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VAIANPAEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITPEPGAAGRHHQPRGDRKPRAWRQCGPQ NGPRRSQAITPEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITPEPGAAGRHHQPRGDRKPRAWRQ CGPQNGPRRSQAITPEPGAAGRHWLDQRPVVPDGVGKSDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3641 | - | - | 100% (180) | hypothetical protein Mb3641 |
| M. bovis AF2122 / 97 | Mb3737 | leuA | 4e-05 | 34.07% (91) | 2-isopropylmalate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4039 | infB | 4e-06 | 29.12% (182) | translation initiation factor IF-2 |
| M. tuberculosis H37Rv | Rv3611 | - | 1e-109 | 100.00% (173) | hypothetical protein Rv3611 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_0680 | - | 2e-05 | 26.32% (152) | hypothetical protein MAV_0680 |
| M. smegmatis MC2 155 | MSMEG_6421 | - | 7e-06 | 30.00% (160) | transcriptional regulator |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2314 | infB | 4e-06 | 29.81% (161) | translation initiation factor IF-2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3641|M.bovis_AF2122/97 --------------------------------MAIANPAEPGAAGRHHQP
Rv3611|M.tuberculosis_H37Rv --------------------------------MAIANPAEPGAAGRHHQP
Mflv_4039|M.gilvum_PYR-GCK MAGKARVHELAKELGVTSKEVLARLGEQGEFVKSASSTVEAPVARRLRES
Mvan_2314|M.vanbaalenii_PYR-1 MAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRES
MSMEG_6421|M.smegmatis_MC2_155 -------------------------MAQRNRPQGHRPGPPAGARRRPRRP
MAV_0680|M.avium_104 --------------------------------MVGAAAVAAGLGISAASL
.
Mb3641|M.bovis_AF2122/97 RGDRKPRAWR--------------------QCGPQNGPRRSQ--------
Rv3611|M.tuberculosis_H37Rv RGDRKPRAWR--------------------QCGPQNGPRRSQ--------
Mflv_4039|M.gilvum_PYR-GCK FGGNKPDAVKPAAG--ASNGAPAKPSAPGARPGPRPGPPAPAQPKEPPAP
Mvan_2314|M.vanbaalenii_PYR-1 YGGSKSDKTKAAPSGNGAAGATVKPSAPQSRPGPKPGPPVAQQPAAPAAP
MSMEG_6421|M.smegmatis_MC2_155 RPRRADRVTR----------------ARVLRRGPHPGPECRRRTRR----
MAV_0680|M.avium_104 NAGSAYSAPLD---------------------PPPPCPNCHGGGGN----
* *
Mb3641|M.bovis_AF2122/97 ----AITPEPGAAGRHHQPRGDRK------------PRAWRQCGPQNGPR
Rv3611|M.tuberculosis_H37Rv ----AITPEPGAAGRHHQPRGDRK------------PRAWRQCGPQNGPR
Mflv_4039|M.gilvum_PYR-GCK AAPAAAAPAPAAPAPPAAPPAPAASAAPPSAPEAPSAR--PTPGPRPGPG
Mvan_2314|M.vanbaalenii_PYR-1 PAAPPAPPTPAAAPPSPAPAAPAA--ATPAEPAAPSARPGPTPGPRPGPS
MSMEG_6421|M.smegmatis_MC2_155 -VVRHVVAHPGAARLGLCQRVGRG----------DHRRGFPAHPPAPTRH
MAV_0680|M.avium_104 ----PGGPGGGPGGQPAGPGGGAG------------GQHGGNTPPQGGQN
. .. : *
Mb3641|M.bovis_AF2122/97 RSQAITPEPGAAG--------RHHQPRGDR-----KPRAWR---QCGPQN
Rv3611|M.tuberculosis_H37Rv RSQAITPEPGAAG--------RHHQPRGDR-----KPRAWR---QCGPQN
Mflv_4039|M.gilvum_PYR-GCK GPKPGAPKPAPRTPRVGNNPFSSQQPVERP-----APRPQGPAGPGGPRP
Mvan_2314|M.vanbaalenii_PYR-1 APKPGAPKPAARTPRVGNNPFSSQQPVERP-----APRPQ---GPGGPRP
MSMEG_6421|M.smegmatis_MC2_155 QPHAGVGALGAAARGLPPLPGLQRGPGQSGDGPGVRLRVAAHRAAVAADH
MAV_0680|M.avium_104 NPPQNGPNNAPQN---GPNNAPQSGPNNPS--------------QGGPNN
. .. * ..
Mb3641|M.bovis_AF2122/97 GPRRSQAIT---PEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITP
Rv3611|M.tuberculosis_H37Rv GPRRSQAIT---PEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITP
Mflv_4039|M.gilvum_PYR-GCK GPGAGGPRPGGGPRPGATPGNMPPRPVGGPRPGGGPRPGGGPRPGAGPRP
Mvan_2314|M.vanbaalenii_PYR-1 GPGAGGPRPGGGPRPGASPGSMPPRPQG-ARPGGGPRPGGGPRPGGGPRP
MSMEG_6421|M.smegmatis_MC2_155 RPHSDRRGRVRRVCPVGATSRLVAVAATYIAEMNGFTPADGDRDPRMRRP
MAV_0680|M.avium_104 APQNG-------PNNPPQGGQNEPGGQYPPNQHGQNPPQNGQNQPPYDHD
* . . * .* .
Mb3641|M.bovis_AF2122/97 -EPGAAG-------------------------------------------
Rv3611|M.tuberculosis_H37Rv -EPGAAGRHHQPRGD----------------------------------R
Mflv_4039|M.gilvum_PYR-GCK -TPGGAGRPGGGGGG--NYRGGGAGGGGGAGGAAAGGFRGRPGGGGG--R
Mvan_2314|M.vanbaalenii_PYR-1 -TPGGAGRPGGGGGGGGNYRGGGAGG--GAPAAGGGGFRGRPGGGGGGGR
MSMEG_6421|M.smegmatis_MC2_155 GTPRPSGEPSQFIRR-----------------------------------
MAV_0680|M.avium_104 QNPPTPGGPTNAPAN-----------------------------------
* .*
Mb3641|M.bovis_AF2122/97 ----------------------------RHWLD--QRPVV-----PDGVG
Rv3611|M.tuberculosis_H37Rv KPRAWRQCGPQNGPRRSQAITPEPGAAGRHWLD--QRPVV-----PDGVG
Mflv_4039|M.gilvum_PYR-GCK PGQRGGAAGAFGRPGGAPKRGRKSKRAKRAEYENMQAPVVGGVRLPHGNG
Mvan_2314|M.vanbaalenii_PYR-1 PGQRGGAAGAFGRPGGAPKRGRKSKRAKRAEYENMQAPVVGGVRLPHGNG
MSMEG_6421|M.smegmatis_MC2_155 -DPNYRPPQPPPRPAPPPPARRVPPPPPRQAPPPPPRRPAAPPPAPPPPG
MAV_0680|M.avium_104 -------------------TQNPPPPPERQRYAALNPPNTQPPHPPYVPR
* . *
Mb3641|M.bovis_AF2122/97 KSDS----------------------------------------------
Rv3611|M.tuberculosis_H37Rv KSDS----------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK ETIRLARGASLSDFADKINANPASLVQALFNLGEMVTATQSVNDETLELL
Mvan_2314|M.vanbaalenii_PYR-1 ETIRLARGASLSDFAEKINANPASLVQALFNLGEMVTATQSVGDETLELL
MSMEG_6421|M.smegmatis_MC2_155 RSPGQSPGQSSRPPRQFPPPPTRRKTSTPTAAAQSAPPAPTVRKPRRRRR
MAV_0680|M.avium_104 HDVVTASAQIGG---------PAGADVQFSIVGRGAPPPP----------
.
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK GGEMNYVVQVVSPEDEDRELLQSFDLSYGEDEGGEDDLEFRPPVVTVMGH
Mvan_2314|M.vanbaalenii_PYR-1 GGEMNYVVQVVSPEDEDRELLESFDLTYGEDEGGEEDLEIRPPVVTVMGH
MSMEG_6421|M.smegmatis_MC2_155 WGRIVLALLMIAVLAGAGAMIWVDTS------------------------
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK VDHGKTRLLDTIRDATVREGEAGGITQHIGAYQVTVDLDGNERPITFIDT
Mvan_2314|M.vanbaalenii_PYR-1 VDHGKTRLLDTIRNATVREGEAGGITQHIGAYQVTVDLDGTERPITFIDT
MSMEG_6421|M.smegmatis_MC2_155 -------------------------LQRIPALAGYPERPAAGRGTTWLLV
MAV_0680|M.avium_104 ---------------------------REHGYGWNDGPPPHHPPPNWYGP
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK PGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAVNHAQAADVPIVV
Mvan_2314|M.vanbaalenii_PYR-1 PGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVV
MSMEG_6421|M.smegmatis_MC2_155 GSDSREGLTPEQQASLTTGGDLGTGRTDTILLVHIPALGSSTPATMVSIP
MAV_0680|M.avium_104 PPPGGWDGPPPPGGWNRPWD--GPPRDVAVARADFGPFSYNTFTVIPVFN
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK AVNKIDKEGADPAKIRGQLTEYGLVPEEYGGDTMFVDISAKAGTNIEALL
Mvan_2314|M.vanbaalenii_PYR-1 AVNKIDKEGADPAKIRGQLTEYGLVPEEYGGDAMFVDISAKQGTNIEALL
MSMEG_6421|M.smegmatis_MC2_155 RDSYVEIPGYGEDKINAAFALG----------------------------
MAV_0680|M.avium_104 ----WQYGGWGYWFFGVWVPLY----------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK EAVVLTADASLDLRANPDMEAQGVAIEAHLDRGRGPVATVLIQRGTLRVG
Mvan_2314|M.vanbaalenii_PYR-1 EAVILTADASLDLRANPDMEAQGVAIEAHLDRGRGPVATVLIQRGTLRVG
MSMEG_6421|M.smegmatis_MC2_155 ---------GAPLLAQTVESATGLRLDHYAEIGFGGFASLVDAVGGVTVC
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK DSVVAGDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNFLVV
Mvan_2314|M.vanbaalenii_PYR-1 DSVVAGDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNFLVV
MSMEG_6421|M.smegmatis_MC2_155 PAEPISDPLAGIDLPAGCQELDGRTALGFVRTRAT---------------
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK DEDRIARQIADRRSARKRNALAARTRKRISLEDLDSALKETSQLNLILKG
Mvan_2314|M.vanbaalenii_PYR-1 DEDRIARQIADRRSARKRNALAARTRKRISLEDLDSALKETSQLNLILKG
MSMEG_6421|M.smegmatis_MC2_155 ARADLDRMIHQREFMSGLLHRAASPAVWLNPLRWSPMMRAATGTLAVDED
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK DNSGTVEALEEALLGIQVDDEVQLRVIDRGVGGVTETNVNLASASDAIII
Mvan_2314|M.vanbaalenii_PYR-1 DNSGTVEALEEALLGIQVDDEVELRVIDRGVGGVTETNVNLASASDAIII
MSMEG_6421|M.smegmatis_MC2_155 AHVWNLARLAWSLRGDPVTMTVPIGEFGS--NGSGDVVMWDSDAAPRLFE
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK GFNVRAEGKATELANREGVEIRYYSIIYQAIDEIESALKGMLKPIYEEKE
Mvan_2314|M.vanbaalenii_PYR-1 GFNVRAEGKATELANREGVEIRYYSIIYQAIDEIESALKGMLKPVYEEKE
MSMEG_6421|M.smegmatis_MC2_155 ALRTDAPVPPDVLENAVN--------------------------------
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK LGRAEIRAIFRSSKVGNIAGCLVQSGIMRRNAKARLLRDNVVVAQNLTVS
Mvan_2314|M.vanbaalenii_PYR-1 LGRAEIRAIFRSSKVGNIAGCLVQSGIMRRNAKARLLRDNVVVAENLTIS
MSMEG_6421|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0680|M.avium_104 --------------------------------------------------
Mb3641|M.bovis_AF2122/97 --------------------------------------------
Rv3611|M.tuberculosis_H37Rv --------------------------------------------
Mflv_4039|M.gilvum_PYR-GCK SLKREKDDATEVREGYECGLTLTYNDIKEGDVIETYELVEKART
Mvan_2314|M.vanbaalenii_PYR-1 SLKREKDDVTEVRDGYECGLTLTYSDIKEGDVIETYELVEKART
MSMEG_6421|M.smegmatis_MC2_155 --------------------------------------------
MAV_0680|M.avium_104 --------------------------------------------