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M. ulcerans Agy99 MUL_4552 (murB)

annotation: UDP-N-acetylenolpyruvoylglucosamine reductase
coordinates: 5051004 - 5052104
length: 366

MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVGVLRELDDRARNGDCGPVLVFAGG
SNVVIGDALADLTVVRVANDRVTVDGNLVRAEAGTVWDEVVVATIERGLGGLECLSGIPGSAGATPVQNV
GAYGVEVSDVITRVRLLDRSTGDVSWVPAADLSFGYRTSVLKQAEGLALPAVVLEVEFALDASGRSAPLR
YGELTAALGMNSGERGEPRAVRDAVLALRTRKGMVLDAADHDTWSVGSFFTNPVVAPEIYERLAAQTGES
VPHYPAPDGVKLAAGWLLERAGFGKGYPGDPHARCRLSSKHALALTNRGGATAADVMVLARTVRDGVRDV
FGITLKPEPVLVGCAL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_4552murB-100% (366)UDP-N-acetylenolpyruvoylglucosamine reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0492murB1e-15675.14% (370) UDP-N-acetylenolpyruvoylglucosamine reductase
M. gilvum PYR-GCKMflv_0090murB1e-12967.41% (359) UDP-N-acetylenolpyruvoylglucosamine reductase
M. tuberculosis H37RvRv0482murB1e-15675.14% (370) UDP-N-acetylenolpyruvoylglucosamine reductase
M. leprae Br4923MLBr_02447murB1e-15173.37% (368) UDP-N-acetylenolpyruvoylglucosamine reductase
M. abscessus ATCC 19977MAB_4066c-1e-11159.28% (361) UDP-N-acetylenolpyruvoylglucosamine reductase MurB
M. marinum MMMAR_0808murB0.098.36% (366) UDP-N-acetylenolpyruvoylglucosamine reductase MurB
M. avium 104MAV_4668murB1e-15271.77% (372) UDP-N-acetylenolpyruvoylglucosamine reductase
M. smegmatis MC2 155MSMEG_0928murB1e-13166.76% (364) UDP-N-acetylenolpyruvoylglucosamine reductase
M. thermoresistible (build 8)TH_0875-1e-13067.40% (365) PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB
M. vanbaalenii PYR-1Mvan_0823murB1e-13269.36% (359) UDP-N-acetylenolpyruvoylglucosamine reductase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_4552|M.ulcerans_Agy99           ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG
MMAR_0808|M.marinum_M               ---MKRRDVGSLFAGARVAESVPLAPLTTLRVGPVARTLVTCDTTDQVVG
Mb0492|M.bovis_AF2122/97            ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA
Rv0482|M.tuberculosis_H37Rv         ---MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVA
MLBr_02447|M.leprae_Br4923          ---MKRSAVGSFFAGAHVAEAVSLAPLTTLRVGPVAQRVITCASTEQVVD
MAV_4668|M.avium_104                ---MKSSGAGAAFAGASVADAVPLAPLTTLRVGPTARRLITCASSEQVIA
MSMEG_0928|M.smegmatis_MC2_155      -------MASSHVAGVEIAEAVPLAPLTTLRIGPVARRMLTCTSTEQLIG
TH_0875|M.thermoresistible__bu      -------VVGSRVAGVPVAEGVPLAPLTTLRVGPVARRLIECTATDQVIG
Mflv_0090|M.gilvum_PYR-GCK          -------MGTSLLGGVPVAENVPLAPLTTLRVGPVARRLVTCVTTDQIVD
Mvan_0823|M.vanbaalenii_PYR-1       -----------MSGGVPFAEQVPLAPLTTLRVGPVARRLITCVATEQIGP
MAB_4066c|M.abscessus_ATCC_199      MGLARTTRAEIEDLGAVVTEGAALAPLTTLRLGPVAATLIRCESTRQVTG
                                                  *. .:: ..********:** *  :: * :: *:  

MUL_4552|M.ulcerans_Agy99           VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTVDGN
MMAR_0808|M.marinum_M               VLRELDDRARNGDCGPVLVFAGGSNVVIGDALADLTVVRVANDRVTIDGN
Mb0492|M.bovis_AF2122/97            ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN
Rv0482|M.tuberculosis_H37Rv         ALRHLDS-AAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGN
MLBr_02447|M.leprae_Br4923          VIRQLDAPAGGRGAGPLLIFAGGSNLVIADTLADLTAVRLANAGITIDGN
MAV_4668|M.avium_104                TLRRLDTERLAGQRDPVLVFAGGSNLVISDALSDLTAVRLANDGITVEGN
MSMEG_0928|M.smegmatis_MC2_155      VLRALTADDE-----PLLILAGGSNVVLADDLTDLTVVRIANTEITVDGD
TH_0875|M.thermoresistible__bu      VLRVLDADRTG----PMLVLAGGSNVVLADDLTDLTVVRLANDRISVDGH
Mflv_0090|M.gilvum_PYR-GCK          AVMAAGPEAL--------ILAGGSNVVLAGDAADLTVVRLANTRISVDGD
Mvan_0823|M.vanbaalenii_PYR-1       AVRAAGPDAL--------ILAGGSNVVIADDLADLTVVRLANTGIVVDGA
MAB_4066c|M.abscessus_ATCC_199      TLAALDG-------HPALLLAGGSNVVLADDLADVTAVHIAAAGVTVDGS
                                    .:                ::*****:*:.   :*:*.*::*   : ::* 

MUL_4552|M.ulcerans_Agy99           LVRAEAGTVWDEVVVATIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV
MMAR_0808|M.marinum_M               LVRAEAGAVWDEVVVAAIERGLGGLECLSGIPGSAGATPVQNVGAYGVEV
Mb0492|M.bovis_AF2122/97            LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
Rv0482|M.tuberculosis_H37Rv         LVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MLBr_02447|M.leprae_Br4923          LVRAEAGAVWDDVVVRAIEHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MAV_4668|M.avium_104                LVRAQAGAVWDDVVLTAIEHGLGGLECLSGIPGSAGATPIQNVGAYGAEV
MSMEG_0928|M.smegmatis_MC2_155      RVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
TH_0875|M.thermoresistible__bu      LVRAEAGALWDDVVVTSLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
Mflv_0090|M.gilvum_PYR-GCK          VVRAEAGAGWDDVVAASLAHGLGGLECLSGIPGSAGATPVQNVGAYGAEV
Mvan_0823|M.vanbaalenii_PYR-1       VVRAEAGAVWDDVVAASLTQGLGGLECLSGIPGSAGATPVQNVGAYGAEV
MAB_4066c|M.abscessus_ATCC_199      LLRAEAGANWDEVVALSLRAGLGGLECLSGIPGTAGATPVQNVGAYGVEV
                                     :**:**: :*:**  ::  *************:*****:*******.**

MUL_4552|M.ulcerans_Agy99           SDVITRVRLLDRSTGDVSWVPAADLSFGYRTSVLKQAE--GLALPAVVLE
MMAR_0808|M.marinum_M               SDVITRVRLLDRSTGEVSWVPAADLSFGYRTSVLKQAD--GLALPAVVLE
Mb0492|M.bovis_AF2122/97            SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE
Rv0482|M.tuberculosis_H37Rv         SDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHAD--GLAVPTVVLE
MLBr_02447|M.leprae_Br4923          SDTITRVRLLERSSGSVRWVSACELRFGYRTSVFKQADPSGSQPPAVVLE
MAV_4668|M.avium_104                SDTLTRVRVLDRGSGQVRWVPGTELEFGYRTSVFKRRADDGLEIPSVVLE
MSMEG_0928|M.smegmatis_MC2_155      ADTITRVRLLDRRTGEDRWATTEELRFGYRTSVLKHSD------AVIVLE
TH_0875|M.thermoresistible__bu      ADTIRRVRLHDRRTGEDRWVAPEYLRFGYRSSILKHSD------TVVVLE
Mflv_0090|M.gilvum_PYR-GCK          ADTIRRVRLLERGTGSVRWVSPEFLRFGYRTSVLKHSS------QWVVLE
Mvan_0823|M.vanbaalenii_PYR-1       SDTIRRVRLLDRSTGDDRWVNPDFLQFGYRTSILKKSS------AWVVLE
MAB_4066c|M.abscessus_ATCC_199      SSLLRRVRVLNRETGRVRWYGPDELRFGYRTSILKGTS------ARVVLE
                                    :. : ***: :* :*   *     * ****:*::*           :***

MUL_4552|M.ulcerans_Agy99           VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRTRKGMV
MMAR_0808|M.marinum_M               VEFALDASGRSAPLRYGELTAALGMNSGERGEPRAVRDAVLALRARKGMV
Mb0492|M.bovis_AF2122/97            VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV
Rv0482|M.tuberculosis_H37Rv         VEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMV
MLBr_02447|M.leprae_Br4923          VEFKLDASGQSAPLHYGELVATLDATSGQRANPHAVREAVLALRVRKGMV
MAV_4668|M.avium_104                VEFALDASGRSAPVRYGELAAELEVPVGERADPRAVREAVLALRARKGMV
MSMEG_0928|M.smegmatis_MC2_155      VEFGLDAAGRSAPVRYRELATALGVEPGERTDPLRVRDAVLRLRTGKGMV
TH_0875|M.thermoresistible__bu      VEFALDPAGRSAPIRYAELARTLDVATGERTDPARVREAVLALRAGKGML
Mflv_0090|M.gilvum_PYR-GCK          VEFGLDAAGHSAPVRYRELATELAVEQGERTDPQRVRAAVLELRARKGMV
Mvan_0823|M.vanbaalenii_PYR-1       VEFALDASGRSAPLRYGELAAELNAEPGERVDPAQVRAAVLSLRARKGMV
MAB_4066c|M.abscessus_ATCC_199      VEFGLSTDGLSAPIRYPELAKELGVAQGDRTDASAVREAVLGLRRRKGMV
                                    *** *.. * ***::* **   *    *:* :.  ** *** **  ***:

MUL_4552|M.ulcerans_Agy99           LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY
MMAR_0808|M.marinum_M               LD----AADHDTWSVGSFFTNPVVAPEIYERLAA----QTGES---VPHY
Mb0492|M.bovis_AF2122/97            LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY
Rv0482|M.tuberculosis_H37Rv         LD----PTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGP---VPHY
MLBr_02447|M.leprae_Br4923          LD----AADHDTWSVGSFFTNPVVAPDVYRQLA----KMVDGP---VPHY
MAV_4668|M.avium_104                LD----AADHDTWSVGSFFTNPVVAPDVYERLAG----SVDGP---VPHY
MSMEG_0928|M.smegmatis_MC2_155      VDPDPDHPDHDTWSVGSFFTNPVVTHADFERVERIARDAGAGP---VPNY
TH_0875|M.thermoresistible__bu      TS-AATVDDHDTWSVGSFFTNPVVSTAEFERIR----DSAPGP---VPNY
Mflv_0090|M.gilvum_PYR-GCK          LD----AADHDTWSVGSFFTNPVVSRAEFERIA----ATVGSA---VPNY
Mvan_0823|M.vanbaalenii_PYR-1       LD----AADHDTWSVGSFFTNPVVSRAEFDQLA----ASVDGP---VPNY
MAB_4066c|M.abscessus_ATCC_199      LD----ESDRDTWSVGSFFTNPVVAEGDVDGVRAR-VHEHLGPGVVMPLY
                                     .      *:**************:      :          .   :* *

MUL_4552|M.ulcerans_Agy99           PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG
MMAR_0808|M.marinum_M               PAPDGVKLAAGWLLERAGFGKGY----PGDPHARCRLSSKHALALTNRGG
Mb0492|M.bovis_AF2122/97            PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG
Rv0482|M.tuberculosis_H37Rv         PAPDGVKLAAGWLVERAGFGKGY----PDAGAAPCRLSTKHALALTNRGG
MLBr_02447|M.leprae_Br4923          PAQDGVKLAAGWLVERAGFGKGY----PDG-AAPCRLSTKHVLALTNRGA
MAV_4668|M.avium_104                PAPGGVKLAAGWLVERAGFGKGYPVPDPGGPEAPCRLSTKHALALTNRGT
MSMEG_0928|M.smegmatis_MC2_155      PAPDGVKLAAGWLVERAGFGKGY----PGE-GARARLSTKHALALTNRGQ
TH_0875|M.thermoresistible__bu      PAPDGVKLAAAWLVERAGFGRGY----PGA-GAPVRLSTKHALALTNRGN
Mflv_0090|M.gilvum_PYR-GCK          PAEDGVKLAAGWLVEQAGFGKGY----PGA-DAPARLSTKHALALTNRGT
Mvan_0823|M.vanbaalenii_PYR-1       PAPDGVKLAAGWLVERAGFGKGY----PDD-EAPARLSTKHALALTNRGT
MAB_4066c|M.abscessus_ATCC_199      SAQHGVKLSAGWLVERAGFDKGY----PGE-RSAVRVSTKHALALTHRGG
                                    .*  ****:*.**:*:***.:**    *.   :  *:*:**.****:** 

MUL_4552|M.ulcerans_Agy99           ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL---
MMAR_0808|M.marinum_M               ATAADVMVLARTVRDGVRDVFGITLKPEPVLVGCAL---
Mb0492|M.bovis_AF2122/97            ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML---
Rv0482|M.tuberculosis_H37Rv         ATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML---
MLBr_02447|M.leprae_Br4923          ATAEDVVTLARTVRNGVLEVFGITLEPEPALVGCVL---
MAV_4668|M.avium_104                ARSDDVIALARTIRDGVRSVFGITLVPEPVLLGCRL---
MSMEG_0928|M.smegmatis_MC2_155      ATTADVMALAGTVRAGVLDVFGIELTPEPILLGCVLSVP
TH_0875|M.thermoresistible__bu      ATTADVIALAREVRDGVRAAFGIELVPEPVLVGCSL---
Mflv_0090|M.gilvum_PYR-GCK          ATTADVLALARTVRDGVKAAFGIELTPEPVLVGCSL---
Mvan_0823|M.vanbaalenii_PYR-1       ATTADVIALARTVRDGVRAAFGIELTPEPVLIGCSL---
MAB_4066c|M.abscessus_ATCC_199      GSTDELLTLARTVRDGVLETFGVRLVPEPVLVGCSL---
                                    . : :::.**  :* **  .**: * *** *:** *