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RRSCEHQENRTTMAEIPPTPTKMRTRSEDIQAHYDVSDDFFALFQDPTRIYSCAYFEPPELTLEEAQYAK IDLNLDKLDLKPGMTLLDIGCGWGTTMKRAVERFDVNVIGLTLSKNQHARCESVLGEIDTNRSRQVRLHG WEDSNEPVDRIVSIEAFEHFGHENYDDFFKRCFDIMPEDGRMTVQSSVSYHPFEMAARGKKLTFETARFI KFIVTEIFPGGRLPSTGMMVEHGEKAGFVVPEPLSLRPYYIKTLRIWGDNLEANKEKAIEVTSEEVYNRY IKYLRGCEHYFTDEMLDCSLVTYLKPGAVSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0729 | mmaA4 | - | 100% (312) | methoxy mycolic acid synthase 4, MmaA4 |
| M. ulcerans Agy99 | MUL_0730 | mmaA3 | 8e-94 | 57.09% (282) | methoxy mycolic acid synthase 3, MmaA3 |
| M. ulcerans Agy99 | MUL_3772 | mmaA5 | 2e-87 | 55.00% (280) | methoxy mycolic acid synthase 5 MmaA5 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0661c | mmaA4 | 1e-160 | 89.67% (300) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_5113 | - | 1e-122 | 68.94% (293) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0642c | mmaA4 | 1e-161 | 90.00% (300) | methoxy mycolic acid synthase |
| M. leprae Br4923 | MLBr_01903 | mmaA4 | 1e-153 | 84.85% (297) | methyl mycolic acid synthase 4 |
| M. abscessus ATCC 19977 | MAB_3881 | - | 4e-90 | 57.40% (277) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0977 | mmaA4 | 1e-176 | 99.00% (299) | methoxy mycolic acid synthase 4, MmaA4 |
| M. avium 104 | MAV_4517 | - | 1e-156 | 86.91% (298) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1351 | - | 3e-90 | 54.20% (286) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_1862 | cmaA1 | 1e-126 | 72.13% (287) | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 CMAA1 |
| M. vanbaalenii PYR-1 | Mvan_1239 | - | 1e-124 | 70.14% (288) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5113|M.gilvum_PYR-GCK -------------MSDNSTGTKDMTPHFEDIQAHYDLSDDFFGVFQDPTR
Mvan_1239|M.vanbaalenii_PYR-1 -------------MSDQSSGTKDMTPHFEDIQAHYDLSDDFFGVFQDPTR
TH_1862|M.thermoresistible__bu -----------------------MRPHFEDIQAHYDLSDDFFGLFQDPTR
MUL_0729|M.ulcerans_Agy99 MRRSCEHQENRTTMAEIPPTPTKMRTRSEDIQAHYDVSDDFFALFQDPTR
MMAR_0977|M.marinum_M -------------MAEIPPTPTKTRTRSEDIQAHYDVSDDFFALFQDPTR
Mb0661c|M.bovis_AF2122/97 ----------MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTR
Rv0642c|M.tuberculosis_H37Rv ----------MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTR
MAV_4517|M.avium_104 -------------MAEQPSSPTKTRTRSEDIQAHYDVSDDFFGLFQDPTR
MLBr_01903|M.leprae_Br4923 -------------MTEQPTGPTKTRTRSEDIQAHYDLSNEFFALFQDPTR
MAB_3881|M.abscessus_ATCC_1997 -------------MS-------KLTPKFSDVQAHYDLSDDFFALFLDPSR
MSMEG_1351|M.smegmatis_MC2_155 -------------MTKQPG---KLQPHFDEVQAHYDLSDDFFALFLDPSR
.: .::*****:*::**.:* **:*
Mflv_5113|M.gilvum_PYR-GCK KYSCAYFTGPNVTLSEAQIANVDQHLDALDLKPGMTLLEVGCGWGLTLQR
Mvan_1239|M.vanbaalenii_PYR-1 KYSCAYFTGPDVTLSEAQIANVDQHLDKLDLKPGMTLLEVGCGWGLTLQR
TH_1862|M.thermoresistible__bu KYSCGYFTGPDATLSDAQIADVDLNLDKLDLKPGMTLLDIGCGWGLTLRR
MUL_0729|M.ulcerans_Agy99 IYSCAYFEPPELTLEEAQYAKIDLNLDKLDLKPGMTLLDIGCGWGTTMKR
MMAR_0977|M.marinum_M IYSCAYFEPPELTLEEAQYAKIDLNLDKLDLKPGMTLLDIGCGWGTTMKR
Mb0661c|M.bovis_AF2122/97 TYSCAYFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRR
Rv0642c|M.tuberculosis_H37Rv TYSCAYFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRR
MAV_4517|M.avium_104 TYSCAYFARDDMSLEEAQYAKIDLNLDKLDLKPGMTLLDIGCGWGTTMKR
MLBr_01903|M.leprae_Br4923 TYSCAYFEPPDLTLEEAQYAKIDLNLNKLDLKPGMTLLDIGCGWGTTMRR
MAB_3881|M.abscessus_ATCC_1997 TYSCAYFEPETLTLEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKR
MSMEG_1351|M.smegmatis_MC2_155 TYSCAYFERDDMTLEEAQLAKIDLSLGKLGLQPGMTLLDVGCGWGATMLR
***.** :*.:** *.:* *. *.*:******::***** *: *
Mflv_5113|M.gilvum_PYR-GCK AMEKYDVNVIGLTLSKNQKAYCDQLLGKLGSERTFDVRLEGWEQFHSPVD
Mvan_1239|M.vanbaalenii_PYR-1 AMEKYDVNVIGLTLSKNQKAYCDQLLSKLDTERTFDVRLEGWEQFHSPVD
TH_1862|M.thermoresistible__bu AIEKYDVNVIGLTLSRNQQAYCTQLLEQLDTNRSFDVRLMGWEQFHDPVD
MUL_0729|M.ulcerans_Agy99 AVERFDVNVIGLTLSKNQHARCESVLGEIDTNRSRQVRLHGWEDSNEPVD
MMAR_0977|M.marinum_M AVERFDVNVIGLTLSKNQHARCESVLGEIDTNRSRQVRLHGWEDFNEPVD
Mb0661c|M.bovis_AF2122/97 AVERLDVNVIGLTLSKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVD
Rv0642c|M.tuberculosis_H37Rv AVERFDVNVIGLTLSKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVD
MAV_4517|M.avium_104 AVERFDVNVIGLTLSKNQHARCEELLASLDSNRCRQVRLQNWEDFNEPVD
MLBr_01903|M.leprae_Br4923 AVEKYDVKVIGLTLSKNQHARCEQVLTALESNRSRQVRLQGWEDFTEPVD
MAB_3881|M.abscessus_ATCC_1997 ALEHYDVNVIGLTLSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVD
MSMEG_1351|M.smegmatis_MC2_155 ALERYDVNVVGLTLSRNQQAHVERRFSESSSPRTKRVLLAGWEEFDEPVD
*:*: **:*:*****:** * : : * * * .**: .**
Mflv_5113|M.gilvum_PYR-GCK RIVSIEAFEHFGFERYDDFFKMCFDVLPEDGRMTIQSSVGYHPYDLAERG
Mvan_1239|M.vanbaalenii_PYR-1 RIVSIEAFEHFGFERYDDFFKTCFDILPEDGRMTIQSSVGYHPYDLAERG
TH_1862|M.thermoresistible__bu RIVSIEAFEHFGFERYDHFFRNCYDIMPDDGRMTIQSSVGYHPDNLRARG
MUL_0729|M.ulcerans_Agy99 RIVSIEAFEHFGHENYDDFFKRCFDIMPEDGRMTVQSSVSYHPFEMAARG
MMAR_0977|M.marinum_M RIVSIEAFEHFGHENYDDFFKRCFDIMPEDGRMTVQSSVSYHPFEMAARG
Mb0661c|M.bovis_AF2122/97 RIVSIEAFEHFGHENYDDFFKRCFNIMPADGRMTVQSSVSYHPYEMAARG
Rv0642c|M.tuberculosis_H37Rv RIVSIEAFEHFGHENYDDFFKRCFNIMPADGRMTVQSSVSYHPYEMAARG
MAV_4517|M.avium_104 RIVSIEAFEHFGHENYDDFFKRTFDIMPDDGRMTVQSSVSYHPYDLAARG
MLBr_01903|M.leprae_Br4923 RIVSIEAFEHFGHENYDDFFKRCFNIMPSDGRMTVQSSVSYHPFDMAARG
MAB_3881|M.abscessus_ATCC_1997 RIVSIGAFEHFGHERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMG
MSMEG_1351|M.smegmatis_MC2_155 RIVSIGAFEHFGHERYDDFFRFAHRVLPDDGVMLLHTITGIHPKHAQELG
***** ******.*.** ** . ::* ** * ::: .. ** . *
Mflv_5113|M.gilvum_PYR-GCK KKLTFELARFVKFMITEIFPGGRLPTTQMMVEHGEKAGFTVPQPLSLRNH
Mvan_1239|M.vanbaalenii_PYR-1 KKLTFELARFIKFMITEIFPGGRLPTTQMMIEHGEKAGFVVPDALSLRNH
TH_1862|M.thermoresistible__bu KKLTFELARFIKFMITEIFPGGRIPTTEMMVEHGEKAGFVVPETMSLRNH
MUL_0729|M.ulcerans_Agy99 KKLTFETARFIKFIVTEIFPGGRLPSTGMMVEHGEKAGFVVPEPLSLRPY
MMAR_0977|M.marinum_M KKLTFETARFIKFIVTEIFPGGRLPSTGMMVEHGEKAGFVVPEPLSLRPH
Mb0661c|M.bovis_AF2122/97 KKLSFETARFIKFIVTEIFPGGRLPSTEMMVEHGEKAGFTVPEPLSLRPH
Rv0642c|M.tuberculosis_H37Rv KKLSFETARFIKFIVTEIFPGGRLPSTEMMVEHGEKAGFTVPEPLSLRPH
MAV_4517|M.avium_104 KKLSFETARFIKFIVTEIFPGGRLPSTQMMVDHGEKAGFVVPEPLSLRPH
MLBr_01903|M.leprae_Br4923 KKLSFETARFIKFIITEIFPGGRLPSTKMMVEHGEKAGFTVSEPLSLQSH
MAB_3881|M.abscessus_ATCC_1997 IPLLMSRVRFIYFIGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPH
MSMEG_1351|M.smegmatis_MC2_155 VPLTFEMARFIRFIVTEIFPGGRLPTVDMVIDHATRASFTLERRQSLQLH
* :. .**: *: ********:*:. *: .*. *.* : **: :
Mflv_5113|M.gilvum_PYR-GCK YIKTLGIWADRLEANKDAAIAATDEENYERYMRYLKGCQYYFIDEAIDVS
Mvan_1239|M.vanbaalenii_PYR-1 YIKTLGIWADRLEQNKDAAIAATDEENYRRYMRYLKGCQYYFIDEAIDVS
TH_1862|M.thermoresistible__bu YIKTLGMWADALERNKERAIAITDEENYHRYMRYLRGCQYYFIDECIDVS
MUL_0729|M.ulcerans_Agy99 YIKTLRIWGDNLEANKEKAIEVTSEEVYNRYIKYLRGCEHYFTDEMLDCS
MMAR_0977|M.marinum_M YIKTLRIWGDNLEANKEKAIEVTSEEVYNRYIKYLRGCEHYFTDEMLDCS
Mb0661c|M.bovis_AF2122/97 YIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHYFTDEMLDCS
Rv0642c|M.tuberculosis_H37Rv YIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHYFTDEMLDCS
MAV_4517|M.avium_104 YIKTLHIWGDTLESNRDKAIEVTSEEVYNRYIKYLRGCEHYFTEEMLDCS
MLBr_01903|M.leprae_Br4923 YVKTLRIWGDTLESNRAKAIEVTSEAVYNRYMKYLRGCAHYFSDEMLDCS
MAB_3881|M.abscessus_ATCC_1997 YARTLDCWATNLAAHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVV
MSMEG_1351|M.smegmatis_MC2_155 YARTLDMWAAALESHHDDAVRIQSQEVYDRYMHYLTGCANAFRVGYIDVN
* :** *. * :. *: .: * **::** ** * :*
Mflv_5113|M.gilvum_PYR-GCK LVTYLKPAVAA-
Mvan_1239|M.vanbaalenii_PYR-1 LVTYLKPGVAA-
TH_1862|M.thermoresistible__bu LVTYLKPGAVR-
MUL_0729|M.ulcerans_Agy99 LVTYLKPGAVSA
MMAR_0977|M.marinum_M LVTYLKPGAVSA
Mb0661c|M.bovis_AF2122/97 LVTYLKPGAAA-
Rv0642c|M.tuberculosis_H37Rv LVTYLKPGAAA-
MAV_4517|M.avium_104 LVTYLKPGAAA-
MLBr_01903|M.leprae_Br4923 LVTYLKPGALD-
MAB_3881|M.abscessus_ATCC_1997 QFTCEK------
MSMEG_1351|M.smegmatis_MC2_155 QFTLAK------
.* *