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NTSLRRVAVAIMVLIVLLLANATVTQVFAADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVSTDGR FRYLRVYPNPQAYAPVTGFYSLGYSSTGLERAEDAVLNGSDERLFGRRLADFFTGRDPRGGNVDTTIKPQ VQQAAWDAMQNGCDGPCRGSVVALEPSTGKILAMVSAPSYDPNLLATHDLAAQADAWEKLRDDPQSPLLN RAISETYPPGSTFKVITTAAALQAGARPQTQLTSAPRTPLPDSTATLENFGGAPCGPGPTVSLQEAFAKS CNTAFVELGLSTGTDKLKAMAQAFGLDTPPPAIPLQVAESTTGPIVDAAALGMSSIGQRDVALTPLQNAQ VAATIANDGIAMRPYLVESLKGPDLATISTTTPEQERRAVSPQVAATLTDLMVAAEQVTQQKGAIAGVQI ASKTGTAEHGTDPRNTPPHAWYIAFAPAQDPKVAVAVLVEDGGDRLSATGGALAAPIGRATIAAALREGS *
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0031 | - | - | 100% (491) | penicillin binding protein transpeptidase domain-containing protein |
M. smegmatis MC2 155 | MSMEG_4233 | - | 2e-26 | 26.98% (430) | penicillin binding protein transpeptidase domain-containing |
M. smegmatis MC2 155 | MSMEG_6319 | - | 2e-18 | 30.73% (358) | penicillin-binding protein, transpeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0016c | pbpA | 0.0 | 80.33% (488) | penicillin-binding protein PbpA |
M. gilvum PYR-GCK | Mflv_0810 | - | 0.0 | 82.48% (491) | penicillin-binding protein, transpeptidase |
M. tuberculosis H37Rv | Rv0016c | pbpA | 0.0 | 80.33% (488) | penicillin-binding protein PbpA |
M. leprae Br4923 | MLBr_00018 | pbpA | 0.0 | 79.47% (492) | putative penicillin-binding protein |
M. abscessus ATCC 19977 | MAB_0035c | - | 0.0 | 69.44% (504) | penicillin-binding protein PbpA |
M. marinum M | MMAR_0018 | pbpA | 0.0 | 83.40% (488) | penicillin-binding protein PbpA |
M. avium 104 | MAV_0020 | - | 0.0 | 80.04% (491) | PbpA protein |
M. thermoresistible (build 8) | TH_0586 | - | 1e-20 | 26.26% (438) | Probable penicillin-binding membrane protein pbpB |
M. ulcerans Agy99 | MUL_0020 | pbpA | 0.0 | 82.58% (488) | penicillin-binding protein PbpA |
M. vanbaalenii PYR-1 | Mvan_0025 | - | 0.0 | 83.10% (491) | penicillin-binding protein, transpeptidase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0810|M.gilvum_PYR-GCK MNTSLRRIS-----------------------------------VMIMAL Mvan_0025|M.vanbaalenii_PYR-1 MNTSLRRIS-----------------------------------VMIMAL MSMEG_0031|M.smegmatis_MC2_155 MNTSLRRVA-----------------------------------VAIMVL Mb0016c|M.bovis_AF2122/97 MNASLRRIS-----------------------------------VTVMAL Rv0016c|M.tuberculosis_H37Rv MNASLRRIS-----------------------------------VTVMAL MMAR_0018|M.marinum_M MNASLRRIS-----------------------------------VTVMAL MUL_0020|M.ulcerans_Agy99 MNASLRRIS-----------------------------------VTVMAL MAV_0020|M.avium_104 MNASLRRIS-----------------------------------VTVMAL MLBr_00018|M.leprae_Br4923 MNTSLRRIS-----------------------------------VTVMAL MAB_0035c|M.abscessus_ATCC_199 MNTSIRRVS-----------------------------------LAVMGL TH_0586|M.thermoresistible__bu MSRAKRQAGQRGEGRSARARRTRQIVTETGAQTASFVFRHRIGNAVIFLV *. : *: . :: : Mflv_0810|M.gilvum_PYR-GCK IVVLLANATLTQVFTADGLRSDPRNQRVLLDEYSRQRGQISAG------- Mvan_0025|M.vanbaalenii_PYR-1 VVVLLANATLTQVFTADGLRSDPRNQRVLLDEYSRQRGQISAG------- MSMEG_0031|M.smegmatis_MC2_155 IVLLLANATVTQVFAADGLRADPRNQRVLLDEYSRQRGQITAG------- Mb0016c|M.bovis_AF2122/97 IVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAG------- Rv0016c|M.tuberculosis_H37Rv IVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAG------- MMAR_0018|M.marinum_M IVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAG------- MUL_0020|M.ulcerans_Agy99 IVLLLLNATMTPVFTADGLRADPRNQRVLLDEYSRQRGQITAG------- MAV_0020|M.avium_104 IVLLLLNATMTQVFAADSLRADPRNQRVLLDEYSRQRGQIVAG------- MLBr_00018|M.leprae_Br4923 IVLLLLNATVTQVFTADGLRADPRNQRVLLDEYSRQRGQITAS------- MAB_0035c|M.abscessus_ATCC_199 VVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISAS------- TH_0586|M.thermoresistible__bu LVVVAAQLFNLQVPRAPALRAEAAGQLKVTDVEPAMRGAIVDRDFDKLAF :*:: : * * .**::. .* : * . ** * Mflv_0810|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0025|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0031|M.smegmatis_MC2_155 -------------------------------------------------- Mb0016c|M.bovis_AF2122/97 -------------------------------------------------- Rv0016c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0018|M.marinum_M -------------------------------------------------- MUL_0020|M.ulcerans_Agy99 -------------------------------------------------- MAV_0020|M.avium_104 -------------------------------------------------- MLBr_00018|M.leprae_Br4923 -------------------------------------------------- MAB_0035c|M.abscessus_ATCC_199 -------------------------------------------------- TH_0586|M.thermoresistible__bu TIESRALTFQPQRIRKQLVEAKEKKSDAPEPADRLTEIAHGVAEKLNHKP Mflv_0810|M.gilvum_PYR-GCK -GQLLAYSVSTEGRFRFLRVYPNPMAYAPVTGFYSLTYSSS--------- Mvan_0025|M.vanbaalenii_PYR-1 -GQLLAYSVSTQGRFRFLRVYPDPMIYAPVTGFYSLSYSST--------- MSMEG_0031|M.smegmatis_MC2_155 -GQLLAYSVSTDGRFRYLRVYPNPQAYAPVTGFYSLGYSST--------- Mb0016c|M.bovis_AF2122/97 -GQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSST--------- Rv0016c|M.tuberculosis_H37Rv -GQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSST--------- MMAR_0018|M.marinum_M -GQLLAYSVATDSRFRFLRVYPNPEVYAPVTGFYSLRYSST--------- MUL_0020|M.ulcerans_Agy99 -GQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSST--------- MAV_0020|M.avium_104 -GQLLAYSVATDNRFRFLRVYPNPAQYAPVTGFYSLRYSST--------- MLBr_00018|M.leprae_Br4923 -GQLLAYSVATDNRFRFLRVYPNPAVYAPITGFYSLRYSST--------- MAB_0035c|M.abscessus_ATCC_199 -GQLLASSVATDSRFRFLRQYADPEVYAPVTGFYSLNYSST--------- TH_0586|M.thermoresistible__bu DATSLLKKLMSNETFVYLARAVDPAVASEITREFPEVGSERQDLRQYPGG . * .: :: * :* :* : :* :. *. Mflv_0810|M.gilvum_PYR-GCK ------------------GLERAEDTILNGSDERLFGRRLADFFTGRDPR Mvan_0025|M.vanbaalenii_PYR-1 ------------------GLERAEDTILNGSDERLFGRRLADFFTGRDPR MSMEG_0031|M.smegmatis_MC2_155 ------------------GLERAEDAVLNGSDERLFGRRLADFFTGRDPR Mb0016c|M.bovis_AF2122/97 ------------------ALERAEDPILNGSDRRLFGRRLADFFTGRDPR Rv0016c|M.tuberculosis_H37Rv ------------------ALERAEDPILNGSDRRLFGRRLADFFTGRDPR MMAR_0018|M.marinum_M ------------------GLERAEDPLLNGSDQRLFGRRLADFFTGRDPR MUL_0020|M.ulcerans_Agy99 ------------------GLERAEDPLLNGSDQRLFGRRLADFFTGRDPR MAV_0020|M.avium_104 ------------------GLERAEDPLLNGSDERLFGRRLADFFTGRDPR MLBr_00018|M.leprae_Br4923 ------------------GLEQAEDALLNGSDERLFGRRLADFFTGRDPR MAB_0035c|M.abscessus_ATCC_199 ------------------GLERAEDTMLNGSDPRLFGRRLADFFTGRDPR TH_0586|M.thermoresistible__bu SLAANIIGGIDWDGHGLLGLEDALDAVLAGTDGSITYDRGSDGVVIPGSY .** * *.:* *:* : * :* .. .. Mflv_0810|M.gilvum_PYR-GCK GGNVSTTINPDVQQAAWDAMEDGCNG-PCKGSVVALEPSTGKILAMVSAP Mvan_0025|M.vanbaalenii_PYR-1 GGTVATTINPQVQRAAWDAMEKGCDG-PCTGSVVALEPSTGKILALVSAP MSMEG_0031|M.smegmatis_MC2_155 GGNVDTTIKPQVQQAAWDAMQNGCDG-PCRGSVVALEPSTGKILAMVSAP Mb0016c|M.bovis_AF2122/97 GGNVDTTINPRIQQAGWDAMQQGCYG-PCKGAVVALEPSTGKILALVSSP Rv0016c|M.tuberculosis_H37Rv GGNVDTTINPRIQQAGWDAMQQGCYG-PCKGAVVALEPSTGKILALVSSP MMAR_0018|M.marinum_M GGNVDTTINPRIQQAGWDAMQQGCGG-PCKGAVVALEPSTGKILALVSSP MUL_0020|M.ulcerans_Agy99 GGNVDTAINPRIQQAGWDAMQQGCGG-PCKGAVVALEPSTGKILALVSSP MAV_0020|M.avium_104 GANVDTTIRPRVQQAAWDGMQQGCGGPPCKGAVVALEPSTGKILAMVSSP MLBr_00018|M.leprae_Br4923 GGNVDTTINPRVQQTGWDAMQQGCGGSPCKGAVVALEPSTGKILAMVSTP MAB_0035c|M.abscessus_ATCC_199 GGSVVTTIRPDVQQAAYDAMHRGCKD-GCRGAVVALEPSTGKILAMVSTP TH_0586|M.thermoresistible__bu RNRHEAVDGSTVQLTIDDDIQFHVQQ----QVQLAKDASGAKNVSAVVLD :. . :* : * :. :* :.* .* :: * Mflv_0810|M.gilvum_PYR-GCK SYDPNLLASHNIDEQAQTWQALRDNPDSPLLNRAISETYPPGSTFKVLTT Mvan_0025|M.vanbaalenii_PYR-1 SYDPNLLATHDVAEQAEAWQRLRDDPGSPLLNRAISEAYPPGSTFKVITT MSMEG_0031|M.smegmatis_MC2_155 SYDPNLLATHDLAAQADAWEKLRDDPQSPLLNRAISETYPPGSTFKVITT Mb0016c|M.bovis_AF2122/97 SYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITT Rv0016c|M.tuberculosis_H37Rv SYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITT MMAR_0018|M.marinum_M SYDPNLLASHDPEAQAEAWKDLRDDPSSPLTNRAISETYPPGSTFKVITT MUL_0020|M.ulcerans_Agy99 SYDPNLLASHDPEAQAEAWKDLRDDPSSALTNRAISETYPPGSTFKVITT MAV_0020|M.avium_104 SYDPNLLSSHDPEVQAQAWQRLRDDPDNPMTNRAISETYPPGSTFKVITT MLBr_00018|M.leprae_Br4923 SYDPNLLASHNPEEQAQAWRRLHDDPNSPLINRAISETYPPGSTFKVITT MAB_0035c|M.abscessus_ATCC_199 SYDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITT TH_0586|M.thermoresistible__bu ARTAEVLAMAN-DNTFDPSQDIGRQGDRQMGNLPVTSPFEPGSVQKLVTA : .::*: : . . : : : * .::..: ***. *::*: Mflv_0810|M.gilvum_PYR-GCK AAALEAGATPQTQLTAAPQIPLPNSTATLENFGGTACGGGPTATLEYAFA Mvan_0025|M.vanbaalenii_PYR-1 AAALQAGATPDTQLTAAPQIALPDSTATLQNFGGVSCGAGPTTSLRNAFA MSMEG_0031|M.smegmatis_MC2_155 AAALQAGARPQTQLTSAPRTPLPDSTATLENFGGAPCGPGPTVSLQEAFA Mb0016c|M.bovis_AF2122/97 AAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFV Rv0016c|M.tuberculosis_H37Rv AAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFV MMAR_0018|M.marinum_M AAALQAGATENDQLTAAANIPLPDSTATLENYGGAPCDSGQTVSLREAFA MUL_0020|M.ulcerans_Agy99 AAALQAGATENDQLTAAANIPLPDSTATLENYGGAPCGSGQTVSLREAFA MAV_0020|M.avium_104 AAALQAGASDTEQLTAAPSIPLPNSTATLENYGGQACGNDPTVSLQQAFA MLBr_00018|M.leprae_Br4923 TAALQAGATTSDQLTAEPTIPLPGSTATLENYGGVSCGPGPTVSLSQAFA MAB_0035c|M.abscessus_ATCC_199 AAALADGKTVNTEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFA TH_0586|M.thermoresistible__bu ATAIEDGLTTPDEVHHVPGSIHMGGVTVGDAWEHGVMPYTTTG----IFG ::*: * :: . .. : : : * * Mflv_0810|M.gilvum_PYR-GCK HSCNTAFVQLGIDTG-ADALRSTAVGFGVDTAPPAIPLQVAESTIGPIVD Mvan_0025|M.vanbaalenii_PYR-1 HSCNTAFVQLGIDTG-ADPLRSTAGDFGVGAVPPAIPLQVAESTVGPIAD MSMEG_0031|M.smegmatis_MC2_155 KSCNTAFVELGLSTG-TDKLKAMAQAFGLDTPPPAIPLQVAESTTGPIVD Mb0016c|M.bovis_AF2122/97 KSCNTAFVQLGIRTG-ADALRSMARAFGLDSPPRPTPLQVAESTVGPIPD Rv0016c|M.tuberculosis_H37Rv KSCNTAFVQLGIRTG-ADALRSMARAFGLDSPPRPTPLQVAESTVGPIPD MMAR_0018|M.marinum_M KSCNTAFVQLGISTG-AAALRSMAHAFGLDTPPSAIPLQVAESTVGPIPD MUL_0020|M.ulcerans_Agy99 KSCNTAFVQLGISTG-AAALRSMAHAFGLDTPPSAIPLQVAESTVGPIPD MAV_0020|M.avium_104 LSCNTAFVQLGILTG-ADALRSMARSFGLDSTPSVIPLQVAESTIGIIPD MLBr_00018|M.leprae_Br4923 MSCNTAFVQLGLLIG-ADALRSMAHSFGLDSNPNVIPLQVAESTVGVIPD MAB_0035c|M.abscessus_ATCC_199 RSCNTAFAKLGAEQLKRDKLVKAAQAFGLDRELDSIPLQVATSTVGPMSD TH_0586|M.thermoresistible__bu KSSNVGTLMLAQRIG-PERYYEMLRKFGLGQRTGVGLPGESAGLLPPIDQ *.*.. *. **:. : . : : Mflv_0810|M.gilvum_PYR-GCK DAALGMTSIGQ-RDVAMTPLQNAMVAATVANNGVTMTPYLVESLKGPDLA Mvan_0025|M.vanbaalenii_PYR-1 DAALGMSSIGQ-RDVALTPLQNAMIAAAVANKGVMMRPYLVESLKGPDLA MSMEG_0031|M.smegmatis_MC2_155 AAALGMSSIGQ-RDVALTPLQNAQVAATIANDGIAMRPYLVESLKGPDLA Mb0016c|M.bovis_AF2122/97 SAALGMTSIGQ-KDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLA Rv0016c|M.tuberculosis_H37Rv SAALGMTSIGQ-KDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLA MMAR_0018|M.marinum_M AAALGMSSIGQ-KDVALTPLQNAQIAATIANGGVVMRPYLVDSLKGPDLA MUL_0020|M.ulcerans_Agy99 AAALGMSSIGQ-KDVALTPLQNAQIAATIANGGVVMRPYLVDGLKGPDLA MAV_0020|M.avium_104 AAALGMSSIGQ-KDVALTPLQNAEIAATIANGGVTMQPYLVDSLKGPDLT MLBr_00018|M.leprae_Br4923 AAALGMSSIGQ-RDVALTPLQNAQIAATIANAGVTMQPYLIDNLKGPDLA MAB_0035c|M.abscessus_ATCC_199 DAAVAMSSIGQ-KDVAMTPLQNAMVAAAVANKGVLMQPHLVDSLKGPDLS TH_0586|M.thermoresistible__bu WSGSTFSNLPIGQGLSMTLLQMAAMYQTIANDGVRVPPRIVKATIAPDGT :. ::.: :.:::* * * : ::** *: : * :: .** : Mflv_0810|M.gilvum_PYR-GCK NIATTSPTEERRAVPEKVADTLTDLMVAAEQV--------TQQKGAIAGV Mvan_0025|M.vanbaalenii_PYR-1 NIATTAPTEERRAVTEQVADTLTDLMVAAEQV--------TQQKGAIAGV MSMEG_0031|M.smegmatis_MC2_155 TISTTTPEQERRAVSPQVAATLTDLMVAAEQV--------TQQKGAIAGV Mb0016c|M.bovis_AF2122/97 NISTTVGYQQRRAVSPQVAAKLTELMVGAEKV--------AQQKGAIPGV Rv0016c|M.tuberculosis_H37Rv NISTTVGYQQRRAVSPQVAAKLTELMVGAEKV--------AQQKGAIPGV MMAR_0018|M.marinum_M NISTTTPHQQRRAVSPQVAAKLTELMVGAEQV--------AQQKGAIPGV MUL_0020|M.ulcerans_Agy99 NISTTAPHQQRRAVSPQVAAKLTELMVGAEQV--------AQQKGAIPGV MAV_0020|M.avium_104 TISTTTPYEQRRAVSPQVAAKLTELMVGAEKV--------AQQKGAIPGV MLBr_00018|M.leprae_Br4923 NIRTTTSYQQHRAVSPQIAATLTELMVGAEKV--------TQQKGAIPGV MAB_0035c|M.abscessus_ATCC_199 NLSTTTPDDIGQAVTPAIANTLTELMIASEQR--------TAQTGALPGV TH_0586|M.thermoresistible__bu RTEEPRP-EGVRVVSAETARIVRDMFRAVVQRDPRGIQQGTGPQAAVEGF . : :.*. * : ::: . : : .*: *. Mflv_0810|M.gilvum_PYR-GCK QIASKTGTAEHGTDPR-NTPPHAWYIAFAPAQ-----------APTVAVA Mvan_0025|M.vanbaalenii_PYR-1 QIASKTGTAEHGTDPR-NTPPHAWYIAFAPAQ-----------APKVAVA MSMEG_0031|M.smegmatis_MC2_155 QIASKTGTAEHGTDPR-NTPPHAWYIAFAPAQ-----------DPKVAVA Mb0016c|M.bovis_AF2122/97 QIASKTGTAEHGTDPR-HTPPHAWYIAFAPAQ-----------APKVAVA Rv0016c|M.tuberculosis_H37Rv QIASKTGTAEHGTDPR-HTPPHAWYIAFAPAQ-----------APKVAVA MMAR_0018|M.marinum_M QIASKTGTAEHGTDPR-HTPPHAWYIAFAPAQ-----------APKVAVA MUL_0020|M.ulcerans_Agy99 QIASKTGTAEHGTDPR-HTPPHAWYIAFAPAQ-----------APKVAVA MAV_0020|M.avium_104 QIASKTGTAEHGSDPR-HTPPHAWYIAFAPAQ-----------TPKVAVA MLBr_00018|M.leprae_Br4923 QIASKTGTAEHGTDPR-HTPPHAWYIAFAPVQ-----------APKVAVA MAB_0035c|M.abscessus_ATCC_199 QIASKTGTAEHGTDPR-NTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIA TH_0586|M.thermoresistible__bu QIAGKTGTAQQINPACGCYYSDVYWITFAGIATAD--------NPRYVIG ***.*****:: . . ...::*:** * .:. Mflv_0810|M.gilvum_PYR-GCK VLVENGGDR-LGATGGALAAPIGRATIAAALRGAS--------------- Mvan_0025|M.vanbaalenii_PYR-1 VLVENGGNR-LSATGGALAAPIGRATIAAALREAS--------------- MSMEG_0031|M.smegmatis_MC2_155 VLVEDGGDR-LSATGGALAAPIGRATIAAALREGS--------------- Mb0016c|M.bovis_AF2122/97 VLVENGADR-LSATGGALAAPIGRAVIEAALQGEP--------------- Rv0016c|M.tuberculosis_H37Rv VLVENGADR-LSATGGALAAPIGRAVIEAALQGEP--------------- MMAR_0018|M.marinum_M VLVENGADR-LSATGGALAAPIGRAVIEAALQGEP--------------- MUL_0020|M.ulcerans_Agy99 VLVENGADR-LSATGGALAAPIGQAVIEAALQGEP--------------- MAV_0020|M.avium_104 VLVENGADR-LSATGGALAAPIGRAVIEAALQGGP--------------- MLBr_00018|M.leprae_Br4923 VLVEKGADS-LFATGGALAAPIGRAVIEAALQGGA--------------- MAB_0035c|M.abscessus_ATCC_199 VLVEDGGDRALAATGGSVAAPIGRQVIAAALQGAS--------------- TH_0586|M.thermoresistible__bu VMMD-APHRAADGSPGSSAAPLFHNIASWLLRRENVPLSPDPGPPLLLQA *::: . . .: *: ***: : *: Mflv_0810|M.gilvum_PYR-GCK - Mvan_0025|M.vanbaalenii_PYR-1 - MSMEG_0031|M.smegmatis_MC2_155 - Mb0016c|M.bovis_AF2122/97 - Rv0016c|M.tuberculosis_H37Rv - MMAR_0018|M.marinum_M - MUL_0020|M.ulcerans_Agy99 - MAV_0020|M.avium_104 - MLBr_00018|M.leprae_Br4923 - MAB_0035c|M.abscessus_ATCC_199 - TH_0586|M.thermoresistible__bu T