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RGVASQRESTEGSAAVTEDERARIPAGEPDLSFDVIVLGAGPVGQNAADRYQAAGLHVAVIERDLVGGEC SYWACVPSKALLRPVIAVADARLVDGAREAISGSISAAAVFDRRDRYVSNWDDGGQADWVSGIGATLIRG HGRLAGPRRISVSDHDGQTLMIAARHAVVVCTGSRPTLPDLPGITEAWPWTNRQATEASSAPRRLAIVGA GGVGVEMETAWQGLGSSVTLLARSRLLSRMEPFVGDFVGRGLTRAGVDVRVGISVRALHRPHPDAPVTLE IDDDTRLEVDEVLFATGRAPRTDDIGLQTVGLAPGNWLDVDDTCRVNAVDGGWLYAAGDVNHRALLTHQG KYQARIAGSAIGARAAGDSLDTAPWGAHATTADHHAVPQAFFTDPEAAAVGLTTEQAARAGHRIKTIDVE IGDVVTGAKLFADGYAGRARMVVDVDRGCLLGVTIVGPRAAELLHAATIAIAGQVPIDRLWHTVPCFPTI SELWLRLLEAYRDSFFVLV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0404 | lpdB | - | 100% (510) | dihydrolipoamide dehydrogenase, LpdB |
| M. ulcerans Agy99 | MUL_2214 | lpd | 6e-36 | 28.18% (472) | dihydrolipoamide dehydrogenase |
| M. ulcerans Agy99 | MUL_2668 | lpdA | 7e-24 | 26.83% (477) | flavoprotein disulfide reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0819c | - | 1e-106 | 71.76% (262) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 1e-45 | 30.61% (477) | mercuric reductase |
| M. tuberculosis H37Rv | Rv0794c | - | 0.0 | 78.11% (498) | oxidoreductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 5e-37 | 29.83% (476) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 5e-47 | 30.08% (472) | mercuric reductase |
| M. marinum M | MMAR_4894 | lpdB | 0.0 | 96.76% (494) | dihydrolipoamide dehydrogenase, LpdB |
| M. avium 104 | MAV_2396 | - | 3e-42 | 29.98% (477) | mercuric reductase |
| M. smegmatis MC2 155 | MSMEG_4023 | - | 0.0 | 64.07% (487) | oxidoreductase |
| M. thermoresistible (build 8) | TH_3945 | - | 4e-41 | 29.21% (469) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 5e-45 | 29.85% (469) | mercuric reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3059|M.gilvum_PYR-GCK -------------------------MSETATQKFDAIIIGAGQAGPPLAA
Mvan_3468|M.vanbaalenii_PYR-1 ----------------------------MSAQHFDAIIVGAGQAGPPLAG
MAV_2396|M.avium_104 -----------------------------MTKHFDAIIVGAGQAGPPLAG
TH_3945|M.thermoresistible__bu ------------------------------------MIIGAGQAGPPLAG
MAB_3014|M.abscessus_ATCC_1997 -----------------------------MSTHFDAVVVGAGQAGPSLAA
MUL_0404|M.ulcerans_Agy99 MRGVASQRESTEGSAAVTEDERARIPAGEPDLSFDVIVLGAGPVGQNAAD
MMAR_4894|M.marinum_M ----------------MTEDERARIPAGEPDLSFDVIVLGAGPVGENAAD
Mb0819c|M.bovis_AF2122/97 ------------MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVAD
Rv0794c|M.tuberculosis_H37Rv ------------MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVAD
MSMEG_4023|M.smegmatis_MC2_155 --------------MKEPDSTALTPSGAETAETYDVVVIGGGPVGINAAD
MLBr_02387|M.leprae_Br4923 ------------------------------MTHYDVVVLGAGPGGYVAAI
:::*.* * *
Mflv_3059|M.gilvum_PYR-GCK RLTAAGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRGADFGI
Mvan_3468|M.vanbaalenii_PYR-1 RLTAAGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRGNDFGV
MAV_2396|M.avium_104 RLTAAGQRVAIIERKLIGGTCVNTGCIPTKTLVASAHAAHLARRGADYGV
TH_3945|M.thermoresistible__bu RLADAGQRVVLIERRLIGGTCVNYGCIPTKTLVASAHAAHLARRAADYGV
MAB_3014|M.abscessus_ATCC_1997 RLRGAGLTVAIVERHLFGGTCVNTGCRPTKALVASAHAAHMAREAARWGV
MUL_0404|M.ulcerans_Agy99 RYQAAGLHVAVIERDLVGGECSYWACVPSKALLRPVIAVADARLVD--GA
MMAR_4894|M.marinum_M RCQAAGLHVAVIERDLVGGECSYWACVPSKALLRPVVAVADARRVD--GA
Mb0819c|M.bovis_AF2122/97 RARAGGLRVAVVERELVGGECSYWACVPSKALLRPVIAISDARRVD--GA
Rv0794c|M.tuberculosis_H37Rv RARAGGLRVAVVERELVGGECSYWACVPSKALLRPVIAISDARRVD--GA
MSMEG_4023|M.smegmatis_MC2_155 RAHAEGLSVALVERELVGGECNFWGCVPSKSLLRPVLAVADARRVD--GA
MLBr_02387|M.leprae_Br4923 RAAQLGLSTAVVEPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAK-TF
* * ..::* ** * .* *:* *: .
Mflv_3059|M.gilvum_PYR-GCK GTS-EVTVDMAAVKARKDRISGGDREGLESWLDGMDGATLIRGHARFESP
Mvan_3468|M.vanbaalenii_PYR-1 AAA-GVTVDMAAVKARKDRISVGDREGLESWLAGMKGCTLIRGHARFENP
MAV_2396|M.avium_104 GTG-AISVDMAKVKARKDEIMLGDRKGVEDWLAGMAGCTVVRGHARFRDP
TH_3945|M.thermoresistible__bu RTG-PVTVDMARVKARKDAIMLDDRRGLESWLQGMDGCTVVRGHARFEDP
MAB_3014|M.abscessus_ATCC_1997 VVDGSVSMDMVRVRERKDAVILPSRNGGQTWLKDLG-CAIYHEHASFLSP
MUL_0404|M.ulcerans_Agy99 REAISGSISAAAVFDRRDRYVSNWDDGGQADWVSGIGATLIRGHGRLAGP
MMAR_4894|M.marinum_M REAISDSISAAAVFDRRDRYVSNWDDGDQADWVSGIGATLIRGHGRLAGP
Mb0819c|M.bovis_AF2122/97 REAVDGSINTAGVFGRRNRYVAHWDDTGQADWVSGIGATLIRGDGRLDGP
Rv0794c|M.tuberculosis_H37Rv REAVDGSINTAGVFGRRNRYVAHWDDTGQADWVSGIGATLIRGDGRLDGP
MSMEG_4023|M.smegmatis_MC2_155 REAVVGAIDSKGVFARRDRYVTNWDDTPVAEAVATMGPRLVRGHATLDGA
MLBr_02387|M.leprae_Br4923 GISGDASFDYGIAYDR-SRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDA
:.. . * . : . : ..
Mflv_3059|M.gilvum_PYR-GCK NTVRVDGT------LLGAERIFLNVGGRAVVPDIPG-LADVDYLTNVGIL
Mvan_3468|M.vanbaalenii_PYR-1 HTLRVDDQ------LLEADRIFLNVGGRAVAPDMPG-LADVDYLTNVGIL
MAV_2396|M.avium_104 HTLQVGED------LLRAERIFLNVGGRAVVPDIPG-LAEVDFLTNVSIL
TH_3945|M.thermoresistible__bu HTVRVGER------LLSADRIFLNVGGRAVVPDLPG-LADVDHLTNVSML
MAB_3014|M.abscessus_ATCC_1997 TELSVGDE------IISAERIFLNVGGRAVVPDWPG-VDDVPLFTNSSLI
MUL_0404|M.ulcerans_Agy99 RRISVSDHDGQTLMIAARHAVVVCTGSRPTLPDLPG-ITEAWPWTNRQAT
MMAR_4894|M.marinum_M RRVSVSDHDGQTLMIAARHAVVVCTGSRPTLPDLPG-ITEAWPWTNRQAT
Mb0819c|M.bovis_AF2122/97 RRVVVTKSSGESVALTARHAVVICTGSRPALPDLPG-ITEARPWTNRQAT
Rv0794c|M.tuberculosis_H37Rv RRVVVTKSSGESVALTARHAVVICTGSRPALPDLPG-ITEARPWTNRQAT
MSMEG_4023|M.smegmatis_MC2_155 RKVCVSTDEHNVLTLNARHAVVICTGSTAALPHLPG-LAEIEPWTNRRAT
MLBr_02387|M.leprae_Br4923 NTLSVELSEGVPETPLKVTFNNVIIATGSKTRLVPGTLLSTNVITYEEQI
: * : . . ** : . *
Mflv_3059|M.gilvum_PYR-GCK DLGVVPEHLVIIGGSYIALEFAQMYRRFGAEVTVVEKGPRLTAREDEDVS
Mvan_3468|M.vanbaalenii_PYR-1 DLDEVPEHLVVIGGSYIALEFAQMYRRFGAAVTVIERGPRLTAREDEDVS
MAV_2396|M.avium_104 ELDRLPTHLVIVGGSYIALEFAQMYRRFGAAVTVVERGPRLASREDEDVS
TH_3945|M.thermoresistible__bu ELDTLPEHLVIVGGGYIALEFAQMYRRFGARVTVVQRGSRLASHEDADVS
MAB_3014|M.abscessus_ATCC_1997 EYDGIPEHLVVIGGSYVGLEFAQIYRRFGSQVTVVHRGPRLVEREDPDAS
MUL_0404|M.ulcerans_Agy99 EASSAPRRLAIVGAGGVGVEMETAWQGLGSSVTLLAR-SRLLSRMEPFVG
MMAR_4894|M.marinum_M EASSVPRRLAIVGAGGVGVEMATAWQGLGSSVILLAR-SRLLSRMEPFVG
Mb0819c|M.bovis_AF2122/97 DNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRMEPFVG
Rv0794c|M.tuberculosis_H37Rv DNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRMEPFVG
MSMEG_4023|M.smegmatis_MC2_155 DSSTVPDRLAVVGGGGVGVEMATAWRGLGANVTLLARTDTLLPRMEPFVG
MLBr_02387|M.leprae_Br4923 LTRELPDSIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNEDAEVS
* :.::*.. :.:*: : * * :: . : ..
Mflv_3059|M.gilvum_PYR-GCK AVIKDILEAEGIRVELGADAISVAKRRNGIAVTP--RDGAAPIDASHLLV
Mvan_3468|M.vanbaalenii_PYR-1 AAIKEILEAEGIDVVVGADAISFAKQADGFTVTP--RAGAEPIGGSHLLV
MAV_2396|M.avium_104 AAVQEILRAEGIDIVVNADDVRIAKTGNGFELTS--RDGAPPIRGSHLLL
TH_3945|M.thermoresistible__bu AAIHDILAGEGIDIVVDASAIRFARCDGGVAVTP--ADGAEPVVGSHLLI
MAB_3014|M.abscessus_ATCC_1997 AIIQEVLEREGITFRLNASCINLARHDEGVAVGVDCTDGAPKVVGSHVLV
MUL_0404|M.ulcerans_Agy99 DFVGRGLTRAGVDVRVGISVRALHRPHPDAPVTLE-IDDDTRLEVDEVLF
MMAR_4894|M.marinum_M DFVGRGLTRSGVDVRVGISVRALHRPHPDAPVTLE-LDDDTRLEVDEVLF
Mb0819c|M.bovis_AF2122/97 ELIGRGLADAGVDVRVGVSVRALGRPNP----------------------
Rv0794c|M.tuberculosis_H37Rv ELIGRGLADAGVDVRVGVSVRALGRPNPTGPVVLE-LDDGTELRVDEVLF
MSMEG_4023|M.smegmatis_MC2_155 EHVRLGLAEAGVDVRTGVSVTAVHRPRPNGPVQVS-LDSGEQIEVDQILF
MLBr_02387|M.leprae_Br4923 KEIEKQFKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQ
: : *: . . . .
Mflv_3059|M.gilvum_PYR-GCK AVGRVPNTDDLGLEAAGVETDKRGYVVVDDQLRTSAEN---IWAMGDCNG
Mvan_3468|M.vanbaalenii_PYR-1 AVGRRPNTDDLNLEAAGVQTDSRGYIVVDDQLRTSADN---IWAMGDCNG
MAV_2396|M.avium_104 AVGRRPNTDDLDLAVAGVRTDARGYILVDDQLKTNVEH---IWAMGDCNG
TH_3945|M.thermoresistible__bu AVGRRPNTDDLALDRAGVAVDERGHIVVDDRLRTTAEH---IWAMGDCNG
MAB_3014|M.abscessus_ATCC_1997 AVGRRPNTDDLGLENAGVATDARGYITVDDQLRTSTPG---IWALGDCNG
MUL_0404|M.ulcerans_Agy99 ATGRAPRTDDIGLQTVGLAPG--NWLDVDDTCRVNAVDGGWLYAAGDVNH
MMAR_4894|M.marinum_M ATGRAPRTDDIGLQTVGLAPG--NWLDVDDTCRVNAVDGGWLYAAGDVNH
Mb0819c|M.bovis_AF2122/97 ---------------LAQWSS--SWTTVPSCGSTR-------YSS-----
Rv0794c|M.tuberculosis_H37Rv ATGRAPRTDDIGLETIGLTPG--SWLDVDDTCRVRAVDDGWLYAAGDVNH
MSMEG_4023|M.smegmatis_MC2_155 ATGRTPNTTHIGLETVGLPPG--TWLDVDDTCSVRGVEGQWLYALGDVNR
MLBr_02387|M.leprae_Br4923 AIGFAPNVDGYGLDKVGVALTADKAVDIDDYMQTNVSH---IYAIGDVTG
. : . . ::
Mflv_3059|M.gilvum_PYR-GCK RGAFTHTSYNDFEIVAANLLDDDPRRVSDRITT-------------YALY
Mvan_3468|M.vanbaalenii_PYR-1 RGAFTHTSYNDFEIVAANLLDDDPRRVSDRVTT-------------YALY
MAV_2396|M.avium_104 RGAFTHTSYNDFEIVAANLLDDDPRRVSDRITT-------------YALY
TH_3945|M.thermoresistible__bu RGAFTHTAYNDFEIVAANLLDADPRGVGDRVRA-------------YAMY
MAB_3014|M.abscessus_ATCC_1997 RGAFTHTSYNDFEIVAANLLDDDPRRVTDRLPC-------------YALY
MUL_0404|M.ulcerans_Agy99 RALLTHQGKYQARIAGSAIGARAAGDSLDTAPWGAHATTADHHAVPQAFF
MMAR_4894|M.marinum_M RALLTHQGKYQARIAGSAIGARAAGDSLDTAPWGAHATTADHHAVPQAFF
Mb0819c|M.bovis_AF2122/97 --------------------PPAEHREPTTSAWRQ---------------
Rv0794c|M.tuberculosis_H37Rv RALLTHQGKYQARIAGTAIGARAAGRPLDTTSWGMHATTADHHAVPQAFF
MSMEG_4023|M.smegmatis_MC2_155 RALLTHQGKYQARIAGAVIGARARGHTVDTAPWSAHAATANNLAVPQAFF
MLBr_02387|M.leprae_Br4923 KLQLAHVAEAQGVVAAEAIAGAETLALSDYRMMP------------RATF
Mflv_3059|M.gilvum_PYR-GCK IDPPLGRAGMTADEVRRTGRKALVGKRPMTRVGRAVEKGET--QGFMKVV
Mvan_3468|M.vanbaalenii_PYR-1 IDPPLGRAGMTVEEVRRSGRKALVGKRPMTRVGRAVEKGET--QGFMKVV
MAV_2396|M.avium_104 IDPPLGRAGMTVAQVRASGRRALVGKRPMTRVGRAVEKGET--QGFMKVV
TH_3945|M.thermoresistible__bu IDPPLGRAGMTEDEVRASGRKALLAKRPMSRVGRAVEKGET--QGFMKVL
MAB_3014|M.abscessus_ATCC_1997 TDPPLGRVGMTEAQARASGRSLLVGRKPMSHVGRALEKGET--DGYMQVL
MUL_0404|M.ulcerans_Agy99 TDPEAAAVGLTTEQAARAGHRIKTIDVEIGDVVTGAKLFADGYAGRARMV
MMAR_4894|M.marinum_M TDPEAAAVGLTAEQAARAGHRIKTIDVDIGDVVTGAKLFADGYAGRARMV
Mb0819c|M.bovis_AF2122/97 --------------------------------------------------
Rv0794c|M.tuberculosis_H37Rv TDPEAAAVGLTADQAAQAGHRIKAIDVEIGDVVMGAKLFADGYTGRARMV
MSMEG_4023|M.smegmatis_MC2_155 TDPEAGSVGLTADEARRRGHRIYIVDVDMG-TVPGANFYADGYRGAARIV
MLBr_02387|M.leprae_Br4923 CQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDP--SGFVKLV
Mflv_3059|M.gilvum_PYR-GCK VDAETEEILGASILGVGGDEVVHLILDVMTAKLPYTAISRTMHIHPTVSE
Mvan_3468|M.vanbaalenii_PYR-1 VDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYTAISRTMHIHPTVSE
MAV_2396|M.avium_104 VDADTREILGAAILGVGGDEAIHGILDVMSAKAPYTTLSRTMHIHPTVSE
TH_3945|M.thermoresistible__bu VDADTAEILGAAILGVGGDEVVHAIVDVMAARQPYTAISRTMHIHPTVSE
MAB_3014|M.abscessus_ATCC_1997 VDADSDLILGATILGVGGDEVVHCLLDTMQYGIPARQLQRTVHIHPTVAE
MUL_0404|M.ulcerans_Agy99 VDVDRGCLLGVTIVGPRAAELLHAATIAIAGQVPIDRLWHTVPCFPTISE
MMAR_4894|M.marinum_M VDVDRGCLLGVTIVGPGAAELLHAATIAIAGQVPIDRLWHAVPCFPTISE
Mb0819c|M.bovis_AF2122/97 --------------------------------------------------
Rv0794c|M.tuberculosis_H37Rv VDVDRGHLLGVTMVGPGAAELLHSATVAVAGQVPIDRLWHAVPCFPTISE
MSMEG_4023|M.smegmatis_MC2_155 VDEDHRYLLGVTMVGPGVVEMLHAATIAVAGQVPIERLWHAVPCFPTVSE
MLBr_02387|M.leprae_Br4923 ADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRNVHTHPTLSE
Mflv_3059|M.gilvum_PYR-GCK LVPTLLQDLHPLT----
Mvan_3468|M.vanbaalenii_PYR-1 LIPTVLQELKPLA----
MAV_2396|M.avium_104 LIPTMLQQMSPLA----
TH_3945|M.thermoresistible__bu LLPTLLQDLQPLR----
MAB_3014|M.abscessus_ATCC_1997 FLPTILGELQPLI----
MUL_0404|M.ulcerans_Agy99 LWLRLLEAYRDSFFVLV
MMAR_4894|M.marinum_M LWLRLLEAYRDSFFVLV
Mb0819c|M.bovis_AF2122/97 -----------------
Rv0794c|M.tuberculosis_H37Rv LWLRLLESYRDSFYLLV
MSMEG_4023|M.smegmatis_MC2_155 VWLKLLEGYRDRHATD-
MLBr_02387|M.leprae_Br4923 ALQECFHGLIGHMINF-