For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. leprae Br4923 MLBr_00643 (-)

annotation: putative secreted protein
coordinates: 776017 - 777039
length: 340

VNRRILTLLVALVPILVFGVLLAVVTVPFVSLGPGPTFDTLGEVDGKQVVAIKGAHTHPTSGHLNMTTVS
QRDDLTLGEALTLWLSGQEQLVPRDLIYPPGKSREDVDKVNYADFKQSEDSAAYAALGYLQYPSAVTVAK
VTDPGQSVGKLKSGDAVDAVNGSPVANVEQFTGLLKKTKPGEVVTIDFRRKNEPPGVVQITLGANKDRDY
GFLGVAVLDAPWAPFVVDFNLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTISIDGKVGPIGGI
AHKMAAARAAGATVFLVPAKNCYEARSDNRTGLRLVKVESLSQAVDALHAMTSGGQLPSC
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_00643--100% (340)putative secreted protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3216c-1e-15980.59% (340) hypothetical protein Mb3216c
M. gilvum PYR-GCKMflv_4655-1e-13567.35% (340) PDZ/DHR/GLGF
M. tuberculosis H37RvRv3194c-1e-15980.59% (340) hypothetical protein Rv3194c
M. abscessus ATCC 19977MAB_3499c-1e-13467.35% (340) hypothetical protein MAB_3499c
M. marinum MMMAR_1370-1e-16584.12% (340) serine protease
M. avium 104MAV_4138-1e-17087.35% (340) PDZ domain-containing protein
M. smegmatis MC2 155MSMEG_1958-1e-14372.51% (342) PDZ domain-containing protein
M. thermoresistible (build 8)TH_1131-1e-13868.53% (340) POSSIBLE CONSERVED SECRETED PROTEIN
M. ulcerans Agy99MUL_2506-1e-16684.71% (340) serine protease
M. vanbaalenii PYR-1Mvan_1813-1e-13568.24% (340) PDZ/DHR/GLGF

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4655|M.gilvum_PYR-GCK          -------------------MNRRISTLVVALAPILIFGILLSAVTVPYVA
Mvan_1813|M.vanbaalenii_PYR-1       MNSGGLRGSPRALTSTVGRVNRRISTMVVALVPILVFGVLLTVVTVPYVA
MSMEG_1958|M.smegmatis_MC2_155      ----------------MNGVNRRILTLLVALVPVVAFGVLLSVVQVPFVS
TH_1131|M.thermoresistible__bu      -------------------VNRRILTLIVALVPIMAFGVLLSVVRVPFVS
Mb3216c|M.bovis_AF2122/97           -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVA
Rv3194c|M.tuberculosis_H37Rv        -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVA
MLBr_00643|M.leprae_Br4923          -------------------MNRRILTLLVALVPILVFGVLLAVVTVPFVS
MAV_4138|M.avium_104                -------------------MNRRILTLMVALVPIVAFGVLLAVVTVPFVS
MMAR_1370|M.marinum_M               -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVS
MUL_2506|M.ulcerans_Agy99           -------------------MNRRILTLMVALVPIVVFGVLLAVVTVPFVS
MAB_3499c|M.abscessus_ATCC_199      -------------------MNRRVATLLVALIPIVVFGLLMSVITVPFVS
                                                       :***: *::*** *:: **:*::.: **:*:

Mflv_4655|M.gilvum_PYR-GCK          LGPGPTFDTLGEVDGKEVVDIEG--ADVHATSGHLNMTTVSQRDGLTLGQ
Mvan_1813|M.vanbaalenii_PYR-1       LGPGPTFDTLGEVDGKQVVDIEG--AHVHKTSGHLNMTTVSQRDGLTLGQ
MSMEG_1958|M.smegmatis_MC2_155      LGPGPTFNTLGEIDGKQVVDIEGPDATVHPTSGHLNMTTVSQRDGLTLGQ
TH_1131|M.thermoresistible__bu      LGPGPTFDTLGQIDGKDVVAIEG--AEVYPTSGQLNMTTVAQRDGLTLGQ
Mb3216c|M.bovis_AF2122/97           LGPGPTFDTLGEIDGKQVVQIVG--TQTYPTSGHLNMTTVSQRDGLTLGE
Rv3194c|M.tuberculosis_H37Rv        LGPGPTFDTLGEIDGKQVVQIVG--TQTYPTSGHLNMTTVSQRDGLTLGE
MLBr_00643|M.leprae_Br4923          LGPGPTFDTLGEVDGKQVVAIKG--AHTHPTSGHLNMTTVSQRDDLTLGE
MAV_4138|M.avium_104                LGPGPTFDTLGEVDGKQVVAIEG--TMTHPTTGHLNMTTVSQRDDLTLGE
MMAR_1370|M.marinum_M               LGPGPTFDTLGEVDGRQVVQIEG--TQTHPTTGHLNMTTVSQRDGLSLGE
MUL_2506|M.ulcerans_Agy99           LGPGPTFDTLGEVDGKQVVQIEG--TQTHPTTGHLNMTTVSQRDGLSLGE
MAB_3499c|M.abscessus_ATCC_199      LGPGPTFNTLGQVEGKEVVDIKG--TKVDPVSGHLNMTTVSQRDGLTLAD
                                    *******:***:::*::** * *  : .  .:*:******:***.*:*.:

Mflv_4655|M.gilvum_PYR-GCK          ALIFWASGRDQLLPRDLVYPPDKTREEIDEANSQDFRQSEDSAEYAALHH
Mvan_1813|M.vanbaalenii_PYR-1       ALVFWASGRDQLVPRELVYPPDKSREEIDEANTRDFRDSEDSAEYAALQY
MSMEG_1958|M.smegmatis_MC2_155      AITLWMSGREQLVPRDLVYPPDKSKDEIDEANTADFKNSEDSAEYAALSF
TH_1131|M.thermoresistible__bu      ALTLWMSGREQLVPRDLVYPPDKSREEIEQANTRDFRQSEDSAEYAALSY
Mb3216c|M.bovis_AF2122/97           ALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGY
Rv3194c|M.tuberculosis_H37Rv        ALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGY
MLBr_00643|M.leprae_Br4923          ALTLWLSGQEQLVPRDLIYPPGKSREDVDKVNYADFKQSEDSAAYAALGY
MAV_4138|M.avium_104                ALTLWLSDTEQLVPRDLIYPPGKSREDVDKANNADFKQSEDSAAYAALGY
MMAR_1370|M.marinum_M               ALTLWLSGQEQLVPRDLVYPPGKSREEVDNANSADFKNSEESAEYAALEY
MUL_2506|M.ulcerans_Agy99           ALTLWLSGQEQLVPRDLVYPPGKSREEVDNANSADFKNSEESAEYAALEY
MAB_3499c|M.abscessus_ATCC_199      ALRLWASGSEQLVPRDVVYPPDRSKDQVDKENDLEFKKSEESAEFAALGY
                                    *: :* *. :**:**:::***.:::::::: *  :*: ** :* :*** .

Mflv_4655|M.gilvum_PYR-GCK          LKYPMAVTVESIDEEGPSKGKLQGGDAIDGVNGKPVATLDQFQELLKAYK
Mvan_1813|M.vanbaalenii_PYR-1       LKYPMAVTVESIDEKGPSKGKLQAGDAIDAVNNTPVASLAQFQELLKSTK
MSMEG_1958|M.smegmatis_MC2_155      LKYPMAVTVQNVTDPGPSAGKLQDGDAIDGVNGKPVANLDEFQALLKETK
TH_1131|M.thermoresistible__bu      LDYPMAVTVDSVEESGPSAGKLRDGDAIDAVDGRPVANLDEFQAVLQETK
Mb3216c|M.bovis_AF2122/97           LKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTK
Rv3194c|M.tuberculosis_H37Rv        LKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTK
MLBr_00643|M.leprae_Br4923          LQYPSAVTVAKVTDPGQSVGKLKSGDAVDAVNGSPVANVEQFTGLLKKTK
MAV_4138|M.avium_104                LKYPSAVTVAKVPEPGPSAGKLKVGDAIDAVNGTPVATVEEFTGLLKNTK
MMAR_1370|M.marinum_M               LKYPDAVTVATVSEPGPSAGKLKAGDAIDAVNGTAVANVEQFTSILKDTK
MUL_2506|M.ulcerans_Agy99           LKYPDAVTVATVSEPGPSAGKLKAGDAIDAVNGTAVANVEQFTSILKDTK
MAB_3499c|M.abscessus_ATCC_199      LKYPAAVTVLTISDDGPSKGKLQQNDAITAVNGHPVATLDEFTGQLKLTK
                                    *.** **** .: : * * .**: .**: .*:. .*..: :*   *:  *

Mflv_4655|M.gilvum_PYR-GCK          PGDTIAVDYRRKNAPMGTAEITLGKHPDRDQGILGVNVLDAPWAPFTIDF
Mvan_1813|M.vanbaalenii_PYR-1       PGDTIIVDYRRKNAPMGTTEITLGSHPDRPQGVVGVNVLDAPWAPFTIDF
MSMEG_1958|M.smegmatis_MC2_155      PGDKLVIDYRRKNAPPGEATITLGDNPDRDYGYLGIAVLDAPWAPFDIEF
TH_1131|M.thermoresistible__bu      PGDTIVIDYRRKNAPPGAVAVTLGENPDREHGYLGIGVLDAPWAPFEITF
Mb3216c|M.bovis_AF2122/97           PGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDF
Rv3194c|M.tuberculosis_H37Rv        PGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDF
MLBr_00643|M.leprae_Br4923          PGEVVTIDFRRKNEPPGVVQITLGANKDRDYGFLGVAVLDAPWAPFVVDF
MAV_4138|M.avium_104                PGQTVTIDYRRKNEPAGVAQITLGANKDRDYGFLGVAVLDAPWAPFVVNF
MMAR_1370|M.marinum_M               PGDVVVIDFRRKNEAPGVAQITLGTNKDRDYGFMGVAVLDAPWAPFVVDF
MUL_2506|M.ulcerans_Agy99           PGDVVVIDFRRKNEAPGVAQITLGTNKDRDYGFMGVAVLDAPWAPFVVDF
MAB_3499c|M.abscessus_ATCC_199      PGDEVMLDYKRKNAPNGTVKITLGKNGDRDYGFLGVGVVQAPWAPFTIDF
                                    **: : :*::*** . * . :*** : **  * :*: *::****** : *

Mflv_4655|M.gilvum_PYR-GCK          NLANIGGPSAGLMFSLAVVDKLTTGDVTGGKFVAGSGTISGDGKVGSIGG
Mvan_1813|M.vanbaalenii_PYR-1       NLANIGGPSAGLMFSLAVVDKLTTGDVNGGKFVAGTGTISGDGKVGSIGG
MSMEG_1958|M.smegmatis_MC2_155      NLANIGGPSAGLMFSLAVVDKLTTGDLNDGKFIAGTGTISGDGKVGSIGG
TH_1131|M.thermoresistible__bu      NLANVGGPSAGMVFSLAVIDKLTEGDLAGSRVVAGSGTITGDGQVGSIGG
Mb3216c|M.bovis_AF2122/97           HLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGG
Rv3194c|M.tuberculosis_H37Rv        HLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGG
MLBr_00643|M.leprae_Br4923          NLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTISIDGKVGPIGG
MAV_4138|M.avium_104                NLANVGGPSAGLMFSLAVVDKLTTGDLAGSNFVAGTGTISADGKVGQIGG
MMAR_1370|M.marinum_M               HLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTITADGKVGPIGG
MUL_2506|M.ulcerans_Agy99           HLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTITADGKVGPIGG
MAB_3499c|M.abscessus_ATCC_199      NLANIGGPSAGLMFSLAVIDKLTPGELDGGKFVAGTGTIDAEGKVGPIGG
                                    :***:******::*****:**** *.: .. .:**:***  :*:** ***

Mflv_4655|M.gilvum_PYR-GCK          ITHKVTAAQEAGATVFLVPADNCAEARTADADGIELLKVETLEQAVDGLR
Mvan_1813|M.vanbaalenii_PYR-1       ITHKIVAARDAGATAFLVPADNCAEAKTADADGIELLKVDTLEHAVDGLR
MSMEG_1958|M.smegmatis_MC2_155      ITHKMLAASEAGAEVFLVPADNCTEARSAPRDGLELVKVETLEGAVDALK
TH_1131|M.thermoresistible__bu      ITHKMAAAADAGATVFLVPAENCVEAKSAQRDGMELVRVETLDDAVTALN
Mb3216c|M.bovis_AF2122/97           ITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALH
Rv3194c|M.tuberculosis_H37Rv        ITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALH
MLBr_00643|M.leprae_Br4923          IAHKMAAARAAGATVFLVPAKNCYEARSDNRTGLRLVKVESLSQAVDALH
MAV_4138|M.avium_104                ITHKMVAAHAAGATVFLVPAKNCYEASSDNPSGLRLVKVETLAQAVDALH
MMAR_1370|M.marinum_M               ITHKMAAARAAGASVFLVPAKNCYEAASDTPSGLRLVKVETLGQAVDALH
MUL_2506|M.ulcerans_Agy99           ITHKMAAARAAGASVFLVPAKNCYEAASDTPSGLRLVKVETLGQAVDALH
MAB_3499c|M.abscessus_ATCC_199      ITHKMFAAKDAGATVFLVPAANCAEAKTDGGQGLTLVKVGTLTEAVDGLN
                                    *:**: **  *** .***** ** ** :    *: *::* :*  ** .*.

Mflv_4655|M.gilvum_PYR-GCK          TLSAGGEPPRC
Mvan_1813|M.vanbaalenii_PYR-1       TLSAGGEPPRC
MSMEG_1958|M.smegmatis_MC2_155      TISAGGEPPRC
TH_1131|M.thermoresistible__bu      TLSAGGEPPRC
Mb3216c|M.bovis_AF2122/97           AMTSGSPTPSC
Rv3194c|M.tuberculosis_H37Rv        AMTSGSPTPSC
MLBr_00643|M.leprae_Br4923          AMTSGGQLPSC
MAV_4138|M.avium_104                AITAGGQPPSC
MMAR_1370|M.marinum_M               AMTAGTATPSC
MUL_2506|M.ulcerans_Agy99           AMTSGTATPSC
MAB_3499c|M.abscessus_ATCC_199      ALNRGEQPPSC
                                    ::. *   * *