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M. bovis AF2122 / 97 Mb0047c (ino1)

annotation: myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)
coordinates: 50005 - 51108
length: 367

MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDV
DAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVD
VLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKSQVGATITHRV
LAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWL
DDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPE
QLPDDIARAQLEEFIIG

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0047c ino1 - 100% (367) myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_0867 - 1e-178 86.11% (360) myo-inositol-1-phosphate synthase
M. tuberculosis H37Rv Rv0046c ino1 0.0 99.73% (367) myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate
M. leprae Br4923 MLBr_02692 - 0.0 91.53% (366) hypothetical protein MLBr_02692
M. abscessus ATCC 19977 MAB_4907 - 1e-178 86.35% (359) myo-inositol-1-phosphate synthase
M. marinum M MMAR_0065 ino1 0.0 88.65% (370) myo-inositol-1-phosphate synthase Ino1
M. avium 104 MAV_0067 - 0.0 92.64% (367) myo-inositol-1-phosphate synthase
M. smegmatis MC2 155 MSMEG_6904 - 0.0 87.53% (361) myo-inositol-1-phosphate synthase
M. thermoresistible (build 8) TH_1311 - 0.0 91.22% (353) MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate
M. ulcerans Agy99 MUL_0064 ino1 0.0 88.92% (370) myo-inositol-1-phosphate synthase Ino1
M. vanbaalenii PYR-1 Mvan_6040 - 1e-180 87.22% (360) myo-inositol-1-phosphate synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0867|M.gilvum_PYR-GCK          MT--------ASN-DVRVAIVGVGNCASSLVQGVQYYKDADENASVPGLM
Mvan_6040|M.vanbaalenii_PYR-1       MT--------ASN-DVRVAIVGVGNCASSLVQGVQYYKDADENATVPGLM
MSMEG_6904|M.smegmatis_MC2_155      MS--------EHAGEIRVAIVGVGNCASSLVQGVQYYRNADENTTVPGLM
MAB_4907|M.abscessus_ATCC_1997      MS--------NTSSEVRVAIVGVGNCASSLVQGVQYYQDADENSTVPGLM
MMAR_0065|M.marinum_M               MSEKKPLGAPGAQPEVRVAIVGVGNCASSLVQGVEYYQNADDNSMVPGLM
MUL_0064|M.ulcerans_Agy99           MSEKKPLGAPGAQPEVRVAIVGVGNCASSLVQGVEYYQNADDNSMVPGLM
Mb0047c|M.bovis_AF2122/97           MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLM
Rv0046c|M.tuberculosis_H37Rv        MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLM
MLBr_02692|M.leprae_Br4923          MSEHNPAGAPGASTEVRVAIVGVGNCASSLVQGIEYYQNADDTSTVPGLM
MAV_0067|M.avium_104                MSDHQPPQAEDAQSEVRVAIVGVGNCASSLVQGVQYYFDADENSTVPGLM
TH_1311|M.thermoresistible__bu      MSEQK---------DIRVAIVGVGNCAASLVQGVEYYKDADENATVPGLM
                                    *:            ::***********:*****::** :**:.: *****

Mflv_0867|M.gilvum_PYR-GCK          HVKLGAYHVRDVKFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTD
Mvan_6040|M.vanbaalenii_PYR-1       HVKLGPYHVRDVKFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTD
MSMEG_6904|M.smegmatis_MC2_155      HVKFGPYHVRDVNFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTD
MAB_4907|M.abscessus_ATCC_1997      HVKFGPYHVRDVKFVAAFDVDAKKVGFDLSEAISASENNTIKIADVPPTD
MMAR_0065|M.marinum_M               HVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTN
MUL_0064|M.ulcerans_Agy99           HVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTN
Mb0047c|M.bovis_AF2122/97           HVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTN
Rv0046c|M.tuberculosis_H37Rv        HVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTN
MLBr_02692|M.leprae_Br4923          HVRFGPYHVRDVKFVAAFDVDAKKVGVDLSDAIFTSENNTIKIADVPPTN
MAV_0067|M.avium_104                HVKFGQYHVRDVKFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTN
TH_1311|M.thermoresistible__bu      HVRFGPYHVRDVNFVAAFDVDAKKVGFDLSEAIVASENNTIKIADVPPTD
                                    **::* ******:*************.***:** :***********.**:

Mflv_0867|M.gilvum_PYR-GCK          VVVQRGPTLDGIGKYYADTIEISDADAVDVVKVLKDAKVDVMVSYLPVGS
Mvan_6040|M.vanbaalenii_PYR-1       VVVQRGPTLDGIGKYYADTIEISDAEAVDVVKVLKDAKVDVLVSYLPVGS
MSMEG_6904|M.smegmatis_MC2_155      VIVQRGPTLDGIGKYYADTIEVSDAEPVDVVKVLKEAEVDVLVSYLPVGS
MAB_4907|M.abscessus_ATCC_1997      VIVQRGPTLDGIGKYYADTIEVSDSEPVDVVKVLKDNNVDVLVSYLPVGS
MMAR_0065|M.marinum_M               AVVQRGPTLDGIGKYYADTIELSDDEPVDVVKVLKDNKVDVLVSYLPVGS
MUL_0064|M.ulcerans_Agy99           VVVQRGPTLDGIGKYYADTIELSDDEPVDVVKVLKDNKVDVLVSYLPVGS
Mb0047c|M.bovis_AF2122/97           VIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGS
Rv0046c|M.tuberculosis_H37Rv        VIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGS
MLBr_02692|M.leprae_Br4923          VVVQRGPTLDGIGKYYTDTIELSDVPPVDVVQALTEAKTDVLVSYLPVGS
MAV_0067|M.avium_104                VTVQRGPTLDGIGKYYADTIEVSDAEPVDVVQVLKEAKVDVLVSYLPVGS
TH_1311|M.thermoresistible__bu      VVVQRGPTLDGIGKYYADTIEVSDAEPVDVVKALKEAEVDVLVSYLPVGS
                                    . **************:****:**  .****:.*.: :.**:********

Mflv_0867|M.gilvum_PYR-GCK          EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFEDAGVPIVGDDIKS
Mvan_6040|M.vanbaalenii_PYR-1       EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFEDAGVPIVGDDIKS
MSMEG_6904|M.smegmatis_MC2_155      EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFEDAGVPIVGDDIKS
MAB_4907|M.abscessus_ATCC_1997      EEADKFYAQCAIDAKVAFVNALPVFIASDPVWAKKFEDAGVPIVGDDIKS
MMAR_0065|M.marinum_M               EEADKFYAQCAIDAGVAFVNALPVFIASDPAWAKKFKDAGVPIIGDDIKS
MUL_0064|M.ulcerans_Agy99           EEADKFYAQCAIDAGVAFVNALPVFIASDPAWAKKFKDAGVPIIGDDIKS
Mb0047c|M.bovis_AF2122/97           EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKS
Rv0046c|M.tuberculosis_H37Rv        EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKS
MLBr_02692|M.leprae_Br4923          EEADKFYAQCAINARVAFVNALPVFIASDPVWAKKFADARVPIVGDDIKS
MAV_0067|M.avium_104                EEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKS
TH_1311|M.thermoresistible__bu      EEADKFYAQCCIDAGVAFVNALPVFIASDPVWAKKFADAGVPIVGDDIKS
                                    **********.*:* ***************.***** ** ***:******

Mflv_0867|M.gilvum_PYR-GCK          QIGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFLNMLERTRLESKKV
Mvan_6040|M.vanbaalenii_PYR-1       QIGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFLNMLERSRLESKKV
MSMEG_6904|M.smegmatis_MC2_155      QVGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFLNMLERSRLESKKV
MAB_4907|M.abscessus_ATCC_1997      QVGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFKNMLERERLESKKV
MMAR_0065|M.marinum_M               QVGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFKNMLERERLESKKV
MUL_0064|M.ulcerans_Agy99           QVGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFKNMLERERLESKKV
Mb0047c|M.bovis_AF2122/97           QVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKI
Rv0046c|M.tuberculosis_H37Rv        QVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKI
MLBr_02692|M.leprae_Br4923          QVGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERVQSKKI
MAV_0067|M.avium_104                QIGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKI
TH_1311|M.thermoresistible__bu      QIGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKI
                                    *:********:********* **** ********** ***** *::***:

Mflv_0867|M.gilvum_PYR-GCK          SKTQAVTSNLSGSLAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFG
Mvan_6040|M.vanbaalenii_PYR-1       SKTQAVTSNLSGSLAGKIEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFG
MSMEG_6904|M.smegmatis_MC2_155      SKTQAVTSNLSGALAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFG
MAB_4907|M.abscessus_ATCC_1997      SKTQAVTSNLNGSLADKVYDKNVHIGPSDYVAWLDDRKWAYVRLEGRAFG
MMAR_0065|M.marinum_M               SKTQAVTSNLTGSLAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFG
MUL_0064|M.ulcerans_Agy99           SKTQAVTSNLTGSLAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFG
Mb0047c|M.bovis_AF2122/97           SKTQAVTSNLKREFK----TKDVHIGPSDHVGWLDDRKWAYVRLEGRAFG
Rv0046c|M.tuberculosis_H37Rv        SKTQAVTSNLKREFK----TKDVHIGPSDHVGWLDDRKWAYVRLEGRAFG
MLBr_02692|M.leprae_Br4923          SKTQAVTSNVHREFN----TKDIHIGPSDHVGWLDDRKWAYVRLEGRGFG
MAV_0067|M.avium_104                SKTQAVTSNLQREFK----TKDVHIGPSDHVSWLDDRKWAYVRLEGRAFG
TH_1311|M.thermoresistible__bu      SKTQAVTSNLQKEFK----TKDVHIGPSDHVGWLDDRKWAYVRLEGRAFG
                                    *********:   :      *::******:*.***************.**

Mflv_0867|M.gilvum_PYR-GCK          DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPIEAASAYLMK
Mvan_6040|M.vanbaalenii_PYR-1       DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPIEAASAYLMK
MSMEG_6904|M.smegmatis_MC2_155      DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPIEAASAYLMK
MAB_4907|M.abscessus_ATCC_1997      DVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIALDRGLGGPILPASAYLMK
MMAR_0065|M.marinum_M               DVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPVIPASAYLMK
MUL_0064|M.ulcerans_Agy99           DVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPVIPASAYLMK
Mb0047c|M.bovis_AF2122/97           DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMK
Rv0046c|M.tuberculosis_H37Rv        DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMK
MLBr_02692|M.leprae_Br4923          DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASSYLMK
MAV_0067|M.avium_104                DVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMK
TH_1311|M.thermoresistible__bu      DVPLNLEYKLEVWDSPNSAGVIIDAIRAAKIAKDRGIGGPIESASAYLMK
                                    ********************:****:****** ***:***: .**:****

Mflv_0867|M.gilvum_PYR-GCK          SPPKQLADDIARVQLEKFIEG--
Mvan_6040|M.vanbaalenii_PYR-1       SPPKQLADDIARVQLEKFIEG--
MSMEG_6904|M.smegmatis_MC2_155      SPPKQLADDVARAELETFIEG--
MAB_4907|M.abscessus_ATCC_1997      SPPKQLADDVARAELEQFIAG--
MMAR_0065|M.marinum_M               SPPKQLADDVARTQLEEFIIEG-
MUL_0064|M.ulcerans_Agy99           SPPKQLADDVARTQLEEFIIEG-
Mb0047c|M.bovis_AF2122/97           SPPEQLPDDIARAQLEEFIIG--
Rv0046c|M.tuberculosis_H37Rv        SPPEQLPDDIARAQLEEFIIG--
MLBr_02692|M.leprae_Br4923          SPPQQLPDEIARAQLEEFIIDTK
MAV_0067|M.avium_104                SPPQQLPDDVARTQLEEFIIGG-
TH_1311|M.thermoresistible__bu      SPPTQMPDDIARAKLEEFIKG--
                                    *** *:.*::**.:** **

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb0047c	ino1	-	100% (367)	myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)