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SIHDFARYPLTFGPSPVHPLQRLSSHLGGAQIWAKREDCNSGLAFGGNKVRKLEYIVPDILASGADTLVS IGGYQSNHTRQVAAVAAVLGMRCHLVQERWVDWDDPGNDKVGNILLSRIMGAHTQLDPAGFDIGIRQSWE EALTAVENAGGKPYPIPAGASEHKYGGLGFANWAYEVAAQEEQLGVFFDTIVVCTVTGSTHAGMIAGFAA LADAGGPPRRVLGIDASATLTQTTDQVTRIARHTADQIGLERELRPEEITVLEGWAGEKYGVPVDSTIEA IQLCGRLEAMITDPVYEGKSMAGLIDLVTNGTIEPGSTVLYAHLGGQPALNAYSGAFTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1704c | - | - | 100% (340) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. abscessus ATCC 19977 | MAB_2644c | - | 1e-06 | 24.57% (232) | tryptophan synthase subunit beta |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1638 | trpB | 8e-05 | 24.89% (225) | tryptophan synthase subunit beta |
| M. gilvum PYR-GCK | Mflv_3599 | - | 1e-06 | 24.22% (351) | tryptophan synthase subunit beta |
| M. tuberculosis H37Rv | Rv1612 | trpB | 8e-05 | 24.89% (225) | tryptophan synthase subunit beta |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2945 | - | 4e-27 | 30.91% (330) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_6740 | - | 1e-146 | 74.56% (338) | 1-aminocyclopropane-1-carboxylate deaminase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1592 | trpB | 3e-05 | 23.28% (232) | tryptophan synthase subunit beta |
| M. vanbaalenii PYR-1 | Mvan_2817 | - | 2e-07 | 24.42% (344) | tryptophan synthase subunit beta |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1638|M.bovis_AF2122/97 -----------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIE
Rv1612|M.tuberculosis_H37Rv -----------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIE
MUL_1592|M.ulcerans_Agy99 MADLSRPDLPRTSSAIAERTSHDPDSGGHFG---AYGGRYVPEALMAVIE
Mflv_3599|M.gilvum_PYR-GCK MVDFAGPDLPRASAAVAEPTPHDPDARGHFG---AYGGRLVPEALMAVIE
Mvan_2817|M.vanbaalenii_PYR-1 MVDFAGPDLPRASAAVAEPTTHDPDARGHFG---VYGGRYVPEALMAVIE
MAB_1704c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6740|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2945|M.marinum_M --------------------------------------------------
Mb1638|M.bovis_AF2122/97 EVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFL
Rv1612|M.tuberculosis_H37Rv EVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFL
MUL_1592|M.ulcerans_Agy99 EVAVAYEKERVNQDFLDTLDRLQTHYAGRPSPLYEATRLSAHAGSARIFL
Mflv_3599|M.gilvum_PYR-GCK EVTAAYEKARSDQTFLDELDRLQRHYTGRPSPLYEAERLSEHAGGARIFL
Mvan_2817|M.vanbaalenii_PYR-1 EVTAAYEKARGDQTFLDELDRLQKHYTGRPSPVFEAERLSEHAGGARIFL
MAB_1704c|M.abscessus_ATCC_199 -------------MSIHDFARYPLTFG--PSPVHPLQRLSSHLGGAQIWA
MSMEG_6740|M.smegmatis_MC2_155 -------------MAIDDFPRYPLTFG--PSPIHPLERLTKHLGGAQIWA
MMAR_2945|M.marinum_M -----MNAYLHQRFPELRTTLERVTLGDGPTPVRPLSHLISACP--SIWI
*:*: :* *:
Mb1638|M.bovis_AF2122/97 KREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGVATAT
Rv1612|M.tuberculosis_H37Rv KREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGVATAT
MUL_1592|M.ulcerans_Agy99 KREDLN---HTGSHKINNVLGQALLARRMGKTRVIAETGAG-QHGVATAT
Mflv_3599|M.gilvum_PYR-GCK KREDLN---HTGSHKINNVLGQALLAKQMGKTRVIAETGAG-QHGVATAT
Mvan_2817|M.vanbaalenii_PYR-1 KREDLN---HTGSHKINNVLGQALLAKQMGKTRVIAETGAG-QHGVATAT
MAB_1704c|M.abscessus_ATCC_199 KREDCNSGLAFGGNKVRKLEYIVPDILASGADTLVSIGGYQSNHTRQVAA
MSMEG_6740|M.smegmatis_MC2_155 KREDVNSGLAYGGNKTRKLEYLIPDALAQGADTLVSIGGVQSNHTRQVAA
MMAR_2945|M.marinum_M KDDGAYGNGGWGGNKVRKLEWLLPEVRRQRRSTILTFGGLGTNWGLAATL
* :. *.:* .:: ::: * : .:
Mb1638|M.bovis_AF2122/97 ACALLGLDCVIYMG-----GIDTARQALNVARMRLLGAEVVAVQTGSKTL
Rv1612|M.tuberculosis_H37Rv ACALLGLDCVIYMG-----GIDTARQALNVARMRLLGAEVVAVQTGSKTL
MUL_1592|M.ulcerans_Agy99 ACALLGLECVIYMG-----AVDTARQALNVARMRLLGAEVVAVETGSKTL
Mflv_3599|M.gilvum_PYR-GCK ACALLGLECVIYMG-----AVDTARQALNVARMRLLGASVVSVESGSKTL
Mvan_2817|M.vanbaalenii_PYR-1 ACALMGLECVIYMG-----AVDTARQALNVARMRLLGASVVAVESGSKTL
MAB_1704c|M.abscessus_ATCC_199 VAAVLGMRCHLVQERWVDWDDPGNDKVGNILLSRIMGAHTQLDPAGFDIG
MSMEG_6740|M.smegmatis_MC2_155 VAAKLGMKAVLVQEKWVDWPDSVNDKVGNILLSRVMGADVRLDASGFGIE
MMAR_2945|M.marinum_M YAAELGIHTALALID----QPVDEHVEAQLDRLRASGADIYLTRS-----
.* :*: : :: * ** :
Mb1638|M.bovis_AF2122/97 KDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQI
Rv1612|M.tuberculosis_H37Rv KDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQI
MUL_1592|M.ulcerans_Agy99 KDAINEAFRDWVTNADRTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQI
Mflv_3599|M.gilvum_PYR-GCK KDAINETFRDWVADADNTYYCFGTAAGPHPFPMMVRDFQRVIGMEARAQM
Mvan_2817|M.vanbaalenii_PYR-1 KDAINETFRDWVTNADNTYYCFGTAAGPHPFPMMVRDFQRVIGLEARAQM
MAB_1704c|M.abscessus_ATCC_199 IRQSWEEALTAVENAGGKPYPIPAGASEHKYGGLG---FANWAYEVAAQE
MSMEG_6740|M.smegmatis_MC2_155 FKDSWRNAIEDVKNAGGTPYAIPAGASDHPLGGLG---FANWAYEVQRQE
MMAR_2945|M.marinum_M -KARTVAAAPYLYLRHRRPYLLPAGG-SSPLGVIG---YVEAAFELAAQL
: * : :.. : . * *
Mb1638|M.bovis_AF2122/97 QGQAGRLPDAVVACVGGGSNAIGIFHAFLDDP-----GVRLVGFEAAGDG
Rv1612|M.tuberculosis_H37Rv QGQAGRLPDAVVACVGGGSNAIGIFHAFLDDP-----GVRLVGFEAAGDG
MUL_1592|M.ulcerans_Agy99 QGQAGKLPDAVVACVGGGSNAIGIFHAFLDDP-----DVRLVGFEAAGDG
Mflv_3599|M.gilvum_PYR-GCK LDQAGRLPDAVVACVGGGSNAIGIFHAFIDDP-----GVDLIGYEAAGDG
Mvan_2817|M.vanbaalenii_PYR-1 LDQAGRLPDAVVACVGGGSNAIGIFHAFIDDP-----GVQLVGYEAAGEG
MAB_1704c|M.abscessus_ATCC_199 E-QLGVFFDTIVVCTVTGSTHAGMIAGFAALADAGGPPRRVLGIDASATL
MSMEG_6740|M.smegmatis_MC2_155 Q-ELGVFFDTIVVCTVTGSTHAGMIAGFAGQN----RPRRVIGIDASATI
MMAR_2945|M.marinum_M RDGALPTPSSIVTAVGSGGTVAGLHLGLTLAG---LTDIQVIGVVVNDKL
.::*... *.. *: .: ::* .
Mb1638|M.bovis_AF2122/97 VETGRHAATFTAGSPGAFHG-SFSYLLQDEDGQTIESHSISAGLDYPGVG
Rv1612|M.tuberculosis_H37Rv VETGRHAATFTAGSPGAFHG-SFSYLLQDEDGQTIESHSISAGLDYPGVG
MUL_1592|M.ulcerans_Agy99 VETGRHAATFAGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDYPGVG
Mflv_3599|M.gilvum_PYR-GCK VETGRHAATFTGGSPGAFQG-SFSYLLQDEDGQTIESHSISAGLDYPGVG
Mvan_2817|M.vanbaalenii_PYR-1 VETGRHAATFTGGSPGAFQG-SYSYLLQDEDGQTIESHSISAGLDYPGVG
MAB_1704c|M.abscessus_ATCC_199 TQTTDQVTRIARHTADQIG------LERELRPEEITVLEGWAGEKYG---
MSMEG_6740|M.smegmatis_MC2_155 DKTREQVTRIARNTADRIG------LGRDLHDDEITVLEGWAGELYG---
MMAR_2945|M.marinum_M RLDHRSITSLARRAARLLQDRGAKLPSIDLPAERLTLLRDWLGPGYG---
: :: :. : : : : * *
Mb1638|M.bovis_AF2122/97 PEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIP-AIESAHAVAGAL
Rv1612|M.tuberculosis_H37Rv PEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIP-AIESAHAVAGAL
MUL_1592|M.ulcerans_Agy99 PEHAWLKDIGRVTYQPITDSEAMEAFGLLCRMEGIIP-AIESAHAVAGAL
Mflv_3599|M.gilvum_PYR-GCK PEHALLKDVGRARYLPITDSEAMDALSLLSRTEGIIP-AIESAHAIAGAL
Mvan_2817|M.vanbaalenii_PYR-1 PEHALLKDVGRAQYRPITDTEAMDALSLLSRTEGIIP-AIESAHAVAGAL
MAB_1704c|M.abscessus_ATCC_199 ----------------VPVDSTIEAIQLCGRLEAMITDPVYEGKSMAGLI
MSMEG_6740|M.smegmatis_MC2_155 ----------------IPVQSTIDAIKLTGRLEGVILDPVYEGKSMAGLI
MMAR_2945|M.marinum_M ----------------HPTSQGTLALKLARESEHLDLEPVYTAKAMAALL
. . *: * . * : .: .:::*. :
Mb1638|M.bovis_AF2122/97 KLG--VELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND-------
Rv1612|M.tuberculosis_H37Rv KLG--VELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND-------
MUL_1592|M.ulcerans_Agy99 KLG--RELGKGAVIVVNLSGRGDKDVETAAKWFGLLTPGGSANKSV
Mflv_3599|M.gilvum_PYR-GCK KLG--VERGPGTVILVNLSGRGDKDVETAAKWFGLMEDGAR-----
Mvan_2817|M.vanbaalenii_PYR-1 KLG--GELGPGSIILVNVSGRGDKDVETAAKWFGLLEDGTK-----
MAB_1704c|M.abscessus_ATCC_199 DLVTNGTIEPGSTVLYAHLG-GQPALNAYSGAFTG-----------
MSMEG_6740|M.smegmatis_MC2_155 DLVRSGEIPPSSTVLYAHLG-GQPALNAYSGIF-------------
MMAR_2945|M.marinum_M DLTTSGRLPVGPTLYLHTNGPR------------------------
.* .. : *