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MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAIDLYLPAGLTSAARLPAILHQTRYYRS LQLRWPLRMLLGGKPLQHIAADKRRRRRFVASGYAWVDVDVRGSGASFGARVCEWSSDEIRDGAEIVDWI VRQPWCNGTVAALGNSYDGTSAELLLVNQHPAVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEA LDRNALHEVVGWWAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSASDPYRGQPD ARLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSGWFDGGYAHAAIKRFLTVSTPGSHLILGPWNH TGGWRVDPLRGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTMVENRWKSADTWPPPATTQSYY LSADRQLRPDAPDCDSGADEYVVDQTAGTGERSRWRSQVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLE VTGHVVVTLFITSTSSDGTFFVYLEDVDPRGRVAYITEGQLRAIHRRLSDGPPPYRQVVPYRTFASGDAW PLVPGEIARLTFDLLPTSYLFQPGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1866c | - | - | 100% (628) | hypothetical protein Mb1866c |
| M. bovis AF2122 / 97 | Mb2823 | - | 5e-19 | 24.35% (612) | hydrolase |
| M. bovis AF2122 / 97 | Mb1247c | - | 2e-14 | 33.33% (183) | hypothetical protein Mb1247c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4032 | - | 3e-12 | 23.97% (584) | peptidase S15 |
| M. tuberculosis H37Rv | Rv1835c | - | 0.0 | 100.00% (628) | hypothetical protein Rv1835c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2222c | - | 4e-34 | 25.04% (643) | peptidase |
| M. marinum M | MMAR_1910 | - | 7e-20 | 24.09% (577) | hydrolase |
| M. avium 104 | MAV_3687 | - | 5e-19 | 24.24% (623) | hydrolase CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_1308 | - | 4e-23 | 25.23% (535) | peptidase S15 |
| M. thermoresistible (build 8) | TH_1432 | - | 8e-14 | 26.47% (272) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_2134 | - | 6e-20 | 23.92% (577) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 5e-17 | 24.72% (623) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1910|M.marinum_M -----MSITSTDVGQPTLRALTKRVGGSAAGGALGGLLGLPRATTRYTVS
MUL_2134|M.ulcerans_Agy99 -----MSITSTHVGQPTLRALTKRVGGSAAGDALGGLLGLPRATTRYTVS
MAV_3687|M.avium_104 -----MSLTSLRPAQPALHTLR-HLGGRAAG----RLLGLPPATTDYTVR
Mflv_4032|M.gilvum_PYR-GCK --------MSSELARRARRALS-------------RVFDLPPPVCDFVVH
Mvan_2322|M.vanbaalenii_PYR-1 --------MSSELSRLARHALS-------------RALHLPPPVCDYAVN
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAIDLYLPA
Rv1835c|M.tuberculosis_H37Rv MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAIDLYLPA
MAB_2222c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1308|M.smegmatis_MC2_155 ----------------------------------------------MIIE
MMAR_1910|M.marinum_M R-VGVPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRG------------
MUL_2134|M.ulcerans_Agy99 R-VGVPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRG------------
MAV_3687|M.avium_104 R-VAVPMRDGVELVADHYAPATSAPAGTLLVRAPYGRG------------
Mflv_4032|M.gilvum_PYR-GCK RELRVPMRDRVELVADHYAPHTASPAGTLLVRGPYGRG------------
Mvan_2322|M.vanbaalenii_PYR-1 RHVRVPMRDGVELVADHYTPRTADPAGTLLVRGPYGRG------------
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 GLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQH------------
Rv1835c|M.tuberculosis_H37Rv GLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQH------------
MAB_2222c|M.abscessus_ATCC_199 --MPATMRDGTILRADIYRPKLKDPVPVILMRTQYGKDTAQ---------
MSMEG_1308|M.smegmatis_MC2_155 RDVAVPCDDGLILRADVFRPDDGEPAPVIMTLGPYGKGVEYSDGYAPQWN
MMAR_1910|M.marinum_M -----------------FPFSLVFARLYAARGYHVVLQSVRGTFGSAGQ-
MUL_2134|M.ulcerans_Agy99 -----------------FPFSLVFARLYAARGYHVVLQSVRGTFGSAGQ-
MAV_3687|M.avium_104 -----------------FPFALVFGGLYAARGYHVVLQSVRGTFGSGGV-
Mflv_4032|M.gilvum_PYR-GCK -----------------LPFATMFASFYAARGYHVVFQSVRGTFGSGGE-
Mvan_2322|M.vanbaalenii_PYR-1 -----------------FPISVLFGSIYAARGYHVVLQSVRGTFGSGGE-
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 -----------------IAADKRRRRRFVASGYAWVDVDVRGSGASFGAR
Rv1835c|M.tuberculosis_H37Rv -----------------IAADKRRRRRFVASGYAWVDVDVRGSGASFGAR
MAB_2222c|M.abscessus_ATCC_199 ----------------IQPSRFRTPDWFASHCYLVVVQDVRGQGTSDGI-
MSMEG_1308|M.smegmatis_MC2_155 WLITTYPEVLPGSSRSYMAWETVDPEIWVPWGYAVVRVDSRGAGRSPGVL
MMAR_1910|M.marinum_M -FEPMVNEAADGADTVEWLRRQPWFTGRFATIGVSYLGFTQWALLQDPPP
MUL_2134|M.ulcerans_Agy99 -FEPMVNEAADGADTVEWLRRQPWFTGRFATIGVSYLGFTQWALLQDPPP
MAV_3687|M.avium_104 -FEPMAHEVADGADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPP
Mflv_4032|M.gilvum_PYR-GCK -FDPFVNEVDDGADTAAWLRDQPWFTGTFATIGLSYLGFTQWALLTDPPP
Mvan_2322|M.vanbaalenii_PYR-1 -FDPFVNEVADGADTAAWLRDQPWFTGTFATMGLSYLGFTQWALLTDPPP
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 VCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAELLLVNQHP
Rv1835c|M.tuberculosis_H37Rv VCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAELLLVNQHP
MAB_2222c|M.abscessus_ATCC_199 -FTEFGNDGDDGYDTVEWAAGLPGATGKVGMYGSSYVGATQWLAATTTPP
MSMEG_1308|M.smegmatis_MC2_155 DMLSP-REVRDYHDAIEWAARQPWSTGKVGLNGISYYAINQWLLAAQQPP
MMAR_1910|M.marinum_M ELAAAVITAGPHDLR--------------SSVWGTGSFAIN-----DFLG
MUL_2134|M.ulcerans_Agy99 ELAAAVITAGPHDLR--------------SSVWGTGSFAIN-----DFLG
MAV_3687|M.avium_104 DMATAVIMVGPHDFN--------------ESTWGTGSFAVN-----DFLG
Mflv_4032|M.gilvum_PYR-GCK ELAAAVITVGPDDVS--------------GPRWGAGSFGLN-----DFLG
Mvan_2322|M.vanbaalenii_PYR-1 ELKAAVITVGPDDVS--------------GPRWGRGSFGLN-----DFLG
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 AVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHEVVG
Rv1835c|M.tuberculosis_H37Rv AVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHEVVG
MAB_2222c|M.abscessus_ATCC_199 HLTTIVPSNTASDYYDG-------------WTYEGGAFRLG------FVQ
MSMEG_1308|M.smegmatis_MC2_155 SLAAMIPWEGAGDFYR---------------DWARHGGIVSN----GFLE
MMAR_1910|M.marinum_M WSELVARQ----EDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGT
MUL_2134|M.ulcerans_Agy99 WSELVARQ----EDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGT
MAV_3687|M.avium_104 WSDMVSHQ----EDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGT
Mflv_4032|M.gilvum_PYR-GCK WSDLVGRQ----EDPNRVRTLLRQARAQRRVTSASLRLPLAAASRELLGD
Mvan_2322|M.vanbaalenii_PYR-1 WSHLVGGQ----EDPNRLRSLLRQAGAQRRVTEASLGLPLGPASRTLLGD
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 WWAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSA
Rv1835c|M.tuberculosis_H37Rv WWAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSA
MAB_2222c|M.abscessus_ATCC_199 PWAMGTIATTAAKNRADLAALEQLRAAAAERGRWLNHLPYQDLPPMQPGD
MSMEG_1308|M.smegmatis_MC2_155 AWYPRQVVSVQHGNPDGRMDRWQGERATGPEDLSADELALNRNDPLP---
MMAR_1910|M.marinum_M G--APWFESWLEHTDHSDPFWDR-----MRSPDALDRVQVPVLLVGGWQD
MUL_2134|M.ulcerans_Agy99 G--APWFESWLEHTDHSDPFWDR-----MRSPDALDRVQVPVLLVGGWQD
MAV_3687|M.avium_104 G--APWFESWIEHADPSDPFWNS-----LRCNEALDRVRVPVLLVGGWQD
Mflv_4032|M.gilvum_PYR-GCK G--ALWFESWLDHPDTDDPFWTR-----LRLRDGLERAEVPVLLLTGWQD
Mvan_2322|M.vanbaalenii_PYR-1 G--APWFESWLEHPETDDPFWSG-----LRLRDALADVDVPVLLLTGWQD
TH_1432|M.thermoresistible__bu --------------------------------------------------
Mb1866c|M.bovis_AF2122/97 S--DPYRGQPDARLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSG
Rv1835c|M.tuberculosis_H37Rv S--DPYRGQPDARLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSG
MAB_2222c|M.abscessus_ATCC_199 PRVAPWYFDWIRHS-TRDDYWKR-----WSIRDRYQNVTVPVLHFEGWYD
MSMEG_1308|M.smegmatis_MC2_155 --------EILKRPLDDEFYRDR--------SPDWSKVTVPFLSAANWAG
MMAR_1910|M.marinum_M VFVQ------QTLQQYRHLRDRGVDVALTIGPWTHS--------------
MUL_2134|M.ulcerans_Agy99 VFVQ------QTLQQYRHLRDRGVDVALTIGPWTHS--------------
MAV_3687|M.avium_104 LFIR------QTLQQYAHLRARGVDVALTVGPWTHT--------------
Mflv_4032|M.gilvum_PYR-GCK LFVD------QTVEHYRMLAGRGVPTGLTIGPWTHG--------------
Mvan_2322|M.vanbaalenii_PYR-1 LFVE------QTLEHYRMLTSRGVTAGLTVGPWTHG--------------
TH_1432|M.thermoresistible__bu -----------------------VPVAMTIGPWTHG--------------
Mb1866c|M.bovis_AF2122/97 WFDGG----YAHAAIKRFLTVSTPGSHLILGPWNHTGGWRVDP------L
Rv1835c|M.tuberculosis_H37Rv WFDGG----YAHAAIKRFLTVSTPGSHLILGPWNHTGGWRVDP------L
MAB_2222c|M.abscessus_ATCC_199 AFLRGGLENFAGMTARGGSPGARRYQRMVIGPWDHLAWGRESSSPSPLLK
MSMEG_1308|M.smegmatis_MC2_155 FGLHP------RGNFEAFTQAASAQKWLEAHPGRHE--------------
: * *
MMAR_1910|M.marinum_M QLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVRVYVTGEG------WR
MUL_2134|M.ulcerans_Agy99 QLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVRVYVTGEG------WR
MAV_3687|M.avium_104 QLLTTGLGVCTRESLQWLETHLG-DAPGRRAGRVHVYVTGVDRA--RAWR
Mflv_4032|M.gilvum_PYR-GCK DMMTKAAPTMLRESLDWLATHLKGEPPQRRS-PVRIHLSRRG------WL
Mvan_2322|M.vanbaalenii_PYR-1 HMMTTAAPTVLGETLDWLATHLGGAAPLRRS-PVRIHLGGRG------WL
TH_1432|M.thermoresistible__bu HILTRAAPRVLRESLAWLDTHLAGTRTASRP-PVRVHVRRRG------WY
Mb1866c|M.bovis_AF2122/97 RGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTMVEN----RWK
Rv1835c|M.tuberculosis_H37Rv RGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTMVEN----RWK
MAB_2222c|M.abscessus_ATCC_199 GLGPGANSPVNEMQLAWFDHFLKGSDNGVATESPRLDYYLMGAN---RWK
MSMEG_1308|M.smegmatis_MC2_155 --EWFYLTQGMALQKEFLDHFLKGEDNGWDTRPPVLLHIRRPFTDEVEVR
:: .: .
MMAR_1910|M.marinum_M HLSDWPPKTTDHELYLHPTGR--------LSEIAP-PDATTPAT-FRYDP
MUL_2134|M.ulcerans_Agy99 HLSDWPPKTTDHELYLHPTGR--------LSEIAP-PDATTPAT-FRYDP
MAV_3687|M.avium_104 RLPDWPPATTERALYLRPGGY--------LGETAPSLKGLAPAT-FRYDP
Mflv_4032|M.gilvum_PYR-GCK NLPDWPPAMPSLVLHPQPGGG--------LAPGAP--G-AADAT-FVYNP
Mvan_2322|M.vanbaalenii_PYR-1 NLPDWPPAMPDVVLHPQPAGR--------LGPAAP--EPDGTAT-FVYNP
TH_1432|M.thermoresistible__bu DLPDWPPELPAQSWYLRPGRHPRT--EACLGTTAPDTGAAAPGWSFTFDP
Mb1866c|M.bovis_AF2122/97 SADTWPPPATTQSYYLSADRQ--------LRPDAPDCDSGADEYVVDQTA
Rv1835c|M.tuberculosis_H37Rv SADTWPPPATTQSYYLSADRQ--------LRPDAPDCDSGADEYVVDQTA
MAB_2222c|M.abscessus_ATCC_199 HASAWPLPQTNWTVYHLGGRG-----TQHNGTLRDSAAAHDAPDVYLYDP
MSMEG_1308|M.smegmatis_MC2_155 THSAWPLENTQWTEVHLDAADMALNFAPVDTEHSVTFDAAGEPLTFLTGP
** . .
MMAR_1910|M.marinum_M TDPTPTIGGP----LLSSKAGYRNDSRLASRNDVLTFTGSALTHDLWIHG
MUL_2134|M.ulcerans_Agy99 TDPTPTIGGP----LLSSKAGYRNDSRLASRNDVLTFTGSALTHDLWIHG
MAV_3687|M.avium_104 AHPTPTTGGP----LLSPNGGYRDDTRLASRDDVLAFTSATLTEDVYVYG
Mflv_4032|M.gilvum_PYR-GCK GDPTPTVGGR----LLSPVGGYRDDTALARRADVLTFTGTALASDLPVVG
Mvan_2322|M.vanbaalenii_PYR-1 ADPTPTVGGR----LLSPAGGYRDDTALARRADVLTFTGTPLPADLYVVG
TH_1432|M.thermoresistible__bu ADPTPTVGGR----LLSPAGGRRRDDRLARRPDVLSFTSQPLPHALRLLG
Mb1866c|M.bovis_AF2122/97 GTGERSRWRS----QVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTG
Rv1835c|M.tuberculosis_H37Rv GTGERSRWRS----QVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTG
MAB_2222c|M.abscessus_ATCC_199 ANPVPSAGGHSCCAAESAPQGRYDQRAVEQRPDVLTYTTEPLSTNTEITG
MSMEG_1308|M.smegmatis_MC2_155 LTAETELTGP------LSARLFVSSSTVDADLFVTVQAFAPDGREVEFQG
: : . . *
MMAR_1910|M.marinum_M HPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQRLGDAP------
MUL_2134|M.ulcerans_Agy99 HPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQRLGDAP------
MAV_3687|M.avium_104 NPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYRRLSAAAKPK---
Mflv_4032|M.gilvum_PYR-GCK VPVLDVAHTCATPHNDLFVRISQVDAHGRSRNVSDGYVASAPDS------
Mvan_2322|M.vanbaalenii_PYR-1 HPVLELAHTCANPHNDLFVRVSQVDEHGRSRNVSDGYLAAAPDS------
TH_1432|M.thermoresistible__bu VPVAELVHSCDNPHHDLFVRISEVDRRGRSVNVSDGFRRCHREAG-----
Mb1866c|M.bovis_AF2122/97 HVVVTLFITSTSSDGTFFVYLEDVDPRGRVAYITEGQLRAIHRRLS----
Rv1835c|M.tuberculosis_H37Rv HVVVTLFITSTSSDGTFFVYLEDVDPRGRVAYITEGQLRAIHRRLS----
MAB_2222c|M.abscessus_ATCC_199 PISVDLWASSSAPDTDFTAKLVAVQADGTAANLNNGIVRTSLAQSLSERR
MSMEG_1308|M.smegmatis_MC2_155 TIDPHTPLAQGWLRASHRKLDVARSLPYRPYHSHDELQPLDPGTIY----
. :
MMAR_1910|M.marinum_M -------ETVRIELDPIAHRFKAGSRIRVLIAGSWFPRYARHLGTDEPTL
MUL_2134|M.ulcerans_Agy99 -------ETVRIELDPIAHRFKAGSRIRVLVAGSWFPRYARHLGTDEPTL
MAV_3687|M.avium_104 -----ADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVL
Mflv_4032|M.gilvum_PYR-GCK -------GTVTVELDPVAWTFPAGSRIRVLIAGGSHPRFLRNLGTGEHAG
Mvan_2322|M.vanbaalenii_PYR-1 -------GTARIELDPVAWTFPAGSRIRLLIAGGSHPRFLRNLGTGETAT
TH_1432|M.thermoresistible__bu -----SIGTVRLELDAVGHTFRAGHRIRVLIAGGSHPRFTRNLGTGEPPV
Mb1866c|M.bovis_AF2122/97 -------DGPPPYRQVVPYRTFASGDAWPLVPGEIARLTFDLLPTSYLFQ
Rv1835c|M.tuberculosis_H37Rv -------DGPPPYRQVVPYRTFASGDAWPLVPGEIARLTFDLLPTSYLFQ
MAB_2222c|M.abscessus_ATCC_199 LMPIGQPHKYHIDIWPVSYQFRTGERIRLEISSSDFPQYAPNPNTAAPFG
MSMEG_1308|M.smegmatis_MC2_155 --------QLDIEIWPTCIVLPAEYRIALQISGHDFEREEPKDGNEAWVS
: :.. .
MMAR_1910|M.marinum_M TGRQVQPATHSVYFGQ-SRLLLGV---DQSANDITDAGSDESPE-----
MUL_2134|M.ulcerans_Agy99 TGRQVQPATHSVYFGQ-SRLLLGV---DQSANDITDAGSDESPE-----
MAV_3687|M.avium_104 TARRLTPVTHSVRYGR-SRLLLPVGPAEPSADGVADPVGDGG-------
Mflv_4032|M.gilvum_PYR-GCK TATDFATARHTVHLGEGTRLTLPAGPPPPSAD-----------------
Mvan_2322|M.vanbaalenii_PYR-1 TATTYKTARHTVHLGEQSRLVLPAGSHPPSTD-----------------
TH_1432|M.thermoresistible__bu SGRRMTPATHTVHPGT--RVLLPADTEPPDPGSGFPSGH----------
Mb1866c|M.bovis_AF2122/97 PGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP---
Rv1835c|M.tuberculosis_H37Rv PGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP---
MAB_2222c|M.abscessus_ATCC_199 RNAELRTATQIILHDAAHPSTLTLPVIPAGDPGTETFPMPRRPDDPPGN
MSMEG_1308|M.smegmatis_MC2_155 RGS--GPWLHTHPEDRPASIYTGRTTIHTGGSTPSTLLLPVIPS-----
.