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VLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAAVGVGDVDNAE RVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSAR DAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPG HAFYMIGVNDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0988c | - | - | 100% (266) | hypothetical protein Mb0988c |
| M. bovis AF2122 / 97 | Mb2820c | - | 7e-34 | 37.55% (253) | hypothetical protein Mb2820c |
| M. bovis AF2122 / 97 | Mb2571 | - | 6e-23 | 34.31% (204) | hypothetical protein Mb2571 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0963c | - | 1e-154 | 100.00% (266) | hypothetical protein Rv0963c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0252 | - | 2e-05 | 25.93% (189) | hypothetical protein MAB_0252 |
| M. marinum M | MMAR_1913 | - | 3e-35 | 39.13% (253) | hypothetical protein MMAR_1913 |
| M. avium 104 | MAV_5292 | - | 5e-14 | 29.06% (234) | hypothetical protein MAV_5292 |
| M. smegmatis MC2 155 | MSMEG_6381 | - | 5e-26 | 33.57% (277) | hypothetical protein MSMEG_6381 |
| M. thermoresistible (build 8) | TH_2578 | - | 4e-30 | 36.93% (241) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_5057 | - | 2e-13 | 29.08% (196) | hypothetical protein MUL_5057 |
| M. vanbaalenii PYR-1 | Mvan_0049 | - | 1e-11 | 26.84% (272) | hypothetical protein Mvan_0049 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0988c|M.bovis_AF2122/97 --------------------------------------------------
Rv0963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1913|M.marinum_M -----------------------MSLTVADIDRWD--AQAVREVFHAAIA
MSMEG_6381|M.smegmatis_MC2_155 -------------------------MQLSDIDSWN--VGALQSIAFELRD
TH_2578|M.thermoresistible__bu -----------------------MALTFEDVEDWTRKTSTLETLQDELNQ
MAV_5292|M.avium_104 MQLRHLSIPFLVAEAGGDPWSIDSGLQAGRPAQIASLARAFHDAGMSTAE
MUL_5057|M.ulcerans_Agy99 MQPRYISNPLLIAEAGGGPWAINQSLQLGRPAQISDLATAFHDAGRSTTE
Mvan_0049|M.vanbaalenii_PYR-1 ---------------------MAVSVSTVRDSKPDRLVDAADATGRHRSE
MAB_0252|M.abscessus_ATCC_1997 ---------------------MRPTISQLRGWNLDALGKAADAARDNART
Mb0988c|M.bovis_AF2122/97 --------------------------------------------------
Rv0963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1913|M.marinum_M RAQVSLEVSRQLATLSIFANSGGKTAEAAAHQNAGLRRDLDAHGNEALAV
MSMEG_6381|M.smegmatis_MC2_155 ELRTIEGVATDLELISRLPGWDSPAADAARGRIGTAKANVLDDAAVIGAV
TH_2578|M.thermoresistible__bu RTTTLAGLQEQLAGIRRLDGWEGSASRAARQSFDPVDDDIANAAAAVGAV
MAV_5292|M.avium_104 ADVAFAAARGRFEASWNHRNGALPINDSAE--VQRVTRALAVEGRQLPRI
MUL_5057|M.ulcerans_Agy99 ADTAFEQARRRFETSWNRENGAHPINDSPQ--VQGLTTSLRSQAARLPEI
Mvan_0049|M.vanbaalenii_PYR-1 LQTIIAGQRESLSHLQEHWSGQAASAALARG-LDDIARQDRVAG-RLLNL
MAB_0252|M.abscessus_ATCC_1997 LDASLDSCDRVFN---DASGWYGKTHDAAKIKVDQELDHGREIRNVLNRI
Mb0988c|M.bovis_AF2122/97 --------------------------------------------------
Rv0963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1913|M.marinum_M ARAADRAADGIVKVQSELAALRKAAAAAELQIDALSSRVVP-----IAGL
MSMEG_6381|M.smegmatis_MC2_155 AQLADETAAAVAKLQSQLEAVRADVAAQGGLLHLAD--------NGDVTI
TH_2578|M.thermoresistible__bu RTQVGETIAELTELRTAISEAKQYASANGYAIQFNGRVIDLW--DLDDRA
MAV_5292|M.avium_104 ATDLETIAAVLAESQRTSTWYIEALEYDLAAIDDEIG--------QALEE
MUL_5057|M.ulcerans_Agy99 GLQLDNIAGGLAGAQRSATGQIVGLETQLCDIDSEIGEVLALEHGAQLTT
Mvan_0049|M.vanbaalenii_PYR-1 ESALRNGGLQMGALRDALLDLVSSLERFGFAVADDGT-----------VT
MAB_0252|M.abscessus_ATCC_1997 SDDAEDAARTLKHAKEFTLQDVDGAVSEGFTVTDTG--------------
Mb0988c|M.bovis_AF2122/97 --------------------------------------------------
Rv0963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1913|M.marinum_M RHTESEWARVLAKQAELQADLGAIVVEANTIDEELASAVNMADGDSPIPA
MSMEG_6381|M.smegmatis_MC2_155 GGSPDDREQLKHIAENIEARAKALIHQAEDIDADCAEVFGHIENGDVTAR
TH_2578|M.thermoresistible__bu NATPAELEQHKAAEAELQTMVSEIVERGNEIEAESARVLWAANSGEISAD
MAV_5292|M.avium_104 ADHCAAEELRYS----AVTETKAITLVLEQIRESYSRLLHSALARLQADG
MUL_5057|M.ulcerans_Agy99 ADRLALEAIVCALEDQAVGDTQSAVSQLHSIRAGYAGLLHQAPTSLSADG
Mvan_0049|M.vanbaalenii_PYR-1 PEQWLVGQFLDSLADKFTGFLQKMLQLFTDLDENTAAAIDQAAGVDSPN-
MAB_0252|M.abscessus_ATCC_1997 -EVSHPDAKKAQAAADHQRRIQSGLDELARLDDMYGKKLREAADDLESMR
Mb0988c|M.bovis_AF2122/97 -----------------------------------------MLQRELTRL
Rv0963c|M.tuberculosis_H37Rv -----------------------------------------MLQRELTRL
MMAR_1913|M.marinum_M EAG------------------APVGPEGLTPTQRASDANEELLREERAKL
MSMEG_6381|M.smegmatis_MC2_155 GSSDFASAQEMGREQSGLSAPYPPEGEGVSPENVNAWWNALSEEEQAKVI
TH_2578|M.thermoresistible__bu GLTDVEQATNAG-------ARFALEP-GAEPQEVENWWNTLSPEQQEWMI
MAV_5292|M.avium_104 VDPANVRGVDE----------LSIPPADTGPEQVKWWWDSLSAAQQRLLI
MUL_5057|M.ulcerans_Agy99 FDPAVIQALDAPQSPAEPAEVIAIAAPTASAEEVKKWWDSLSPQQRGRLI
Mvan_0049|M.vanbaalenii_PYR-1 -PPVEVG-GQD----------IHIPSPDTDPADVKQWWDSLSEQQRRELI
MAB_0252|M.abscessus_ATCC_1997 DGQHDVTLPSGERVDP---DALVDRVSKMSADERAAFLATLSPETVDAMV
:
Mb0988c|M.bovis_AF2122/97 QN--GWLS--------------RDGVWHTDTD------------------
Rv0963c|M.tuberculosis_H37Rv QN--GWLS--------------RDGVWHTDTD------------------
MMAR_1913|M.marinum_M RARIGQLQGRYDQLAARAACDYNNGILDSDAMGQLAALGDQ---------
MSMEG_6381|M.smegmatis_MC2_155 SEHPDWIGNRDGVPVAVRSEVNKAALDRELAEAQAAVDAMPSRDEFRREH
TH_2578|M.thermoresistible__bu DNRPDWVRNVDGIPTEVRDESNRIWLPQERARLEDELRQELAANPNPNRP
MAV_5292|M.avium_104 DQHPQELGNLNGIPAEARDSVNRATMTDDLSKVEAVARVRGVSVQALRDN
MUL_5057|M.ulcerans_Agy99 DEHPPELGNLNGINAITRDLVNQAVMDDDITRVESVAMQRGVSADDIVN-
Mvan_0049|M.vanbaalenii_PYR-1 DRHPPMLGNLNGIPAEVRDQVNVAVMDDDLDRVQNVADRNGVSTDEVAG-
MAB_0252|M.abscessus_ATCC_1997 IANPEVMGNSDGIPFDTRIAANEINIRNALSDELQKQPPDQARVN-----
: :
Mb0988c|M.bovis_AF2122/97 ------------------------KLADLRALRDTLAAHP----------
Rv0963c|M.tuberculosis_H37Rv ------------------------KLADLRALRDTLAAHP----------
MMAR_1913|M.marinum_M ------------------LTAAKGRLGDLDAVDQALRNAP----------
MSMEG_6381|M.smegmatis_MC2_155 PGWN---GAQLNAAYNKMMFERQGRLDDAKAMKDALSVDGK---------
TH_2578|M.thermoresistible__bu P-------------FGMPARALERKINDLRKIEQVLDQK-----------
MAV_5292|M.avium_104 ALHNRDIDMFRNPAAYGLCATDIVRYQNAVKTNDCLN-------------
MUL_5057|M.ulcerans_Agy99 -----------NPQKYGLSASDVTRYRNAIRTRDGLIYDR----------
Mvan_0049|M.vanbaalenii_PYR-1 -----------NPGRYGLTDGDVTRYQNAKRTQEGLLHQLGAQDGETRRY
MAB_0252|M.abscessus_ATCC_1997 -----------------QLQDMLKPMEDPLVTRPADAGPR----------
:
Mb0988c|M.bovis_AF2122/97 -------------GTSLILLDTASDP-RKVLAAVGVGDVDN-AERVGVTM
Rv0963c|M.tuberculosis_H37Rv -------------GTSLILLDTASDP-RKVLAAVGVGDVDN-AERVGVTM
MMAR_1913|M.marinum_M -------------ETYLAQLRVPDDPHQQVLAAVAVGNPDT-AANVSVTV
MSMEG_6381|M.smegmatis_MC2_155 ----------YDPNKYLMLLEFPEDR--EPRAAIAVGNPDT-AEHVTVTT
TH_2578|M.thermoresistible__bu -------------DTYLIGLDTSGD---ATKAILAVGNPDE-ADHVAVTV
MAV_5292|M.avium_104 -------KACDPGLPLMLWAYDPLAFAGKGRAGIAIGNPDK-SRNTAVVV
MUL_5057|M.ulcerans_Agy99 ------EHATDDPRPVMLWAYDPLAFNGEGKAAIAIGNPDY-ARNTAVIV
Mvan_0049|M.vanbaalenii_PYR-1 SEIGEQERRDKNWRPTMLWAYDPQAFDGKGRAAVSIGNPDR-ASNTAVIV
MAB_0252|M.abscessus_ATCC_1997 -------------DFMVDRKYVMFSTEGNGRMIEMIGDIKPGVRGVGVIV
: :*: . . *
Mb0988c|M.bovis_AF2122/97 GGLNTRVSS--SVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGY
Rv0963c|M.tuberculosis_H37Rv GGLNTRVSS--SVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGY
MMAR_1913|M.marinum_M PGVGSTTRG--TLPGMVTEARNLQSEEMRQLKNAGKP--TSVAAIAWMGY
MSMEG_6381|M.smegmatis_MC2_155 PGVGTRPES---LGGMVSEADALRQEAQTQLDRAGRSG-EQVATIAWLGY
TH_2578|M.thermoresistible__bu PGMGSQDDAGSTIEGMTREGTLMQAEAQTQLERAGRGD-ETVATVAWMNY
MAV_5292|M.avium_104 PGTNSSVRG-----GWMSDGADDAINLYTQAQRADP--HHATAVLAWMGY
MUL_5057|M.ulcerans_Agy99 PGAGSSVAQ-----GWMSD-HDDATNLYDQALAADPE-HHYTAVIAWMGY
Mvan_0049|M.vanbaalenii_PYR-1 PGTSASVRD-----GWLSDGHNDAIHLYGQSLKADP--ADPTAVISWMGY
MAB_0252|M.abscessus_ATCC_1997 PGTNTNLNG----------SGSNHESAVKLAKESGSP------IFLYLGG
* .: :. . ::.
Mb0988c|M.bovis_AF2122/97 DAPDG---------LKDVMHDWS----------ARDAAGPLNRFDKGLA-
Rv0963c|M.tuberculosis_H37Rv DAPDG---------LKDVMHDWS----------ARDAAGPLNRFDKGLA-
MMAR_1913|M.marinum_M EPPPNPLDTATAGDLWQTMTDGQ----------ARAGAGDLSRYLQQVR-
MSMEG_6381|M.smegmatis_MC2_155 EPPGTDI------SVAEAGFERR----------ANEAAPDLADFYRGIN-
TH_2578|M.thermoresistible__bu DTPPG--------LLEGAGSDAR----------ATGAAPVLSNYLESID-
MAV_5292|M.avium_104 DAPEFDD-----SHWEQAVTDPAKLEQVGTPWRARQAGVLLAGDVNGLA-
MUL_5057|M.ulcerans_Agy99 DAPN--------GFSDVRVTEPG---------LARSGGALLANDVNGLW-
Mvan_0049|M.vanbaalenii_PYR-1 NTPE--------SFTDPNIANTG---------LARAGGDALAWDVNGLN-
MAB_0252|M.abscessus_ATCC_1997 DFPQG----------LDKAADPS---------YAAAMAPKLVDFGHEVDR
: * : * . * . :
Mb0988c|M.bovis_AF2122/97 ATTNV-SDQHITAFGHSYGSLVTSLALQQG-----APVSDVVLYGSPGTE
Rv0963c|M.tuberculosis_H37Rv ATTNV-SDQHITAFGHSYGSLVTSLALQQG-----APVSDVVLYGSPGTE
MMAR_1913|M.marinum_M ANN---PSGHLTVLGHSYGSLTASLALQDLNAHGAHPVNDVVFYGSPGLE
MSMEG_6381|M.smegmatis_MC2_155 ATNEHGSDVHLSAFGHSYGSLTTAQALYELG--ETGVVDDAAFYGSPGLG
TH_2578|M.thermoresistible__bu VTSTGTEEPHLTLVGHSYGSLAAGLSLQEG---ASDVVDDYVAYGSPGFY
MAV_5292|M.avium_104 ATHDAGSRAHVTVIGHSYGSTTVADAFANSG----MRANDAVLTGCPGTD
MUL_5057|M.ulcerans_Agy99 VTHNSLTPQHVTVIGHSYGSTTVADAFAGSG----MQANDAILIGCPGTD
Mvan_0049|M.vanbaalenii_PYR-1 VTHEAGVPEHVTVIGHSYGSTTVADAFANSG----MQADDAILLGSPGTD
MAB_0252|M.abscessus_ATCC_1997 AVGQNAPGTPVTYVGHSYGGAIVGTAEQMG-----LRADRILHASSAGTG
. :: .*****. .. : .. ...*
Mb0988c|M.bovis_AF2122/97 LTH---------------------ASQLGVEPGHAFYMIGVNDHVAN---
Rv0963c|M.tuberculosis_H37Rv LTH---------------------ASQLGVEPGHAFYMIGVNDHVAN---
MMAR_1913|M.marinum_M LYS---------------------PAQLGLEHGHAYVMQAPHDLITG---
MSMEG_6381|M.smegmatis_MC2_155 HTDSTETYISPRGVPIEVMAPIRDESDMFLADGRAFVMSAPGDPISGDPT
TH_2578|M.thermoresistible__bu AMD---------------------ESQLGMQQGHVFVMQAPDDPIR----
MAV_5292|M.avium_104 LAHS--------------------AADFHLDGGRLYVGAASTDAISWIGE
MUL_5057|M.ulcerans_Agy99 LARS--------------------AADFHFDGGQVYVGSASTDPVSWIGE
Mvan_0049|M.vanbaalenii_PYR-1 VARS--------------------AADFNLDGGQVYIGDASTDPVGWLGQ
MAB_0252|M.abscessus_ATCC_1997 ILPGG----------YTDPNPNVQRYSMTAPGDPIAIVQSLPRDVRLSDV
.: . . :
Mb0988c|M.bovis_AF2122/97 ----TIP--EFG---AFGSAPQDVPGMTQLSVNTGLA--PGPLLGD----
Rv0963c|M.tuberculosis_H37Rv ----TIP--EFG---AFGSAPQDVPGMTQLSVNTGLA--PGPLLGD----
MMAR_1913|M.marinum_M ----VVA--PLAPLHGWGPDPYLTPGLTELSSQAGFD--PGGIWRDGVYA
MSMEG_6381|M.smegmatis_MC2_155 WNGVPLP--SAGDLGQFGPNPLTLP-LEQLSADAAVT--PDGVSREGAVA
TH_2578|M.thermoresistible__bu ---------LVAETPWFGGDPADGS-FVQLSTTAGTT--PDGVYREGASG
MAV_5292|M.avium_104 SGSGLP----NGLNETLGGPLGPFAGLGTDPAHAGFG--AARFRAEVAGS
MUL_5057|M.ulcerans_Agy99 S-SGVPGELLKGKLREYGVPIPLDAGLGRDPAGDGFG--SVRFHAEVPGS
Mvan_0049|M.vanbaalenii_PYR-1 MGNTLP----GELNDSLGNMVGPTAGLGADPAFEDFG--ATRFRAEVPGA
MAB_0252|M.abscessus_ATCC_1997 PGVDQIPGIPHNVEGRIGNPLGGLPSATDPDKIPGVTRLDTGYYGEFGKH
* . :
Mb0988c|M.bovis_AF2122/97 --------------GQLHERA-----------------------------
Rv0963c|M.tuberculosis_H37Rv --------------GQLHERA-----------------------------
MMAR_1913|M.marinum_M HGDYPR--VFQDAAGQPQLRMSGYNLAAIAAGLPDNKVGAPLLPPVLGGG
MSMEG_6381|M.smegmatis_MC2_155 HADYPR--PVELPSGEKVLRTPAYNLAVIAAGLADVPGPNGEDRLVR---
TH_2578|M.thermoresistible__bu HSEYPR--PFN-ADGTDRLRVTGYNTAAVIAGLSETAVRK----------
MAV_5292|M.avium_104 HSVMPW--FTDHSDYYDVGSEALHNMTEIVTGRGNELAAEGMLAPDRNAA
MUL_5057|M.ulcerans_Agy99 GTMD----RHDHSHYYVMGSESLRSITDISSGHPDRLASDDLIAE-----
Mvan_0049|M.vanbaalenii_PYR-1 DMID----PSDHSYYYTVGSESLRSMTEIVTGNGGRLDELGLLAQPRTEL
MAB_0252|M.abscessus_ATCC_1997 PNQVIVGPDGHGSYWDDPSSDAFHNIAAVIGGGEATGYVERGIQTNYVDI
Mb0988c|M.bovis_AF2122/97 --------------------------------------------------
Rv0963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1913|M.marinum_M MPAAPGHVLAGGH-------------------------------------
MSMEG_6381|M.smegmatis_MC2_155 --------------------------------------------------
TH_2578|M.thermoresistible__bu --------------------------------------------------
MAV_5292|M.avium_104 RVSILGRVHT-PLGTL---------SLPRVEIRMPVVVDPEWERPARSVT
MUL_5057|M.ulcerans_Agy99 -----GRRQP-HVGPL---------RVP----GVPAYIDPESDRPRDTVH
Mvan_0049|M.vanbaalenii_PYR-1 TVSTPQQLDVPVLGEV---------PLPHLEVETPVIYDPEWNRAGGSVT
MAB_0252|M.abscessus_ATCC_1997 NVGDDGNFRAEAWDQSRAAAGAQVPGLPWDDPGTIDRRHHPWDNPRVTDH
Mb0988c|M.bovis_AF2122/97 ------------
Rv0963c|M.tuberculosis_H37Rv ------------
MMAR_1913|M.marinum_M ------------
MSMEG_6381|M.smegmatis_MC2_155 ------------
TH_2578|M.thermoresistible__bu ------------
MAV_5292|M.avium_104 NEHGF-------
MUL_5057|M.ulcerans_Agy99 DDHHYPAYQPPR
Mvan_0049|M.vanbaalenii_PYR-1 NDHGY-------
MAB_0252|M.abscessus_ATCC_1997 PEHGQKIQVK--