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RSVEEHQRVVTNMVRARPVAKVPLQQAQGLVLADDVVAPLPLPVFDNSAMDGYAVRAEDTVGASAQHPVV LPVAEDIPAGRVDQLRLHPGTAHRIMTGAPVPAGATAIVPVEATDGGLETVQIGQPAVAGKHIRRAGEDV AAGTTVLQAGQLVTPAALGLAAALGLAELSVIPRQRVLVVSTGTELVPPGTPLQPGQIYESNAESNAVML TAAARDAGAVVVATDTAGDDVAQFVAILDRHAGAADLIITSGGVSAGAYEVVKDPFGREGDQGVEFVKVA MQPGMPQGVGLVAGTPIVTLPGNPVSALVSFEVFIRPALRLAMGLPDPRRPQRTAVMTETVTSPRGKRQF RRAILDIGTGQVTSYGPPASHHLRWLASANALLEIPEDDVEVSAGTQVQVWDLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1390 | moeA2 | - | 100% (405) | molybdopterin biosynthesis protein MoeA2 |
| M. ulcerans Agy99 | MUL_4692 | moeA1 | 4e-62 | 36.83% (429) | molybdopterin biosynthesis protein MoeA1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0446c | moeA2 | 1e-178 | 79.22% (409) | molybdopterin biosynthesis protein MoeA |
| M. gilvum PYR-GCK | Mflv_0152 | - | 1e-153 | 70.62% (405) | molybdenum cofactor synthesis domain-containing protein |
| M. tuberculosis H37Rv | Rv0438c | moeA2 | 1e-177 | 79.22% (409) | molybdopterin biosynthesis protein MoeA2 |
| M. leprae Br4923 | MLBr_00183 | moeA | 2e-64 | 37.50% (424) | putative molybdopterin biosynthesis protein |
| M. abscessus ATCC 19977 | MAB_0640c | - | 1e-141 | 64.44% (405) | molybdopterin biosynthesis protein MoeA |
| M. marinum M | MMAR_0756 | moeA2 | 0.0 | 98.27% (405) | molybdopterin biosynthesis protein MoeA2 |
| M. avium 104 | MAV_4711 | - | 1e-174 | 76.73% (404) | molybdopterin biosynthesis protein MoeA |
| M. smegmatis MC2 155 | MSMEG_0862 | - | 1e-153 | 70.62% (405) | molybdopterin biosynthesis protein MoeA |
| M. thermoresistible (build 8) | TH_3612 | - | 1e-155 | 70.62% (405) | PUTATIVE molybdopterin molybdochelatase |
| M. vanbaalenii PYR-1 | Mvan_0752 | - | 1e-151 | 69.12% (408) | molybdenum cofactor synthesis domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1390|M.ulcerans_Agy99 ------MRSVEEHQRVVTNMVRARPVAKVPLQQAQGLVLADDVVAPLPLP
MMAR_0756|M.marinum_M ------MRSVEEHQRVVTNMVRARPVAKVPLQQAQGLVLADDVVAPLPLP
Mb0446c|M.bovis_AF2122/97 ------MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLP
Rv0438c|M.tuberculosis_H37Rv ------MRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLP
MAV_4711|M.avium_104 ---MAAMRSVAEHQRVVAGLIRARPPVAVPLAQAQGLVLAEDVVAGLALP
Mflv_0152|M.gilvum_PYR-GCK MRARSDMRSVDEHRRVVADLITPRPALTVPLADALGLALAADVVAPLSLP
Mvan_0752|M.vanbaalenii_PYR-1 ------MRTVDEHRRVVAGLITARAPLAVPVADALGLALACDVVAPLSLP
MSMEG_0862|M.smegmatis_MC2_155 ---MRIMRTVEEHQRIVAGLIKARDPQCVPIADALGLVLASDVVAPLSLP
TH_3612|M.thermoresistible__bu ------MRSVAEHRRVVADLITTRPPSIVPLDDALGLVLADDVTAPLSLP
MAB_0640c|M.abscessus_ATCC_199 ------MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLP
MLBr_00183|M.leprae_Br4923 ------MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLP
**:* *:: : :.: * * . :* : **
MUL_1390|M.ulcerans_Agy99 VFDNSAMDGYAVRAEDTVGASAQH-------------PVVLPVAEDIPAG
MMAR_0756|M.marinum_M VFDNSAMDGYAVRAEDTVGASAQH-------------PVVLPVAEDIPAG
Mb0446c|M.bovis_AF2122/97 VFDNSAMDGYAVRAEDTSGATPQN-------------PVMLPVAEDIPAG
Rv0438c|M.tuberculosis_H37Rv VFDNSAMDGYAVRAEDTSGATPQN-------------PVMLPVAEDIPAG
MAV_4711|M.avium_104 VFDNSAMDGYAVRAEDIAGATPER-------------PVVLPVAEDIPAG
Mflv_0152|M.gilvum_PYR-GCK GFDNSAMDGYAVLAGDIAAATDST-------------PVELPVAEDIPAG
Mvan_0752|M.vanbaalenii_PYR-1 GFDNSAMDGYAVVAEDIATAADDT-------------PVRLPVTEDIPAG
MSMEG_0862|M.smegmatis_MC2_155 GFDNSAMDGYAVVAEDIACATADT-------------PVLLPVAEDIPAG
TH_3612|M.thermoresistible__bu GFDNSAMDGYAVLAEDVAGASPQN-------------PVHLPVAEDIPAG
MAB_0640c|M.abscessus_ATCC_199 VFDNSAMDGYAVRHEDLVGASPAG-------------PITLPVTEDIPAG
MLBr_00183|M.leprae_Br4923 GFDQAAIDGYAVRSVDVSGIGESDGGESGSSDEDGRYVLTLPVMGTIEAG
**::*:***** * : *** * **
MUL_1390|M.ulcerans_Agy99 RVDQLRLHPGTAHRIMTGAPVPAGATAIVPVEATDGGLETVQIGQPAVAG
MMAR_0756|M.marinum_M RVDQLRLHPGTAHRIMTGAPVPAGATAIVPVEATDGGLETVQIGQPAVAG
Mb0446c|M.bovis_AF2122/97 RADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVDSVAIRQQATPG
Rv0438c|M.tuberculosis_H37Rv RADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVDSVAIRQQATPG
MAV_4711|M.avium_104 RTDELTLQPGTAHRIMTGAPVPAGATAVVPVEDTDGGVDVVSIRAPREPG
Mflv_0152|M.gilvum_PYR-GCK RTDIPTLTPGTAHRIMTGAPLPFGADTVVPVESTDAGVHTVTIREAKPVG
Mvan_0752|M.vanbaalenii_PYR-1 RTDIPTLRPGTAHRIMTGAPLPAGATAVIPVEATDRGVDTVAIRAAARQG
MSMEG_0862|M.smegmatis_MC2_155 RTDALTLKAGTAHRIMTGAPVPAGATAVIPVEATDGATDTVTIRAAARPG
TH_3612|M.thermoresistible__bu RTDRLVLKPGTAHRIMTGAPLPARATAVVPVEATDGGTDTVVIRAAVEPG
MAB_0640c|M.abscessus_ATCC_199 RTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTETVTITQEPAAG
MLBr_00183|M.leprae_Br4923 ARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRGAPSG
* . * *: ****:* * :::**. ** . * * *
MUL_1390|M.ulcerans_Agy99 KHIRRAGEDVAAGTTVLQAGQLVTPAALGLAAALGLAELSVIPRQRVLVV
MMAR_0756|M.marinum_M KHIRRAGEDVAAGTTVLQAGQLVTPAALGLAAALGLAELSVIPRQRVLVV
Mb0446c|M.bovis_AF2122/97 KHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAAALGLAELPVLPRQRVLVI
Rv0438c|M.tuberculosis_H37Rv KHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAAALGLAELPVLPRQRVLVI
MAV_4711|M.avium_104 KHIRRAGEDVSPGTTVLRRGQVVTPAVLGLAAALGIAELSVIPRQRVLVI
Mflv_0152|M.gilvum_PYR-GCK RHIRRAGEDVTEGTTVLHAGQVVTPAALGLAAALGLSELSVIPRQRVLVV
Mvan_0752|M.vanbaalenii_PYR-1 QHIRRAGEDVTAGTTVLQTGQVITPAAIGLAAALGLAELTVIPRQRVLVV
MSMEG_0862|M.smegmatis_MC2_155 QHIRRAGEDVTAGTTVLHAGQMVTPAALGLAAALGLSELTVIPPQRVMVM
TH_3612|M.thermoresistible__bu KHIRRAGEDVTAGTTVLRAGQVVTPPMLGLAAALGLSTLPVVPRPRVLVM
MAB_0640c|M.abscessus_ATCC_199 QHVRCAGEDVRAGDTVLTAGTRLNAPALGLAAALGLDELTVHPRLRVVIA
MLBr_00183|M.leprae_Br4923 AYVRRVGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSIM
::* *:** * ..: * : .. :** **:* : * * *: :
MUL_1390|M.ulcerans_Agy99 STGTELVPPGTPLQPGQIYESNAESNAVMLTAAARDAGAVVVATDTAGDD
MMAR_0756|M.marinum_M STGTELVPPGTPLQPGQIYES----NAVMLAAAARDAGAVVVATDTAGDD
Mb0446c|M.bovis_AF2122/97 STGSELASPGTPLQPGQIYES----NSIMLAAAVRDAGAAVVATATAGDD
Rv0438c|M.tuberculosis_H37Rv STGSELASPGTPLQPGQIYES----NSIMLAAAVRDAGAAVVATATAGDD
MAV_4711|M.avium_104 STGSELVAPGAALRPGQIYES----NSIMLAGAVRDAGAELVAVTTAEDE
Mflv_0152|M.gilvum_PYR-GCK STGTELVTAGTPLQPGQIYES----NGAMLAAAVRDAGGEVVASPMTGDD
Mvan_0752|M.vanbaalenii_PYR-1 STGTELVAAGGPLQPGQIYES----NGAMLAAAVRNAGGEVVASPMTGDD
MSMEG_0862|M.smegmatis_MC2_155 STGTELVKPGTPLQPGQIYES----NAVMLSAAVRDAGAQVISSPMSHDD
TH_3612|M.thermoresistible__bu STGSELVAAGTPLRPGQIYES----NAVMLAAAIRDAGGHVVATPMTGDD
MAB_0640c|M.abscessus_ATCC_199 STGSELVPPGTPLRPGQIYES----NAVMLAAAVQEAGADAVVAPTVADD
MLBr_00183|M.leprae_Br4923 AVGGELVDISRTPGNGQVYDV----NSYALTAAGRDAGAEVNRIGIVSNN
:.* **. . . **:*: *. *:.* ::**. ::
MUL_1390|M.ulcerans_Agy99 VAQFVAILDRHAGAADLIITSGGVSAGAYEVVKDPFG----REGDQGVEF
MMAR_0756|M.marinum_M VAQFVAILDRHAGAADLIITSGGVSAGAYEVVKDAFG----REGDQGVEF
Mb0446c|M.bovis_AF2122/97 VAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEF
Rv0438c|M.tuberculosis_H37Rv VAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEF
MAV_4711|M.avium_104 VAQFSSIIDRYAAGTDLIITSGGVSAGAYEVVKDAFG----REGDQGVEF
Mflv_0152|M.gilvum_PYR-GCK VEAFTATLRAHAGDADLIVTTGGVSAGAYEVVKDALG------PGERVEF
Mvan_0752|M.vanbaalenii_PYR-1 VDSFREVLRRHCADADLVITTGGVSAGAYEVVKDALT------EG-GVQF
MSMEG_0862|M.smegmatis_MC2_155 VDNFRAVLAEHARDIDLIITTGGVSAGAYEVVKDALA------KQ--VDF
TH_3612|M.thermoresistible__bu VHTFHSALDRHTADADLIITTGGVSAGAYEVVKDSLG------DD--VEF
MAB_0640c|M.abscessus_ATCC_199 VEQFLAVLEEFGAQADLVITTGGVSAGAYEVVKDALT-------DAGVRF
MLBr_00183|M.leprae_Br4923 LKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLS------EIGEMEV
: * : :::: :***...* *.*: : : .
MUL_1390|M.ulcerans_Agy99 VKVAMQPGMPQGVGLVAG----TPIVTLPGNPVSALVSFEVFIRPALRLA
MMAR_0756|M.marinum_M VKVAMQPGMPQGVGLVAG----TPIVTLPGNPVSALVSFEVFIRPALRLA
Mb0446c|M.bovis_AF2122/97 VKVAMQPGMPQGVGRVAG----TPIVTLPGNPVSALVSFEVFIRPPLRMA
Rv0438c|M.tuberculosis_H37Rv VKVAMQPGMPQGVGRVAG----TPIVTLPGNPVSALVSFEVFIRPPLRMA
MAV_4711|M.avium_104 VKVAMQPGMPQGVGRVAG----ATIVTLPGNPVSALVSFEVFIRPALRAA
Mflv_0152|M.gilvum_PYR-GCK VKVAMQPGMPQGAGTWEG---GTPIVTLPGNPVSALVSFEVFLRPALRAA
Mvan_0752|M.vanbaalenii_PYR-1 VKVAMQPGMPQGAGLLDDGADGTPIITLPGNPVSALVSFEVFVRPALRAA
MSMEG_0862|M.smegmatis_MC2_155 VKVAMQPGMPQGSGVVGT----TPIITLPGNPVSALVSFEVFVRAPLRAA
TH_3612|M.thermoresistible__bu VKVAMQPGMPQGAGRLSG----IPIITLPGNPVSALVSFEVFVREPLRAA
MAB_0640c|M.abscessus_ATCC_199 VSVAMQPGKPQGAGHVNG----VPVLTLPGNPVSALVSFEVFIREPLRAA
MLBr_00183|M.leprae_Br4923 VRVAMHPGSVQGFGQLGR--EGVPTFLLPANPVSALVVFEVMVRPLIRLS
* ***:** ** * . . **.******* ***::* :* :
MUL_1390|M.ulcerans_Agy99 MGLPDPRRPQRTAVMTETVTSPRGKRQFRRAILDIGTGQ----VTSYG--
MMAR_0756|M.marinum_M MGLPDPRRPQRTAVLTETVTSPRGKRQFRRAILDIGTGQ----VTSYG--
Mb0446c|M.bovis_AF2122/97 MGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQAGT----VISYG--
Rv0438c|M.tuberculosis_H37Rv MGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQAGT----VISYG--
MAV_4711|M.avium_104 MGLPDPERPHRSAVLAESLTSPRGKRQFRRAVLDDDAGT----VVSYG--
Mflv_0152|M.gilvum_PYR-GCK MGLTDTQRPRRTAMLTEDLTSPRGKRQFRRGVFDPVTDT----VTGYG--
Mvan_0752|M.vanbaalenii_PYR-1 MGLPHTERPRRTAMLTEDLVSPRGKRQFRRGVFDPVTDT----VTGYG--
MSMEG_0862|M.smegmatis_MC2_155 MGHPEPERPKLTATLTEPLTSPAGKRQFRRGVLT--GDT----VTSYG--
TH_3612|M.thermoresistible__bu MRLPHPRRPRLTAVLAEDLTSPGGKRQFRRGRYDAEAGT----VTSYG--
MAB_0640c|M.abscessus_ATCC_199 MGLT-PARTRHEAVLTDAISAPAGKRQFRRGYWAADKGT----VTAVG--
MLBr_00183|M.leprae_Br4923 LGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGA
: . * * : : *:: : *. . * . *
MUL_1390|M.ulcerans_Agy99 -PPASHHLRWLASANALLEIPEDDVEVSAGTQVQVWDLT---
MMAR_0756|M.marinum_M -PPASHHLRWLASANALLEIPEDDVEVSAGTQVQVWDLT---
Mb0446c|M.bovis_AF2122/97 -PPASHHLRWLASANGLLDIPEDVVEVAAGTQLQVWDLT---
Rv0438c|M.tuberculosis_H37Rv -PPASHHLRWLASANGLLDIPEDVVEVAAGTQLQVWDLT---
MAV_4711|M.avium_104 -PPASHHLRWLASANGLLDIPEDVVEVPEGTTLEVWDLR---
Mflv_0152|M.gilvum_PYR-GCK -PPASHHLRWLASANCLLELDEDTAEVAAGSRVQVWDLR---
Mvan_0752|M.vanbaalenii_PYR-1 -PPASHHLRWLASANCLLELDEDTAEVAAGSRVQLWDLR---
MSMEG_0862|M.smegmatis_MC2_155 -PPASHHLRWLASANCLLEIGEDVTEVPAGTSVQVWDLS---
TH_3612|M.thermoresistible__bu -PPASHHLRWLASANCLLEIDEDTTRIAAGTEVTIWDLSGC-
MAB_0640c|M.abscessus_ATCC_199 -PPASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS---
MLBr_00183|M.leprae_Br4923 LGASSHLLATLAEANCLVVIPSGAEQIRTGEVVDVAFLAQRG
.:** * ** :* *: : .. .: * : : *