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MPWDFSTEPEFEKKLDWIRGFVREEVEPLEVVFPGCEFLPLNDERRRIVDPLKQRVRDEGLWAPHLGPEL GGQGFGAVKLTLINEILGRSPWAPIVFGTQAPDTGNAEIIARFGTPDQKDRYLQGLLSGEIFSCFSMTEP QGGADPRVFTTRAVRDGDGWVISGRKYFSSNASVPSFFIVVAITNPDVAVHHGASTFLVPAGTKGLTIEA NHHLVGALPHEPGHSLMHYDDVRVGADALLGEPGQGFLILQTRLAGGRLHHAMRSIGVAQRAVEMMSRRA KSRFTQGSSLADKQLVQAFIADSYTELMPFRLAVLHAAWMIDTAGEHAARAEIGACKILASQVLKSIGLR AIQVHGALGTTDQLPLVSVLLGGVALGLADGPTEAHKVNLARMLLKNYEPEDPQWPSESLAVRQAAARAK YGQLVDRVPALPDSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4385 | fadE1_1 | - | 100% (435) | acyl-CoA dehydrogenase FadE1_1 |
| M. ulcerans Agy99 | MUL_4790 | fadE1 | e-119 | 50.35% (425) | acyl-CoA dehydrogenase FadE1 |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 4e-31 | 27.40% (354) | acyl-CoA dehydrogenase FadE25 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0136c | fadE1 | 1e-118 | 49.31% (432) | acyl-CoA dehydrogenase FADE1 |
| M. gilvum PYR-GCK | Mflv_2451 | - | 1e-144 | 56.71% (425) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0131c | fadE1 | 1e-118 | 49.31% (432) | acyl-CoA dehydrogenase FADE1 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-29 | 26.27% (354) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4911c | - | 1e-106 | 45.95% (420) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_5311 | fadE1_1 | 0.0 | 98.16% (435) | acyl-CoA dehydrogenase FadE1_1 |
| M. avium 104 | MAV_5173 | - | 1e-122 | 51.52% (429) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4826 | - | 1e-146 | 57.38% (427) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2939 | - | 1e-144 | 57.54% (431) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_4200 | - | 1e-143 | 56.47% (425) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4385|M.ulcerans_Agy99 ------------MPWDFSTEPEFEK-KLDWIRGFVREEVEPLEVVFPGCE
MMAR_5311|M.marinum_M ------------MPWDFSTEPEFEK-KLDWIREFVREEVEPLEVVFPGCE
Mflv_2451|M.gilvum_PYR-GCK -------------MWSFETDPEYQK-VLDWADEFVREEVEPLDLAFPHQQ
Mvan_4200|M.vanbaalenii_PYR-1 -------------MWSFETDPEYQK-VLDWADEFVREEVEPLDLAFPHQQ
TH_2939|M.thermoresistible__bu ------------MAWDFETDPEYQK-VLDWADEFVRTEVEPLDLAFPHQQ
MSMEG_4826|M.smegmatis_MC2_155 ------------MAWDFETDPQYQE-VLDWADEFVREKVEPLDLVWPHLQ
Mb0136c|M.bovis_AF2122/97 MPVRRRAGERLPTVWDFETDPQYQS-KLDWVEKFMAEELEPLDLVALDP-
Rv0131c|M.tuberculosis_H37Rv MPVRRRAGERLPTVWDFETDPQYQS-KLDWVEKFMAEELEPLDLVALDP-
MAV_5173|M.avium_104 -------------MWDFETDPEYQA-KLDWVEKFMAEELEPLDLVALDP-
MAB_4911c|M.abscessus_ATCC_199 ---------MTAMAWDFETDPEYQE-LLDWADEFVRTEVEPLDYVFPNP-
MLBr_00737|M.leprae_Br4923 -------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP-
.:. :* :: * : :..*
MUL_4385|M.ulcerans_Agy99 FLPLNDERRRIVDPLKQRVRDEGLWAPHLGPELGGQGFGAVKLTLINEIL
MMAR_5311|M.marinum_M FLPLNDERRRIVDPLKQRVRDEGLWAPHLGPELGGQGFGAVKLTLINEIL
Mflv_2451|M.gilvum_PYR-GCK FVPLDGKRREAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
Mvan_4200|M.vanbaalenii_PYR-1 FVPLDGERRRAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
TH_2939|M.thermoresistible__bu FVPLEGTRREAIEPLKQEVRRRGLWATHLGPELGGQGYGQLKLALLNEIL
MSMEG_4826|M.smegmatis_MC2_155 FTPLNEARRQVVDPLKEQVRRKGLWATHLGPELGGQGYGQLKLALLNEIL
Mb0136c|M.bovis_AF2122/97 YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
Rv0131c|M.tuberculosis_H37Rv YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
MAV_5173|M.avium_104 YDKKNAEMMAILRPLQQQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIL
MAB_4911c|M.abscessus_ATCC_199 YDKSDTVAMDYVRPLKEEVKRRGLWACHLGPELGGPGYGQLKLALLNEIL
MLBr_00737|M.leprae_Br4923 HAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEV
. :. *: * *: : ** * . : :: * :
MUL_4385|M.ulcerans_Agy99 GRSPWAPIVFGTQAPDTGNAEIIARFGTPDQKDRYLQGLLSGEIFSCFSM
MMAR_5311|M.marinum_M GRSPWAPIVFGTQAPDTGNAEIIARFGTQDQKERYLQGLLSGEIFSCFSM
Mflv_2451|M.gilvum_PYR-GCK GRSQWAPIIFGCQAPDTGNAEIIAHYGTEEQKQRYLRPLLDGELFSCYSM
Mvan_4200|M.vanbaalenii_PYR-1 GRSQWAPVIFGCQAPDTGNAEIIAHYGTEEQKQKYLRPLLDGELFSCYSM
TH_2939|M.thermoresistible__bu GRSQWAPVVFGCQAPDTGNAEIIAHYGTEEQQKRYLQPLLDGELFSCYSM
MSMEG_4826|M.smegmatis_MC2_155 GRSQWAPIVFGCQAPDTGNAEIIAHYGTDEQKERYLRPLLEGELFSSYSM
Mb0136c|M.bovis_AF2122/97 GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
Rv0131c|M.tuberculosis_H37Rv GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
MAV_5173|M.avium_104 GRSRWAPSVFGCQAPDSGNAEILALFGTDEQKARYLQPLLDGEITSCYSM
MAB_4911c|M.abscessus_ATCC_199 GRSVWAPSIFGCQAPDTGNAEILAHYGTEAQKAKYLQPLMDGDIGSCYVM
MLBr_00737|M.leprae_Br4923 ARVDASASLIPAVN-KLGTMGLILR-GSEELKKQVLPSLAAEGAMASYAL
.* :. : . *. :: *: : : * * :.: :
MUL_4385|M.ulcerans_Agy99 TEPQGGADPRVFTTRAVRDGD----GWVISGRKYFSSNASVPSFFIVVAI
MMAR_5311|M.marinum_M TEPQGGADPRVFTTRAVRDGD----DWVISGRKYFSSNASVASFFIVVAI
Mflv_2451|M.gilvum_PYR-GCK TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
Mvan_4200|M.vanbaalenii_PYR-1 TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
TH_2939|M.thermoresistible__bu TEPHAGADPTLFKTTAVRDGAGPDADWVINGWKFFSSNATTASFLIVMAV
MSMEG_4826|M.smegmatis_MC2_155 TEPHAGADPTLFTTRAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
Mb0136c|M.bovis_AF2122/97 TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
Rv0131c|M.tuberculosis_H37Rv TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
MAV_5173|M.avium_104 TEPQGGSDPGQFVTAATRDGD----YWVINGEKWFSTNAKHASFFIVMAV
MAB_4911c|M.abscessus_ATCC_199 TEPQGGSDPTLFKTTAVRDGD----EWILNGEKWFNSEARHAAFWIVMAV
MLBr_00737|M.leprae_Br4923 SEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAV
:* ..*:*. : * * *. *::.* * : ::. .:: *:.:
MUL_4385|M.ulcerans_Agy99 TNPDVAVHHGASTFLVPAGTKGLTIEANHHLVGALPHEPGHSLMHYDDVR
MMAR_5311|M.marinum_M TNPDVAVHHGASTFLVPAGIKGLTIEANHHLVGALPHEPGHSLVHYDDVR
Mflv_2451|M.gilvum_PYR-GCK TNPDVSAYQGMSMFLVPTDTPGVTIERNVGLYGEREGEGSHALIHYDNVR
Mvan_4200|M.vanbaalenii_PYR-1 TNREVSAYQGMSMFLVPTDTPGVKIERNIGLYGEGAEHGSHALIHYDNVR
TH_2939|M.thermoresistible__bu TNPDVSAYQGMSMFLVPTDTPGVKIERSIGLYGDPPGTGSHALIHYDNVR
MSMEG_4826|M.smegmatis_MC2_155 TNPDVSAYQGMSMFLVPTDTPGVEIVRNVGLYGERDNEGSHALIHYDNVR
Mb0136c|M.bovis_AF2122/97 TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
Rv0131c|M.tuberculosis_H37Rv TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
MAV_5173|M.avium_104 TNPEARTYDKMSLFIVPAETPGIEIVRNVGVGAESSSRASHGYVGYTDVR
MAB_4911c|M.abscessus_ATCC_199 TNTEVSPYQGMSMFIVDPNAPGVEIVRNITVHGFS---EDEAYTRFTNAR
MLBr_00737|M.leprae_Br4923 TDPDKGAN-GISAFIVHKDDEGFSIGPKEKKLGIKG--SPTTELYFDKCR
*. : * *:* *. * . . : . *
MUL_4385|M.ulcerans_Agy99 VGADALLGEPGQGFLILQTRLAGGRLHHAMRSIGVAQRAVEMMSRRAKSR
MMAR_5311|M.marinum_M VGADALLGEPGQGFLILQTRLAGGRLHHAMRSIGVAQRAVEMMSRRAKSR
Mflv_2451|M.gilvum_PYR-GCK VPSEALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
Mvan_4200|M.vanbaalenii_PYR-1 VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
TH_2939|M.thermoresistible__bu VPADALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
MSMEG_4826|M.smegmatis_MC2_155 VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
Mb0136c|M.bovis_AF2122/97 VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
Rv0131c|M.tuberculosis_H37Rv VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
MAV_5173|M.avium_104 VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARSAFDMMCERAVSR
MAB_4911c|M.abscessus_ATCC_199 IPAENMLGAEGGAFAIAQTRLGGGRVHHAMRTVAQVRKAFDMMCERVVSR
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
: .: ::* * .* : * * . :::. : *.: . .*
MUL_4385|M.ulcerans_Agy99 FTQGSSLADKQLVQAFIADSYTELMPFRLAVLHAAWMIDTAGEH-AARAE
MMAR_5311|M.marinum_M FTQGSSLADKQLVQAFIADSYTELMPFRLAVLHAAWMIDTAGEH-AARAE
Mflv_2451|M.gilvum_PYR-GCK ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
Mvan_4200|M.vanbaalenii_PYR-1 ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
TH_2939|M.thermoresistible__bu QTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
MSMEG_4826|M.smegmatis_MC2_155 KTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKLVRKD
Mb0136c|M.bovis_AF2122/97 QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
Rv0131c|M.tuberculosis_H37Rv QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MAV_5173|M.avium_104 KTRHGRLADFQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MAB_4911c|M.abscessus_ATCC_199 EARGGTIAKLQMTQERIADSWIEMESFRLLVLRTAWLIDKHQDYLKVRKD
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS-
:: * * :** :: ** * :* :
MUL_4385|M.ulcerans_Agy99 IGACKILASQVLKSIGLRAIQVHGALGTTDQLPLVSVLLGGVALGLADGP
MMAR_5311|M.marinum_M IGACKILASQVLKSIGLRAIQVHGALGTTDQLPLVSVLLGGVALGLADGP
Mflv_2451|M.gilvum_PYR-GCK IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
Mvan_4200|M.vanbaalenii_PYR-1 IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
TH_2939|M.thermoresistible__bu IAAVKATMPTVLHDIAWRAMQVHGALGVTDEMPFMGMITGAAVMGLADGP
MSMEG_4826|M.smegmatis_MC2_155 IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEMPFLGMVTGAAVMGLADGP
Mb0136c|M.bovis_AF2122/97 IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
Rv0131c|M.tuberculosis_H37Rv IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
MAV_5173|M.avium_104 IAAVKVAMPQVLHDVAQRALHLHGALGVSDEMPFVKMLVAAESLGIADGA
MAB_4911c|M.abscessus_ATCC_199 ISAIKAAMPKVMHDVAQRALHLHGSLGVSEEMPLAKMFLYSEVMGLVDGP
MLBr_00737|M.leprae_Br4923 -AASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGT
.* * . : .: *:::.*. * :.:.*. .. . : :*.
MUL_4385|M.ulcerans_Agy99 TEAHKVNLARMLLKNYEPEDPQWPSESLAVRQAAARAKYGQLVDRVPALP
MMAR_5311|M.marinum_M TEAHKVNLARMLLKNYEPEDPQWPSESLTVRQAAARAKYGQLVDRVPALP
Mflv_2451|M.gilvum_PYR-GCK TEVHKTTVAKQVLRDHRPAEGMWPSEWIPAKREAAQAKYADFIEHEVGNL
Mvan_4200|M.vanbaalenii_PYR-1 TEVHKTTVAKQVLRDYRPAEGLWPSEWIPAKREAARAKYAEYLENEVGNL
TH_2939|M.thermoresistible__bu TEVHKATVAKQVLRDYRPSDDVWPSEWIPRKREAALAKYAEYLEHEVGNL
MSMEG_4826|M.smegmatis_MC2_155 TEVHKTTVAKQVLRDYQPTEDTWPTEWIPRKREAARAKLADYLENEVGNL
Mb0136c|M.bovis_AF2122/97 TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
Rv0131c|M.tuberculosis_H37Rv TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
MAV_5173|M.avium_104 TELHKMTVARRTLREYEPVSTPFPSAHIPTRRAEAQARLAERLEHAVAEF
MAB_4911c|M.abscessus_ATCC_199 TEVHKVTIAKEVLKDYTPYEGLFPPSHIPALTEKARAHVAARLEHRVGNL
MLBr_00737|M.leprae_Br4923 NQIQRVVMSRALLR------------------------------------
.: :: ::: *:
MUL_4385|M.ulcerans_Agy99 DSP
MMAR_5311|M.marinum_M DSP
Mflv_2451|M.gilvum_PYR-GCK ---
Mvan_4200|M.vanbaalenii_PYR-1 ---
TH_2939|M.thermoresistible__bu ---
MSMEG_4826|M.smegmatis_MC2_155 ---
Mb0136c|M.bovis_AF2122/97 ---
Rv0131c|M.tuberculosis_H37Rv ---
MAV_5173|M.avium_104 ---
MAB_4911c|M.abscessus_ATCC_199 ---
MLBr_00737|M.leprae_Br4923 ---