHY
MAV_4668|M.avium_104 LD----AADHDTWSVGSFFTNPVVAPDVYERLAG----SVDGP---VPHY
MMAR_0808|M.marinum_M LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY
MUL_4552|M.ulcerans_Agy99 LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY
Mflv_0090|M.gilvum_PYR-GCK LD----AADHDTWSVGSFFTNPVVSRAEFERIA----ATVGSA---VPNY
Mvan_0823|M.vanbaalenii_PYR-1 LD----AADHDTWSVGSFFTNPVVSRAEFDQLA----ASVDGP---VPNY
MSMEG_0928|M.smegmatis_MC2_155 VDPDPDHPDHDTWSVGSFFTNPVVTHADFERVERIARDAGAGP---VPNY
TH_0875|M.thermoresistible__bu TS-AATVDDHDTWSVGSFFTNPVVSTAEFERIR----DSAPGP---VPNY
MAB_4066c|M.abscessus_ATCC_199 LD----ESDRDTWSVGSFFTNPVVAEGDVDGVRAR-VHEHLGPGVVMPLY
. *:**************: : . :* *
Mb0492|M.bovis_AF2122/97 PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG
Rv0482|M.tuberculosis_H37Rv PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG
MLBr_02447|M.leprae_Br4923 PAQDGVKLAAGWLVERAGFGKGY----PDG-AAPCRLSTKHVLALTNRGA
MAV_4668|M.avium_104 PAPGGVKLAAGWLVERAGFGKGYPVPDPGGPEAPCRLSTKHALALTNRGT
MMAR_0808|M.marinum_M PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG
MUL_4552|M.ulcerans_Agy99 PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG
Mflv_0090|M.gilvum_PYR-GCK PAEDGVKLAAGWLVEQAGFGKGY----PGA-DAPARLSTKHALALTNRGT
Mvan_0823|M.vanbaalenii_PYR-1 PAPDGVKLAAGWLVERAGFGKGY----PDD-EAPARLSTKHALALTNRGT
MSMEG_0928|M.smegmatis_MC2_155 PAPDGVKLAAGWLVERAGFGKGY----PGE-GARARLSTKHALALTNRGQ
TH_0875|M.thermoresistible__bu PAPDGVKLAAAWLVERAGFGRGY----PGA-GAPVRLSTKHALALTNRGN
MAB_4066c|M.abscessus_ATCC_199 SAQHGVKLSAGWLVERAGFDKGY----PGE-RSAVRVSTKHALALTHRGG
.* ****:*.**:*:***.:** *. : *:*:**.****:**
Mb0492|M.bovis_AF2122/97 ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML---
Rv0482|M.tuberculosis_H37Rv ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML---
MLBr_02447|M.leprae_Br4923 ATAEDVVTLARTVRNGVLEVFGITLEPEPALVGCVL---
MAV_4668|M.avium_104 ARSDDVIALARTIRDGVRSVFGITLVPEPVLLGCRL---
MMAR_0808|M.marinum_M ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL---
MUL_4552|M.ulcerans_Agy99 ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL---
Mflv_0090|M.gilvum_PYR-GCK ATTADVLALARTVRDGVKAAFGIELTPEPVLVGCSL---
Mvan_0823|M.vanbaalenii_PYR-1 ATTADVIALARTVRDGVRAAFGIELTPEPVLIGCSL---
MSMEG_0928|M.smegmatis_MC2_155 ATTADVMALAGTVRAGVLDVFGIELTPEPILLGCVLSVP
TH_0875|M.thermoresistible__bu ATTADVIALAREVRDGVRAAFGIELVPEPVLVGCSL---
MAB_4066c|M.abscessus_ATCC_199 GSTDELLTLARTVRDGVLETFGVRLVPEPVLVGCSL---
. : :::.** :* ** .**: * *** *:** *