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M. ulcerans Agy99 MUL_2506 (-)

annotation: serine protease
coordinates: 2799380 - 2800402
length: 340

NRRILTLMVALVPIVVFGVLLAVVTVPFVSLGPGPTFDTLGEVDGKQVVQIEGTQTHPTTGHLNMTTVSQ
RDGLSLGEALTLWLSGQEQLVPRDLVYPPGKSREEVDNANSADFKNSEESAEYAALEYLKYPDAVTVATV
SEPGPSAGKLKAGDAIDAVNGTAVANVEQFTSILKDTKPGDVVVIDFRRKNEAPGVAQITLGTNKDRDYG
FMGVAVLDAPWAPFVVDFHLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTITADGKVGPIGGIT
HKMAAARAAGASVFLVPAKNCYEAASDTPSGLRLVKVETLGQAVDALHAMTSGTATPSC*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_2506--100% (340)serine protease
M. ulcerans Agy99MUL_3003lon1e-0743.94% (66) Lon, ATP-dependent Lon protease

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3216c-1e-16483.24% (340) hypothetical protein Mb3216c
M. gilvum PYR-GCKMflv_4655-1e-13567.35% (340) PDZ/DHR/GLGF
M. tuberculosis H37RvRv3194c-1e-16483.24% (340) hypothetical protein Rv3194c
M. leprae Br4923MLBr_00643-1e-16684.71% (340) putative secreted protein
M. abscessus ATCC 19977MAB_3499c-1e-13367.35% (340) hypothetical protein MAB_3499c
M. marinum MMMAR_1370-0.099.41% (340) serine protease
M. avium 104MAV_4138-1e-16585.29% (340) PDZ domain-containing protein
M. smegmatis MC2 155MSMEG_1958-1e-14372.81% (342) PDZ domain-containing protein
M. thermoresistible (build 8)TH_1131-1e-13868.82% (340) POSSIBLE CONSERVED SECRETED PROTEIN
M. vanbaalenii PYR-1Mvan_1813-1e-13768.82% (340) PDZ/DHR/GLGF

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4655|M.gilvum_PYR-GCK          -------------------MNRRISTLVVALAPILIFGILLSAVTVPYVA
Mvan_1813|M.vanbaalenii_PYR-1       MNSGGLRGSPRALTSTVGRVNRRISTMVVALVPILVFGVLLTVVTVPYVA
MSMEG_1958|M.smegmatis_MC2_155      ----------------MNGVNRRILTLLVALVPVVAFGVLLSVVQVPFVS
TH_1131|M.thermoresistible__bu      -------------------VNRRILTLIVALVPIMAFGVLLSVVRVPFVS
Mb3216c|M.bovis_AF2122/97           -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVA
Rv3194c|M.tuberculosis_H37Rv        -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVA
MUL_2506|M.ulcerans_Agy99           -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVS
MMAR_1370|M.marinum_M               -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVS
MLBr_00643|M.leprae_Br4923          -------------------MNRRILTLLVALVPILVFGVLLAVVTVPFVS
MAV_4138|M.avium_104                -------------------MNRRILTLMVALVPIVAFGVLLAVVTVPFVS
MAB_3499c|M.abscessus_ATCC_199      -------------------MNRRVATLLVALIPIVVFGLLMSVITVPFVS
                                                       :***: *::*** *:: **:*::.: **:*:

Mflv_4655|M.gilvum_PYR-GCK          LGPGPTFDTLGEVDGKEVVDIEG--ADVHATSGHLNMTTVSQRDGLTLGQ
Mvan_1813|M.vanbaalenii_PYR-1       LGPGPTFDTLGEVDGKQVVDIEG--AHVHKTSGHLNMTTVSQRDGLTLGQ
MSMEG_1958|M.smegmatis_MC2_155      LGPGPTFNTLGEIDGKQVVDIEGPDATVHPTSGHLNMTTVSQRDGLTLGQ
TH_1131|M.thermoresistible__bu      LGPGPTFDTLGQIDGKDVVAIEG--AEVYPTSGQLNMTTVAQRDGLTLGQ
Mb3216c|M.bovis_AF2122/97           LGPGPTFDTLGEIDGKQVVQIVG--TQTYPTSGHLNMTTVSQRDGLTLGE
Rv3194c|M.tuberculosis_H37Rv        LGPGPTFDTLGEIDGKQVVQIVG--TQTYPTSGHLNMTTVSQRDGLTLGE
MUL_2506|M.ulcerans_Agy99           LGPGPTFDTLGEVDGKQVVQIEG--TQTHPTTGHLNMTTVSQRDGLSLGE
MMAR_1370|M.marinum_M               LGPGPTFDTLGEVDGRQVVQIEG--TQTHPTTGHLNMTTVSQRDGLSLGE
MLBr_00643|M.leprae_Br4923          LGPGPTFDTLGEVDGKQVVAIKG--AHTHPTSGHLNMTTVSQRDDLTLGE
MAV_4138|M.avium_104                LGPGPTFDTLGEVDGKQVVAIEG--TMTHPTTGHLNMTTVSQRDDLTLGE
MAB_3499c|M.abscessus_ATCC_199      LGPGPTFNTLGQVEGKEVVDIKG--TKVDPVSGHLNMTTVSQRDGLTLAD
                                    *******:***:::*::** * *  : .  .:*:******:***.*:*.:

Mflv_4655|M.gilvum_PYR-GCK          ALIFWASGRDQLLPRDLVYPPDKTREEIDEANSQDFRQSEDSAEYAALHH
Mvan_1813|M.vanbaalenii_PYR-1       ALVFWASGRDQLVPRELVYPPDKSREEIDEANTRDFRDSEDSAEYAALQY
MSMEG_1958|M.smegmatis_MC2_155      AITLWMSGREQLVPRDLVYPPDKSKDEIDEANTADFKNSEDSAEYAALSF
TH_1131|M.thermoresistible__bu      ALTLWMSGREQLVPRDLVYPPDKSREEIEQANTRDFRQSEDSAEYAALSY
Mb3216c|M.bovis_AF2122/97           ALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGY
Rv3194c|M.tuberculosis_H37Rv        ALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGY
MUL_2506|M.ulcerans_Agy99           ALTLWLSGQEQLVPRDLVYPPGKSREEVDNANSADFKNSEESAEYAALEY
MMAR_1370|M.marinum_M               ALTLWLSGQEQLVPRDLVYPPGKSREEVDNANSADFKNSEESAEYAALEY
MLBr_00643|M.leprae_Br4923          ALTLWLSGQEQLVPRDLIYPPGKSREDVDKVNYADFKQSEDSAAYAALGY
MAV_4138|M.avium_104                ALTLWLSDTEQLVPRDLIYPPGKSREDVDKANNADFKQSEDSAAYAALGY
MAB_3499c|M.abscessus_ATCC_199      ALRLWASGSEQLVPRDVVYPPDRSKDQVDKENDLEFKKSEESAEFAALGY
                                    *: :* *. :**:**:::***.:::::::: *  :*: ** :* :*** .

Mflv_4655|M.gilvum_PYR-GCK          LKYPMAVTVESIDEEGPSKGKLQGGDAIDGVNGKPVATLDQFQELLKAYK
Mvan_1813|M.vanbaalenii_PYR-1       LKYPMAVTVESIDEKGPSKGKLQAGDAIDAVNNTPVASLAQFQELLKSTK
MSMEG_1958|M.smegmatis_MC2_155      LKYPMAVTVQNVTDPGPSAGKLQDGDAIDGVNGKPVANLDEFQALLKETK
TH_1131|M.thermoresistible__bu      LDYPMAVTVDSVEESGPSAGKLRDGDAIDAVDGRPVANLDEFQAVLQETK
Mb3216c|M.bovis_AF2122/97           LKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTK
Rv3194c|M.tuberculosis_H37Rv        LKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTK
MUL_2506|M.ulcerans_Agy99           LKYPDAVTVATVSEPGPSAGKLKAGDAIDAVNGTAVANVEQFTSILKDTK
MMAR_1370|M.marinum_M               LKYPDAVTVATVSEPGPSAGKLKAGDAIDAVNGTAVANVEQFTSILKDTK
MLBr_00643|M.leprae_Br4923          LQYPSAVTVAKVTDPGQSVGKLKSGDAVDAVNGSPVANVEQFTGLLKKTK
MAV_4138|M.avium_104                LKYPSAVTVAKVPEPGPSAGKLKVGDAIDAVNGTPVATVEEFTGLLKNTK
MAB_3499c|M.abscessus_ATCC_199      LKYPAAVTVLTISDDGPSKGKLQQNDAITAVNGHPVATLDEFTGQLKLTK
                                    *.** **** .: : * * .**: .**: .*:. .*..: :*   *:  *

Mflv_4655|M.gilvum_PYR-GCK          PGDTIAVDYRRKNAPMGTAEITLGKHPDRDQGILGVNVLDAPWAPFTIDF
Mvan_1813|M.vanbaalenii_PYR-1       PGDTIIVDYRRKNAPMGTTEITLGSHPDRPQGVVGVNVLDAPWAPFTIDF
MSMEG_1958|M.smegmatis_MC2_155      PGDKLVIDYRRKNAPPGEATITLGDNPDRDYGYLGIAVLDAPWAPFDIEF
TH_1131|M.thermoresistible__bu      PGDTIVIDYRRKNAPPGAVAVTLGENPDREHGYLGIGVLDAPWAPFEITF
Mb3216c|M.bovis_AF2122/97           PGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDF
Rv3194c|M.tuberculosis_H37Rv        PGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDF
MUL_2506|M.ulcerans_Agy99           PGDVVVIDFRRKNEAPGVAQITLGTNKDRDYGFMGVAVLDAPWAPFVVDF
MMAR_1370|M.marinum_M               PGDVVVIDFRRKNEAPGVAQITLGTNKDRDYGFMGVAVLDAPWAPFVVDF
MLBr_00643|M.leprae_Br4923          PGEVVTIDFRRKNEPPGVVQITLGANKDRDYGFLGVAVLDAPWAPFVVDF
MAV_4138|M.avium_104                PGQTVTIDYRRKNEPAGVAQITLGANKDRDYGFLGVAVLDAPWAPFVVNF
MAB_3499c|M.abscessus_ATCC_199      PGDEVMLDYKRKNAPNGTVKITLGKNGDRDYGFLGVGVVQAPWAPFTIDF
                                    **: : :*::*** . * . :*** : **  * :*: *::****** : *

Mflv_4655|M.gilvum_PYR-GCK          NLANIGGPSAGLMFSLAVVDKLTTGDVTGGKFVAGSGTISGDGKVGSIGG
Mvan_1813|M.vanbaalenii_PYR-1       NLANIGGPSAGLMFSLAVVDKLTTGDVNGGKFVAGTGTISGDGKVGSIGG
MSMEG_1958|M.smegmatis_MC2_155      NLANIGGPSAGLMFSLAVVDKLTTGDLNDGKFIAGTGTISGDGKVGSIGG
TH_1131|M.thermoresistible__bu      NLANVGGPSAGMVFSLAVIDKLTEGDLAGSRVVAGSGTITGDGQVGSIGG
Mb3216c|M.bovis_AF2122/97           HLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGG
Rv3194c|M.tuberculosis_H37Rv        HLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGG
MUL_2506|M.ulcerans_Agy99           HLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTITADGKVGPIGG
MMAR_1370|M.marinum_M               HLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTITADGKVGPIGG
MLBr_00643|M.leprae_Br4923          NLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTISIDGKVGPIGG
MAV_4138|M.avium_104                NLANVGGPSAGLMFSLAVVDKLTTGDLAGSNFVAGTGTISADGKVGQIGG
MAB_3499c|M.abscessus_ATCC_199      NLANIGGPSAGLMFSLAVIDKLTPGELDGGKFVAGTGTIDAEGKVGPIGG
                                    :***:******::*****:**** *.: .. .:**:***  :*:** ***

Mflv_4655|M.gilvum_PYR-GCK          ITHKVTAAQEAGATVFLVPADNCAEARTADADGIELLKVETLEQAVDGLR
Mvan_1813|M.vanbaalenii_PYR-1       ITHKIVAARDAGATAFLVPADNCAEAKTADADGIELLKVDTLEHAVDGLR
MSMEG_1958|M.smegmatis_MC2_155      ITHKMLAASEAGAEVFLVPADNCTEARSAPRDGLELVKVETLEGAVDALK
TH_1131|M.thermoresistible__bu      ITHKMAAAADAGATVFLVPAENCVEAKSAQRDGMELVRVETLDDAVTALN
Mb3216c|M.bovis_AF2122/97           ITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALH
Rv3194c|M.tuberculosis_H37Rv        ITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALH
MUL_2506|M.ulcerans_Agy99           ITHKMAAARAAGASVFLVPAKNCYEAASDTPSGLRLVKVETLGQAVDALH
MMAR_1370|M.marinum_M               ITHKMAAARAAGASVFLVPAKNCYEAASDTPSGLRLVKVETLGQAVDALH
MLBr_00643|M.leprae_Br4923          IAHKMAAARAAGATVFLVPAKNCYEARSDNRTGLRLVKVESLSQAVDALH
MAV_4138|M.avium_104                ITHKMVAAHAAGATVFLVPAKNCYEASSDNPSGLRLVKVETLAQAVDALH
MAB_3499c|M.abscessus_ATCC_199      ITHKMFAAKDAGATVFLVPAANCAEAKTDGGQGLTLVKVGTLTEAVDGLN
                                    *:**: **  *** .***** ** ** :    *: *::* :*  ** .*.

Mflv_4655|M.gilvum_PYR-GCK          TLSAGGEPPRC
Mvan_1813|M.vanbaalenii_PYR-1       TLSAGGEPPRC
MSMEG_1958|M.smegmatis_MC2_155      TISAGGEPPRC
TH_1131|M.thermoresistible__bu      TLSAGGEPPRC
Mb3216c|M.bovis_AF2122/97           AMTSGSPTPSC
Rv3194c|M.tuberculosis_H37Rv        AMTSGSPTPSC
MUL_2506|M.ulcerans_Agy99           AMTSGTATPSC
MMAR_1370|M.marinum_M               AMTAGTATPSC
MLBr_00643|M.leprae_Br4923          AMTSGGQLPSC
MAV_4138|M.avium_104                AITAGGQPPSC
MAB_3499c|M.abscessus_ATCC_199      ALNRGEQPPSC
                                    ::. *   * *