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MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVGVLRELDDRARNGDCGPVLVFAGG SNVVIGDALADLTVVRVANDRVTVDGNLVRAEAGTVWDEVVVATIERGLGGLECLSGIPGSAGATPVQNV GAYGVEVSDVITRVRLLDRSTGDVSWVPAADLSFGYRTSVLKQAEGLALPAVVLEVEFALDASGRSAPLR YGELTAALGMNSGERGEPRAVRDAVLALRTRKGMVLDAADHDTWSVGSFFTNPVVAPEIYERLAAQTGES VPHYPAPDGVKLAAGWLLERAGFGKGYPGDPHARCRLSSKHALALTNRGGATAADVMVLARTVRDGVRDV FGITLKPEPVLVGCAL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4552 | murB | - | 100% (366) | UDP-N-acetylenolpyruvoylglucosamine reductase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0492 | murB | 1e-156 | 75.14% (370) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. gilvum PYR-GCK | Mflv_0090 | murB | 1e-129 | 67.41% (359) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. tuberculosis H37Rv | Rv0482 | murB | 1e-156 | 75.14% (370) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. leprae Br4923 | MLBr_02447 | murB | 1e-151 | 73.37% (368) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. abscessus ATCC 19977 | MAB_4066c | - | 1e-111 | 59.28% (361) | UDP-N-acetylenolpyruvoylglucosamine reductase MurB |
M. marinum M | MMAR_0808 | murB | 0.0 | 98.36% (366) | UDP-N-acetylenolpyruvoylglucosamine reductase MurB |
M. avium 104 | MAV_4668 | murB | 1e-152 | 71.77% (372) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. smegmatis MC2 155 | MSMEG_0928 | murB | 1e-131 | 66.76% (364) | UDP-N-acetylenolpyruvoylglucosamine reductase |
M. thermoresistible (build 8) | TH_0875 | - | 1e-130 | 67.40% (365) | PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB |
M. vanbaalenii PYR-1 | Mvan_0823 | murB | 1e-132 | 69.36% (359) | UDP-N-acetylenolpyruvoylglucosamine reductase |
CLUSTAL 2.0.9 multiple sequence alignment MUL_4552|M.ulcerans_Agy99 ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG MMAR_0808|M.marinum_M ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG Mb0492|M.bovis_AF2122/97 ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA Rv0482|M.tuberculosis_H37Rv ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA MLBr_02447|M.leprae_Br4923 ---MKRSAVGSFFAGAHVAEAVSLAPLTTLRVGPVAQRVITCASTEQVVD MAV_4668|M.avium_104 ---MKSSGAGAAFAGASVADAVPLAPLTTLRVGPTARRLITCASSEQVIA MSMEG_0928|M.smegmatis_MC2_155 -------MASSHVAGVEIAEAVPLAPLTTLRIGPVARRMLTCTSTEQLIG TH_0875|M.thermoresistible__bu -------VVGSRVAGVPVAEGVPLAPLTTLRVGPVARRLIECTATDQVIG Mflv_0090|M.gilvum_PYR-GCK -------MGTSLLGGVPVAENVPLAPLTTLRVGPVARRLVTCVTTDQIVD Mvan_0823|M.vanbaalenii_PYR-1 -----------MSGGVPFAEQVPLAPLTTLRVGPVARRLITCVATEQIGP MAB_4066c|M.abscessus_ATCC_199 MGLARTTRAEIEDLGAVVTEGAALAPLTTLRLGPVAATLIRCESTRQVTG *. .:: ..********:** * :: * :: *: MUL_4552|M.ulcerans_Agy99 VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTVDGN MMAR_0808|M.marinum_M VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTIDGN Mb0492|M.bovis_AF2122/97 ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN Rv0482|M.tuberculosis_H37Rv ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN MLBr_02447|M.leprae_Br4923 VIRQLDAPAGGRGAGPLLIFAGGSNLVIADTLADLTAVRLANAGITIDGN MAV_4668|M.avium_104 TLRRLDTERLAGQRDPVLVFAGGSNLVISDALSDLTAVRLANDGITVEGN MSMEG_0928|M.smegmatis_MC2_155 VLRALTADDE-----PLLILAGGSNVVLADDLTDLTVVRIANTEITVDGD TH_0875|M.thermoresistible__bu VLRVLDADRTG----PMLVLAGGSNVVLADDLTDLTVVRLANDRISVDGH Mflv_0090|M.gilvum_PYR-GCK AVMAAGPEAL--------ILAGGSNVVLAGDAADLTVVRLANTRISVDGD Mvan_0823|M.vanbaalenii_PYR-1 AVRAAGPDAL--------ILAGGSNVVIADDLADLTVVRLANTGIVVDGA MAB_4066c|M.abscessus_ATCC_199 TLAALDG-------HPALLLAGGSNVVLADDLADVTAVHIAAAGVTVDGS .: ::*****:*:. :*:*.*::* : ::* MUL_4552|M.ulcerans_Agy99 LVRAEAGTVWDEVVVATIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV MMAR_0808|M.marinum_M LVRAEAGAVWDEVVVAAIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV Mb0492|M.bovis_AF2122/97 LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV Rv0482|M.tuberculosis_H37Rv LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV MLBr_02447|M.leprae_Br4923 LVRAEAGAVWDDVVVRAIEHGLGGLECLSGIPGSAGATPVQNVGAYGAEV MAV_4668|M.avium_104 LVRAQAGAVWDDVVLTAIEHGLGGLECLSGIPGSAGATPIQNVGAYGAEV MSMEG_0928|M.smegmatis_MC2_155 RVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV TH_0875|M.thermoresistible__bu LVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV Mflv_0090|M.gilvum_PYR-GCK VVRAEAGAGWDDVVAASLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV Mvan_0823|M.vanbaalenii_PYR-1 VVRAEAGAVWDDVVAASLTQGLGGLECLSGIPGSAGATPVQNVGAYGAEV MAB_4066c|M.abscessus_ATCC_199 LLRAEAGANWDEVVALSLRAGLGGLECLSGIPGTAGATPVQNVGAYGVEV :**:**: :*:** :: *************:*****:*******.** MUL_4552|M.ulcerans_Agy99 SDVITRVRLLDRSTGDVSWVPAADLSFGYRTSVLKQAE--GLALPAVVLE MMAR_0808|M.marinum_M SDVITRVRLLDRSTGEVSWVPAADLSFGYRTSVLKQAD--GLALPAVVLE Mb0492|M.bovis_AF2122/97 SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE Rv0482|M.tuberculosis_H37Rv SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE MLBr_02447|M.leprae_Br4923 SDTITRVRLLERSSGSVRWVSACELRFGYRTSVFKQADPSGSQPPAVVLE MAV_4668|M.avium_104 SDTLTRVRVLDRGSGQVRWVPGTELEFGYRTSVFKRRADDGLEIPSVVLE MSMEG_0928|M.smegmatis_MC2_155 ADTITRVRLLDRRTGEDRWATTEELRFGYRTSVLKHSD------AVIVLE TH_0875|M.thermoresistible__bu ADTIRRVRLHDRRTGEDRWVAPEYLRFGYRSSILKHSD------TVVVLE Mflv_0090|M.gilvum_PYR-GCK ADTIRRVRLLERGTGSVRWVSPEFLRFGYRTSVLKHSS------QWVVLE Mvan_0823|M.vanbaalenii_PYR-1 SDTIRRVRLLDRSTGDDRWVNPDFLQFGYRTSILKKSS------AWVVLE MAB_4066c|M.abscessus_ATCC_199 SSLLRRVRVLNRETGRVRWYGPDELRFGYRTSILKGTS------ARVVLE :. : ***: :* :* * * ****:*::* :*** MUL_4552|M.ulcerans_Agy99 VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRTRKGMV MMAR_0808|M.marinum_M VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRARKGMV Mb0492|M.bovis_AF2122/97 VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV Rv0482|M.tuberculosis_H37Rv VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV MLBr_02447|M.leprae_Br4923 VEFKLDASGQSAPLHYGELVATLDATSGQRANPHAVREAVLALRVRKGMV MAV_4668|M.avium_104 VEFALDASGRSAPVRYGELAAELEVPVGERADPRAVREAVLALRARKGMV MSMEG_0928|M.smegmatis_MC2_155 VEFGLDAAGRSAPVRYRELATALGVEPGERTDPLRVRDAVLRLRTGKGMV TH_0875|M.thermoresistible__bu VEFALDPAGRSAPIRYAELARTLDVATGERTDPARVREAVLALRAGKGML Mflv_0090|M.gilvum_PYR-GCK VEFGLDAAGHSAPVRYRELATELAVEQGERTDPQRVRAAVLELRARKGMV Mvan_0823|M.vanbaalenii_PYR-1 VEFALDASGRSAPLRYGELAAELNAEPGERVDPAQVRAAVLSLRARKGMV MAB_4066c|M.abscessus_ATCC_199 VEFGLSTDGLSAPIRYPELAKELGVAQGDRTDASAVREAVLGLRRRKGMV *** *.. * ***::* ** * *:* :. ** *** ** ***: MUL_4552|M.ulcerans_Agy99 LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY MMAR_0808|M.marinum_M LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY Mb0492|M.bovis_AF2122/97 LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY Rv0482|M.tuberculosis_H37Rv LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY MLBr_02447|M.leprae_Br4923 LD----AADHDTWSVGSFFTNPVVAPDVYRQLA----KMVDGP---VPHY MAV_4668|M.avium_104 LD----AADHDTWSVGSFFTNPVVAPDVYERLAG----SVDGP---VPHY MSMEG_0928|M.smegmatis_MC2_155 VDPDPDHPDHDTWSVGSFFTNPVVTHADFERVERIARDAGAGP---VPNY TH_0875|M.thermoresistible__bu TS-AATVDDHDTWSVGSFFTNPVVSTAEFERIR----DSAPGP---VPNY Mflv_0090|M.gilvum_PYR-GCK LD----AADHDTWSVGSFFTNPVVSRAEFERIA----ATVGSA---VPNY Mvan_0823|M.vanbaalenii_PYR-1 LD----AADHDTWSVGSFFTNPVVSRAEFDQLA----ASVDGP---VPNY MAB_4066c|M.abscessus_ATCC_199 LD----ESDRDTWSVGSFFTNPVVAEGDVDGVRAR-VHEHLGPGVVMPLY . *:**************: : . :* * MUL_4552|M.ulcerans_Agy99 PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG MMAR_0808|M.marinum_M PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG Mb0492|M.bovis_AF2122/97 PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG Rv0482|M.tuberculosis_H37Rv PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG MLBr_02447|M.leprae_Br4923 PAQDGVKLAAGWLVERAGFGKGY----PDG-AAPCRLSTKHVLALTNRGA MAV_4668|M.avium_104 PAPGGVKLAAGWLVERAGFGKGYPVPDPGGPEAPCRLSTKHALALTNRGT MSMEG_0928|M.smegmatis_MC2_155 PAPDGVKLAAGWLVERAGFGKGY----PGE-GARARLSTKHALALTNRGQ TH_0875|M.thermoresistible__bu PAPDGVKLAAAWLVERAGFGRGY----PGA-GAPVRLSTKHALALTNRGN Mflv_0090|M.gilvum_PYR-GCK PAEDGVKLAAGWLVEQAGFGKGY----PGA-DAPARLSTKHALALTNRGT Mvan_0823|M.vanbaalenii_PYR-1 PAPDGVKLAAGWLVERAGFGKGY----PDD-EAPARLSTKHALALTNRGT MAB_4066c|M.abscessus_ATCC_199 SAQHGVKLSAGWLVERAGFDKGY----PGE-RSAVRVSTKHALALTHRGG .* ****:*.**:*:***.:** *. : *:*:**.****:** MUL_4552|M.ulcerans_Agy99 ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL--- MMAR_0808|M.marinum_M ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL--- Mb0492|M.bovis_AF2122/97 ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML--- Rv0482|M.tuberculosis_H37Rv ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML--- MLBr_02447|M.leprae_Br4923 ATAEDVVTLARTVRNGVLEVFGITLEPEPALVGCVL--- MAV_4668|M.avium_104 ARSDDVIALARTIRDGVRSVFGITLVPEPVLLGCRL--- MSMEG_0928|M.smegmatis_MC2_155 ATTADVMALAGTVRAGVLDVFGIELTPEPILLGCVLSVP TH_0875|M.thermoresistible__bu ATTADVIALAREVRDGVRAAFGIELVPEPVLVGCSL--- Mflv_0090|M.gilvum_PYR-GCK ATTADVLALARTVRDGVKAAFGIELTPEPVLVGCSL--- Mvan_0823|M.vanbaalenii_PYR-1 ATTADVIALARTVRDGVRAAFGIELTPEPVLIGCSL--- MAB_4066c|M.abscessus_ATCC_199 GSTDELLTLARTVRDGVLETFGVRLVPEPVLVGCSL--- . : :::.** :* ** .**: * *** *:** *