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DNWPVAIIGSGVVGTDLMSRIGNGDGRLRVSAMVGTNPHCDGLARAAAAGISTSPGGVDGLLSMPEFANI RLVFDTTNPGAHQSNWARLADTGVRMLDLTASAIGPCCVPAVNLDAQLDAPNLSMATCSAQAAVPIVAAV RRHGVVRYAEVVSAIASQALGPAERVTLDEFAELTTTAVQELGGARRAKTLTIVNPADPPMPMRTTVFCL VDQADEVARNEADVLAVVDGVQALLPGYRLKHRVQFERLGSGNTLYIPGTGEFGGTRITVLLEITAAGGY LPACAGNVAIVTSAAKATAEAIVERHAQTLKAKI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2436 | mhpF | - | 100% (315) | acetaldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4096 | mhpF_1 | 2e-58 | 41.12% (304) | acetaldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3565c | - | 1e-60 | 42.00% (300) | acetaldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1521 | - | 4e-60 | 40.78% (309) | acetaldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv3535c | - | 1e-60 | 42.00% (300) | acetaldehyde dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4374 | - | 6e-71 | 46.86% (303) | acetaldehyde dehydrogenase |
| M. marinum M | MMAR_1505 | mhpF | 1e-173 | 97.46% (315) | acetaldehyde dehydrogenase, MhpF |
| M. avium 104 | MAV_0626 | - | 4e-59 | 41.58% (303) | acetaldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4149 | - | 4e-71 | 44.98% (309) | acetaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_0370 | - | 3e-57 | 41.58% (303) | PROBABLE ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE DEHYDROGENASE |
| M. vanbaalenii PYR-1 | Mvan_0596 | - | 8e-82 | 51.78% (309) | acetaldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1521|M.gilvum_PYR-GCK --------------------MADKLSVAIVGSGNISTDLLYKLLRSE-WL
TH_0370|M.thermoresistible__bu ----------------MTATTGRKLQAAIVGSGNISTDLLYKLLRSD-WL
Mb3565c|M.bovis_AF2122/97 --------------------MPSKAKVAIVGSGNISTDLLYKLLRSE-WL
Rv3535c|M.tuberculosis_H37Rv --------------------MPSKAKVAIVGSGNISTDLLYKLLRSE-WL
MAV_0626|M.avium_104 --------------------MPTKAKVAIVGSGNISTDLLYKLLRSD-WL
MAB_4374|M.abscessus_ATCC_1997 --------------------------MAIIGSGNIGTDLMIKVIRRSRIL
MSMEG_4149|M.smegmatis_MC2_155 ---------------------MDKVKVAIIGSGNIGTDLMMKTLRSS-SL
MUL_2436|M.ulcerans_Agy99 ---------------------MDNWPVAIIGSGVVGTDLMSRIGNGDGRL
MMAR_1505|M.marinum_M MSLGAADVGAGAGPPGQHAGAVDNWPVAIIGSGVVGADLMSRIGNGDGRL
Mvan_0596|M.vanbaalenii_PYR-1 ------------------MTPTVKCPVAILGSGDVGTDLMMKILRSDGPL
**:*** :.:**: : . . *
Mflv_1521|M.gilvum_PYR-GCK EPRWMIGIDPESEGLARARKLGLETSHEGVDWLLARDEKPD--MVFEATS
TH_0370|M.thermoresistible__bu EPRWMIGIDPASEGLARARKLGLETSHEGVDWLFAQDEKPD--IVFEATS
Mb3565c|M.bovis_AF2122/97 EPRWMVGIDPESDGLARAAKLGLETTHEGVDWLLAQPDKPD--LVFEATS
Rv3535c|M.tuberculosis_H37Rv EPRWMVGIDPESDGLARAAKLGLETTHEGVDWLLAQPDKPD--LVFEATS
MAV_0626|M.avium_104 EPRWMVGIDPQSEGLARARKLGLETTHEGVDWLLAQPEKPD--LVFEATS
MAB_4374|M.abscessus_ATCC_1997 SMGAMVGIDPTSDGLARAARLGVATTADGVEGLIHMEQFAEVAIIFDATS
MSMEG_4149|M.smegmatis_MC2_155 EMAVLVGVDPRSDGLARAERLGIATTSGGLDHFVTTPEFEDVAIVFDATS
MUL_2436|M.ulcerans_Agy99 RVSAMVGTNPHCDGLARAAAAGISTSPGGVDGLLSMPEFANIRLVFDTTN
MMAR_1505|M.marinum_M RVSAMVGTNPHCDGLARAAAAGISTSPGGVDGLLIMPEFANIRLVFDTTN
Mvan_0596|M.vanbaalenii_PYR-1 TVGALVGLDPEPGGLARAERLGVPTSAAGIDGLPAMPEFGDIGIVFDATP
::* :* ***** *: *: *:: : : : ::*::*
Mflv_1521|M.gilvum_PYR-GCK AYVHRDAAPRYAEAGIRAIDLTPAAIGPGVIPPANLREH--LDAPNVNMV
TH_0370|M.thermoresistible__bu AYVHREAAPRYAEAGIRAIDLTPAAVGPGVIPPANLREH--LDAPNVNMV
Mb3565c|M.bovis_AF2122/97 AYVHRDAAPKYAEAGIRAIDLTPAAVGPAVIPPANLREH--LDAPNVNMI
Rv3535c|M.tuberculosis_H37Rv AYVHRDAAPKYAEAGIRAIDLTPAAVGPAVIPPANLREH--LDAPNVNMI
MAV_0626|M.avium_104 AYVHRDAAPKYEAAGIRAIDLTPAAVGPAVIPPANLRQH--LDAPNVNMI
MAB_4374|M.abscessus_ATCC_1997 AATHRENAARLAPYDKRLIDLTPAAVGPYVVPPVNLGAHIASGATNLNMV
MSMEG_4149|M.smegmatis_MC2_155 AAAHERHASILAQLNKQVVDLTPAAVGPYVIPTVNMDR--VVGEPNVNMV
MUL_2436|M.ulcerans_Agy99 PGAHQSNWARLADTGVRMLDLTASAIGPCCVPAVNLDAQ--LDAPNLSMA
MMAR_1505|M.marinum_M PGARQSNWARLADTGVRMLDLTASAIGPCCVPAVNLDAQ--LDAPNLSMA
Mvan_0596|M.vanbaalenii_PYR-1 AGAPR---AELEKAGVCVLDLNPAVVGPHCVPAVNLEDH--LDTPNLNLV
. . . . . :**..:.:** :*..*: . .*:.:
Mflv_1521|M.gilvum_PYR-GCK TCGGQATIPMVHAVSRVVD-----VPYAEIVASVSSASAGPGTRANIDEF
TH_0370|M.thermoresistible__bu TCGGQATIPIVHAVVRAVAAHGGTVPYAEIVASVASVSAGPGTRANIDEF
Mb3565c|M.bovis_AF2122/97 TCGGQATIPIVYAVSRIVE-----VPYAEIVASVASVSAGPGTRANIDEF
Rv3535c|M.tuberculosis_H37Rv TCGGQATIPIVYAVSRIVE-----VPYAEIVASVASVSAGPGTRANIDEF
MAV_0626|M.avium_104 TCGGQATIPIVYAVSRVVE-----VPYAEIVASVASVSAGPGTRANIDEF
MAB_4374|M.abscessus_ATCC_1997 TCGGQATIPIVHAVSRVAP-----VVYAEIVASISSRSAGPGTRANIDEF
MSMEG_4149|M.smegmatis_MC2_155 TCGGQATVPIVAAISGVTP-----VHYAEIVASIASRSAGPGTRANIDEF
MUL_2436|M.ulcerans_Agy99 TCSAQAAVPIVAAVRRHGV-----VRYAEVVSAIASQALGPAERVTLDEF
MMAR_1505|M.marinum_M TCSAQAAVPIVAAVRRHGV-----VRYAEVVSAIASQALGPAERVTLDEF
Mvan_0596|M.vanbaalenii_PYR-1 TGAGQATVPIVAAVGRVGA-----VSYAETVTSVAAKSADPATRANIDES
* ..**::*:* *: * *** *::::: : .*. *..:**
Mflv_1521|M.gilvum_PYR-GCK TKTTSAGVEVIGGARRGKAIIILNPADPPMIMRDTIFCAIPEDADHAAIT
TH_0370|M.thermoresistible__bu TKTTSKGVETIGGAQRGKAIIILNPAEPPMIMRDTIFCAIPEDADHDAIT
Mb3565c|M.bovis_AF2122/97 TKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIA
Rv3535c|M.tuberculosis_H37Rv TKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIA
MAV_0626|M.avium_104 TKTTSRGVETIGGAKRGKAIIILNPADPPMIMRDTIFCAIPEDADRDAIA
MAB_4374|M.abscessus_ATCC_1997 TETTARAIEQVGGAARGKAIIVLNPADPPPLMRDTVFCLV-GDADHGTIR
MSMEG_4149|M.smegmatis_MC2_155 TETTALALESVGGATQGKAIIVLNPAEPPLIMRDTVLCLC-DEADETEIE
MUL_2436|M.ulcerans_Agy99 AELTTTAVQELGGARRAKTLTIVNPADPPMPMRTTVFCLVDQADEVARNE
MMAR_1505|M.marinum_M AELTTTAVQELGGARRAKTLTIVNPADPPMPMRTTVFCLVDQADEVARIE
Mvan_0596|M.vanbaalenii_PYR-1 IETTTAALRTVGGARRARSIFIINPADPPILMRNTVYCLVDGDVPRGDIE
: *: .:. :*** :.::: ::***:** ** *: *
Mflv_1521|M.gilvum_PYR-GCK QSVKDVVAEVQTYVPGYRLLNEPQFD----------EPSVVNGGNHLVTI
TH_0370|M.thermoresistible__bu ESIHDVVAEVQTYVPGYRLLNEPQFD----------EPSVVNGGNHLVTT
Mb3565c|M.bovis_AF2122/97 ASIHDVVKEVQTYVPGYRLLNEPQFD----------EPSINSGGQALVTT
Rv3535c|M.tuberculosis_H37Rv ASIHDVVKEVQTYVPGYRLLNEPQFD----------EPSINSGGQALVTT
MAV_0626|M.avium_104 QSIHDVVKEVQSYVPGYRLLNEPQFD----------DPSLNSGGQALVTT
MAB_4374|M.abscessus_ATCC_1997 RSVKEMIAEVSTYVPGYRLKQDVQFDRVDEPMRALLRDTTGTVT-TKVSV
MSMEG_4149|M.smegmatis_MC2_155 AAVERMVASVAEFVPGYRLKQKVQFQRYTRNSPLRLPEQEADFTGLQVSV
MUL_2436|M.ulcerans_Agy99 ADVLAVVDGVQALLPGYRLKHRVQFERLG-SGNTLYIPGTGEFGGTRITV
MMAR_1505|M.marinum_M ADVLAVVDGVQALLPGYRLKHRVQFERLG-SGNTLYIPGTGEFGGTRITV
Mvan_0596|M.vanbaalenii_PYR-1 QSIAAMVERVTSYVPGYRLKQRVQFETFT-ATDPLHIPETGGFTGTRVTV
: :: * :***** : **: ::
Mflv_1521|M.gilvum_PYR-GCK FVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIARERVATSTTGAQA
TH_0370|M.thermoresistible__bu FIEVEGAGDYLPPYAGNLDIMTAAATKVGEEIARES-LTATAGGQA
Mb3565c|M.bovis_AF2122/97 FVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETL-VVGGAR--
Rv3535c|M.tuberculosis_H37Rv FVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETL-VVGGAR--
MAV_0626|M.avium_104 FVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETLSVAGGTR--
MAB_4374|M.abscessus_ATCC_1997 FLEVEGAGHYLPSYAGNLDIMTSAALHTAESMVRGGDSSQEFGI--
MSMEG_4149|M.smegmatis_MC2_155 FLEVEGAAHYLPAYAGNLDIMTSAALRTAERMTELDAIRGK-----
MUL_2436|M.ulcerans_Agy99 LLEITAAGGYLPACAGNVAIVTSAAKATAEAIVERHAQTLKAKI--
MMAR_1505|M.marinum_M LLEITAAGGYLPACAGNVAIVTSAAKATAEAIVEHHAQTVKAEL--
Mvan_0596|M.vanbaalenii_PYR-1 LVEVTAGEPHLPGYAGNLEMMTSAAKAAAERIALHRSRTAGAAT--
::*: .. :** ***: ::*:** ..* :.