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NASLRRISVTVMALIVLLLLNATMTPVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDGR FRFLRVYPNPEVYAPVTGFYSLRYSSTGLERAEDPLLNGSDQRLFGRRLADFFTGRDPRGGNVDTAINPR IQQAGWDAMQQGCGGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHDPEAQAEAWKDLRDDPSSALTN RAISETYPPGSTFKVITTAAALQAGATENDQLTAAANIPLPDSTATLENYGGAPCGSGQTVSLREAFAKS CNTAFVQLGISTGAAALRSMAHAFGLDTPPSAIPLQVAESTVGPIPDAAALGMSSIGQKDVALTPLQNAQ IAATIANGGVVMRPYLVDGLKGPDLANISTTAPHQQRRAVSPQVAAKLTELMVGAEQVAQQKGAIPGVQI ASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGQAVIEAALQGEP *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0020 | pbpA | - | 100% (491) | penicillin-binding protein PbpA |
| M. ulcerans Agy99 | MUL_2089 | - | 2e-17 | 27.10% (321) | penicillin-binding lipoprotein |
| M. ulcerans Agy99 | MUL_3508 | pbpB | 4e-16 | 22.85% (442) | penicillin-binding membrane protein PbpB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0016c | pbpA | 0.0 | 90.63% (491) | penicillin-binding protein PbpA |
| M. gilvum PYR-GCK | Mflv_0810 | - | 0.0 | 78.94% (489) | penicillin-binding protein, transpeptidase |
| M. tuberculosis H37Rv | Rv0016c | pbpA | 0.0 | 90.63% (491) | penicillin-binding protein PbpA |
| M. leprae Br4923 | MLBr_00018 | pbpA | 0.0 | 85.92% (490) | putative penicillin-binding protein |
| M. abscessus ATCC 19977 | MAB_0035c | - | 0.0 | 69.32% (502) | penicillin-binding protein PbpA |
| M. marinum M | MMAR_0018 | pbpA | 0.0 | 98.37% (491) | penicillin-binding protein PbpA |
| M. avium 104 | MAV_0020 | - | 0.0 | 87.20% (492) | PbpA protein |
| M. smegmatis MC2 155 | MSMEG_0031 | - | 0.0 | 82.58% (488) | penicillin binding protein transpeptidase domain-containing |
| M. thermoresistible (build 8) | TH_1396 | - | 7e-18 | 28.21% (319) | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN |
| M. vanbaalenii PYR-1 | Mvan_0025 | - | 0.0 | 80.12% (488) | penicillin-binding protein, transpeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0810|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_0025|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_0031|M.smegmatis_MC2_155 -------------------------------------------------M
MUL_0020|M.ulcerans_Agy99 -------------------------------------------------M
MMAR_0018|M.marinum_M -------------------------------------------------M
Mb0016c|M.bovis_AF2122/97 -------------------------------------------------M
Rv0016c|M.tuberculosis_H37Rv -------------------------------------------------M
MAV_0020|M.avium_104 -------------------------------------------------M
MLBr_00018|M.leprae_Br4923 -------------------------------------------------M
MAB_0035c|M.abscessus_ATCC_199 -------------------------------------------------M
TH_1396|M.thermoresistible__bu VLAVLGAVGTAVALSSCTPRPDGPELAAERFFAALAEGDTGAAADLSDRP
Mflv_0810|M.gilvum_PYR-GCK NTSLRRISVMIMALIVVLLANATLTQVFTADG------------------
Mvan_0025|M.vanbaalenii_PYR-1 NTSLRRISVMIMALVVVLLANATLTQVFTADG------------------
MSMEG_0031|M.smegmatis_MC2_155 NTSLRRVAVAIMVLIVLLLANATVTQVFAADG------------------
MUL_0020|M.ulcerans_Agy99 NASLRRISVTVMALIVLLLLNATMTPVFTADG------------------
MMAR_0018|M.marinum_M NASLRRISVTVMALIVLLLLNATMTQVFTADG------------------
Mb0016c|M.bovis_AF2122/97 NASLRRISVTVMALIVLLLLNATMTQVFTADG------------------
Rv0016c|M.tuberculosis_H37Rv NASLRRISVTVMALIVLLLLNATMTQVFTADG------------------
MAV_0020|M.avium_104 NASLRRISVTVMALIVLLLLNATMTQVFAADS------------------
MLBr_00018|M.leprae_Br4923 NTSLRRISVTVMALIVLLLLNATVTQVFTADG------------------
MAB_0035c|M.abscessus_ATCC_199 NTSIRRVSLAVMGLVVLLLANATITQVFTAPG------------------
TH_1396|M.thermoresistible__bu DLARQGLNAAWAGLQAEGLDAQVVGSRYSEDTGAVSYRYTWKLPKNRTWT
: : : : * . * .: ::
Mflv_0810|M.gilvum_PYR-GCK ----------------------------------LRSDPRNQRVLLD---
Mvan_0025|M.vanbaalenii_PYR-1 ----------------------------------LRSDPRNQRVLLD---
MSMEG_0031|M.smegmatis_MC2_155 ----------------------------------LRADPRNQRVLLD---
MUL_0020|M.ulcerans_Agy99 ----------------------------------LRADPRNQRVLLD---
MMAR_0018|M.marinum_M ----------------------------------LRADPRNQRVLLD---
Mb0016c|M.bovis_AF2122/97 ----------------------------------LRADPRNQRVLLD---
Rv0016c|M.tuberculosis_H37Rv ----------------------------------LRADPRNQRVLLD---
MAV_0020|M.avium_104 ----------------------------------LRADPRNQRVLLD---
MLBr_00018|M.leprae_Br4923 ----------------------------------LRADPRNQRVLLD---
MAB_0035c|M.abscessus_ATCC_199 ----------------------------------LRADPRNQRILLD---
TH_1396|M.thermoresistible__bu YDGHLNMVRNNGQWQVRWTATNLHPRLGENQTFALRADPPPRASVHERTG
**:** : : :
Mflv_0810|M.gilvum_PYR-GCK --------EYSRQRGQISAGGQLLAYSVSTEGRFRFLRVYPNPMAYAPVT
Mvan_0025|M.vanbaalenii_PYR-1 --------EYSRQRGQISAGGQLLAYSVSTQGRFRFLRVYPDPMIYAPVT
MSMEG_0031|M.smegmatis_MC2_155 --------EYSRQRGQITAGGQLLAYSVSTDGRFRYLRVYPNPQAYAPVT
MUL_0020|M.ulcerans_Agy99 --------EYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVT
MMAR_0018|M.marinum_M --------EYSRQRGQITAGGQLLAYSVATDSRFRFLRVYPNPEVYAPVT
Mb0016c|M.bovis_AF2122/97 --------EYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVT
Rv0016c|M.tuberculosis_H37Rv --------EYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVT
MAV_0020|M.avium_104 --------EYSRQRGQIVAGGQLLAYSVATDNRFRFLRVYPNPAQYAPVT
MLBr_00018|M.leprae_Br4923 --------EYSRQRGQITASGQLLAYSVATDNRFRFLRVYPNPAVYAPIT
MAB_0035c|M.abscessus_ATCC_199 --------EYSRQRGQISASGQLLASSVATDSRFRFLRQYADPEVYAPVT
TH_1396|M.thermoresistible__bu TSVLRPGFRYHYALDARAAGAQLMTTAHAVVDALRPFNDTLDPQRLAEQA
.* . *..**:: : :. . :* :. :* * :
Mflv_0810|M.gilvum_PYR-GCK GFYSLTYSSSGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGNVSTTI
Mvan_0025|M.vanbaalenii_PYR-1 GFYSLSYSSTGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGTVATTI
MSMEG_0031|M.smegmatis_MC2_155 GFYSLGYSSTGLERAEDAVLNGSDERLFGRRLADFFTGRDPRGGNVDTTI
MUL_0020|M.ulcerans_Agy99 GFYSLRYSSTGLERAEDPLLNGSDQRLFGRRLADFFTGRDPRGGNVDTAI
MMAR_0018|M.marinum_M GFYSLRYSSTGLERAEDPLLNGSDQRLFGRRLADFFTGRDPRGGNVDTTI
Mb0016c|M.bovis_AF2122/97 GFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTI
Rv0016c|M.tuberculosis_H37Rv GFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTI
MAV_0020|M.avium_104 GFYSLRYSSTGLERAEDPLLNGSDERLFGRRLADFFTGRDPRGANVDTTI
MLBr_00018|M.leprae_Br4923 GFYSLRYSSTGLEQAEDALLNGSDERLFGRRLADFFTGRDPRGGNVDTTI
MAB_0035c|M.abscessus_ATCC_199 GFYSLNYSSTGLERAEDTMLNGSDPRLFGRRLADFFTGRDPRGGSVVTTI
TH_1396|M.thermoresistible__bu SAQRGPMSLITLRQADHDPVAAAIGALPG-VVITPHPDLVPTDERFAPAL
. * *.:*:. : .: * * : ... * . . .::
Mflv_0810|M.gilvum_PYR-GCK NPDVQQAAWDAME--------------------DGCNG-PCKGSVVALEP
Mvan_0025|M.vanbaalenii_PYR-1 NPQVQRAAWDAME--------------------KGCDG-PCTGSVVALEP
MSMEG_0031|M.smegmatis_MC2_155 KPQVQQAAWDAMQ--------------------NGCDG-PCRGSVVALEP
MUL_0020|M.ulcerans_Agy99 NPRIQQAGWDAMQ--------------------QGCGG-PCKGAVVALEP
MMAR_0018|M.marinum_M NPRIQQAGWDAMQ--------------------QGCGG-PCKGAVVALEP
Mb0016c|M.bovis_AF2122/97 NPRIQQAGWDAMQ--------------------QGCYG-PCKGAVVALEP
Rv0016c|M.tuberculosis_H37Rv NPRIQQAGWDAMQ--------------------QGCYG-PCKGAVVALEP
MAV_0020|M.avium_104 RPRVQQAAWDGMQ--------------------QGCGGPPCKGAVVALEP
MLBr_00018|M.leprae_Br4923 NPRVQQTGWDAMQ--------------------QGCGGSPCKGAVVALEP
MAB_0035c|M.abscessus_ATCC_199 RPDVQQAAYDAMH--------------------RGCKD-GCRGAVVALEP
TH_1396|M.thermoresistible__bu LSRVKQAVFDDIDGTAGWRVVTVNQNGVEVDILHEVPGEPAPAVTLTLDR
. :::: :* :. . . . .::*:
Mflv_0810|M.gilvum_PYR-GCK STGKILAMVSAPSYDPNLLASHNIDEQAQTWQALRDNPDSPLLNRAISET
Mvan_0025|M.vanbaalenii_PYR-1 STGKILALVSAPSYDPNLLATHDVAEQAEAWQRLRDDPGSPLLNRAISEA
MSMEG_0031|M.smegmatis_MC2_155 STGKILAMVSAPSYDPNLLATHDLAAQADAWEKLRDDPQSPLLNRAISET
MUL_0020|M.ulcerans_Agy99 STGKILALVSSPSYDPNLLASHDPEAQAEAWKDLRDDPSSALTNRAISET
MMAR_0018|M.marinum_M STGKILALVSSPSYDPNLLASHDPEAQAEAWKDLRDDPSSPLTNRAISET
Mb0016c|M.bovis_AF2122/97 STGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISET
Rv0016c|M.tuberculosis_H37Rv STGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISET
MAV_0020|M.avium_104 STGKILAMVSSPSYDPNLLSSHDPEVQAQAWQRLRDDPDNPMTNRAISET
MLBr_00018|M.leprae_Br4923 STGKILAMVSTPSYDPNLLASHNPEEQAQAWRRLHDDPNSPLINRAISET
MAB_0035c|M.abscessus_ATCC_199 STGKILAMVSTPSYDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQT
TH_1396|M.thermoresistible__bu RVQEAAQGAVDTTGKQAMIVAIRPSTG-EILAVAQNAAADAEGLLATTGL
. : . .: . :: : : . .. * :
Mflv_0810|M.gilvum_PYR-GCK YPPGSTFKVLTTAAALEAGATPQTQLTAAPQIPLPNSTATLENFGGTACG
Mvan_0025|M.vanbaalenii_PYR-1 YPPGSTFKVITTAAALQAGATPDTQLTAAPQIALPDSTATLQNFGGVSCG
MSMEG_0031|M.smegmatis_MC2_155 YPPGSTFKVITTAAALQAGARPQTQLTSAPRTPLPDSTATLENFGGAPCG
MUL_0020|M.ulcerans_Agy99 YPPGSTFKVITTAAALQAGATENDQLTAAANIPLPDSTATLENYGGAPCG
MMAR_0018|M.marinum_M YPPGSTFKVITTAAALQAGATENDQLTAAANIPLPDSTATLENYGGAPCD
Mb0016c|M.bovis_AF2122/97 YPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCG
Rv0016c|M.tuberculosis_H37Rv YPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCG
MAV_0020|M.avium_104 YPPGSTFKVITTAAALQAGASDTEQLTAAPSIPLPNSTATLENYGGQACG
MLBr_00018|M.leprae_Br4923 YPPGSTFKVITTTAALQAGATTSDQLTAEPTIPLPGSTATLENYGGVSCG
MAB_0035c|M.abscessus_ATCC_199 YPPGSTFKVITTAAALADGKTVNTEVTASPTIFLPGSNATLENYNRASCG
TH_1396|M.thermoresistible__bu FPPGSTFKIVTAGAALDRDMATPNTLLPCPGHMDIG-HRRVPNYGGFDLG
:*******::*: *** . : . . . : *:. .
Mflv_0810|M.gilvum_PYR-GCK GGPTATLEYAFAHSCNTAFVQLGIDTG-ADALRSTAVGFGVDTAPPAIPL
Mvan_0025|M.vanbaalenii_PYR-1 AGPTTSLRNAFAHSCNTAFVQLGIDTG-ADPLRSTAGDFGVGAVPPAIPL
MSMEG_0031|M.smegmatis_MC2_155 PGPTVSLQEAFAKSCNTAFVELGLSTG-TDKLKAMAQAFGLDTPPPAIPL
MUL_0020|M.ulcerans_Agy99 SGQTVSLREAFAKSCNTAFVQLGISTG-AAALRSMAHAFGLDTPPSAIPL
MMAR_0018|M.marinum_M SGQTVSLREAFAKSCNTAFVQLGISTG-AAALRSMAHAFGLDTPPSAIPL
Mb0016c|M.bovis_AF2122/97 DEPTVSLREAFVKSCNTAFVQLGIRTG-ADALRSMARAFGLDSPPRPTPL
Rv0016c|M.tuberculosis_H37Rv DEPTVSLREAFVKSCNTAFVQLGIRTG-ADALRSMARAFGLDSPPRPTPL
MAV_0020|M.avium_104 NDPTVSLQQAFALSCNTAFVQLGILTG-ADALRSMARSFGLDSTPSVIPL
MLBr_00018|M.leprae_Br4923 PGPTVSLSQAFAMSCNTAFVQLGLLIG-ADALRSMAHSFGLDSNPNVIPL
MAB_0035c|M.abscessus_ATCC_199 GGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLVKAAQAFGLDRELDSIPL
TH_1396|M.thermoresistible__bu ---TVPLSRAFASSCNTTFAELASRMP-PRGLSTAAAQYGLGPEYSISGL
*..* **. ****:*.:*. * * :*:. *
Mflv_0810|M.gilvum_PYR-GCK QVAESTIGPIVDDAALGMTSIGQRDVAMTPLQNAMVAATVANNGVTMTPY
Mvan_0025|M.vanbaalenii_PYR-1 QVAESTVGPIADDAALGMSSIGQRDVALTPLQNAMIAAAVANKGVMMRPY
MSMEG_0031|M.smegmatis_MC2_155 QVAESTTGPIVDAAALGMSSIGQRDVALTPLQNAQVAATIANDGIAMRPY
MUL_0020|M.ulcerans_Agy99 QVAESTVGPIPDAAALGMSSIGQKDVALTPLQNAQIAATIANGGVVMRPY
MMAR_0018|M.marinum_M QVAESTVGPIPDAAALGMSSIGQKDVALTPLQNAQIAATIANGGVVMRPY
Mb0016c|M.bovis_AF2122/97 QVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPY
Rv0016c|M.tuberculosis_H37Rv QVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPY
MAV_0020|M.avium_104 QVAESTIGIIPDAAALGMSSIGQKDVALTPLQNAEIAATIANGGVTMQPY
MLBr_00018|M.leprae_Br4923 QVAESTVGVIPDAAALGMSSIGQRDVALTPLQNAQIAATIANAGVTMQPY
MAB_0035c|M.abscessus_ATCC_199 QVATSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANKGVLMQPH
TH_1396|M.thermoresistible__bu PAVTGSVPPTVILAERTEDGFGQGKVLASPFGMAMVAATVAAG----KPP
.. .: * .:** .* :*: * :**::* *
Mflv_0810|M.gilvum_PYR-GCK LVESLKGPDLANIATTSPTEERRAVPEKVADTLTDLMVAAEQVTQQKGAI
Mvan_0025|M.vanbaalenii_PYR-1 LVESLKGPDLANIATTAPTEERRAVTEQVADTLTDLMVAAEQVTQQKGAI
MSMEG_0031|M.smegmatis_MC2_155 LVESLKGPDLATISTTTPEQERRAVSPQVAATLTDLMVAAEQVTQQKGAI
MUL_0020|M.ulcerans_Agy99 LVDGLKGPDLANISTTAPHQQRRAVSPQVAAKLTELMVGAEQVAQQKGAI
MMAR_0018|M.marinum_M LVDSLKGPDLANISTTTPHQQRRAVSPQVAAKLTELMVGAEQVAQQKGAI
Mb0016c|M.bovis_AF2122/97 LVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAI
Rv0016c|M.tuberculosis_H37Rv LVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAI
MAV_0020|M.avium_104 LVDSLKGPDLTTISTTTPYEQRRAVSPQVAAKLTELMVGAEKVAQQKGAI
MLBr_00018|M.leprae_Br4923 LIDNLKGPDLANIRTTTSYQQHRAVSPQIAATLTELMVGAEKVTQQKGAI
MAB_0035c|M.abscessus_ATCC_199 LVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTLTELMIASEQRTAQTGAL
TH_1396|M.thermoresistible__bu VPRLIDG-RLTEINGEIP-----PISPEMVEGLRPMMRLVVTNGTAEHLQ
: :.* *: : .:. :. * :*
Mflv_0810|M.gilvum_PYR-GCK AGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQ-----------APTVA
Mvan_0025|M.vanbaalenii_PYR-1 AGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQ-----------APKVA
MSMEG_0031|M.smegmatis_MC2_155 AGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQ-----------DPKVA
MUL_0020|M.ulcerans_Agy99 PGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ-----------APKVA
MMAR_0018|M.marinum_M PGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ-----------APKVA
Mb0016c|M.bovis_AF2122/97 PGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ-----------APKVA
Rv0016c|M.tuberculosis_H37Rv PGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ-----------APKVA
MAV_0020|M.avium_104 PGVQIASKTGTAEHGSDPRHTPPHAWYIAFAPAQ-----------TPKVA
MLBr_00018|M.leprae_Br4923 PGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPVQ-----------APKVA
MAB_0035c|M.abscessus_ATCC_199 PGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVA
TH_1396|M.thermoresistible__bu GAGDVRGKTGEAEFAGG-----SHSWFAGYRGDL---------------A
. :: .*** **.. . .*:*: .: *
Mflv_0810|M.gilvum_PYR-GCK VAVLVENGGDR-LGATGGALAAPIGRATIAAALRGAS-
Mvan_0025|M.vanbaalenii_PYR-1 VAVLVENGGNR-LSATGGALAAPIGRATIAAALREAS-
MSMEG_0031|M.smegmatis_MC2_155 VAVLVEDGGDR-LSATGGALAAPIGRATIAAALREGS-
MUL_0020|M.ulcerans_Agy99 VAVLVENGADR-LSATGGALAAPIGQAVIEAALQGEP-
MMAR_0018|M.marinum_M VAVLVENGADR-LSATGGALAAPIGRAVIEAALQGEP-
Mb0016c|M.bovis_AF2122/97 VAVLVENGADR-LSATGGALAAPIGRAVIEAALQGEP-
Rv0016c|M.tuberculosis_H37Rv VAVLVENGADR-LSATGGALAAPIGRAVIEAALQGEP-
MAV_0020|M.avium_104 VAVLVENGADR-LSATGGALAAPIGRAVIEAALQGGP-
MLBr_00018|M.leprae_Br4923 VAVLVEKGADS-LFATGGALAAPIGRAVIEAALQGGA-
MAB_0035c|M.abscessus_ATCC_199 IAVLVEDGGDRALAATGGSVAAPIGRQVIAAALQGAS-
TH_1396|M.thermoresistible__bu FAALIVGGGSS-------EYAVRMTKMMLDALPPDYLA
.*.*: *.. *. : : : *