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MAIDDFPRYPLTFGPSPIHPLERLTKHLGGAQIWAKREDVNSGLAYGGNKTRKLEYLIPDALAQGADTLV SIGGVQSNHTRQVAAVAAKLGMKAVLVQEKWVDWPDSVNDKVGNILLSRVMGADVRLDASGFGIEFKDSW RNAIEDVKNAGGTPYAIPAGASDHPLGGLGFANWAYEVQRQEQELGVFFDTIVVCTVTGSTHAGMIAGFA GQNRPRRVIGIDASATIDKTREQVTRIARNTADRIGLGRDLHDDEITVLEGWAGELYGIPVQSTIDAIKL TGRLEGVILDPVYEGKSMAGLIDLVRSGEIPPSSTVLYAHLGGQPALNAYSGIF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6740 | - | - | 100% (334) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. smegmatis MC2 155 | MSMEG_3220 | trpB | 2e-08 | 27.52% (218) | tryptophan synthase subunit beta |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1638 | trpB | 4e-09 | 26.96% (230) | tryptophan synthase subunit beta |
| M. gilvum PYR-GCK | Mflv_3599 | - | 2e-08 | 27.54% (207) | tryptophan synthase subunit beta |
| M. tuberculosis H37Rv | Rv1612 | trpB | 4e-09 | 26.96% (230) | tryptophan synthase subunit beta |
| M. leprae Br4923 | MLBr_01272 | trpB | 1e-06 | 24.09% (220) | tryptophan synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_1704c | - | 1e-146 | 74.56% (338) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. marinum M | MMAR_2945 | - | 1e-28 | 32.11% (327) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. avium 104 | MAV_3174 | trpB | 1e-05 | 27.44% (215) | tryptophan synthase subunit beta |
| M. thermoresistible (build 8) | TH_1075 | trpB | 7e-06 | 26.13% (222) | Probable tryptophan synthase, beta subunit trpB |
| M. ulcerans Agy99 | MUL_1592 | trpB | 1e-08 | 27.31% (216) | tryptophan synthase subunit beta |
| M. vanbaalenii PYR-1 | Mvan_2817 | - | 1e-09 | 24.19% (339) | tryptophan synthase subunit beta |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1638|M.bovis_AF2122/97 ---------------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALM
Rv1612|M.tuberculosis_H37Rv ---------------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALM
MUL_1592|M.ulcerans_Agy99 ----MADLSRPDLPRTSSAIAERTSHDPDSGGHFG---AYGGRYVPEALM
MLBr_01272|M.leprae_Br4923 --------MMPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALM
MAV_3174|M.avium_104 MTVDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFG---VYGGRYVAEALM
Mflv_3599|M.gilvum_PYR-GCK ----MVDFAGPDLPRASAAVAEPTPHDPDARGHFG---AYGGRLVPEALM
Mvan_2817|M.vanbaalenii_PYR-1 ----MVDFAGPDLPRASAAVAEPTTHDPDARGHFG---VYGGRYVPEALM
TH_1075|M.thermoresistible__bu ----MADLAGPELPRSSAAVAEPTRHDPDDRGHFG---VYGGRLVAEALM
MSMEG_6740|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1704c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2945|M.marinum_M --------------------------------------------------
Mb1638|M.bovis_AF2122/97 AVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSA
Rv1612|M.tuberculosis_H37Rv AVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSA
MUL_1592|M.ulcerans_Agy99 AVIEEVAVAYEKERVNQDFLDTLDRLQTHYAGRPSPLYEATRLSAHAGSA
MLBr_01272|M.leprae_Br4923 AVIEEVTAAYEKERVNQDFLDLLDKLQANYAGRPSPLYEATRLSEYAGSV
MAV_3174|M.avium_104 AVIEEVTTAYEKERVNQDFLDTLDYLQANYAGRPSPLYEAPRLSEQAG-A
Mflv_3599|M.gilvum_PYR-GCK AVIEEVTAAYEKARSDQTFLDELDRLQRHYTGRPSPLYEAERLSEHAGGA
Mvan_2817|M.vanbaalenii_PYR-1 AVIEEVTAAYEKARGDQTFLDELDRLQKHYTGRPSPVFEAERLSEHAGGA
TH_1075|M.thermoresistible__bu AVIEEVTAAYEKARGDQTFLDELDRLQRHYTGRPSPLYEAVRLSEHAG-V
MSMEG_6740|M.smegmatis_MC2_155 -----------------MAIDDFPRYPLTFG--PSPIHPLERLTKHLGGA
MAB_1704c|M.abscessus_ATCC_199 -----------------MSIHDFARYPLTFG--PSPVHPLQRLSSHLGGA
MMAR_2945|M.marinum_M ---------MNAYLHQRFPELRTTLERVTLGDGPTPVRPLSHLISACP--
*:*: :*
Mb1638|M.bovis_AF2122/97 RIFLKREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGV
Rv1612|M.tuberculosis_H37Rv RIFLKREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGV
MUL_1592|M.ulcerans_Agy99 RIFLKREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGV
MLBr_01272|M.leprae_Br4923 RIFLKREDLN---HTGSHKINNVLGQTLLAQRMGKTRVIAETGAG-QHGV
MAV_3174|M.avium_104 RIFLKREDLN---HTGSHKINNVLGQALLAQRMGKKRVIAETGAG-QHGV
Mflv_3599|M.gilvum_PYR-GCK RIFLKREDLN---HTGSHKINNVLGQALLAKQMGKTRVIAETGAG-QHGV
Mvan_2817|M.vanbaalenii_PYR-1 RIFLKREDLN---HTGSHKINNVLGQALLAKQMGKTRVIAETGAG-QHGV
TH_1075|M.thermoresistible__bu RIFLKREDLS---HTGSHKINNVLGQALLAKQMGKTRVIAETGAG-QHGV
MSMEG_6740|M.smegmatis_MC2_155 QIWAKREDVNSGLAYGGNKTRKLEYLIPDALAQGADTLVSIGGVQSNHTR
MAB_1704c|M.abscessus_ATCC_199 QIWAKREDCNSGLAFGGNKVRKLEYIVPDILASGADTLVSIGGYQSNHTR
MMAR_2945|M.marinum_M SIWIKDDGAYGNGGWGGNKVRKLEWLLPEVRRQRRSTILTFGGLGTNWGL
*: * :. *.:* .:: ::: * :
Mb1638|M.bovis_AF2122/97 ATATACALLGLDCVIYMG-----GIDTARQALNVARMRLLGAEVVAVQTG
Rv1612|M.tuberculosis_H37Rv ATATACALLGLDCVIYMG-----GIDTARQALNVARMRLLGAEVVAVQTG
MUL_1592|M.ulcerans_Agy99 ATATACALLGLECVIYMG-----AVDTARQALNVARMRLLGAEVVAVETG
MLBr_01272|M.leprae_Br4923 ATATACALFGLDCVIYMG-----ALDTARQALNVARMRLLGAEVVSVETG
MAV_3174|M.avium_104 ATATACALLGLECVIYMG-----AVDTERQALNVARMRLLGATVVSVQSG
Mflv_3599|M.gilvum_PYR-GCK ATATACALLGLECVIYMG-----AVDTARQALNVARMRLLGASVVSVESG
Mvan_2817|M.vanbaalenii_PYR-1 ATATACALMGLECVIYMG-----AVDTARQALNVARMRLLGASVVAVESG
TH_1075|M.thermoresistible__bu ATATACALLGLECVIYMG-----AVDTARQALNVARMRLLGAEVVSVEAG
MSMEG_6740|M.smegmatis_MC2_155 QVAAVAAKLGMKAVLVQEKWVDWPDSVNDKVGNILLSRVMGADVRLDASG
MAB_1704c|M.abscessus_ATCC_199 QVAAVAAVLGMRCHLVQERWVDWDDPGNDKVGNILLSRIMGAHTQLDPAG
MMAR_2945|M.marinum_M AATLYAAELGIHTALALID----QPVDEHVEAQLDRLRASGADIYLTRS-
.: .* :*: : :: * ** :
Mb1638|M.bovis_AF2122/97 SKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEA
Rv1612|M.tuberculosis_H37Rv SKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEA
MUL_1592|M.ulcerans_Agy99 SKTLKDAINEAFRDWVTNADRTYYCFGTAAGPHPFPTMVRDFQRIIGMEA
MLBr_01272|M.leprae_Br4923 SRTLKDAINDAFRDWVTNADNTYYCFGTASGPHPFPTMVRDLQRVIGLET
MAV_3174|M.avium_104 SKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIIGLEA
Mflv_3599|M.gilvum_PYR-GCK SKTLKDAINETFRDWVADADNTYYCFGTAAGPHPFPMMVRDFQRVIGMEA
Mvan_2817|M.vanbaalenii_PYR-1 SKTLKDAINETFRDWVTNADNTYYCFGTAAGPHPFPMMVRDFQRVIGLEA
TH_1075|M.thermoresistible__bu SKTLKDAINEAFRDWVTNADSTYYCFGTAAGPHPFPMMVRDFQRVIGLET
MSMEG_6740|M.smegmatis_MC2_155 FGIEFKDSWRNAIEDVKNAGGTPYAIPAGASDHPLGGLG---FANWAYEV
MAB_1704c|M.abscessus_ATCC_199 FDIGIRQSWEEALTAVENAGGKPYPIPAGASEHKYGGLG---FANWAYEV
MMAR_2945|M.marinum_M -----KARTVAAAPYLYLRHRRPYLLPAGG-SSPLGVIG---YVEAAFEL
: * : :.. : . *
Mb1638|M.bovis_AF2122/97 RVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDP-----GVRLVGFEA
Rv1612|M.tuberculosis_H37Rv RVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDP-----GVRLVGFEA
MUL_1592|M.ulcerans_Agy99 RVQIQGQAGKLPDAVVACVGGGSNAIGIFHAFLDDP-----DVRLVGFEA
MLBr_01272|M.leprae_Br4923 RRQIQYQAGRLPDAVTACIGGGSNAIGIFHAFLDDP-----GVRLVGFEA
MAV_3174|M.avium_104 RAQIQAQAGRLPDAVVACIGGGSNAIGIFHPFIDDP-----GVRLVGFEA
Mflv_3599|M.gilvum_PYR-GCK RAQMLDQAGRLPDAVVACVGGGSNAIGIFHAFIDDP-----GVDLIGYEA
Mvan_2817|M.vanbaalenii_PYR-1 RAQMLDQAGRLPDAVVACVGGGSNAIGIFHAFIDDP-----GVQLVGYEA
TH_1075|M.thermoresistible__bu RAQIQAQAGRLPDAVTACIGGGSNAIGIFHAFIDDP-----GVRLIGFEA
MSMEG_6740|M.smegmatis_MC2_155 QRQEQ-ELGVFFDTIVVCTVTGSTHAGMIAGFAGQN----RPRRVIGIDA
MAB_1704c|M.abscessus_ATCC_199 AAQEE-QLGVFFDTIVVCTVTGSTHAGMIAGFAALADAGGPPRRVLGIDA
MMAR_2945|M.marinum_M AAQLRDGALPTPSSIVTAVGSGGTVAGLHLGLTLAG---LTDIQVIGVVV
* .::... *.. *: : ::* .
Mb1638|M.bovis_AF2122/97 AGDGVETGRHAATFTAGSPGAFHG-SFSYLLQDEDGQTIESHSISAGLDY
Rv1612|M.tuberculosis_H37Rv AGDGVETGRHAATFTAGSPGAFHG-SFSYLLQDEDGQTIESHSISAGLDY
MUL_1592|M.ulcerans_Agy99 AGDGVETGRHAATFAGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDY
MLBr_01272|M.leprae_Br4923 AGDGVETGRHAATLTGGLPGAFQG-TFSYLLQDEDGQTIESHSIAAGLDY
MAV_3174|M.avium_104 AGDGVETGRHAATFSGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDY
Mflv_3599|M.gilvum_PYR-GCK AGDGVETGRHAATFTGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDY
Mvan_2817|M.vanbaalenii_PYR-1 AGEGVETGRHAATFTGGSPGAFQG-SYSYLLQDEDGQTIESHSISAGLDY
TH_1075|M.thermoresistible__bu AGDGVETGRHAATFTGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDY
MSMEG_6740|M.smegmatis_MC2_155 SATIDKTREQVTRIARNTADRIG------LGRDLHDDEITVLEGWAGELY
MAB_1704c|M.abscessus_ATCC_199 SATLTQTTDQVTRIARHTADQIG------LERELRPEEITVLEGWAGEKY
MMAR_2945|M.marinum_M NDKLRLDHRSITSLARRAARLLQDRGAKLPSIDLPAERLTLLRDWLGPGY
: :: . : : : : * *
Mb1638|M.bovis_AF2122/97 PGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIP-AIESAHAV
Rv1612|M.tuberculosis_H37Rv PGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIP-AIESAHAV
MUL_1592|M.ulcerans_Agy99 PGVGPEHAWLKDIGRVTYQPITDSEAMEAFGLLCRMEGIIP-AIESAHAV
MLBr_01272|M.leprae_Br4923 PGVGPEHAWLRETGRAEYQPITDSEAIEAFRLLCRTEGILP-ALESAHAV
MAV_3174|M.avium_104 PGVGPEHAYLRETGRAEYRPITDAEAMDAFRVLCRTEGIIP-AIESAHAV
Mflv_3599|M.gilvum_PYR-GCK PGVGPEHALLKDVGRARYLPITDSEAMDALSLLSRTEGIIP-AIESAHAI
Mvan_2817|M.vanbaalenii_PYR-1 PGVGPEHALLKDVGRAQYRPITDTEAMDALSLLSRTEGIIP-AIESAHAV
TH_1075|M.thermoresistible__bu PGVGPEHAHLKDVGRAEYRPITDAEAMDAFALLCRTEGIIP-AIESAHAV
MSMEG_6740|M.smegmatis_MC2_155 G-------------------IPVQSTIDAIKLTGRLEGVILDPVYEGKSM
MAB_1704c|M.abscessus_ATCC_199 G-------------------VPVDSTIEAIQLCGRLEAMITDPVYEGKSM
MMAR_2945|M.marinum_M G-------------------HPTSQGTLALKLARESEHLDLEPVYTAKAM
. . *: : . * : .: .:::
Mb1638|M.bovis_AF2122/97 AGALKLG--VELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND-------
Rv1612|M.tuberculosis_H37Rv AGALKLG--VELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND-------
MUL_1592|M.ulcerans_Agy99 AGALKLG--RELGKGAVIVVNLSGRGDKDVETAAKWFGLLTPGGSANKSV
MLBr_01272|M.leprae_Br4923 AGALKLA--SEIGKGAVIVVNLSGRGDKDIEAAAKWFGLLGTR-------
MAV_3174|M.avium_104 AGALKLG--PELGRGAIIVVNLSGRGDKDVETAAKWFGLLGSSDR-----
Mflv_3599|M.gilvum_PYR-GCK AGALKLG--VERGPGTVILVNLSGRGDKDVETAAKWFGLMEDGAR-----
Mvan_2817|M.vanbaalenii_PYR-1 AGALKLG--GELGPGSIILVNVSGRGDKDVETAAKWFGLLEDGTK-----
TH_1075|M.thermoresistible__bu AGALKLG--PELGSDAIVVVNLSGRGDKDVETAAKWFDLLDTGGAG----
MSMEG_6740|M.smegmatis_MC2_155 AGLIDLVRSGEIPPSSTVLYAHLG-GQPALNAYSGIF-------------
MAB_1704c|M.abscessus_ATCC_199 AGLIDLVTNGTIEPGSTVLYAHLG-GQPALNAYSGAFTG-----------
MMAR_2945|M.marinum_M AALLDLTTSGRLPVGPTLYLHTNGPR------------------------
*. :.* .. : *