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AQAPDREKALELAMAQIEKSYGKGSVMRLGDEVRQPISIIPTGSIALDVALGIGGLPRGRVIEIYGPESS GKTTVALHAVANAQAAGGVAAFIDAEHALDPEYAKKLGVDTDSLLVSQPDTGEQALEIVDMLIRSGALDI VVIDSVAALVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDKIGVMFGSPETTT GGKALKFYASVRMDVRRIETLKDGTNAVGNRTRVKIVKNKVSPPFKQAEFDILYGRGISREGSLIDMGVD QGFIRKSGAWFTYEGEQLGQGKENARNFLLENGGVANEIEKKIKEKLGIGAVVTDDGVLPAPVDF*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_3380 | recA | - | 100% (346) | recombinase A |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2756c | recA | 1e-134 | 96.41% (251) | DNA recombination protein RecA |
M. gilvum PYR-GCK | Mflv_3975 | recA | 1e-177 | 89.91% (347) | recA protein |
M. tuberculosis H37Rv | Rv2737c | recA | 1e-134 | 96.41% (251) | DNA recombination protein RecA |
M. leprae Br4923 | MLBr_00987 | recA | 1e-105 | 91.47% (211) | RecA protein |
M. abscessus ATCC 19977 | MAB_3060c | - | 0.0 | 92.49% (346) | RecA protein |
M. marinum M | MMAR_1977 | recA | 0.0 | 99.42% (346) | recombinase A RecA |
M. avium 104 | MAV_3627 | recA | 0.0 | 95.43% (350) | protein RecA |
M. smegmatis MC2 155 | MSMEG_2723 | recA | 1e-180 | 92.49% (346) | protein RecA |
M. thermoresistible (build 8) | TH_1955 | recA | 1e-105 | 90.52% (211) | RECA PROTEIN (RECOMBINASE A) |
M. vanbaalenii PYR-1 | Mvan_2420 | recA | 1e-178 | 90.49% (347) | recA protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3975|M.gilvum_PYR-GCK MAQQAPDREKALELALAQIDKNFGKGSVMRLGEDVRPPIAVIPTGSIALD Mvan_2420|M.vanbaalenii_PYR-1 MAQQAPDREKALELALAQIDKNFGKGSVMRLGEEVRQPIAVIPTGSIALD MAB_3060c|M.abscessus_ATCC_199 -MAQAPDREKALELALAQIDKSFGKGSVMRLGDEVRQPISVIPTGSIALD TH_1955|M.thermoresistible__bu -MAQAPDREKALELALAQIEKNHGKGSVMRLGDEARQPISVIPTGSIALD MLBr_00987|M.leprae_Br4923 -MAQVPDREKALELAMAQIEKNYGKGSVMRLGDEMCQPISVIPTGSIALD MSMEG_2723|M.smegmatis_MC2_155 MAQQAPDREKALELAMAQIDKNFGKGSVMRLGEEVRQPISVIPTGSISLD MAV_3627|M.avium_104 -MTQAPDREKALELAMAQIEKSYGKGSVMRLGDEMRQPISVIPTGSIALD Mb2756c|M.bovis_AF2122/97 -MTQTPDREKALELAVAQIEKSYGKGSVMRLGDEARQPISVIPTGSIALD Rv2737c|M.tuberculosis_H37Rv -MTQTPDREKALELAVAQIEKSYGKGSVMRLGDEARQPISVIPTGSIALD MUL_3380|M.ulcerans_Agy99 -MAQAPDREKALELAMAQIEKSYGKGSVMRLGDEVRQPISIIPTGSIALD MMAR_1977|M.marinum_M -MAQAPDREKALELAMAQIEKSYGKGSVMRLGDEVRQPISIIPTGSIALD *.**********:***:*..*********:: **::******:** Mflv_3975|M.gilvum_PYR-GCK VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGIAAFIDAEHA Mvan_2420|M.vanbaalenii_PYR-1 VALGIGGLPRGRVVEIYGPESSGKTTVALHAVANAQAAGGIAAFIDAEHA MAB_3060c|M.abscessus_ATCC_199 VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQRAGGIAAFIDAEHA TH_1955|M.thermoresistible__bu VALGIGGLPRGRVVEIYGPESSGKTTVALHAVANAQAAGGIAAFIDAEHA MLBr_00987|M.leprae_Br4923 VALGIGGLPRGRIVEIYGPESSGKTTVALHAVANAQAVGGVAAFIDAEHA MSMEG_2723|M.smegmatis_MC2_155 VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGIAAFIDAEHA MAV_3627|M.avium_104 VALGIGGLPRGRVVEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHA Mb2756c|M.bovis_AF2122/97 VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHA Rv2737c|M.tuberculosis_H37Rv VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHA MUL_3380|M.ulcerans_Agy99 VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHA MMAR_1977|M.marinum_M VALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHA ************::********************** .**:********* Mflv_3975|M.gilvum_PYR-GCK LDPDYAKKLGVDTDALLVSQPDTGEQALEIADMLIRSGALDILVIDSVAA Mvan_2420|M.vanbaalenii_PYR-1 LDPDYAQKLGVDTDALLVSQPDTGEQALEIADMLIRSGALDILVIDSVAA MAB_3060c|M.abscessus_ATCC_199 LDPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLVRSGAIDLIVIDSVAA TH_1955|M.thermoresistible__bu LDPEYAKKLGVDTDALLVSQPDTGEQALEIADMLIRSGALDILVVDSVAA MLBr_00987|M.leprae_Br4923 LEPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAA MSMEG_2723|M.smegmatis_MC2_155 LDPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLVRSGALDIIVIDSVAA MAV_3627|M.avium_104 LDPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDILVIDSVAA Mb2756c|M.bovis_AF2122/97 LDPDYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAA Rv2737c|M.tuberculosis_H37Rv LDPDYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAA MUL_3380|M.ulcerans_Agy99 LDPEYAKKLGVDTDSLLVSQPDTGEQALEIVDMLIRSGALDIVVIDSVAA MMAR_1977|M.marinum_M LDPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAA *:*:**:*******:***************.***:****:*::*:***** Mflv_3975|M.gilvum_PYR-GCK LVPRAEIEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLREK Mvan_2420|M.vanbaalenii_PYR-1 LVPRAEIEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLREK MAB_3060c|M.abscessus_ATCC_199 LVPRAEIEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLREK TH_1955|M.thermoresistible__bu LVPRAEIEGEMGDSHVGLQARLMSQALRKITGALSNSGTTAIFINQLREK MLBr_00987|M.leprae_Br4923 LVPRAELEGEMGDSYVGLQARLMSQALRKMTGALSNSGTTAIFINQLREK MSMEG_2723|M.smegmatis_MC2_155 LVPRAEIEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLREK MAV_3627|M.avium_104 LVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLREK Mb2756c|M.bovis_AF2122/97 LVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDK Rv2737c|M.tuberculosis_H37Rv LVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDK MUL_3380|M.ulcerans_Agy99 LVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDK MMAR_1977|M.marinum_M LVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDK ******:*******:**************:****.*************:* Mflv_3975|M.gilvum_PYR-GCK IGVMFG-------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 IGVMFG-------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 IGVMFG-------------------------------------------- TH_1955|M.thermoresistible__bu IGVMFGCFDYST--------------------------------RVQLAD MLBr_00987|M.leprae_Br4923 IGVMFGCMNYST--------------------------------RVTLAD MSMEG_2723|M.smegmatis_MC2_155 IGVMFG-------------------------------------------- MAV_3627|M.avium_104 IGVMFG-------------------------------------------- Mb2756c|M.bovis_AF2122/97 IGVMFGSPETTTGGKALKFYASVRMDVRRVETLKDGTNAVGNRTRVKVVK Rv2737c|M.tuberculosis_H37Rv IGVMFGSPETTTGGKALKFYASVRMDVRRVETLKDGTNAVGNRTRVKVVK MUL_3380|M.ulcerans_Agy99 IGVMFGSPETTTGGKALKFYASVRMDVRRIETLKDGTNAVGNRTRVKIVK MMAR_1977|M.marinum_M IGVMFGSPETTTGGKALKFYASVRMDVRRIETLKDGTNAVGNRTRVKIVK ****** Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu GTTEKIGKIVDNKMDVEVLSYDPDTDRIVPRKVVNWFNNGPAEQFLQFTV MLBr_00987|M.leprae_Br4923 GSTEKIGKIVNNKMDVRVLSYDPVTDRIVPRKVVNWFNNGPAEQFLQFTV MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 NKCLAEGTRIFDPVTGTTHRIEDVVDGRKPIHVVAAAKDGTLHARPVVSW Rv2737c|M.tuberculosis_H37Rv NKCLAEGTRIFDPVTGTTHRIEDVVDGRKPIHVVAAAKDGTLHARPVVSW MUL_3380|M.ulcerans_Agy99 N------------------------------------------------- MMAR_1977|M.marinum_M N------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu EKSGGN--------GRARFAATPNHLIRTPGGWTEAGDLIAGDRVLAAEP MLBr_00987|M.leprae_Br4923 EKSGSN--------GKSQFAATPNHLIRTPGGWTEAGNLIAGDRVLAVEP MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 FDQGTRDVIGLRIAGGAIVWATPDHKVLTEYGWRAAGELRKGDRVAQPRR Rv2737c|M.tuberculosis_H37Rv FDQGTRDVIGLRIAGGAIVWATPDHKVLTEYGWRAAGELRKGDRVAQPRR MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu HRLSDQQFQIVLGSLMGDGTLSPDPRGRNGVRFRMG-HGADRVDYLEWKT MLBr_00987|M.leprae_Br4923 HMLSDQQFQVVLGSLMGDGNLSPNLCDRNGVRFRLLGYGCKQVEYLQWKK MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 FDGFGDSAPIPADHARLLGYLIGDGRDGWVGGKTPINFINVQRALIDDVT Rv2737c|M.tuberculosis_H37Rv FDGFGDSAPIPADHARLLGYLIGDGRDGWVGGKTPINFINVQRALIDDVT MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu ALLGNIKHSTGENAEGARFVDFTPLPELAELRRAVYLGDDGRKFISEEYL MLBr_00987|M.leprae_Br4923 ALMGNIRHTVRENSMGASFIDFTPLPELVELQRAVYLGD-GKKFLSEEYL MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 RIAATLGCAAHPQGRISLAIAHRPGERNGVADLCQQAGIYGKLAWEKTIP Rv2737c|M.tuberculosis_H37Rv RIAATLGCAAHPQGRISLAIAHRPGERNGVADLCQQAGIYGKLAWEKTIP MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu KALTPLALAIWYMDDGSLTV-RSEGLQQGTAGGSGRIEICVEAMTEGSRI MLBr_00987|M.leprae_Br4923 KALTPLVLAIWYMDDGSFTV-GSKRVQERTAGGSGRIEICVDAMTEGTRV MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 NWFFEPDIAADIVGNLLFGLFESDGWVSREQTGALRVGYTTTSEQLAHQI Rv2737c|M.tuberculosis_H37Rv NWFFEPDIAADIVGNLLFGLFESDGWVSREQTGALRVGYTTTSEQLAHQI MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu RLRDHLRDTHGLDVRLRQAGAGGKAVLVFSTAATAEFQELVAPYMAPSME MLBr_00987|M.leprae_Br4923 RLRDYLCDTHGLDVRLREVGSAGKAVLVFSTAATAKFQSLIAPYVAPSME MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 HWLLLRFGVGSTVRDYDPTQKRPSIVNGRRIQSKRQVFEVRISGMDNVTA Rv2737c|M.tuberculosis_H37Rv HWLLLRFGVGSTVRDYDPTQKRPSIVNGRRIQSKRQVFEVRISGMDNVTA MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2420|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3060c|M.abscessus_ATCC_199 -------------------------------------------------- TH_1955|M.thermoresistible__bu YKLLPRFRGQSRVVPQFVEPTQRLVPARILDVHVEPHTRSMNRYDIEVEG MLBr_00987|M.leprae_Br4923 YKLLPQFRGRGSVTPQFVEPTQQLVPARVLDVHVKLSTRSMNRFDIEVEG MSMEG_2723|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3627|M.avium_104 -------------------------------------------------- Mb2756c|M.bovis_AF2122/97 FAESVPMWGPRGAALIQAIPEATQGRRRGSQATYLAAEMTDAVLNYLDER Rv2737c|M.tuberculosis_H37Rv FAESVPMWGPRGAALIQAIPEATQGRRRGSQATYLAAEMTDAVLNYLDER MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK -------------SPETTTGG---------------KALK---------- Mvan_2420|M.vanbaalenii_PYR-1 -------------SPETTTGG---------------KALK---------- MAB_3060c|M.abscessus_ATCC_199 -------------SPETTTGG---------------KALK---------- TH_1955|M.thermoresistible__bu NHNYFVDGVMVHNSPETTTGG---------------KALK---------- MLBr_00987|M.leprae_Br4923 NHNYFVDGVMVHNSPETTTGG---------------KALK---------- MSMEG_2723|M.smegmatis_MC2_155 -------------SPETTTGG---------------KALK---------- MAV_3627|M.avium_104 -------------SPETTTGG---------------KALK---------- Mb2756c|M.bovis_AF2122/97 GVTAQEAAAMIGVASGDPRGGMKQVLGASRLRRDRVQALADALDDKFLHD Rv2737c|M.tuberculosis_H37Rv GVTAQEAAAMIGVASGDPRGGMKQVLGASRLRRDRVQALADALDDKFLHD MUL_3380|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1977|M.marinum_M -------------------------------------------------- Mflv_3975|M.gilvum_PYR-GCK ------FYSSVR--LDVRRIETLKDGTDAVGNRTRVKVVKNKVSPPFKQA Mvan_2420|M.vanbaalenii_PYR-1 ------FYASVR--MDVRRIETLKDGTDAVGNRTRVKVVKNKVSPPFKQA MAB_3060c|M.abscessus_ATCC_199 ------FYSSVR--LDVRRIETLKDGTDAVGNRTRVKVVKNKVSPPFKQA TH_1955|M.thermoresistible__bu ------FYASVR--IDVRRIETLKDGTEAVGNRTRAKIVKNKVSPPFKQA MLBr_00987|M.leprae_Br4923 ------FYASVR--MDVRRIETLKDGVDAVGNRTRVKIVKNKVSPPFKQA MSMEG_2723|M.smegmatis_MC2_155 ------FYASVR--LDVRRIETLKDGTDAVGNRTRVKVVKNKVSPPFKQA MAV_3627|M.avium_104 ------FYASVR--MDVRRIETLKDGTNAVGNRTRVKIVKNKVSPPFKQA Mb2756c|M.bovis_AF2122/97 MLAEELRYSVIREVLPTRRARTFDLEVEELHTLVAEGVVVHNCSPPFKQA Rv2737c|M.tuberculosis_H37Rv MLAEELRYSVIREVLPTRRARTFDLEVEELHTLVAEGVVVHNCSPPFKQA MUL_3380|M.ulcerans_Agy99 -----------------------------------------KVSPPFKQA MMAR_1977|M.marinum_M -----------------------------------------KVSPPFKQA : ******* Mflv_3975|M.gilvum_PYR-GCK EFDILYGKGISREGSLIDMGVEQGFIRKSGSWFTYDGEQLGQGKENARNF Mvan_2420|M.vanbaalenii_PYR-1 EFDILYGKGISREGSLIDMGVEHGFIRKSGSWFTYDGEQLGQGKENARNF MAB_3060c|M.abscessus_ATCC_199 EFDILYGKGISKEGSLIDMGVEQGFIRKSGSWFTYEGEQLGQGKENARNF TH_1955|M.thermoresistible__bu EFDILYGKGISKEGSLIDMGVEQGFIRKSGSWYTYEGEQLGQGKENARNF MLBr_00987|M.leprae_Br4923 EFDILYGKGISREGSLIDMGVEQGFVRKSGSWFTYEGEQLGQGKENARNF MSMEG_2723|M.smegmatis_MC2_155 EFDILYGQGISREGSLIDMGVEHGFIRKSGSWFTYEGEQLGQGKENARKF MAV_3627|M.avium_104 EFDILYGRGISREGSLIDMGVDQGFIRKSGSWFTYEGEQLGQGKENARTF Mb2756c|M.bovis_AF2122/97 EFDILYGKGISREGSLIDMGVDQGLIRKSGAWFTYEGEQLGQGKENARNF Rv2737c|M.tuberculosis_H37Rv EFDILYGKGISREGSLIDMGVDQGLIRKSGAWFTYEGEQLGQGKENARNF MUL_3380|M.ulcerans_Agy99 EFDILYGRGISREGSLIDMGVDQGFIRKSGAWFTYEGEQLGQGKENARNF MMAR_1977|M.marinum_M EFDILYGRGISREGSLIDMGVDQGFIRKSGAWFTYEGEQLGQGKENARNF *******:***:*********::*::****:*:**:************.* Mflv_3975|M.gilvum_PYR-GCK LLQNPDVGNEIEKKIKEKLGIGAQLTDDVA-DDALPAPVDF Mvan_2420|M.vanbaalenii_PYR-1 LLQNVDVANEIEKKIKEKLGIGAQLTDDAN-DDALPAPVDF MAB_3060c|M.abscessus_ATCC_199 LLENVDVANEIEKKIKEKLGIGAVLTD----DEVVPAPVDF TH_1955|M.thermoresistible__bu LIENVDVANEIEKKIKEKLGIGPVITD----DEALPAPVDF MLBr_00987|M.leprae_Br4923 LLENADVANEIEKKIKEKLGIGAVVTD----DDILPTPVDF MSMEG_2723|M.smegmatis_MC2_155 LLENTDVANEIEKKIKEKLGIGAVVTAEA--DDVLPAPVDF MAV_3627|M.avium_104 LMENDEVANEIEKKIKEKLGIGAVVTDDLSDDGVLPAPVDF Mb2756c|M.bovis_AF2122/97 LVENADVADEIEKKIKEKLGIGAVVTDDPSNDGVLPAPVDF Rv2737c|M.tuberculosis_H37Rv LVENADVADEIEKKIKEKLGIGAVVTDDPSNDGVLPAPVDF MUL_3380|M.ulcerans_Agy99 LLENGGVANEIEKKIKEKLGIGAVVTDD----GVLPAPVDF MMAR_1977|M.marinum_M LLENGEVANEIEKKIKEKLGIGAVVTDD----GVLPAPVDF *::* *.:*************. :* :*:****