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M. ulcerans Agy99 MUL_3652 (nirA_2)

annotation: ferredoxin-dependent nitrite reductase, NirA_2
coordinates: 4063107 - 4064774
length: 555

MTTARPAKPRNEGQWALGNREPFNANEELKKAGNPLDVRERIENIYAKAGFDSIDKSDLRGLFRWWGLYT
QREQGYDGSWTGDENIDKLEAKYFMLRVRCDGGALSTAALRTLGAISTEFARDTADISDRENLQYHWIEV
EKVPEIWRRLDEVGLHTTEACGDCPRVVLGSPLAGESLDEVLDPTWAIDEIVRRYIGKPDFADLPRKYKT
AISGLQDVVHEVNDVAFIGVNHPEHGPGLDLWVGGGLSTNPMLAKRVGAWVPLEEVPEVWAAVTSVFRDY
GYRRLRSKARLKFLIKDWGIEKFREVLETEYLKRPLIDGPAPEPAKHPIDHVGVQRLKNGHNAVGVSPIA
GRVSGTILTAVAELAERAGSDRIRFTPYQKLVILDIPDDKLDETIAGLQALGLRAQPSHWRRNLMACSGI
EFCKLSFAETRVRAQSLVPELEERLDDINSTLDVPVAVNINGCPNSCARIQVADIGFKGQMVDDGAGGQV
EGFQVHLGGSLGLDSGFGRKLRQHKVTSDELGDYIDRVVRNFVKNRAAGERFAQWAIRAEEDDLR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3652nirA_2-100% (555)ferredoxin-dependent nitrite reductase, NirA_2

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2412nirA0.090.45% (555) ferredoxin-dependant nitrite reductase NIRA
M. gilvum PYR-GCKMflv_2686-0.081.74% (553) ferredoxin--nitrite reductase
M. tuberculosis H37RvRv2391nirA0.090.45% (555) ferredoxin-dependent nitrite reductase NIRA
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1662c-0.078.26% (552) sulfite reductase
M. marinum MMMAR_3710nirA_20.099.28% (555) ferredoxin-dependent nitrite reductase, NirA_2
M. avium 104MAV_1787-0.087.03% (555) sulfite reductase
M. smegmatis MC2 155MSMEG_4527-0.084.24% (552) ferredoxin sulfite reductase
M. thermoresistible (build 8)TH_1443nirA0.082.97% (552) PROBABLE FERREDOXIN-DEPENDENT NITRITE REDUCTASE NIRA
M. vanbaalenii PYR-1Mvan_3857-0.080.04% (561) ferredoxin--nitrite reductase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2686|M.gilvum_PYR-GCK          --------MTTAKT---------PPAKPAKRPRGEGQWALGYREPLNPNE
Mvan_3857|M.vanbaalenii_PYR-1       --------MTTAQD---------KPVKPVKRPRGEGQWALGYREPLNPNE
MSMEG_4527|M.smegmatis_MC2_155      --------MTSSEAPAKTAEKPAPKTRPAKRPRGEGQWALGYREPLNANE
MUL_3652|M.ulcerans_Agy99           ----------------------MTTARPAK-PRNEGQWALGNREPFNANE
MMAR_3710|M.marinum_M               ----------------------MTTARPAK-PRNEGQWALGNREPLNANE
Mb2412|M.bovis_AF2122/97            ------MSAKENPQ--------MTTARPAK-ARNEGQWALGHREPLNANE
Rv2391|M.tuberculosis_H37Rv         ------MSAKENPQ--------MTTARPAK-ARNEGQWALGHREPLNANE
MAV_1787|M.avium_104                MLAALAIFFRGERP--------MTTARPAK-ARNEGQWALGNREPLNPNE
TH_1443|M.thermoresistible__bu      --------MTEAKT--------QAKPRPARKPRSEGQWALGERDPLNPNE
MAB_1662c|M.abscessus_ATCC_199      --------MTTSET---------RPARPKQ-QRSEGQWALGELEPLNSNE
                                                              :* :  *.*******  :*:*.**

Mflv_2686|M.gilvum_PYR-GCK          QSKKDDNPLNVRERIENIYAKNGFESIDKGDLRGRFRWWGLYTQRKPGYD
Mvan_3857|M.vanbaalenii_PYR-1       RSKRDDNPLNVRARIENIYAQGGFDSIDKGDLRGRFRWWGLYTQRKPGYD
MSMEG_4527|M.smegmatis_MC2_155      QAKKDDNPLNVRARIENIYAKNGFESIDKGDLRGRFRWWGLYTQRKPGYD
MUL_3652|M.ulcerans_Agy99           ELKKAGNPLDVRERIENIYAKAGFDSIDKSDLRGLFRWWGLYTQREQGYD
MMAR_3710|M.marinum_M               ELKKAGNPLDVRERIENIYAKAGFDSIDKSDLRGLFRWWGLYTQREQGYD
Mb2412|M.bovis_AF2122/97            ELKKAGNPLDVRERIENIYAKQGFDSIDKTDLRGRFRWWGLYTQREQGYD
Rv2391|M.tuberculosis_H37Rv         ELKKAGNPLDVRERIENIYAKQGFDSIDKTDLRGRFRWWGLYTQREQGYD
MAV_1787|M.avium_104                EMKQAGAPLAVRERIETIYAKNGFDSIDKSDLRGRFRWWGLYTQREQGYD
TH_1443|M.thermoresistible__bu      QFKQEDDALNVRDRIINTYAKNGFDSIDKTDLRGRFRWMGLYTQREQGYD
MAB_1662c|M.abscessus_ATCC_199      QVKKDDHPLNVRERIETIYSKQGFDSIDKADLRGRFRWWGLYTQRKQGYD
                                    . *: . .* ** ** . *:: **:**** **** *** ******: ***

Mflv_2686|M.gilvum_PYR-GCK          GTWTGDENTDMLEDEYFMLRVRSDGGALTAAALRTLGTISTEFARDTADI
Mvan_3857|M.vanbaalenii_PYR-1       GTWTGDENTDMLEDSYFMLRVRSDGGALSAEALRTLGGISTEFARDTADL
MSMEG_4527|M.smegmatis_MC2_155      GTWTGDENTDMLEDEYFMLRVRCDGGALTTAALRTLGGISTEFARDTADI
MUL_3652|M.ulcerans_Agy99           GSWTGDENIDKLEAKYFMLRVRCDGGALSTAALRTLGAISTEFARDTADI
MMAR_3710|M.marinum_M               GSWTGDENIDKLEAKYFMLRVRCDGGALSAAALRTLGAISTEFARDTADI
Mb2412|M.bovis_AF2122/97            GTWTGDDNIDKLEAKYFMMRVRCDGGALSAAALRTLGQISTEFARDTADI
Rv2391|M.tuberculosis_H37Rv         GTWTGDDNIDKLEAKYFMMRVRCDGGALSAAALRTLGQISTEFARDTADI
MAV_1787|M.avium_104                GSWTGDENIEKLEARYFMMRVRCDGGAISAAALRTLGQISVDFARDTADI
TH_1443|M.thermoresistible__bu      GTWTGDENADLLEAKYFMMRVRCDGKALSAAALRTLGEISTEFARDTADI
MAB_1662c|M.abscessus_ATCC_199      GTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGELSTQYARDTADI
                                    *:****:* : **  :**:***.** *::: ****:* :*.::******:

Mflv_2686|M.gilvum_PYR-GCK          SDRQNVQYHWIDVKDMPEIWRRLDEVGLQTTEACGDCPRVVLGSPLAGES
Mvan_3857|M.vanbaalenii_PYR-1       SDRQNVQYHWIEVENMPEIWRRLDAVGLQTTEACGDCPRVVLGSPLAGES
MSMEG_4527|M.smegmatis_MC2_155      SDRENVQYHWIQVENMPEIWKRLDAVGLQTTEACGDCPRVVLGSPLAGES
MUL_3652|M.ulcerans_Agy99           SDRENLQYHWIEVEKVPEIWRRLDEVGLHTTEACGDCPRVVLGSPLAGES
MMAR_3710|M.marinum_M               SDRENLQYHWIEVEKVPEIWRRLDEVGLHTTEACGDCPRVVLGSPLAGES
Mb2412|M.bovis_AF2122/97            SDRQNVQYHWIEVENVPEIWRRLDDVGLQTTEACGDCPRVVLGSPLAGES
Rv2391|M.tuberculosis_H37Rv         SDRQNVQYHWIEVENVPEIWRRLDDVGLQTTEACGDCPRVVLGSPLAGES
MAV_1787|M.avium_104                TDRENIQYHWIEVENVPEIWRRLDAVGLRTTEACGDCPRVILGSPLAGES
TH_1443|M.thermoresistible__bu      SDRMNLQYHWIEIENVPEIWRRLDEHGLQTTEACGDCPRALLGSPLAGES
MAB_1662c|M.abscessus_ATCC_199      SDRQNVQYHWIRVEDMPEIWRRLDEVGLYTTQACGDCPRVILGSPLAGES
                                    :** *:***** ::.:****:***  ** **:*******.:*********

Mflv_2686|M.gilvum_PYR-GCK          LDEVIDGTPAVNEIVKRYIGKKEYSNLPRKFKTAISGLQDVVHEVNDVAF
Mvan_3857|M.vanbaalenii_PYR-1       LDEVIDGTPAVDEIVKRYIGKPEYSNLPRKFKTAISGLQDVVHEVNDVAF
MSMEG_4527|M.smegmatis_MC2_155      LDEVIDGTPAIDEIVRRYIGKPEYSNLPRKFKTAISGLQDVVHEVNDVAF
MUL_3652|M.ulcerans_Agy99           LDEVLDPTWAIDEIVRRYIGKPDFADLPRKYKTAISGLQDVVHEVNDVAF
MMAR_3710|M.marinum_M               LDEVLDPTWAIDEIVRRYIGKPDFADLPRKYKTAISGLQDVVHEVNDVAF
Mb2412|M.bovis_AF2122/97            LDEVLDPTWAIEEIVRRYIGKPDFADLPRKYKTAISGLQDVAHEINDVAF
Rv2391|M.tuberculosis_H37Rv         LDEVLDPTWAIEEIVRRYIGKPDFADLPRKYKTAISGLQDVAHEINDVAF
MAV_1787|M.avium_104                LEEVIDPSWAIAEIARRYIGQPEFADLPRKYKTAISGLQDVAHEVNDVAF
TH_1443|M.thermoresistible__bu      LDEVLDPTPALDEIVRRYIGNPEYSNLPRKYKTAISGLQDVAHEVNDVAF
MAB_1662c|M.abscessus_ATCC_199      LDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAF
                                    *:**:* : *: **.:****: ::::****:**********.**:*****

Mflv_2686|M.gilvum_PYR-GCK          IGVNHPEHGPGFDLWVGGGLSTNPMLGQRVGAWVPLDEVPDVWEGVVSVF
Mvan_3857|M.vanbaalenii_PYR-1       IGVNHPEHGPGFDLWVGGGLSTNPMLAQRVGVWVPLDEVPDVWEGVVSVF
MSMEG_4527|M.smegmatis_MC2_155      IGVNHPEHGPGFDLWVGGGLSTNPMLAQRVGVWVPLDEVPDVWEGVVSIF
MUL_3652|M.ulcerans_Agy99           IGVNHPEHGPGLDLWVGGGLSTNPMLAKRVGAWVPLEEVPEVWAAVTSVF
MMAR_3710|M.marinum_M               IGVNHPEHGPGLDLWVGGGLSTNPMLAKRVGAWVPLEEVPEVWAAVTSVF
Mb2412|M.bovis_AF2122/97            IGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLGEVPEVWAAVTSVF
Rv2391|M.tuberculosis_H37Rv         IGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLGEVPEVWAAVTSVF
MAV_1787|M.avium_104                IGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLHEVPEVWAAVTSVF
TH_1443|M.thermoresistible__bu      IGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLDEVPDVWEAVTAVF
MAB_1662c|M.abscessus_ATCC_199      VGVVHPEHGPGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIF
                                    :** *******:*:************.:*:*.**** ***:** .*..:*

Mflv_2686|M.gilvum_PYR-GCK          RDYGYRRLRAKARLKFLIKDWGVEKFRQVLEEEYLKRPLIDGPAPEPVTR
Mvan_3857|M.vanbaalenii_PYR-1       RDYGYRRLRSKARLKFLIKDWGAQKFREVLETEYLHRPLLDGPAPEPVTR
MSMEG_4527|M.smegmatis_MC2_155      RDYGYRRLRSKARLKFLIKDWGVEKFREVLETEYLKRPLIDGPAPEPVTR
MUL_3652|M.ulcerans_Agy99           RDYGYRRLRSKARLKFLIKDWGIEKFREVLETEYLKRPLIDGPAPEPAKH
MMAR_3710|M.marinum_M               RDYGYRRLRSKARLKFLIKDWGIEKFREVLETEYLKRPLIDGPAPEPAKH
Mb2412|M.bovis_AF2122/97            RDYGYRRLRAKARLKFLIKDWGIAKFREVLETEYLKRPLIDGPAPEPVKH
Rv2391|M.tuberculosis_H37Rv         RDYGYRRLRAKARLKFLIKDWGIAKFREVLETEYLKRPLIDGPAPEPVKH
MAV_1787|M.avium_104                RDYGYRRLRSKARLKFLVKDWGIEKFREVLETEYLKRPLIDGPAPEPVAH
TH_1443|M.thermoresistible__bu      RDYGYRRLRSKARLKFLIKDWGVEKFREVLETEYLKRPLIDGPAPEPVKH
MAB_1662c|M.abscessus_ATCC_199      RDYGYRRLRSKARLKFLVKDWGVAKFREILETEYLKRPLIDGPAPVPPTH
                                    *********:*******:****  ***::** ***:***:***** *  :

Mflv_2686|M.gilvum_PYR-GCK          PIDHVGVQKLKNGLNAVGVAPIAGRVSGTILTKVADLAEAAGSDRIRFTP
Mvan_3857|M.vanbaalenii_PYR-1       PIDHVGVQKLKNGLNAVGVAPIAGRVSGTILTKVADLAEAAGSDRIRFTP
MSMEG_4527|M.smegmatis_MC2_155      PIDHVGVQKLKNGLNAVGVAPIAGRVSGTILTKVADLAEAAGSDRIRFTP
MUL_3652|M.ulcerans_Agy99           PIDHVGVQRLKNGHNAVGVSPIAGRVSGTILTAVAELAERAGSDRIRFTP
MMAR_3710|M.marinum_M               PIDHVGVQRLKNGHNAVGVSPIAGRVSGTILTAVAELAERAGSDRIRFTP
Mb2412|M.bovis_AF2122/97            PIDHVGVQRLKNGLNAVGVAPIAGRVSGTILTAVADLMARAGSDRIRFTP
Rv2391|M.tuberculosis_H37Rv         PIDHVGVQRLKNGLNAVGVAPIAGRVSGTILTAVADLMARAGSDRIRFTP
MAV_1787|M.avium_104                PIDHVGVQRLKNGLNAVGVAPIAGRVSGTILLAVADLAQQAGCDRIRFTP
TH_1443|M.thermoresistible__bu      PIDHVGVQKLKNGLNAVGIAPIAGRVSGTILQAVADLMAQAGSDRARFTP
MAB_1662c|M.abscessus_ATCC_199      PIDHVGVQRLKNGLNAIGISAIAGRVSGTILSAIADLAEKAGSNRVALTP
                                    ********:**** **:*::.**********  :*:*   **.:*  :**

Mflv_2686|M.gilvum_PYR-GCK          YQKLIVLDVPDDKLDELRAGLDALGLPSTPSHWRRNLMACTGIEFCKLSF
Mvan_3857|M.vanbaalenii_PYR-1       YQKLIILDVADENVAKLVEQLDALGLPSTPSHWRRNLMACTGIEFCKLSF
MSMEG_4527|M.smegmatis_MC2_155      YQKLIILDVPDDKIDELRAGLDALGLPSTPSHWRRNLMACTGIEFCKLSF
MUL_3652|M.ulcerans_Agy99           YQKLVILDIPDDKLDETIAGLQALGLRAQPSHWRRNLMACSGIEFCKLSF
MMAR_3710|M.marinum_M               YQKLVILDIPDDKLDETIAGLQALGLRAQPSHWRRNLMACSGIEFCKLSF
Mb2412|M.bovis_AF2122/97            YQKLVILDIPDALLDDLIAGLDALGLQSRPSHWRRNLMACSGIEFCKLSF
Rv2391|M.tuberculosis_H37Rv         YQKLVILDIPDALLDDLIAGLDALGLQSRPSHWRRNLMACSGIEFCKLSF
MAV_1787|M.avium_104                YQKLVLLDIPDDKLDEVVAGLEALGLQSQPSHWRRNLMACSGIEFCKLSF
TH_1443|M.thermoresistible__bu      YQKLIVLDIADDKLDEFTAGLDRLGLQWQPSHWRRNLMACTGIEFCKLSF
MAB_1662c|M.abscessus_ATCC_199      HQKLIILDVSDDELPALEAGLNALGLPSRPSHWRKNLLACTGIEYCKLSF
                                    :***::**:.*  :      *: ***   *****:**:**:***:*****

Mflv_2686|M.gilvum_PYR-GCK          AETRSRSQVLVPELEKRLEDINAQLDVPVTININGCPNSCARIQVADIGF
Mvan_3857|M.vanbaalenii_PYR-1       AETRSRSQVLVPELEKRLDDINAQLDVPVTININGCPNSCARIQVADIGF
MSMEG_4527|M.smegmatis_MC2_155      AETRKRAQVLVPELEKRLDDINAQLDVPITVNINGCPNSCARIQVADIGF
MUL_3652|M.ulcerans_Agy99           AETRVRAQSLVPELEERLDDINSTLDVPVAVNINGCPNSCARIQVADIGF
MMAR_3710|M.marinum_M               AETRVRAQSLVPELEERLDDLNSTLDVPVTVNINGCPNSCARIQVADIGF
Mb2412|M.bovis_AF2122/97            AETRVRAQHLVPELERRLEDINSQLDVPITVNINGCPNSCARIQIADIGF
Rv2391|M.tuberculosis_H37Rv         AETRVRAQHLVPELERRLEDINSQLDVPITVNINGCPNSCARIQIADIGF
MAV_1787|M.avium_104                AETRVRAQGLVPELERRLADVNRQLDVPITINLNGCPNSCARIQVADIGL
TH_1443|M.thermoresistible__bu      TETRVRAQSLVPELEKRLEDINARLDVPITVNINGCPNSCARIQVADIGF
MAB_1662c|M.abscessus_ATCC_199      TETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADIGF
                                    :*** *:* ******.** *:*  :*.*:::*:********* * ****:

Mflv_2686|M.gilvum_PYR-GCK          KGQMVDDGDG-PEEGFQVHLGGSLGLDSGFGRKLRQHKVVATELGDYIER
Mvan_3857|M.vanbaalenii_PYR-1       KGQMVDDGNG-PEEGFQVHLGGSLGLDSGFGRKLRQHKVLATELGDYIER
MSMEG_4527|M.smegmatis_MC2_155      KGQMVDDGNG-PEEGFQVHLGGSLGLDSGFGRKLRQHKVLSSELGDYIER
MUL_3652|M.ulcerans_Agy99           KGQMVDDGAGGQVEGFQVHLGGSLGLDSGFGRKLRQHKVTSDELGDYIDR
MMAR_3710|M.marinum_M               KGQMVDDGAGGQVEGFQVHLGGSLGLDSGFGRKLRQHKVTSDELGDYIDR
Mb2412|M.bovis_AF2122/97            KGQMIDDGHGGSVEGFQVHLGGHLGLDAGFGRKLRQHKVTSDELGDYIDR
Rv2391|M.tuberculosis_H37Rv         KGQMIDDGHGGSVEGFQVHLGGHLGLDAGFGRKLRQHKVTSDELGDYIDR
MAV_1787|M.avium_104                KGQMVDDGEGGSVEGFQVHLGGSLGQDSGFGRKLRQHKVTSDELGDYIER
TH_1443|M.thermoresistible__bu      KGMIVDDGDG-PEEGFQVHLGGGLGLDSGFGRKLRQHRVLSSELGDYIDR
MAB_1662c|M.abscessus_ATCC_199      KGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDR
                                    ** ::*** *   ********* ** *:*********:* : ******:*

Mflv_2686|M.gilvum_PYR-GCK          VVRNFVKQREQGERFATWALRADDADLR
Mvan_3857|M.vanbaalenii_PYR-1       VVRNFVKQREDGERFATWALRADEADLR
MSMEG_4527|M.smegmatis_MC2_155      VVRNFVKQREDGERFAQWAVRADEADLR
MUL_3652|M.ulcerans_Agy99           VVRNFVKNRAAGERFAQWAIRAEEDDLR
MMAR_3710|M.marinum_M               VVRNFVKNRAAGERFAQWAIRAEEDDLR
Mb2412|M.bovis_AF2122/97            VVRNFVKHRSEGERFAQWVIRAEEDDLR
Rv2391|M.tuberculosis_H37Rv         VVRNFVKHRSEGERFAQWVIRAEEDDLR
MAV_1787|M.avium_104                VARNFLKYRGEGERFAQWAMRADEDDLR
TH_1443|M.thermoresistible__bu      VVRNFVKQREDGERFATWALRADEADLR
MAB_1662c|M.abscessus_ATCC_199      VVRNFVAQRTDGERFAQWAVRAEEADLR
                                    *.***:  *  ***** *.:**:: ***