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M. leprae Br4923 MLBr_00183 (moeA)

annotation: putative molybdopterin biosynthesis protein
coordinates: 248117 - 249391
length: 424

VRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAAIDGYAVRSVDVSGIGESDGG
ESGSSDEDGRYVLTLPVMGTIEAGARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRG
APSGAYVRRVGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSIMAVGGELVDISRTPGNG
QVYDVNSYALTAAGRDAGAEVNRIGIVSNNLKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIG
EMEVVRVAMHPGSVQGFGQLGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLSP
ITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCLVVIPSGAEQIRTGEVVDVAFL
AQRG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_00183moeA-100% (424)putative molybdopterin biosynthesis protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1021moeA10.088.73% (426) molybdopterin biosynthesis protein MoeA1
M. gilvum PYR-GCKMflv_1898-0.083.37% (427) molybdenum cofactor synthesis domain-containing protein
M. tuberculosis H37RvRv0994moeA10.088.50% (426) molybdopterin biosynthesis protein MoeA1
M. abscessus ATCC 19977MAB_1087-0.075.00% (436) molybdopterin biosynthesis protein MoeA1
M. marinum MMMAR_4520moeA10.086.08% (431) molybdopterin biosynthesis protein MoeA1
M. avium 104MAV_1103-0.085.55% (429) molybdopterin biosynthesis protein moeA
M. smegmatis MC2 155MSMEG_5470-0.080.75% (426) molybdopterin biosynthesis protein MoeA 1
M. thermoresistible (build 8)TH_0939moeA0.080.44% (409) PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1
M. ulcerans Agy99MUL_4692moeA10.086.08% (431) molybdopterin biosynthesis protein MoeA1
M. vanbaalenii PYR-1Mvan_4832-0.084.11% (428) molybdenum cofactor synthesis domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_00183|M.leprae_Br4923          MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPGFDQAA
MAV_1103|M.avium_104                MRSVEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAA
Mb1021|M.bovis_AF2122/97            MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAA
Rv0994|M.tuberculosis_H37Rv         MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAA
MMAR_4520|M.marinum_M               MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPLPGFDQAA
MUL_4692|M.ulcerans_Agy99           MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPLPGFDQAA
Mflv_1898|M.gilvum_PYR-GCK          MRSVEEQQARVAAAAVAPRPVRVAIAEAQGLMCAEEVVTERPLPGFDQAA
Mvan_4832|M.vanbaalenii_PYR-1       MRSVEDQQARVAAAAVAPRPVRVAIAEAQGLMCAEEVVTERPMPGFDQAA
MSMEG_5470|M.smegmatis_MC2_155      MRSVEEQQARVAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAA
TH_0939|M.thermoresistible__bu      ---------------VAPRPVRVAIAEAQGLMCAEEVVTERPLPGFDQAA
MAB_1087|M.abscessus_ATCC_1997      MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAA
                                                   *.***:******:***:*****:* **:*******

MLBr_00183|M.leprae_Br4923          IDGYAVRSVDVSGIGES--------DGGESGSSD---EDGRY-VLTLPVM
MAV_1103|M.avium_104                IDGYAVRSVDVLGVGEVG------AEGLPAPLDDS-VDDARD-GLVLPVM
Mb1021|M.bovis_AF2122/97            IDGYAVRSVDVAGVG---------DTGGVQVFADHGDLDGRD-VLTLPVM
Rv0994|M.tuberculosis_H37Rv         IDGYAVRSVDVAGVG---------DTGGVQVFADHGDLDGRD-VLTLPVM
MMAR_4520|M.marinum_M               IDGYAVRSVDVVGVGQDL------ASGAAEFFVDDGSATSRD-AVTLPVM
MUL_4692|M.ulcerans_Agy99           IDGYAVRSVDVMGVGQDL------ASGAAEFFVDDGSAISRD-AVTLPVM
Mflv_1898|M.gilvum_PYR-GCK          IDGYAVRSVDVLGIGGP-------ADGQDDAYGDRDESRPR--EISLPVM
Mvan_4832|M.vanbaalenii_PYR-1       IDGYAVRSVDVLGIGGSD------EDAGLDGESDRDESRPR--EISLPVM
MSMEG_5470|M.smegmatis_MC2_155      IDGYAVRSVDVLGVGSDS------EDGG---------------EISLPVM
TH_0939|M.thermoresistible__bu      IDGYAVRSVDVLGVGGG-------PDGEEG---------PDR-QVSLPVM
MAB_1087|M.abscessus_ATCC_1997      IDGYAVRSVDVQAAGGVVRVISPGEGGSPDDEDDIEESAGEIGTVELPVV
                                    *********** . *           .                 : ***:

MLBr_00183|M.leprae_Br4923          GTIEAGARTPSRLLPHQAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRIL
MAV_1103|M.avium_104                GTVEAGSRTPSRLQPRQAVRVQTGAPLPTLADAVLPLGWTDGGTQRVRIY
Mb1021|M.bovis_AF2122/97            GTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVL
Rv0994|M.tuberculosis_H37Rv         GTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVL
MMAR_4520|M.marinum_M               GTIEAGARTPTRLQPKQAVRVQTGAPLPTLADAVLPLRWTDGGMNRVRVL
MUL_4692|M.ulcerans_Agy99           GTIEAGARTPTRLQPKQVVRVQTGAPLPTLADAVLPLRWTDGGMNRVRVL
Mflv_1898|M.gilvum_PYR-GCK          GLIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGDARVRVL
Mvan_4832|M.vanbaalenii_PYR-1       GLIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGDSRVTVL
MSMEG_5470|M.smegmatis_MC2_155      GVIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGENRVRVL
TH_0939|M.thermoresistible__bu      ATIEAGSRTPTRLQPKQAARIQTGAPMPTLADAVLPLRWTDGGEKRVRVL
MAB_1087|M.abscessus_ATCC_1997      GTVRVGERTPTRLQPRQAVRVQTGAPMPTLADAVLPLRWSEGGESRVKVL
                                    . :..* ** :** *:*..*:*****:*.*******: *::**  ** : 

MLBr_00183|M.leprae_Br4923          RGAPSGAYVRRVGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPR
MAV_1103|M.avium_104                RGAPSGAYVRRAGDDVQPGDVAVRAGAVIGAAQVGLLAAVGRERVLVHPR
Mb1021|M.bovis_AF2122/97            RGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPR
Rv0994|M.tuberculosis_H37Rv         RGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPR
MMAR_4520|M.marinum_M               RGAPSGAYVRHAGDDVQPGDVAVRSGTIIGAAQVGLLAAVGRERVLVHPR
MUL_4692|M.ulcerans_Agy99           RGAPSGAYVRHAGDDVQPGDVAVRSGTIIGAAQVGLLAAVGRERVLVHPR
Mflv_1898|M.gilvum_PYR-GCK          RGVRSGAYVRRTGDDVQPGDVAVRAGAIIGPAQVGLLAAVGRERVLVHPR
Mvan_4832|M.vanbaalenii_PYR-1       RGVRSGAYVRRTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPR
MSMEG_5470|M.smegmatis_MC2_155      RGVRSGAYVRRTGDDVQPGDVAVRAGTIIGPAQVGLLAAVGRDKVLVHPR
TH_0939|M.thermoresistible__bu      RGVRSGAYVRRTGDDVQPGDVAVRAGTIIGPAQVGLLAAVGRERVLVHPR
MAB_1087|M.abscessus_ATCC_1997      RAVRSGDYVRRTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPR
                                    *.. ** ***:.************:*::**.***********::******

MLBr_00183|M.leprae_Br4923          PRLSIMAVGGELVDISRTPGNGQVYDVNSYALTAAGRDAGAEVNRIGIVS
MAV_1103|M.avium_104                PRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVG
Mb1021|M.bovis_AF2122/97            PRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
Rv0994|M.tuberculosis_H37Rv         PRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
MMAR_4520|M.marinum_M               PRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
MUL_4692|M.ulcerans_Agy99           PRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
Mflv_1898|M.gilvum_PYR-GCK          PRLSVMCVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVP
Mvan_4832|M.vanbaalenii_PYR-1       PRLSVMCVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
MSMEG_5470|M.smegmatis_MC2_155      PRLSVMCVGGELVDVSRTPGTGQVYDVNSYALAAAGRDAGAEVNRVGIIS
TH_0939|M.thermoresistible__bu      PRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGILD
MAB_1087|M.abscessus_ATCC_1997      PRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAGADVNRVGIVS
                                    **::::.:******:.****.***********:**.*** *:***:**: 

MLBr_00183|M.leprae_Br4923          NNLKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGEMEVVRVA
MAV_1103|M.avium_104                GGPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVA
Mb1021|M.bovis_AF2122/97            NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVA
Rv0994|M.tuberculosis_H37Rv         NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVA
MMAR_4520|M.marinum_M               SDPKQLGEIVEGQINRAELVVIAGGVGGAAAEAVRSVLSELGDMEVVRIA
MUL_4692|M.ulcerans_Agy99           NDPNQLGEIVEGQINRAEVVVIAGGVGGAAAEAVRSVLSELGDMEVVRIA
Mflv_1898|M.gilvum_PYR-GCK          TDPAQLREVVEGQLSRAEIVVISGAVGGAAAEGVRTVLSQLGDMEVARIA
Mvan_4832|M.vanbaalenii_PYR-1       TDPKQLREVVEGQLSRAEVVVIAGAVGGAAAEAVRSVLAGLGDMEVARIA
MSMEG_5470|M.smegmatis_MC2_155      TDPRELRETVEGQVNRNEIVVIAGAVGGAAAESVRTVLSELGDMEVARIA
TH_0939|M.thermoresistible__bu      PDPKELREVIEGQVNRSEVVVIAGGVGGAATEPVRRVLSELGEMEVTRIA
MAB_1087|M.abscessus_ATCC_1997      AEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIA
                                         : : :***:.* *::**:*.*****:* :* .*: :*::** *:*

MLBr_00183|M.leprae_Br4923          MHPGSVQGFGQLGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQP
MAV_1103|M.avium_104                MHPGSIQGFGQLGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQP
Mb1021|M.bovis_AF2122/97            MHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHP
Rv0994|M.tuberculosis_H37Rv         MHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHP
MMAR_4520|M.marinum_M               MHPGSVQGFGQLGRDRVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQP
MUL_4692|M.ulcerans_Agy99           MHPGSVQGFGQLGRDRVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQP
Mflv_1898|M.gilvum_PYR-GCK          MHPGSVQGFGQLGPEGVPVFLLPANPVSALVVFEVMVRPLIRLSLGKRQA
Mvan_4832|M.vanbaalenii_PYR-1       MHPGSVQGFGQLGPDGVPVFLLPANPVSALVVFEVMVRPLIRLSLGKRQA
MSMEG_5470|M.smegmatis_MC2_155      MHPGSVQGFGQLGRDRVPVFLLPANPVSALVVFEIMVRPLIRLSLGKRQP
TH_0939|M.thermoresistible__bu      MHPGSVQGFGQLGRDGVPVFLLPANPVSALVVFEVMVRPLIRMALGRRHP
MAB_1087|M.abscessus_ATCC_1997      MHPGSVQGFGQLGRDAVPTFLLPANPVGALVVFEVMVRPLIRLALGRRQS
                                    *****:******* : **.********.******:*******::**:*:.

MLBr_00183|M.leprae_Br4923          MRRIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSH
MAV_1103|M.avium_104                MRRIVQARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSH
Mb1021|M.bovis_AF2122/97            MRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSH
Rv0994|M.tuberculosis_H37Rv         MRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSH
MMAR_4520|M.marinum_M               MRRIVQARTLSPITSVAGRKGYLRGQLMRDQESGEYLVQALGGAPGASSH
MUL_4692|M.ulcerans_Agy99           MRRIVQARTLSPITSVAGRKGYLRGQLMRDQESGEYLVQALGGAPGASSH
Mflv_1898|M.gilvum_PYR-GCK          MRRIVPARALSPISSVAGRKGYLRGQLMRDQDTGEYLVQALGGAPGASSH
Mvan_4832|M.vanbaalenii_PYR-1       TRRIVPARALSPISSVAGRKGYLRGQLMRDQDTGEYLVQALGGAPGASSH
MSMEG_5470|M.smegmatis_MC2_155      MRRIVQARTLSPITSMPGRKGYLRGQLMRDQDTGEYLVQALGGAPGASTH
TH_0939|M.thermoresistible__bu      MRRIVKARTLSPIVSVPGRKGFLRGQLMRDHETGEYLVQTLGGASGASSH
MAB_1087|M.abscessus_ATCC_1997      QRRIIQARTVSPITSIAGRKGFLRGQLMRDQDNGEYLVQILG-APGASSH
                                     ***: **::*** *:.****:********::.****** ** * ***:*

MLBr_00183|M.leprae_Br4923          LLATLAEANCLVVIPSGAEQIRTGEVVDVAFLAQRG
MAV_1103|M.avium_104                LLATLAEANCLVVVPSGAEQIRTGEIVDVAFLAQRG
Mb1021|M.bovis_AF2122/97            LLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
Rv0994|M.tuberculosis_H37Rv         LLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
MMAR_4520|M.marinum_M               LLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
MUL_4692|M.ulcerans_Agy99           LLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
Mflv_1898|M.gilvum_PYR-GCK          LLATLAEANCLVIVPSEAEQIRTGEVVDVAFLAQRG
Mvan_4832|M.vanbaalenii_PYR-1       LLATLAEANCLVIVPSEAEQIRTGEIVDVAFLAQRG
MSMEG_5470|M.smegmatis_MC2_155      LLATLAEANCLVIVPADVEEVRTGETVDVAFLAQRG
TH_0939|M.thermoresistible__bu      LLATLAEANCLVIVPAETEEVRTGEIVDVAFLAQRG
MAB_1087|M.abscessus_ATCC_1997      LLATLAEANCLVIVPAEVEQVRTGEIVEVAFLAQRG
                                    ************::*: .*::**** *:******:*